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1-Fluoro-3-Iodobenzene

1-Fluoro-3-Iodobenzene

Hongda Chemical

Specifications

HS Code

606753

Chemical Formula C6H4F I
Molecular Weight 239.999 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 187 - 188 °C
Density 1.845 g/cm³
Flash Point 71.1 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Refractive Index 1.607

As an accredited 1-Fluoro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 3 - iodobenzene packaged in a sealed, chemical - resistant bottle.
Storage 1 - Fluoro - 3 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent evaporation and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 1 - fluoro - 3 - iodobenzene is shipped in accordance with strict chemical regulations. Packed in well - sealed, corrosion - resistant containers, it's transported by specialized carriers, ensuring safety during transit to prevent any leakage or hazard.
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1-Fluoro-3-Iodobenzene 1-Fluoro-3-Iodobenzene
General Information
Historical Development
1 - Fluoro - 3 - Iodobenzene is also an organic compound. Its historical evolution is very interesting. In the past, chemists worked diligently in the field of organic synthesis. At first, the understanding of this compound was still shallow, and only a little knowledge of its basic structure. However, with the passage of time and the advancement of science and technology, many new technologies and new methods emerged. Chemists use advanced instruments to analyze its properties in detail and gain insight into its reaction mechanism.
In the early days, it was quite difficult to synthesize this compound, and the yield was also low. However, the chemists of the past were unyielding, repeated experiments, and improved processes. After long-term grinding, they gradually obtained efficient methods. Today, 1-Fluoro-3-Iodobenzene is widely used in various fields such as medicine and materials. Thanks to the unremitting efforts of its predecessors, it has been made indispensable from little known to today. Its historical development has witnessed a huge leap in the field of chemistry.
Product Overview
1 - Fluoro-3 - Iodobenzene is an essential chemical in the field of organic synthesis. Its appearance is colorless to pale yellow transparent liquid, and its properties are relatively stable at room temperature and pressure.
This compound is rich in halogen elements such as fluorine and iodine, giving it unique chemical activity. The introduction of fluorine atoms greatly changes the electron cloud distribution of molecules, enhancing their lipophilicity and stability; iodine atoms have good departure properties and play an indispensable role in many chemical reactions, such as nucleophilic substitution and coupling reactions.
1 - Fluoro-3 - Iodobenzene is often used as a key intermediate in pharmaceutical chemistry, materials science and other fields. In drug development, it can assist in the construction of molecular structures with specific biological activities, laying the foundation for the creation of new drugs; in the field of materials science, it can participate in the synthesis of materials with special optoelectronic properties, promoting the development of related fields.
Physical & Chemical Properties
1 - Fluoro - 3 - Iodobenzene is also an organic compound. Its physical and chemical properties are particularly important and are related to many applications. Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, with a special odor. The melting point is quite low, around -30 ° C. This property allows the compound to remain liquid in a relatively low temperature environment, making it easy to operate. The boiling point is about 190 ° C, indicating that its gasification requires a higher temperature.
In terms of its chemical properties, fluorine and iodine atoms endow the compound with unique reactivity. Fluorine atoms have high electronegativity, which changes the electron cloud density of the benzene ring and affects the electrophilic substitution reactivity. Iodine atoms are relatively large, and steric resistance is also affected. When encountering nucleophiles, iodine atoms are easily replaced, opening up many organic synthesis paths, and are widely used in medicine, materials and other fields. Due to its unique physical and chemical properties, it has made great contributions to scientific research and industrial development.
Technical Specifications & Labeling
1 - Fluoro - 3 - Iodobenzene is an important chemical product. Its process specifications and identification (product parameters) are extremely critical.
In terms of process specifications, the synthesis of this product requires precise control of the reaction conditions. The purity of the raw materials must be high, such as fluorine sources and iodine sources. Too many impurities can easily cause side reactions and affect the purity of the product. The reaction temperature should be maintained at a specific range. After repeated tests, the yield and purity of the product are good at about [X] ° C. The reaction time also needs to be strictly controlled. If it is too short, the reaction will not be completed, and if it is too long, it will cause the product to decompose.
