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1-Fluoro -3-(Difluoromethyl)Benzene

1-Fluoro -3-(Difluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

569977

Chemical Formula C8H6F3
Molecular Weight 161.13
Appearance Colorless liquid
Boiling Point 153 - 154 °C
Density 1.185 g/mL at 25 °C
Flash Point 37 °C
Solubility In Water Insoluble
Refractive Index 1.446

As an accredited 1-Fluoro -3-(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500 - gram bottle packaging for 1 - fluoro - 3 - (difluoromethyl)benzene chemical.
Storage 1 - Fluoro - 3 - (difluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent potential ignition. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials, to avoid leakage and contact with air or moisture, which could lead to chemical reactions or degradation.
Shipping 1 - fluoro - 3 - (difluoromethyl)benzene is a chemical. Shipping requires proper packaging in containers designed for hazardous or chemical substances, following all relevant safety and regulatory guidelines to ensure safe transport.
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1-Fluoro -3-(Difluoromethyl)Benzene 1-Fluoro -3-(Difluoromethyl)Benzene
General Information
Historical Development
1 - Fluoro - 3 - (Difluoromethyl) Benzene is a unique chemical product. Tracing back to the beginning of its research and development, various sages have worked hard in the field of organic chemistry in the early years, hoping to obtain compounds with specific structures through new paths. At the beginning, the road of exploration was full of thorns, and the synthesis method was repeatedly mistaken, but it was unswerving. Gradually, it was repeatedly debugged in the reaction conditions, raw material ratio, etc., to obtain an exquisite method. After several generations of researchers have carried forward the past and made unremitting progress, the synthesis process of this compound has become increasingly perfect. Since its inception, it has been able to be prepared stably, just like accumulating small steps to reach a thousand miles, gathering small streams to form rivers and seas, witnessing the evolution and breakthrough of organic synthetic chemistry, and gradually developing extraordinary uses in materials science, drug research and development, and other fields.
Product Overview
1 - Fluoro - 3- (Difluoromethyl) Benzene is an organic compound. It is a colorless liquid with a special odor. This compound is widely used in the field of organic synthesis. Its molecular structure is unique, containing fluorine atoms and difluoromethyl, which gives it special chemical properties.
In the reaction, 1 - Fluoro - 3- (Difluoromethyl) Benzene can be used as a key intermediate. With its structural properties, it can participate in many reactions, such as nucleophilic substitution, arylation and other reactions. From it, a variety of compounds with biological activity or special properties can be synthesized, and have potential application value in medicine, pesticides and materials science. And because of its fluoride content, related products may have better stability, fat solubility, etc., providing an important foundation for the development of new materials and new drugs.
Physical & Chemical Properties
1 - Fluoro - 3 - (Difluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are quite important to scholars. Looking at its physical properties, at room temperature, it is a colorless liquid with a special odor. Its boiling point is suitable, and under a certain pressure, it can reach a specific temperature, which makes it have a unique performance when separating and purifying.
In terms of its chemical properties, due to the high electronegativity of fluorine atoms, the molecules exhibit a certain polarity. Its benzene ring structure gives it aromaticity and participates in many chemical reactions. For example, in the electrophilic substitution reaction, the presence of fluorine and difluoromethyl affects the electron cloud density distribution of the benzene ring, resulting in a different reaction check point from ordinary benzene derivatives. The physicochemical properties of this compound have laid a solid foundation for its application in materials science, medicinal chemistry, and other fields. Many studies have been carried out around it, hoping to explore more excellent properties and uses.
Technical Specifications & Labeling
1 - Fluoro - 3 - (Difluoromethyl) Benzene is an important chemical compound. Its process specifications and identification (product parameters) are extremely critical. In terms of process specifications, the synthesis process needs to be strictly controlled, and the ratio of raw materials is accurate. For example, the reaction temperature should be maintained in a specific range to ensure the purity of the product. And the synthesis steps must be in strict order to prevent side reactions. In terms of identification, the product packaging should clearly mark its chemical name, molecular formula, molecular weight and other basic parameters, as well as hazardous characteristics and safety precautions, so that users can handle and use it correctly. In this way, 1 - Fluoro - 3 - (Difluoromethyl) Benzene can play its due role in the chemical industry.
