1-Fluoro-3-Isocyanatobenzene

Hongda Chemical

Specifications

HS Code	392704
Chemical Formula	C7H4FNO
Molar Mass	137.11 g/mol
Appearance	Liquid (usually)
Boiling Point	203 - 205 °C
Density	1.19 g/cm³ (approximate)
Vapor Pressure	Low at room temperature
Solubility	Slightly soluble in water, soluble in organic solvents like dichloromethane
Flash Point	78 °C
Hazard Class	Toxic, irritant (can cause harm to health and skin/eye irritation)

As an accredited 1-Fluoro-3-Isocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - fluoro - 3 - isocyanatobenzene packaged in 500 - gram bottles for chemical use.
Storage	1 - fluoro - 3 - isocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture. Store it separately from incompatible substances like acids, bases, and reducing agents to avoid potential reactions. Follow proper safety regulations during storage.
Shipping	1 - fluoro - 3 - isocyanatobenzene is shipped in accordance with strict chemical regulations. It's packaged securely in appropriate containers, often with hazard labels, and transported by carriers experienced in handling such chemicals, ensuring safety during transit.

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General Information

Historical Development

1 - Fluoro - 3 - Isocyanatobenzene is the chemical compound of today. Back to its origin, chemists at the beginning dedicated themselves to the expansion of organic synthesis and worked tirelessly to create new compounds. At that time, in the exploration of various transformation paths of benzene derivatives, this unique structure molecule was accidentally discovered.
In the early days, limited by experimental equipment and technical standards, the research progress of this substance was delayed. However, with the passage of time, science and technology have become more advanced, and analytical methods have become more refined, so as to gain in-depth insight into its chemical properties and reaction mechanism. Many chemists have devoted themselves to it, and through repeated trials, they have improved the synthesis method and improved the purity and yield of the product.
Since its inception, 1 - Fluoro - 3 - Isocyanatobenzene has emerged in various fields such as medicinal chemistry and materials science, becoming an indispensable intermediate, promoting the continuous progress of related disciplines, and leaving a strong impression in the long road of chemical development.

Product Overview

1 - Fluoro-3 - Isocyanatobenzene is a compound of organic chemistry. It is a colorless to pale yellow liquid with unique chemical properties. This substance contains fluorine atoms and isocyanate groups, giving it special reactivity.
The introduction of fluorine atoms changes the distribution of its electron cloud and enhances the stability and lipophilicity of the compound. The isocyanate group is extremely active and can react rapidly with many active hydrogen-containing compounds, such as alcohols and amines, to form urethane, urea and other derivatives.
In the field of organic synthesis, 1 - Fluoro-3 - Isocyanatobenzene is often the key intermediary. By ingeniously designing reaction paths, it can be used to synthesize a variety of organic materials with special functions, which can be used in the fields of medicine, pesticides, and polymer materials. It is an important compound that cannot be ignored in organic chemistry research.

Physical & Chemical Properties

1 - Fluoro - 3 - Isocyanatobenzene is a special chemical substance. Its physical properties, depending on its form, under room temperature, or a colorless to light yellow liquid with a clear texture. Smell, with a unique pungent odor. Regarding the boiling point, it is about a certain temperature range. This temperature makes it change from liquid to gaseous under specific conditions, showing the transformation of the phase state of matter. The melting point also has a specific value, which defines the critical temperature of its solid state and liquid state.
As for the chemical properties, the fluorine atoms in this molecule are electronegative, which makes the distribution of the surrounding electron cloud uneven, which affects the reactivity of the molecule. The isocyanate group (-NCO) is active and easily reacts with compounds containing active hydrogen, such as alcohols and amines, to form carbamate, urea and other derivatives. This reaction property is of great application in the field of organic synthesis and can be used to prepare a variety of functional materials and fine chemicals.

Technical Specifications & Labeling

Nowadays, there are 1 - Fluoro - 3 - Isocyanatobenzene chemical products, and its technical specifications and identification (commodity parameters) are the key. In terms of technical specifications, it is necessary to ensure that the synthesis path is accurate, and the selection of raw materials and reaction conditions should be carefully controlled. For example, the reaction temperature must be maintained in a specific range to ensure the purity and yield of the product. The identification (commodity parameters) should be clear and clear, indicating the exact composition, content, physical and chemical properties, etc. The ingredients are correct, the content is accurate, and the physical and chemical properties can help the user to understand its characteristics and use it safely and properly. These two, technical specifications and identification (commodity parameters), are of great significance and indispensable for the quality assurance and market circulation of 1 - Fluoro - 3 - Isocyanatobenzene.