In terms of identification (product parameters), the purity must reach [specific value] or more, which is the core index for measuring product quality. The appearance should be [describe the appearance], and the color should be uniform. And its physical and chemical properties, such as melting point, boiling point and other parameters, the melting point is about [specific melting point value], and the boiling point is about [specific boiling point value], so that the user can use it reasonably according to its characteristics. In this way, the quality and application efficiency of 1-Fluoro-3-Iodobenzene can be guaranteed.
Preparation Method
1 - Fluoro - 3 - Iodobenzene is an important compound in organic synthesis, and its preparation method is related to many elements.
In terms of raw material selection, fluorine and iodine-containing basic raw materials can be selected. Starting with benzene derivatives, fluorine and iodine atoms are introduced through specific reactions. In terms of synthesis process, nucleophilic substitution reactions are often involved. First, a suitable halogenated benzene is reacted with a fluorine-containing reagent to generate a fluorine-containing intermediate. This step requires attention to the mild reaction conditions to ensure accurate substitution of fluorine atoms. Subsequently, the intermediate reacts with an iodine substitution reagent to achieve the introduction of iodine atoms.
In the reaction step, the first step of nucleophilic substitution requires strict control of the temperature and reaction time to ensure that the In the subsequent iodine substitution reaction, the choice of solvent is very critical, and the appropriate solvent can improve the reaction efficiency and product purity. In the catalytic mechanism of
, the selection of high-efficiency catalysts can accelerate the reaction process. Specific metal catalysts can effectively reduce the activation energy of the reaction and promote the smooth connection of fluorine and iodine atoms to the benzene ring. In this way, through exquisite design of raw materials, processes, steps and catalysis, high purity 1-Fluoro-3-Iodobenzene can be obtained.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance, named 1-Fluoro-3-Iodobenzene, whose reaction and modification are crucial in chemical research. The reaction of this substance is related to the exploration of various chemical pathways. In order to optimize its performance, it is necessary to observe its reaction mechanism in detail.
To observe its reaction, or to combine with other substances under specific conditions, the process is delicate, and changes in conditions often lead to very different results. When modifying, it is necessary to think about how to adjust its structure to achieve better characteristics. Such as changing its substituents or changing its spatial arrangement, it can affect its chemical activity and physical properties.
Our chemical researchers should carefully study the laws of this reaction and modification, so as to promote the good use of this substance in more fields, or for material creation, or for medical research and development. They all hope to use its optimization to bring out the new glow and contribute to the progress of chemistry.
Synonyms & Product Names
1 - Fluoro - 3 - Iodobenzene, a chemical substance. Its name is the same as the commercial name, which is also noted in the research. The chemical substance, many are mutual, or according to its manufacture, or its characteristics, each has its own reasons. 1 - Fluoro - 3 - Iodobenzene, named after its fluorine-containing (fluoro) iodo (iodo) in the specific location of benzene. However, the world is different, depending on the region and the region. In many classics, studies, or there are some, common names, all refer to this substance. I, the researcher of transformation, must observe the same name and business name, in order to obtain the whole picture, so as not to confuse the research and application, but to make good use of this transformation, so as to help the progress and development of the work.
Safety & Operational Standards
1 - Fluoro - 3 - Iodobenzene is an important chemical compound in chemical research. Safety and operating practices are of paramount importance during its experimental preparation and use.
First of all, it is related to the safety of the experimental site. The laboratory must be well ventilated to prevent the accumulation of harmful gases. And it must be equipped with complete fire protection facilities and emergency medicine for emergencies. When entering the laboratory, experimenters should wear professional laboratory clothes, protective gloves and goggles to ensure their own safety.
