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1-Fluoro-3,4-Dimethoxybenzene

1-Fluoro-3,4-Dimethoxybenzene

Hongda Chemical

Specifications

HS Code

107766

Chemical Formula C8H9FO2
Molecular Weight 156.154 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approximately 207 - 209 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature

As an accredited 1-Fluoro-3,4-Dimethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 3,4 - dimethoxybenzene packaged in a sealed, labeled bottle.
Storage 1 - fluoro - 3,4 - dimethoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions.
Shipping 1 - fluoro - 3,4 - dimethoxybenzene is shipped in well - sealed, appropriate containers. The shipment adheres to strict chemical transportation regulations, ensuring safe transit to prevent leakage and potential hazards.
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1-Fluoro-3,4-Dimethoxybenzene 1-Fluoro-3,4-Dimethoxybenzene
General Information
Historical Development
1 - Fluoro - 3,4 - Dimethoxybenzene is an organic compound, and its historical development is quite remarkable. In the past, chemists worked hard in the field of organic synthesis. At the beginning, the exploration of benzene compounds containing fluorine and methoxy groups was not deep. However, the public studied diligently and experimented unremittingly. After a long time of exploration, the organic reaction conditions and the selection of raw materials were pondered a lot. Finally, the method of synthesizing 1 - Fluoro - 3,4 - Dimethoxybenzene was obtained. Initially, the yield was not ideal. After repeated improvement of the process and optimization of the reaction process, the synthesis efficiency gradually increased. With the advance of chemical technology, the preparation of this compound is more accurate and efficient, and its application in medicine, materials and other fields is also becoming more and more extensive, contributing to chemical research and industrial practice, and promoting the vigorous development of related industries.
Product Overview
1 - Fluoro - 3,4 - Dimethoxybenzene, also an organic compound. It is a colorless to pale yellow liquid with a special odor. In this compound, fluorine atoms and methoxy groups are connected to the benzene ring, and the structure is unique.
The preparation method is often obtained by a specific reaction path. Using benzene derivatives as starting materials, fluorine atoms are introduced through halogenation, methoxylation is repeated, and methoxy groups are added to obtain this product.
It has a wide range of uses and is often a key intermediate for the synthesis of specific drugs in the field of medicinal chemistry. Due to its special structure, it can react with other compounds in a variety of ways, helping to build complex drug molecular structures. In the field of materials science, it can also be used as a raw material for the synthesis of special materials to endow materials with unique properties.
Physical & Chemical Properties
1 - Fluoro - 3,4 - Dimethoxybenzene is an organic compound with unique physical and chemical properties. This substance is a liquid at room temperature and has a specific odor. From the perspective of physical properties, its boiling point, melting point and other characteristics are of great significance for separation and purification. After determination, its boiling point is about [X] ° C, its melting point is about [X] ° C, and its density is about [X] g/cm ³.
In terms of chemical properties, the fluorine atom and methoxy group in 1 - Fluoro - 3,4 - Dimethoxybenzene give it unique reactivity. Fluorine atoms have strong electronegativity, which can affect the distribution of molecular electron clouds, causing them to be prone to nucleophilic substitution reactions. Methoxy group is the power supply group, which can enhance the electron cloud density of the benzene ring and make the benzene ring more susceptible to attack by electrophilic reagents. In the field of organic synthesis, this substance is often used as a key intermediate to build complex organic molecular structures through various reactions, making great contributions to the development of organic chemistry.
Technical Specifications & Labeling
1 - Fluoro - 3,4 - Dimethoxybenzene is an important chemical product. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, the proportion of raw materials synthesized should be accurate, and the reaction temperature and duration should also be strictly controlled. If the purity of raw materials must reach a very high standard, so as not to affect the quality of the product due to impurities. The temperature during the reaction should be maintained at a specific range, and the duration should also meet the established requirements to obtain the ideal product yield and purity.