Preparation Method

1 - Fluoro - 3 - Isocyanatobenzene is an important organic compound. The method of its preparation, the selection of raw materials is very critical. Fluorine-containing and benzene-containing compounds are often used as starting materials.
In the preparation process, there are many multi-step reactions. The first step is usually the substitution reaction of benzene ring. Under specific conditions, a fluorine-containing group is connected to the benzene ring. Then, through a modification reaction, an isocyanate group is introduced.
The reaction steps are rigorous and orderly. First create a suitable reaction environment, such as precise regulation of temperature and pressure, and choose a suitable catalyst. For example, when adding fluorine groups, the temperature may be controlled in a certain range, so that the reaction is efficient and there are few side reactions.
In terms of activation mechanism, the catalyst activates the reactant molecules and reduces the reaction energy barrier. For example, metal catalysts can be complexed with reactants, which greatly increases the activity of the reaction check point and promotes the smooth progress of the reaction. In this way, through carefully designed raw materials, processes, steps and activation mechanisms, 1-Fluoro-3-Isocyanatobenzene can be obtained.

Chemical Reactions & Modifications

1 - Fluoro - 3 - Isocyanatobenzene is an important compound in organic synthesis. Its chemical reaction and modification are related to many applications in the chemical industry.
Looking at its chemical reaction, it can be added to nucleophiles such as alcohols and amines. When reacting with alcohols, isocyanate groups will combine with alcohol hydroxyl groups to form carbamate compounds. The reaction conditions are mild, usually at room temperature or slightly higher temperatures, and the yield is quite high.
Talking about modification, the physicochemical properties of the compound can be adjusted by introducing different substituents. For example, the introduction of alkyl groups on the benzene ring can change its solubility and stability. In this way, it can be more suitable for specific reaction systems and application scenarios, providing more possibilities for the development of fine chemical products.

Synonyms & Product Names

1 - Fluoro - 3 - Isocyanatobenzene, its synonym and trade name, are key to chemical research. Looking at various ancient books, such substances are of great significance in the field of chemical industry.
In the past, chemists explored the properties of substances and gave them many synonyms in order to accurately describe this compound. Or from its structure analysis, or its characteristics are defined, resulting in various appellations. As for the trade name, merchants also take a unique name in recognition of its characteristics.
Looking at this 1 - Fluoro - 3 - Isocyanatobenzene, synonyms are like different paths, all pointing to this specific chemical entity. Trade names are like signs, marking their unique value in the market. With these names, chemists can discuss their properties and uses, promote academic exchanges, and promote the progress of chemical technology. The names complement each other and help our generation to deeply explore the mysteries of this compound, and move forward steadily in the path of chemical research.

Safety & Operational Standards

1 - Fluoro - 3 - Isocyanatobenzene is also a chemical product. Its safe operation is essential.
If you want to make this product, you must first clarify its properties. This compound is specialized, and it is very special in the reaction. In the operation, follow the formula.

In the room, the operation of 1 - Fluoro - 3 - Isocyanatobenzene is the first priority for safety. Operators must use appropriate protective equipment, such as protective clothing, gloves and eyewear, to prevent their skin from touching and eye contact. Because it may be irritating, if it is accidentally contaminated, quickly wash it with a lot of water and seek treatment.
Furthermore, its survival also needs to be paid attention to. It should be placed in a dry, dry and well-ventilated environment, where there are dangerous materials such as fire sources and oxidation. The storage container must be sealed to prevent leakage.
The operation process is tight, and the reverse parts must be precisely controlled. Factors such as degree and force can all affect the safety of the reverse. After the reverse is completed, the principle of the reverse should not be ignored. It should be properly placed according to the relevant protection laws to avoid contamination of the environment.

Therefore, the safe operation of 1-Fluoro-3-Isocyanatobenzene is the cornerstone of ensuring human safety, safety and environmental protection. Those who do this must not be ignored.

Application Area

1 - Fluoro - 3 - Isocyanatobenzene is also a chemical substance. Its application field is quite wide. In the field of organic synthesis, it is often used as a key reagent and can combine with many compounds to produce a variety of novel organic materials.
In the field of pharmaceutical research and development, this compound may have unique effects. Because of its special structure, it may be combined with specific targets in organisms to help create new drugs and cure various diseases.
In the field of materials science, it can participate in the synthesis of polymers, so that polymers have specific properties, such as better stability and heat resistance, which contribute to material innovation.
From this perspective, 1 - Fluoro - 3 - Isocyanatobenzene has outstanding applications in many fields and has broad prospects. It is worthy of in-depth investigation by our chemists to make the best use of it and benefit the world.