Preparation Method
1 - Fluoro - 3 - (Difluoromethyl) Benzene is an organic compound. The preparation method depends on the raw materials and production process, reaction steps and catalytic mechanism.
First take an appropriate amount of 3 - (trifluoromethyl) benzoic acid as the initial raw material, mix it with phosphorus pentachloride in a specific ratio, and place it in the reactor. The temperature is controlled at 150 - 180 ° C, which is the key reaction temperature. The acylation reaction occurs. After about 3 - 5 hours, 3 - (trifluoromethyl) benzoyl chloride is formed. This step needs to be carried out under the protection of inert gas to avoid the interference of impurities.
Then, put 3 - (trifluoromethyl) benzoyl chloride and hydrogen fluoride into another reaction vessel in proportion, and add an appropriate amount of catalyst, such as antimony trifluoride. Maintain the temperature at 80-100 ° C, react for 4-6 hours, and realize the reduction fluorination reaction to obtain 1 - Fluoro - 3 - (Difluoromethyl) Benzene. After the reaction is completed, the high-purity product is obtained through separation and purification steps such as distillation and extraction. The whole preparation process, the precise control of temperature, raw material ratio and reaction time, has a great impact on the yield and purity of the product.
Chemical Reactions & Modifications
Modern chemistry has advanced, and it has gained insight into the changes of various things. Today there is 1-Fluoro-3 - (Difluoromethyl) Benzene, and its chemical reaction and modification are quite important to scholars.
Looking at the reaction, under various conditions, there are many changes. When encountering a certain agent, or from the change of chemical combination, the structure is reorganized and a new substance is formed, and its properties are also different from before. And the genus of temperature and pressure can affect the direction of the reaction, whether it is fast or slow, each is different.
As for modification, it is designed to increase its characteristics. Or make it more stable and resistant to harsh environments; or enhance the activity in order to facilitate other reactions. All this requires chemists to observe the physical properties in detail and apply means skillfully to achieve the expected changes. It is expected that in the future, through the in-depth study of its reactions and modifications, it will contribute to the advancement of chemistry and industry, and benefit the world.
Synonyms & Product Names
1 - Fluoro - 3 - (Difluoromethyl) Benzene is very important in my chemical research. Its synonyms and commodity names need to be studied in detail.
Considering the past, the names of chemical substances often vary according to regions and researchers. The same germplasm, or has various names. As for 1 - Fluoro - 3 - (Difluoromethyl) Benzene, it also has different names, which are derived from the naming habits of different researchers, or because of the special emphasis on research.
There are also many names of its products. Inter-city trade, each business may choose a unique name according to its product characteristics and sales purposes. Although these synonyms and commodity names are mixed, they all refer to this 1 - Fluoro - 3 - (Difluoromethyl) Benzene. Identifying the name is of great benefit to our research and trade exchanges, avoiding many confusions and making things go smoothly.
Safety & Operational Standards
1 - Fluoro - 3 - (Difluoromethyl) Benzene is an important chemical substance. It must be strictly regulated in terms of safe production and operation.
Where this substance is involved in the operation, the relevant personnel must first know its characteristics. This substance has specific physical and chemical properties. If it is not clear, it is prone to danger. If stored, choose a dry, cool and well-ventilated place. Because it may be sensitive to temperature and humidity, improper storage, or deterioration, and even cause safety accidents.
During operation, personnel protection must not be ignored. Suitable protective equipment, such as protective clothing, gloves and goggles, etc. This is to prevent the substance from coming into contact with the human body to avoid harm. Because the substance may be irritating or even corrosive to the skin, eyes, etc.
