1-Fluoro-3-Methyl-2-Nitrobenzene

Hongda Chemical

Specifications

HS Code	109566
Chemical Formula	C7H6FNO2
Molecular Weight	155.13
Appearance	liquid
Color	yellowish
Odor	characteristic
Boiling Point	213 - 214 °C
Melting Point	N/A
Density	1.307 g/cm³
Solubility In Water	insoluble
Solubility In Organic Solvents	soluble in common organic solvents
Flash Point	92 °C
Refractive Index	1.536

As an accredited 1-Fluoro-3-Methyl-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 1 - fluoro - 3 - methyl - 2 - nitrobenzene packaged in a sealed, corrosion - resistant bottle.
Storage	1 - fluoro - 3 - methyl - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources to prevent fire and explosion risks. It should be kept in a tightly - sealed container to avoid contact with air and moisture, which could potentially lead to decomposition or other chemical reactions. Store it separately from incompatible substances like oxidizing agents and reducing agents.
Shipping	1 - fluoro - 3 - methyl - 2 - nitrobenzene, a chemical, must be shipped in accordance with strict hazardous materials regulations. Use properly labeled, sturdy containers to prevent leakage, and ensure carriers are certified for such chemicals.

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General Information

Historical Development

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is also a product of chemistry. Looking at the history of its development, chemists in the past have gone through countless arduous attempts when exploring new substances. At the beginning, the research on benzene compounds containing fluorine, methyl and nitro groups was still shallow, only that their structures were unique and their properties or specificities were known.
At that time, many researchers tried to synthesize this compound by different methods. Or in a simple laboratory, with basic chemical raw materials and complicated reaction steps, it was hoped that this product could be obtained. Although there were many failures, it was not abandoned.
With the gradual development of science and technology, the analytical methods became more refined, and the understanding of the reaction mechanism became deeper. Chemists have improved the synthesis method to improve the yield and purity. As a result, 1-Fluoro-3-Methyl-2-Nitrobenzene has gradually emerged in the field of chemical research from the hazy exploration to the clear preparation, laying the foundation for many subsequent studies and opening a new chapter.

Product Overview

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is an organic compound. Its properties are yellowish in color, like oily liquid, with a special smell.
This compound is widely used in the field of organic synthesis. Due to the unique electronic effect and steric resistance of fluorine atoms, methyl and nitro groups, it is endowed with special chemical activity. It can be used as a key intermediate for the preparation of various drugs, pesticides and functional materials.
Preparation of 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene often goes through a multi-step reaction. First, a specific aromatic hydrocarbon is used as the starting material, nitro is introduced through nitrification reaction, then fluorine atoms are introduced through halogenation reaction, and finally methyl is introduced by a suitable method.
However, the preparation process needs to pay attention to the precise control of the reaction conditions. Each step of the reaction requires strict requirements on temperature, catalyst, and reactant ratio. A slight deviation will affect the purity and yield of the product. And this compound has certain toxicity and irritation, and safety procedures must be strictly followed during operation. Take protective measures.

Physical & Chemical Properties

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, it may be liquid at room temperature, and it is slightly yellow in color or transparency. Its boiling point and melting point are fixed, which is related to the strength of the intermolecular force. For boiling point, due to the existence of van der Waals force between molecules, a specific energy is required to overcome it and make it gasify. The same is true for the melting point, which is related to the lattice energy.
On its chemistry, fluorine atoms have strong electronegativity, which changes the density of the ortho-electron cloud and affects the activity of nucleophilic and electrophilic reactions. Methyl-powered ions increase the density of the electron cloud of the benzene ring, which is conducive to electrophilic substitution. The nitro group is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring and also affects the selectivity of the reaction check point. These many properties are of important use in the fields of organic synthesis, and scholars should study them in detail.

Technical Specifications & Labeling

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is also a chemical product. Its process regulations and identification (commodity parameters) are very important. If you want to make this product, you should follow the delicate method. First take an appropriate amount of raw materials, measure them accurately, and place them in a special device in sequence. Control its temperature and pressure to make the reaction go smoothly.
As for the logo, when you specify its name, the book "1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene" cannot be wrong. Repeat its purity, properties and other parameters. Purity must be recorded with precise numbers, and the properties describe its color, state, taste, etc. In this way, the process regulations and labeling of this chemical can be made clear, which is beneficial to people and the industry.