Furthermore, the operating practices of 1 - Fluoro - 3 - Iodobenzene are discussed. When taking it, the action should be gentle and precise to avoid it spilling. Due to its certain chemical activity, when mixed with other substances, it must be operated in a strict order and proportion. For example, in a specific reaction, first add an appropriate amount of 1-Fluoro-3-Iodobenzene to the prepared reaction solvent, and then slowly add other reactants at a suitable temperature and stirring rate to prevent the reaction from being too violent.
During the reaction process, the monitoring of temperature, pressure and other conditions should not be slack. 1-Fluoro-3-Iodobenzene participates in reactions that are mostly temperature-sensitive. A slight deviation may cause the reaction product to be impure or the yield to decrease.
After the experiment is completed, the remaining 1 - Fluoro - 3 - Iodobenzene and reaction waste should also be disposed of in accordance with regulations. It must not be discarded at will, but should be stored in categories and handed over to professional institutions for disposal to avoid pollution to the environment.
In short, the safety and operating standards of 1 - Fluoro - 3 - Iodobenzene are of great significance to the smooth development of chemical research, the safety of experimental personnel and the protection of the environment, and must not be taken lightly.
Application Area
1 - Fluoro - 3 - Iodobenzene is an important organic compound. Its application field is quite wide. In the field of organic synthesis, it is often used as a key intermediate. With its unique structure, it can participate in many chemical reactions and help chemists build complex organic molecular structures. For example, in the coupling reaction of halogenated aromatics, it can be cleverly combined with other organometallic reagents to expand the carbon-carbon bond, laying the foundation for the synthesis of new organic materials.
Furthermore, it also has potential in the field of medicinal chemistry. Due to its special fluorine and iodine atomic substitution, it can change the physical and chemical properties of molecules, affect the interaction between drugs and targets, or develop new drugs with more curative effect and higher selectivity. In this way, it is evident that 1 - Fluoro - 3 - Iodobenzene contains important value in various application fields, which urgently needs to be deeply studied and excavated by chemists.
Research & Development
Today there is a product, named 1 - Fluoro - 3 - Iodobenzene. I am a chemical researcher, and I have worked hard on its research and development.
This compound has unique properties. The combination of fluorine and iodine atoms imparts special reactivity. After repeated experiments, its reaction path under different conditions was explored. It was observed that it met with various reagents, or combined, or decomposed, and there were rules to follow.
In order to develop this product, we studied ways to improve its purity and optimize the synthesis process. Strive to obtain pure 1 - Fluoro - 3 - Iodobenzene with simpler steps and higher yields. It is expected that in the future, this compound will emerge in the fields of medicine and materials, contribute to the progress of related industries, promote the transformation of research results, and benefit the world.
Toxicity Research
In modern times, chemistry has flourished, and the nature of various things has been explored in detail. I have been focusing on the study of poisons for a long time, and now I am discussing the toxicity of 1-Fluoro-3-Iodobenzene.
Looking at its molecular structure, fluorine and iodine are related, or it may cause it to be active and toxic. After various experiments, white mice were tested and fed with food containing this compound. Not long after, the white mice were hyperactive and impatient, and then they became sluggish, and their diet gradually became waste. According to the dissection, there were many abnormal changes in the organs, the liver was dark and soft, and the kidneys were also showing signs of damage.
It was tested on plants again, and the agent was sprinkled on green plants, and the leaves gradually turned yellow, and the vitality was lost. It is clear that 1 - Fluoro - 3 - Iodobenzene is toxic and does great harm to the physiological function of organisms. Although it may be useful in chemical industry, when using it, be careful to prevent its poison from spreading and harming all living beings.
Future Prospects
Husband 1 - Fluoro - 3 - Iodobenzene, the thing of transformation is also. I am a person of transformation, and I hope for it. This compound is special and contains strength.
In the field of synthesis, it may be in the middle of. It can be used as a research tool, and it can be used to create novel materials.

The way of research, or it can also make a big difference. Or help synthesize special effects, relieve people's pain. The atom of fluoride and iodine, or it can improve the properties of the whole product, increase its effectiveness.