When it comes to identification (product parameters), the appearance should be in a specific color state, and the purity should be determined and clearly marked by accurate detection methods. Physical parameters such as melting point and boiling point are also important identification contents, which can provide key basis for product quality identification. The accurate grasp of these process specifications and identification (product parameters) is the key to ensuring the high quality of 1-Fluoro-3,4-Dimethoxybenzene.
Preparation Method
If you want to make 1 - Fluoro - 3,4 - Dimethoxybenzene now, you need to understand the method of making it. Prepare all raw materials first, starting with 3,4 - dimethoxyphenol, which is the main material. With fluorination reagents, such as Selectfluor, etc.
The process of making, in a temperature-appropriate reactor, put raw materials, temperature control, generally in organic solvents, such as acetonitrile, to make homogeneous. Slowly add fluoridation reagents, stir to promote their response.
The reaction step is to first make 3,4 - dimethoxyphenol react with reagents, electron cloud translocation, phenolic hydroxyl fluoride generation. After separation, purification, removal of impurities, pure products can be obtained.
catalytic mechanism, fluorination reagent as the source, which in the reaction for fluorine ions, and phenol hydroxyl oxygen interaction, through the intermediate, into C-F bond, to obtain the target 1 - Fluoro - 3,4 - Dimethoxybenzene, according to this process, can be prepared.
Chemical Reactions & Modifications
1 - Fluoro - 3,4 - Dimethoxybenzene is an important chemical substance that has attracted much attention in chemical research. Its chemical reaction and modification are crucial.
In the past, the reaction path for preparing this substance was complicated and the yield was low. However, after unremitting exploration, it has been improved. The new reaction conditions were optimized and high-efficiency catalysts were selected to make the reaction milder and more efficient. For example, using a new type of metal complex as a catalyst can precisely regulate the reaction check point and improve the purity and yield of the product.
In terms of modification, researchers have tried to introduce different substituents to improve its physicochemical properties. After experiments, the solubility and stability of 1-Fluoro-3,4-Dimethoxybenzene can be optimized by introducing specific groups at specific positions. In this way, the application prospect of 1-Fluoro-3,4-Dimethoxybenzene is broader, and it is expected to play a greater role in the fields of medicine and materials.
Synonyms & Product Names
1 - Fluoro - 3,4 - Dimethoxybenzene has a unique use in today's chemical products. However, to seek its synonymous name and commodity name, it is also necessary to study the classics in detail to investigate its root cause.
Looking at the records of the past, there may be those who are called "fluorinated dimethoxybenzene", which is based on its chemical composition, with fluorine atoms replaced by dimethoxybenzene, hence the name. Or some merchants use "fine fluoroxane" as the name of their products, because it has a certain aroma and fluoride-containing characteristics. This name is used to highlight its characteristics, which is eye-catching.
Nowadays, the research of 1 - Fluoro - 3,4 - Dimethoxybenzene is deepening, and its synonymous name and commodity name are also advancing with the research, or there are new changes. However, tracing its source is inseparable from the essence of chemistry and the needs of application.
Safety & Operational Standards
1 - Fluoro - 3,4 - Dimethoxybenzene is an important chemical substance that is of great value in our field of chemical research. In order to operate it safely and standardized, there are many key points that need to be carefully considered.
In terms of safety, the first to bear the brunt is the toxicity of this substance. Studies have shown that it may pose a potential hazard to human health. Therefore, when exposed, complete protective measures must be taken. Experimenters must wear professional laboratory clothes, which should have good protective properties and can effectively block the substance from direct contact with the body. At the same time, it is also essential to wear protective gloves. The material of the gloves must be able to resist the erosion of 1-Fluoro-3,4-Dimethoxybenzene and prevent it from contacting the skin through the gap of the gloves. Facial protection is also indispensable. Protective glasses should be able to block the substance from splashing into the eyes to avoid damage to the eyes.
Furthermore, the operating environment is also extremely critical. It should be ensured that the operation is carried out in a well-ventilated laboratory. The ventilation equipment must be kept in normal operation at all times, and the 1-Fluoro-3,4-Dimethoxybenzene gas evaporated during the experiment should be discharged outdoors in time to prevent it from accumulating indoors and reduce the risk of the experimenter inhaling harmful gases.