Preparation Method

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is an important compound in organic synthesis. The preparation method is as follows:
In terms of raw materials, 3 - Methyl - 2 - Nitrobenzenamine is used as the starting material. In the preparation process, 3 - Methyl - 2 - Nitrobenzenamine is mixed with an appropriate amount of hydrofluoric acid and stirred in a low temperature environment to make it fully contacted. Then, slowly add the sodium nitrite solution. This process requires strict control of the reaction temperature and drip rate. The reaction undergoes a diazotization reaction to form a diazonium salt intermediate.
Next, the intermediate undergoes a substitution reaction in the hydrofluoric acid environment, and the fluorine atom replaces the diazo group to obtain 1-Fluoro-3-Methyl-2-Nitrobenzene.
In the post-treatment stage, after the reaction is completed, the reaction liquid is poured into ice water, the solid is precipitated, the solid is collected by filtration, and washed with cold water for many times to remove impurities. Then recrystallization is carried out in an organic solvent to further purify the product, and finally the high purity 1-Fluoro-3-Methyl-2-Nitrobenzene is obtained.

Chemical Reactions & Modifications

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is an important intermediate in organic synthesis. The chemical reaction and modification involved in its synthesis are related to the delicacy of the chemical process.
In the synthesis reaction, the ratio of raw materials, reaction temperature and duration are all key elements. Specific fluorides, methylating reagents and nitrifying reagents are used as raw materials and react under suitable conditions. The introduction of fluorine atoms often requires precise control because of its high activity and easy to trigger side reactions.
The modification of this compound is designed to optimize its properties. Or by changing the substituent or adjusting the molecular structure, its stability and reactivity can be improved. After modification, the compound may have better application prospects in the fields of medicine and materials. Through in-depth study of its chemical reaction and modification, it is expected to open up new synthesis paths and contribute to the development of the chemical industry.

Synonyms & Product Names

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene, its synonyms and trade name, are really the key to chemical research. The study of Fu Gu is very strict in the name of the object. Today's 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene, synonymous or named according to its structural characteristics, and also named according to its chemical properties. Trade names vary depending on factors such as marketing and use by merchants. Or because of the unique effect of the substance in a certain type of reaction, merchants name it to highlight its characteristics. Its synonyms can help researchers communicate accurately and clarify the meaning; trade names are easy to circulate in the market and be known by people. Therefore, a detailed study of the synonyms and trade names of 1-Fluoro-3-Methyl-2-Nitrobenzene is of great benefit to chemical research and industrial applications.

Safety & Operational Standards

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is also a chemical product. Its safe operation is not to be ignored.
The quality, storage, and use of this product are all safe. This is the key, and the operator is responsible for the basic operation of the chemical. The equipment used must be clean and intact to prevent the mixing, causing disorder and accidents.
The quality of the product needs to be clean, dry and clear.
1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene or affected by factors such as degree, degree, and space. If it is used in a tidal place, or due to water invasion, it may cause damage or even ignition.
To use this equipment, the operator must use appropriate anti-toxins, such as protective clothing, gloves, eyes, etc. This is to protect the body from toxins, muscles, and eyes. The operation should be carried out in the common environment, so that the equipment can be arranged quickly, not in the room, and avoid inhalation, which is harmful to health.
If you accidentally contact this object, it will cause damage to the skin, eyes, or food or inhalation, which is a quick way to perform first aid. When the skin is connected, wash it immediately with a lot of water; when the eyes are connected, be especially careful, and also use clean water to wash it, and ask for it quickly. Feeding and inhaling, let alone delay, urgent delivery and treatment, do not delay.
Of course, 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene safety operation, the most important thing. The operator must be careful, and keep this situation, so as to ensure safety, avoid danger, and make research and production work.

Application Area

1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is a unique chemical substance. In many application fields, it shows unique efficacy. In the field of pharmaceutical research and development, because of its special molecular structure, it may be a key starting material for the creation of new drugs, helping medical researchers to open up new treatment paths. In the field of materials science, this compound may participate in the synthesis of special materials, giving materials unique properties, such as enhancing their stability or unique optical properties. And in the fine chemical industry, it may be used as a key intermediate to prepare high-end fine chemicals to meet different industrial needs. From this perspective, 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene plays an important role in many application fields, providing potential help and opportunities for the development of related fields.

Research & Development

In the field of chemical industry, new products are emerging one after another. 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene is also the object of our dedicated research. Its unique nature is related to many reaction mechanisms, which is the key to the field of organic synthesis.
We gather in the research room and operate day and night. At first, we analyzed its structure, explored its physical and chemical properties, and then found a way to prepare it. After several years of repeated attempts and changes, it was difficult to express. However, everyone has a firm will and is determined.
Looking at this product today, the preparation method is gradually becoming more refined, and the yield has also increased. And its application prospects in medicine and materials are also becoming clearer. Although the road ahead is still long, we firmly believe that with time, we will be able to make great achievements in the research and development of 1-Fluoro-3-Methyl-2-Nitrobenzene, which will contribute to the rise of chemical industry.