Research & Development

In recent years, I have studied a chemical substance, named 1 - Fluoro - 3 - Isocyanatobenzene. The nature of this substance can be particularly investigated. I have carefully observed its structure and explored the law of its transformation.
At the beginning, I analyzed its molecular framework, clarified the cloth of atoms, and understood the connection of bonds. Then, observe its state in various realms, examine the changes in temperature and pressure on its shadow. Repeat with various agents to test it, test the difficulty of its application, and find the best piece.
After months of research, its nature gradually became clear. However, if you want to use it widely, you still need to explore it diligently. Hoping for the future, we can expand our path and make outstanding achievements in the fields of work and medicine, contributing to the progress of the world.

Toxicity Research

Toxicity of 1 - Fluoro - 3 - Isocyanatobenzene. This substance is chemically active, and its fluorine atoms and isocyanate groups may be involved in toxicity. Fluorine atoms are active, or can cause abnormal chemical reactions in organisms, interfering with biochemical processes. And isocyanate groups, as is well known, are highly reactive, or irritate the respiratory tract, skin and eyes.
According to animal experiments, exposure to this substance, or respiratory symptoms such as cough, asthma, severe or breathing difficulties. Skin contact, or redness, swelling, itching. Long-term low-dose exposure may also damage organs, such as liver and kidneys, causing dysfunction.
In summary, the toxicity of 1 - Fluoro - 3 - Isocyanatobenzene should not be underestimated. During production and use, strict protective measures should be taken to ensure personnel safety and environmental harmlessness.

Future Prospects

1 - Fluoro - 3 - Isocyanatobenzene is a chemical that I have dedicated myself to studying. Looking to the future, its development prospects are like shining stars and full of infinite possibilities.
In the field of materials, or with its unique chemical structure, new polymer materials with excellent performance can be developed. This material may have extraordinary heat and corrosion resistance, shining in key fields such as aerospace and high-end electronic equipment, helping related industries to achieve leapfrog development.
In the field of medicinal chemistry, it is expected to become a key intermediate for the synthesis of special drugs. Through exquisite chemical synthesis paths, innovative drugs for difficult diseases can be created, bringing dawn to human health and well-being.
I firmly believe that with time, through unremitting exploration and innovation, 1 - Fluoro - 3 - Isocyanatobenzene will emerge in various fields, bring immeasurable positive impact to the world, and open a new chapter in technological and industrial development.

Where to Buy 1-Fluoro-3-Isocyanatobenzene in China?

As a trusted 1-Fluoro-3-Isocyanatobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-3-Isocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-3-Isocyanatobenzene?

1-Fluoro-3-isocyanate is an important compound in organic chemistry. It has a wide range of uses and plays a key role in many fields such as materials science and medicinal chemistry.
In materials science, it can be used as a raw material to make special polymers. Capped isocyanate has high reactivity and can be additively polymerized with polyols and other compounds containing active hydrogen to form polyurethane polymers. This polymer has excellent wear resistance, chemical resistance and mechanical properties, and is often used in the manufacture of high-performance coatings, adhesives and foams. Taking coatings as an example, the coatings made from them can firmly adhere to the surface of a variety of substrates, forming a tough and protective coating. They can be used in protective coatings for automobiles, ships, etc., to resist external environmental erosion and prolong the service life of objects.
In the field of pharmaceutical chemistry, 1-fluoro-3-isocyanate benzene also has important applications. The introduction of fluorine atoms can significantly change the physicochemical properties and biological activities of drug molecules. It can react with drug intermediates containing amino groups, hydroxyl groups, etc., to construct new compounds with unique biological activities. By designing such reactions, pharmaceutical researchers are expected to develop new drugs with better efficacy and fewer side effects, contributing to human health.
In addition, in organic synthetic chemistry, as a special synthesizer, it participates in the construction of many complex organic molecules. Chemists use its unique reactivity and selectivity to ingeniously design synthetic routes to synthesize organic compounds with novel structures and unique functions, promoting the development of organic synthetic chemistry and providing a rich material basis for the development of new materials and new drugs.

What are the physical properties of 1-Fluoro-3-Isocyanatobenzene?

The physical properties of 1-fluoro-3-isocyanate benzene are quite important and have considerable use in various fields of chemical industry.
Looking at its appearance, under room temperature, it is mostly a colorless to light yellow transparent liquid. This state is easy to miscible with other substances in various reaction systems, which is conducive to the progress of the reaction. Its smell is unique, irritating, and pungent, because it contains isocyanate.
When it comes to the boiling point, it is about a certain temperature range. This boiling point characteristic determines the choice of conditions in separation, purification and other operations. If you want to separate it from the mixture, you need to adjust the temperature reasonably according to this boiling point to achieve the goal.
Melting point is also a key property. Knowing its melting point, when storing and transporting, appropriate measures can be taken according to external temperature conditions to ensure that its shape is stable and its quality will not be affected by temperature fluctuations.
Density has specific values. This density is of great significance to the analysis of material ratio and stratification when it comes to mixing systems. For example, in a liquid-liquid mixing system, the distribution of substances can be predicted according to the density difference, providing a basis for the control of the reaction process.
In terms of solubility, 1-fluoro-3-isocyanate benzene exhibits good solubility in common organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents. However, in water, the solubility is poor. This difference in solubility can be used as a reference for solvent selection in the extraction, washing and other steps of chemical production.
In addition, its vapor pressure varies at different temperatures. The characteristics of vapor pressure are related to its volatilization in a closed space, which is extremely important for the control of safe production and storage environments. If the vapor pressure is too high, it is easy to increase the pressure in the storage container, which poses a safety hazard. Therefore, it is necessary to strictly control the storage environment temperature and other factors.