As for the operating instructions, be sure to use accurate measuring tools when using this substance. According to the exact amount required for the experiment, carefully measure 1 - Fluoro - 3,4 - Dimethoxybenzene, and do not estimate it at will, so as not to affect the accuracy of the experimental results. When conducting chemical reactions, the established reaction conditions must be strictly followed, such as temperature, pressure and reaction time, which must be precisely controlled. A slight deviation may lead to reaction failure and even cause danger.
After the experiment is completed, the remaining 1 - Fluoro - 3,4 - Dimethoxybenzene should not be discarded at will. It should be properly disposed of in accordance with specific waste disposal practices to avoid pollution to the environment.
Only by strictly adhering to the above safety and operating practices can we ensure that the research process of 1-Fluoro-3,4-Dimethoxybenzene not only achieves the purpose of scientific research, but also protects the safety of the experimenter and the health of the environment.
Application Area
1 - Fluoro - 3,4 - Dimethoxybenzene is a unique chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create a variety of specific drugs or help in the treatment of specific diseases. In the field of materials science, its unique chemical structure may endow materials with novel properties, such as improved material stability and conductivity, thus playing a role in the research and development of new materials.
In the field of fragrance synthesis, or with its unique chemical properties, it can add a different flavor to fragrances and create a unique olfactory experience. And it also has potential uses in the preparation of fine chemical products, which can optimize product performance, improve product quality, and contribute to the development of the fine chemical industry.
Research & Development
I have been engaged in the research of chemical products for many years, and recently I focused on the investigation of 1 - Fluoro - 3,4 - Dimethoxybenzene. This substance has unique properties and has great potential in the field of organic synthesis.
At the beginning of the investigation, its structure and properties were analyzed, and the previous works were carefully examined to clarify its physicochemical properties. Then the preparation method was developed, and different paths were tried, hoping to optimize the process and improve the yield and purity. After repeated experiments, some methods have been achieved, and some methods have achieved remarkable results, but there are still areas for improvement.
Looking to the future, this substance may shine in many fields such as medicine and materials. We should make unremitting efforts to explore its potential, with the hope of promoting its wide application, contributing to the development of the chemical field, and assisting this product in moving from research to broader practical applications, thus realizing the sublimation of its value.
Toxicity Research
The recent toxicity study of 1 - Fluoro - 3,4 - Dimethoxybenzene is quite important. We have investigated in detail to observe its properties and reactions, and to observe its changes in various environments.
Although this substance is a chemical raw material, the impact of toxicity should not be underestimated. After repeated experiments, various organisms were used as samples to observe the symptoms after exposure to this substance. There may be physiological discomfort or abnormal behavior. At the microscopic level, explore its effect on cells and observe changes in cell structure and function.
From this perspective, the toxicity of 1 - Fluoro - 3,4 - Dimethoxybenzene is related to the health of organisms and the stability of the environment. We should deeply study its toxic mechanism, seek preventive measures, and dissolve methods to ensure the harmony of all things and avoid its harm. This is the important task of our generation of chemical researchers.
Future Prospects
The future prospect concerns 1 - Fluoro - 3,4 - Dimethoxybenzene, which is the key to our chemical research. The properties of this substance are unique, and it has potential and great uses in the fields of medicine and materials.
Looking at today's world, science and technology travel thousands of miles every day, and the road of chemical industry also moves with the waves. 1 - Fluoro - 3,4 - Dimethoxybenzene, with its unique structure, may pave the way for the creation of new drugs and heal diseases; it may also emerge in the research and development of new materials, making the equipment exquisite and the material strong.
Our scientific researchers should study the mystery of this substance with diligence and tenacity. In the future, we may be able to use its power to create a new environment, to help the common people's diseases in medicine, to help the prosperity of all industries in materials, and to seek well-being for future generations. This is our eagerness for the future, and we are committed to it.
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Frequently Asked Questions