Toxicity Research

Since modern times, chemical refinement has made all kinds of compounds appear in the world. Today there is 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene, and the study of its toxicity is crucial.
Considering this substance, its molecular structure is unique, fluorine, methyl and nitro co-structure on the benzene ring. The nature of nitro groups is active and potentially harmful. The whole picture of its toxicity has not been studied in detail in the past, but it should be explored in depth now.
To clarify its toxicity, multiple methods need to be applied. Observe its effects on physiological functions of organisms, such as organ damage and behavioral abnormalities, through animal experiments. Supplemented by cell experiments, observe its effects on cell metabolism and proliferation.
And the migration and transformation path of this substance in the environment is also related to ecotoxicity. If it accidentally flows into water bodies, soils, and biological communities, it will be threatened. Therefore, a detailed study of the toxicity of 1-Fluoro-3-Methyl-2-Nitrobenzene is of great significance in ensuring the well-being of organisms and maintaining ecological stability.

Future Prospects

I have studied the product of 1 - Fluoro - 3 - Methyl - 2 - Nitrobenzene. Looking at this product, its nature is very different, and it is quite promising among all things.
Although the technique is limited today, it looks forward to the future, and its path is bright. It can be expanded in the field of medicine, and it can be used in the field of medicine, or it can be used to make special agents, to heal all kinds of diseases. It is also expected to be used in the creation of materials, to add new energy, and to meet all needs.
Although there may be thorns in the road ahead, we researchers must be determined. Concentrate our efforts, and use our magic, hoping to be able to develop the power of this product to the best of our ability. Looking forward to the near future, we can see it shining brightly, being used by the world and benefiting all people, which is our grand hope for the future.

Where to Buy 1-Fluoro-3-Methyl-2-Nitrobenzene in China?

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Frequently Asked Questions

As a leading 1-Fluoro-3-Methyl-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-3-Methyl-2-Nitrobenzene?

1-Fluoro-3-methyl-2-nitrobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
First, it can be used to create medicine. Due to the characteristics of fluorine, methyl and nitro groups attached to the benzene ring, it can be modified by chemical reaction to meet the structural requirements of specific drug molecules, and help to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. Pharmaceutical developers start with it, and through multi-step reactions, modify functional groups, and then form pharmaceutical ingredients with specific biological activities.
Second, in the field of pesticides, this compound is also very useful. It can be synthesized and transformed to produce pesticides, fungicides and other pesticides. With its special chemical structure, it has a unique mechanism of action against pests and pathogens, or interferes with its physiological metabolism, or destroys its cell structure, in order to control pests and diseases and protect the growth of crops.
Third, in the field of materials science, 1-fluoro-3-methyl-2-nitrobenzene can be used as a raw material for synthesizing special materials. After polymerization or reaction with other monomers, it can endow materials with special properties, such as improving the heat resistance and corrosion resistance of materials, or adjusting their electrical properties, and has potential applications in high-end fields such as electronics and aerospace.
In conclusion, although 1-fluoro-3-methyl-2-nitrobenzene is a small organic molecule, it is the cornerstone of organic synthesis in many fields such as medicine, pesticides, and materials due to its unique structure, promoting the progress and development of various industries.

What are the physical properties of 1-Fluoro-3-Methyl-2-Nitrobenzene?

1-Fluoro-3-methyl-2-nitrobenzene, its physical properties are as follows:
This substance is mostly liquid at room temperature. Looking at it, it is a colorless to light yellow transparent liquid with a special smell. However, the smell is not fragrant and pleasant, but rather irritating, and the smell is pungent.
Its density is slightly larger than that of water, about [X] g/cm ³, so if mixed with water, it will sink to the bottom. The melting point is in the [specific melting point range], and the boiling point is in the [specific boiling point range].
In terms of solubility, it is extremely difficult to dissolve in water. Due to the characteristics of its molecular structure, it is difficult to form effective interactions with water molecules. However, in organic solvents, such as ethanol, ether, acetone, etc., it exhibits good solubility and can be miscible with these organic solvents in any ratio.
In addition, 1-fluoro-3-methyl-2-nitrobenzene is volatile and will evaporate slowly in the air. Its vapor is also irritating and can cause irritation to the human respiratory tract and eyes. When storing, store in a cool and ventilated place, away from fire and heat sources to prevent the concentration from increasing due to volatilization and causing safety hazards.

What is the chemistry of 1-Fluoro-3-Methyl-2-Nitrobenzene?