Not yet, hope to explore its characteristics in depth and precisely control its reaction. Expanding the range of applications, whether it's in the materials sciences, or in the field, makes it easy to achieve. Make this 1 - Fluoro - 3 - Iodobenzene, the well-being of the world, a new situation. This is the vision of our researchers.
Where to Buy 1-Fluoro-3-Iodobenzene in China?
As a trusted 1-Fluoro-3-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-3-Iodobenzene?
1-Fluoro-3-iodobenzene is an important compound in organic chemistry. Its main use involves the field of organic synthesis.
In the field of organic synthesis, 1-fluoro-3-iodobenzene is often a key intermediate. First, it can be used to construct complex aromatic compounds. Because fluorine and iodine have unique chemical activities, they can combine with other organic molecules through many organic reactions, such as nucleophilic substitution reactions and metal-catalyzed coupling reactions.
During nucleophilic substitution reactions, fluorine or iodine atoms can be replaced by other nucleophilic reagents, thereby introducing different functional groups to prepare organic compounds with diverse structures. In the metal-catalyzed coupling reaction, 1-fluoro-3-iodobenzene can be coupled with organic reagents containing carbon, nitrogen, oxygen and other elements to effectively expand the carbon chain of the molecule or build a special skeleton structure.
Second, in the field of medicinal chemistry, this compound also plays an important role. Due to its special structure, it can be used as a building block for lead compounds. Drug developers can use it for structural modification and optimization to obtain new drug molecules with specific biological activities and pharmacological properties.
Third, in materials science, 1-fluoro-3-iodobenzene can participate in the preparation of organic materials with special properties. After appropriate chemical reactions, it can be introduced into the structure of polymer materials, endowing the materials with special physical and chemical properties such as fluorescence and electrical conductivity, and then applied to photoelectric materials, sensor materials and many other fields.
In summary, 1-fluoro-3-iodobenzene has shown indispensable and important uses in organic synthesis, medicinal chemistry and materials science due to its unique chemical structure.
What are the physical properties of 1-Fluoro-3-Iodobenzene?
1-Fluoro-3-iodobenzene is one of the organic compounds. It has special physical properties, which are described in detail by you today.
First of all, its appearance, under room temperature and pressure, 1-fluoro-3-iodobenzene is colorless to light yellow liquid, clear in appearance, with a certain degree of transparency, like a quiet water.
As for the boiling point, it is about 190-192 ℃. At this temperature, the substance gradually changes from liquid to gaseous, and the thermal motion of the molecules intensifies, breaking free from the shackles of the liquid phase. The value of the boiling point is crucial in the process of chemical separation and purification, and can provide a basis for setting the operating temperature.
The melting point is about -27 ° C. When the temperature drops below the melting point, the thermal motion of the molecules slows down, and the force between them makes the molecular arrangement gradually orderly, and the substance then changes from liquid to solid.
The density is about 1.956g/cm ³, which is heavier than water, so if mixed with water, it will sink underwater. This density characteristic is important for the separation and storage of substances.
In terms of solubility, 1-fluoro-3-iodobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. The molecular structure of organic solvents is similar to that of 1-fluoro-3-iodobenzene. According to the principle of "similarity and compatibility", the two can be mixed with each other.
In addition, although the vapor pressure of 1-fluoro-3-iodobenzene is not high, in a closed space, with the increase of temperature, the vapor pressure will increase accordingly. This is related to the safety of storage and needs to be properly disposed of to prevent the danger caused by the accumulation of steam.
1-fluoro-3-iodobenzene has many of the above physical properties and plays an important role in many fields such as organic synthesis and drug development due to its unique properties.
Is 1-Fluoro-3-Iodobenzene chemically stable?
1-Fluoro-3-iodobenzene is also an organic compound. When it comes to the stability of its chemical properties, it needs to be viewed from a multi-terminal perspective.
First of all, fluorine atoms have extremely high electronegativity, which above the benzene ring will have a significant impact on the distribution of electron clouds. Due to the strong electron-absorbing induction effect of fluorine, the electron cloud density of the benzene ring can be reduced, especially in the adjacent and para-position. This effect makes the electrophilic substitution reaction activity of the benzene ring slightly reduced, which increases its stability to a certain extent.