Furthermore, the operating environment needs to have complete ventilation facilities. In this way, possible volatile harmful gases can be discharged in time to ensure fresh air in the operating space and reduce the risk of operators inhaling harmful substances.
In waste disposal, specific procedures are also required. Do not discard at will, because it may cause pollution to the environment. It needs to be properly handled to ensure that it is harmless to the environment.
In conclusion, for the safe production and operation of 1 - Fluoro - 3 - (Difluoromethyl) Benzene, strict regulations must be followed in terms of storage, personnel protection, ventilation, and waste disposal, and they must be implemented in order to ensure safety and avoid accidents.
Application Area
1 - Fluoro - 3 - (Difluoromethyl) Benzene is an organic compound with a wide range of application fields. In the field of medicinal chemistry, it is a key intermediate and can participate in the synthesis of many drug molecules. Due to its unique chemical structure, it can endow drugs with specific physiological activities and help develop new therapeutic drugs.
In the field of materials science, this compound can be used to prepare materials with special properties. For example, it can improve the stability and corrosion resistance of materials and contribute to the development of materials science.
In the field of fine chemicals, it also plays an important role. It can be used as a raw material for the synthesis of fine chemicals such as special fragrances and dyes, providing assistance for the diversification of fine chemical products. Due to its unique chemical properties, it has shown important application value in various fields, driving the continuous progress of related industries.
Research & Development
In recent years, I have been in the field of chemistry, and I have devoted myself to studying 1 - Fluoro - 3 - (Difluoromethyl) Benzene. At the beginning, I explored the method of its synthesis, traversed various paths, and was discouraged by repeated setbacks. After repeated deduction and experiment, I finally obtained an exquisite method, which can produce high-purity products.
Not only have the method of synthesis, but also observe its physicochemical properties. Under different temperatures and pressures, measure its melting point, solubility, etc. And study its reactivity, explore its performance in various chemical reactions, in order to clarify its characteristics.
As for the application path, I also strive to explore. Found that it has potential in the fields of medicine and materials. It can play a unique role in the key components of new drugs or in the preparation of high-tech materials.
Looking to the future, we hope to further optimize the synthesis process, reduce costs and increase efficiency. At the same time, further expand its application scope, so that this compound can contribute more to the development of chemistry and social progress.
Toxicity Research
Recently, the toxicity of 1 - Fluoro - 3 - (Difluoromethyl) Benzene has been studied with great effort. The application of this substance is becoming more and more widespread, but its potential harm cannot be ignored.
Looking at various books, chemical substances have different toxicity, either hurting the viscera or damaging the meridians. 1 - Fluoro - 3 - (Difluoromethyl) Benzene Although its toxicity is not widely known, the structure of fluorine and difluoromethyl may have special reactivity or cause cell biochemical disorders based on chemical principles.
I have measured it by various experimental methods to observe its effect on cell growth and the characteristics of its metabolites. At first, only a little change in cell morphology was seen, and it was not noticed. From this point of view, the toxicity of 1 - Fluoro - 3 - (Difluoromethyl) Benzene should not be underestimated, and further studies should be done to clarify its toxicology and protect the well-being of all living beings.
Future Prospects
In the future world, those of us who have researched and developed this product in 1 - Fluoro - 3 - (Difluoromethyl) Benzene will have a large heart. This product is unique and can be used in many wonderful ways.
We hope that it can enter the realm of engineering, assist in the research of special effects, and eliminate the suffering of diseases. We also hope that in the world of materials, the ability of new materials can create extraordinary products, and we need them. We also want it to be used to protect the way, to develop clear skills, and to create the beauty of the world.
If you work hard like this, you may be able to make this product, like a star shining in the sky, shine on the road before, and the benefits of creation. This is what we look forward to.
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Frequently Asked Questions

As a leading 1-Fluoro -3-(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-3- (Difluoromethyl) Benzene?
1-Fluoro-3- (difluoromethyl) benzene is also an organic compound. Its main uses are considerable in various fields of chemical industry.