Is 1-Fluoro-3-Isocyanatobenzene chemically stable?

The stability of the chemical properties of 1-fluoro-3-isocyanate benzene is of concern in chemical research. In this compound, the fluorine atom is electronegative and connected to the benzene ring, which has a significant impact on the electron cloud distribution of the molecule. The electron-absorbing property of fluorine atoms reduces the electron cloud density of the benzene ring, which affects the chemical reaction activity on the benzene ring.
And isocyanate (-NCO) is also an active functional group. Its nitrogen atom and carbon atom are connected by heavy bonds, and have a unique electronic structure. This structure makes isocyanate easily react with compounds containing active hydrogen, such as alcohols and amines.
Under normal conditions, 1-fluoro-3-isocyanate benzene is not extremely stable. The activity of isocyanate makes it easy to participate in a variety of chemical reactions. If there are nucleophiles in the environment, it is easy to attack the carbon atoms of isocyanate, causing the reaction to occur.
However, its stability is also affected by the surrounding chemical environment. If it is in an environment without active hydrogen and nucleophiles, and the temperature, light and other conditions are suitable, this compound can maintain a relatively stable state for a certain period of time. However, in general, due to the active nature of isocyanate, the chemical properties of 1-fluoro-3-isocyanate benzene are difficult to say stable, and its reactivity should be carefully considered during storage and use to prevent unnecessary chemical reactions.

What is the production process of 1-Fluoro-3-Isocyanatobenzene?

1-Fluoro-3-isocyanate benzene is also a key intermediate in organic synthesis. Its preparation process is exquisite, involving many steps, and it needs to be carried out in a fine way.
At the beginning, 3-amino-1-fluorobenzene is often used as the base material. This compound is diazotized, that is, it reacts with sodium nitrite and acid together, and converts the amino group into a diazonium salt at a low temperature and a controlled rate. The process of diazotization must be cautious. Temperature and reaction rate are both critical, otherwise it is easy to cause side reactions.
Diazonium salt is completed, and the step of isocyanation is continued. Here, a specific reagent, such as metal cyanate or organocyanate, is used to react with it. During this time, the diazo group is ingeniously converted into isocyanate, and 1-fluoro-3-isocyanate is obtained. This step also requires precise temperature control and control to make the reaction smooth and the product pure.
The reaction device should use a glass instrument to facilitate the observation of the reaction process. Stirring is also important to allow the reactants to mix evenly and accelerate the reaction. And a cooling or heating device is required to meet the needs of different stages of temperature.
After the reaction is completed, the separation and purification of the product is also important. It is often done by distillation, extraction, column chromatography, etc. Distillation can separate the product and impurities according to the difference in boiling point; extraction selects a suitable solvent to extract the target; column chromatography uses the fixed phase and the mobile phase to purify the product according to the difference between adsorption and distribution. Through these steps, high-purity 1-fluoro-3-isocyanate benzene can be obtained for subsequent organic synthesis.

What 1-Fluoro-3-Isocyanatobenzene need to pay attention to when storing and transporting

1-Fluoro-3-isocyanate benzene, when its storage and transportation, all kinds of matters must not be ignored. This is a highly toxic product, strong and dangerous, and if you are not careful, disaster will occur.
When storing, choose a cool, dry and well-ventilated place. Avoid open flames, hot topics, and keep away from fire sources to prevent accidents. The container must be firm and airtight to prevent leakage. Because it is sensitive to moisture, it must not be damp, otherwise it is easy to react and cause qualitative changes.
When shipping, be sure to follow the regulations of hazardous chemicals. Choose the appropriate equipment to ensure that it is intact. The transporter must be skilled in operation and familiar with emergency methods. Check the container often on the way to prevent leakage before it occurs. In case of leakage, quickly initiate emergency measures, evacuate everyone, and prohibit unrelated people from approaching it.
And this thing is also very harmful to the environment. Therefore, in the storage and transportation room, make sure that it does not leak out, and does not pollute the water, soil and air. In this way, the storage and transportation are safe, and people, things and the environment are not harmed.