1-Fluoro-3-methyl-2-nitrobenzene, an organic compound, has unique and important chemical properties.
First of all, the fluorine atom has extremely high electronegativity, resulting in strong C-F bond energy. This property not only makes the molecular structure more stable, but also greatly affects the polarity and reactivity of the molecule. Because of its strong electron absorption, it can change the electron cloud density distribution of the benzene ring, so that the electron cloud density of the benzene ring is reduced. Therefore, in the electrophilic substitution reaction, the ortho and para are more difficult to be attacked by electrophilic reagents, and the interposition is relatively easier, and the reaction check point is shifted.
Looking at methyl group again, which is the power supply group, will increase the electron cloud density of the benzene ring. During the electrophilic substitution reaction, the reactivity can be improved, and the reaction is more inclined to ortho and para-substitution. However, in this compound, due to the influence of fluorine and nitro groups, its role may change.
Nitro is a strong electron-absorbing group, which has a strong attraction to the benzene ring electron cloud, significantly reducing the electron cloud density of the benzene ring, making the activity of the benzene ring significantly reduced, and the electrophilic substitution reaction is more difficult to occur. At the same time, nitro can participate in the reduction reaction and can be reduced to other groups such as amino groups, thereby realizing the structural transformation and functional derivatization of the compound.
In some organic synthesis reactions, 1-fluoro-3-methyl-2-nitrobenzene can be used as a key intermediate. Due to its different substituent properties, a group can be selectively reacted according to specific reaction conditions and requirements to synthesize a variety of complex organic compounds.
Its chemical properties are complex and interrelated, and each substituent affects each other, showing unique value and application potential in the field of organic synthesis chemistry.

What are 1-Fluoro-3-Methyl-2-Nitrobenzene synthesis methods?

The synthesis method of 1-fluoro-3-methyl-2-nitrobenzene has been around for a long time. There are many methods, and I will describe them in detail today.
First, 3-methyl-2-nitroaniline is used as the starting material. First, this raw material is mixed with an appropriate amount of hydrofluoric acid and sodium nitrite, and stirred slowly in a low temperature environment. At this time, a diazotization reaction occurs to form a diazosalt. Then, the diazosalt is decomposed under heat, and the fluorine atom replaces the diazoyl group to obtain 1-fluoro-3-methyl-2-nitrobenzene. This process requires fine control of temperature and reaction time. If the temperature is too high, the side reactions will increase, and if the time is too short, the reaction will be incomplete.
Second, 3-methylanisole is used as the starting material. It is first nitrified. The mixed acid of nitric acid and sulfuric acid is used as the nitrifying reagent. At a suitable temperature, the nitro group is introduced into the benzene ring to form 3-methyl-2-nitroanisole. Subsequently, the product is reacted with anhydrous hydrofluoric acid in the presence of a specific catalyst, and the methoxy group is replaced by a fluorine atom. After a series of post-treatments, the target product can also be obtained. In this path, special attention should be paid to the localization selectivity of the nitrification reaction, and the choice and dosage of the catalyst
Third, m-methylphenol is used as the starting material. First nitrate with nitric acid to obtain 3-methyl-2-nitrophenol. After that, the product is reacted with fluorinated reagents such as potassium fluoride under appropriate solvents and conditions, and the hydroxyl group is replaced by fluorine atoms. After purification, 1-fluoro-3-methyl-2-nitrobenzene is finally obtained. In this method, the fluorination reaction conditions are more stringent, and the requirements for solvents and reaction equipment are higher.
All synthesis methods have advantages and disadvantages. Careful choices should be made according to the actual situation, such as the availability of raw materials, cost, product purity requirements, etc., in order to achieve the desired synthesis effect.

What are the precautions in storage and transportation of 1-Fluoro-3-Methyl-2-Nitrobenzene?

1-Fluoro-3-methyl-2-nitrobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound has a certain degree of activity, and should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, due to light or promote photochemical reactions, causing it to deteriorate. And must be kept away from fires and heat sources to prevent fires. Because of its flammability, there is a risk of combustion and explosion in case of open flames and hot topics.
Furthermore, the storage place should be separated from oxidants, reducing agents, alkalis, etc., and must not be mixed. It may cause severe chemical reactions with other substances and cause danger. The storage area should also be equipped with suitable materials to contain leaks to prevent accidental leakage and deal with them in a timely manner.
As for transportation, it should not be neglected. The transportation vehicle must ensure that the vehicle is in good condition and has corresponding safety facilities. During transportation, it is necessary to prevent exposure to the sun, rain and high temperature. When loading and unloading, the operation should be light and light. It is strictly forbidden to drop and heavy pressure to avoid damage to the packaging and leakage of materials.
The escort personnel should also be familiar with the characteristics of this compound and emergency treatment methods. Once there is an accident such as leakage on the way, it can be dealt with quickly according to the established emergency plan to ensure the safety of personnel and the environment from pollution. Therefore, when storing and transporting 1-fluoro-3-methyl-2-nitrobenzene, risks can be minimized and everything goes smoothly.