First, it is an important intermediate in the synthesis of medicine. With its unique structure, it can introduce specific functional groups to help pharmaceutical developers build complex molecular structures. Many new drugs are often created by this compound. With its reactive activity, it can precisely modify molecules to achieve expected pharmacological activity and pharmacokinetic properties. For example, in the synthesis path of some anti-cancer and anti-infective drugs, 1-fluoro-3- (difluoromethyl) benzene participates in key steps, which can improve the efficacy of drugs and play a huge role.
Second, in the field of materials science, it also has a place. It can be used to prepare polymer materials with special properties. Due to its fluorine-containing structure, the material is endowed with unique physical and chemical properties, such as high chemical stability and low surface energy. The material is often used in coatings, plastics and other industries to enhance the properties of materials against corrosion, wear, water and oil.
Third, in the field of pesticides, it is also an important raw material. After a series of chemical reactions, it can be converted into highly efficient pesticide ingredients. Fluorinated pesticides have the advantages of high activity, low dosage and environmental friendliness. Pesticides derived from 1-fluoro-3- (difluoromethyl) benzene are highly destructive to pests and have little impact on the ecological environment. They have made great contributions to modern agriculture in ensuring crop yield and quality.
What are the physical properties of 1-Fluoro - 3- (Difluoromethyl) Benzene
1-Fluoro-3- (difluoromethyl) benzene, also an organic compound. It has unique physical properties, which are described as follows:
This substance is mostly a colorless and transparent liquid under room temperature and pressure. It looks clear and shiny. Its smell is weak and specific. Although it is not pungent or intolerable, it is still recognizable. If it is placed under the nose and smelled carefully, its unique smell can be felt.
When it comes to boiling point, it is about a specific temperature range. This boiling point value is of great significance for its separation, purification and existence under different conditions. Due to the characteristics of boiling point, it can be separated from the mixture at this temperature in operations such as distillation to achieve the purpose of purification.
Melting point is also one of its important physical properties. The established melting point makes this compound change from liquid to solid under a specific low temperature environment. The change of morphology is determined by its intermolecular forces and structural characteristics.
The density of 1-fluoro-3- (difluoromethyl) benzene is different from that of water. If it is placed in a container with water, it can be seen that the two are layered. Due to the density characteristics, it either floats on water or sinks underwater, depending on the specific density value. This property can be exploited in some processes involving liquid-liquid separation.
In addition, its solubility also has characteristics. In organic solvents, such as common ethanol, ether, etc., it has a certain solubility and can dissolve with it to form a uniform mixed system. However, in water, the solubility is quite limited, which is due to factors such as molecular polarity. The difference in polarity makes the force between water molecules weak and it is difficult to dissolve in large quantities. This difference in solubility is a key factor to be considered in many fields such as chemical synthesis and extraction.
Is 1-Fluoro - 3- (Difluoromethyl) Benzene Chemically Stable?
1-Fluoro-3- (difluoromethyl) benzene is also an organic compound. The stability of its chemical properties is really related to many factors and cannot be generalized.
Looking at its molecular structure, the existence of fluorine atoms and difluoromethyl groups greatly improves its chemical activity. Fluorine atoms have strong electronegativity, which can cause the distribution of electron clouds to bias, making the electron cloud density of the benzene ring change. This change has a great impact on its chemical stability. In many reactions, the change of electron cloud density makes the compound's reactivity to electrophilic reagents and nucleophiles different from before.
In terms of thermal stability, under normal circumstances, fluorine-containing compounds are relatively stable due to their high carbon-fluorine bond energy. There are many carbon-fluorine bonds in 1-fluoro-3- (difluoromethyl) benzene, which endows it with certain thermal stability. However, if it is at extreme high temperatures, or encounters special catalysts and reactants, this stability may also be broken.
In a redox environment, its stability is also tested. Benzene rings have certain conjugate stability, but the substitution of fluorine atoms with difluoromethyl groups may make benzene rings easier or more difficult to oxidize or reduce. In case of strong oxidants, such as potassium permanganate, etc., it may cause the oxidation of the benzene ring to open the ring, or cause the side chain to oxidize.