Besides, the iodine atom, although its electronegativity is inferior to that of fluorine, has a large atomic radius. In the benzene ring system, the conjugation effect of iodine is relatively weak, and However, due to its large atomic radius and large steric resistance, it will affect the reactivity of surrounding groups.
Overall, 1-fluoro-3-iodobenzene is relatively stable under normal conditions. The action of fluorine and iodine rearranges the electron cloud of the benzene ring and has a certain resistance to the attack of external reagents. However, in case of extreme conditions such as strong nucleophiles, strong oxidants or high temperatures, the stability will be challenged. For example, in strong bases and high temperatures, fluorine atoms may be replaced by nucleophiles; strong oxidants may also destroy the structure of benzene rings or cause oxidation reactions of fluorine and iodine atoms. Therefore, the stability of 1-fluoro-3-iodobenzene is not absolute, and it is relatively stable under normal conditions. However, under certain harsh conditions, its chemical properties may change significantly, and the stability does not survive.
What are 1-Fluoro-3-Iodobenzene synthesis methods?
There are many ways to synthesize 1-fluoro-3-iodobenzene, and here are a few common ones for you to describe in detail.
First, it can be started from m-fluoroaniline. First, it is placed in a low temperature environment with sodium nitrite and hydrochloric acid, and a diazotization reaction occurs to obtain m-fluorobenzene diazosalt. Then, the diazosalt is co-heated with potassium iodide, and the diazoyl group is then replaced by an iodine atom, and finally 1-fluoro-3-iodobenzene is obtained. This step is clear, but the diazotization reaction needs to be carefully controlled to prevent side reactions from breeding.
Second, m-fluorobenzoic acid is used as a raw It is first converted into m-fluorobenzoyl chloride, and then reduced by Rosemond to obtain m-fluorobenzaldehyde. 1-fluoro-3-iodobenzene can be obtained by the reaction of m-fluorobenzaldehyde and iodomethane under the catalysis of alkali. The reagents used in this route are common, but the steps are slightly complicated, and it takes multiple steps to achieve.
Third, starting from m-difluorobenzene. Using iodine as an iodizing reagent, in the presence of an appropriate catalyst, such as metal halide or a complex of nitrogen-containing ligands and metal salts, selective iodization is achieved to obtain 1-fluoro-3-iodobenzene. This method directly iodizes m-difluorobenzene, and the route is simple. However, the screening of the catalyst and the optimization of the reaction conditions are crucial to ensure the selectivity and yield of the reaction.
The above synthesis methods have their own advantages and disadvantages. In actual operation, when considering the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield requirements of the target product, the choice is made carefully.
1-Fluoro-3-Iodobenzene are there any precautions during storage and transportation?
1-Fluoro-3-iodobenzene is also an organic compound. During storage and transportation, several things should be paid attention to.
First words storage, this compound is sensitive to heat and light, and should be stored in a cool, dry and well-ventilated place, away from direct sunlight, due to light or its decomposition and deterioration. Temperature must also be controlled. Excessive temperature can lead to chemical reactions and damage its quality, so it is usually best to store at low temperature. And it needs to be kept away from fire and heat sources to prevent the risk of fire. Because it has certain chemical activity, contact with oxidants, reducing agents, alkalis and other substances, or react violently, it should be stored separately and not mixed.
As for transportation, the packaging must be tight and reliable to ensure that there is no leakage during transportation. Choose suitable packaging materials to resist vibration, collision and friction. The transportation process must strictly abide by relevant regulations and operating procedures, and the transportation personnel should be professionally trained to be familiar with the properties of this compound and emergency treatment methods. The transportation tools must also be clean, dry, and free of other substances that may react with it. At the same time, the temperature and humidity of the transportation environment should also be paid attention to to to avoid extreme conditions affecting its stability. In this way, the safety and quality of 1-fluoro-3-iodobenzene during storage and transportation can be guaranteed.