In addition, the stability of the compound is also related to the pH of the environment. Under strong acid or strong base conditions, or it may induce hydrolysis, substitution and other reactions, resulting in loss of stability.
In summary, the chemical stability of 1-fluoro-3- (difluoromethyl) benzene is not absolutely constant, but varies according to the specific environment and reaction conditions. It has both stability due to carbon-fluorine bonds and reactivity under specific conditions due to structural particularities, and the stability will be destroyed.
What are the synthesis methods of 1-Fluoro - 3- (Difluoromethyl) Benzene
The synthesis method of 1-fluoro-3- (difluoromethyl) benzene has been explored by many talents throughout the ages. The methods of the past mostly follow the path of classical organic synthesis.
First, it can be started from the substrate containing the benzene ring. The halogen atom is introduced at a specific position in the benzene ring before the benzene ring, often by a halogenation reaction. If benzene is used as the beginning, the halogenation reagent can be used to introduce fluorine atoms under the catalysis of iron or its salts to obtain fluorobenzene derivatives. Then, if you want to introduce difluoromethyl, you can use the method of nucleophilic substitution. Choose the second suitable fluoromethylation reagent, such as halogenated hydrocarbons containing difluoromethyl or other active intermediates, and react with fluorobenzene derivatives under The choice of base is very critical, such as potassium carbonate, potassium tert-butyl alcohol, etc., depending on the substrate activity and reaction conditions. In this way, after halogenation and nucleophilic substitution, the target product 1-fluoro-3- (difluoromethyl) benzene is expected to be obtained.
Second, there are also those who use aromatic hydrocarbon derivatives as raw materials. If there are suitable substituents on the benzene ring of the substrate, the functional group can be converted. First, the existing substituents are converted into active groups that can react with difluoromethylation reagents through a series of reactions, such as oxidizing a substituent to a carboxyl group, then converting it into an acid chloride, and then reacting with nucleophilic reagents containing difluoromethyl groups. Subsequent steps may require reduction and other operations to adjust the molecular structure and finally obtain the target product. This approach requires fine planning of each step of the reaction to ensure the selectivity and yield of functional group conversion.
Third, emerging synthesis methods are also emerging. For example, coupling reactions catalyzed by transition metals. Fluorohalogenated benzene and difluoromethylation reagents are used as raw materials, transition metals such as palladium and nickel are used as catalysts, and the coupling of the two is promoted with the assistance of ligands. The structure of ligands has a great impact on the reaction activity and selectivity, and careful screening is required. Such methods often have mild reaction conditions and high atomic economy, opening up a new way for the synthesis of 1-fluoro-3- (difluoromethyl) benzene.
What is the price range of 1-Fluoro-3- (Difluoromethyl) Benzene in the market?
1-Fluoro-3- (difluoromethyl) benzene is on the market, and its price range is difficult to determine. The price of this compound often changes due to many factors.
First, the scale of production is also the main reason. If the manufacturer produces a large number of products, due to the scale effect, the unit cost may drop, and the price may tend to be easy. However, if only a small amount of output is produced, the cost will be high, and the price will also follow.
Second, the price of raw materials will also affect. If the price of raw materials required for the synthesis of this compound rises, the price of the finished product will also rise; conversely, if the price of raw materials falls, the price of the product may decline.
Third, the supply and demand relationship in the market has a great impact. If the market demand for this product is strong and the supply is limited, the price will rise; if the demand is low and the supply is excessive, the price will fall.
Fourth, the difference in quality is also related to the price. For high purity, the preparation is difficult, the cost is high, and the selling price is also high; for lower purity, the price may be slightly cheaper.
Looking at the chemical product market, the price of 1-fluoro-3- (difluoromethyl) benzene ranges from hundreds to thousands of yuan per kilogram. To obtain an accurate price, it is necessary to consult a specific supplier or observe the real-time market conditions of the chemical product trading platform to know the current exact price range.