As a leading 1-Fluoro-3,4-Dimethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-Fluoro-3,4-Dimethoxybenzene?
1-Fluoro-3,4-dimethoxybenzene is also an organic compound. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
In this compound, the characteristics of fluorine atoms and dimethoxy groups make its chemical activity unique. Fluorine atoms have extremely high electronegativity, which can significantly affect the electron cloud distribution of molecules, which in turn plays a significant role in their reactivity and selectivity. In nucleophilic substitution reactions, due to the electron-withdrawing effect of fluorine atoms, the electron cloud density of the benzene ring can be reduced, making it easier for nucleophiles to attack. The presence of dimethoxy groups also affects the properties of molecules. Methoxy groups are the power supply subgroups, which can increase the electron cloud density of the adjacent and para-sites of the benzene ring. Therefore, in the aromatic electrophilic substitution reaction, it can guide the electrophilic reagent to preferentially attack the neighbor and para-position of the methoxy group.
1-fluoro-3,4-dimethoxy benzene exhibits unique activities in many chemical reactions. For example, when reacting with metal-organic reagents, carbon-carbon bonds can be constructed through cross-coupling reactions to prepare organic molecules with complex structures. And because of its chemical properties, it has potential applications in pharmaceutical chemistry, materials science and other fields. In drug research and development, compounds with specific biological activities can be designed and synthesized by virtue of their structural properties; in materials science, it can be used to synthesize materials with special photoelectric properties.
What are the main uses of 1-Fluoro-3,4-Dimethoxybenzene?
1-Fluoro-3,4-dimethoxybenzene is one of the organic compounds. It has a wide range of uses and is involved in various fields.
In the field of medicinal chemistry, this compound is often an important synthetic intermediate. It can be combined with other chemical groups through various chemical reactions to prepare drug molecules with specific pharmacological activities. By ingeniously designing the reaction path and using it as the starting material, drugs with complex structures and unique physiological effects can be constructed, such as inhibitors that act on specific targets, which are of great significance for the treatment of diseases.
In the field of materials science, 1-fluoro-3,4-dimethoxybenzene also shows certain value. It may participate in the synthesis of organic materials with special properties, such as optoelectronic materials. Due to the characteristics of fluorine atoms and methoxy groups in the molecular structure, it may endow materials with unique electrical and optical properties, such as good charge transfer ability and specific fluorescence emission properties, etc., providing materials for the development of new optoelectronic devices.
In the field of organic synthetic chemistry, as a key raw material, it can introduce other functional groups through nucleophilic substitution, coupling and other reactions, expand the molecular skeleton, and help organic chemists build a richer and more diverse library of organic compounds, laying the foundation for the discovery and performance research of new compounds in the future. In summary, 1-fluoro-3,4-dimethoxybenzene plays an important role in many fields such as medicine, materials and organic synthesis, and promotes the continuous progress of related science and technology.
What are the synthesis methods of 1-Fluoro-3,4-Dimethoxybenzene?
There are many ways to synthesize 1-fluoro-3,4-dimethoxybenzene. One common one is to use 3,4-dimethoxyphenol as the starting material. First, 3,4-dimethoxyphenol is reacted with a base to form phenolic salts. If it reacts with sodium hydroxide, it can promote the conversion of phenolic hydroxyl groups into phenolic anions, because phenolic hydroxyl groups have a certain acidity. Then, let it interact with fluorinating reagents, such as potassium fluoride, cesium fluoride, etc. In a suitable solvent, such as N, N-dimethylformamide (DMF), heating and stirring, phenolic anions will undergo nucleophilic substitution reaction with fluorine ions, resulting in 1-fluoro-3,4-dimethoxybenzene. This process requires attention to the reaction temperature and time. If the temperature is too high or the time is too long, or side reactions may occur, which will affect the purity and yield of the product.
Furthermore, 3,4-dimethoxyaniline can also be used as a raw material. After the diazotization reaction, 3,4-dimethoxyaniline is treated with sodium nitrite and hydrochloric acid to form a diazonium salt. The diazonium salt is extremely unstable and needs to be operated at low temperature to prevent its decomposition. Subsequently, fluoroborate acid is added to convert the diazonium salt into diazofluoroborate. Then, the diazofluoroborate salt is decomposed by heating to obtain 1-fluoro-3,4-dimethoxybenzene. In this approach, it is crucial to control the conditions of the diazotization reaction. The amount of sodium nitrite, reaction temperature and pH value all have a significant impact on the reaction process and product formation.
In addition, it can also be synthesized by palladium-catalyzed cross-coupling reaction. Select suitable halogenated aromatics, such as 3,4-dimethoxy halobenzene (halogen atoms can be bromine, iodine, etc.), and cross-couple with fluorinated reagents under the action of palladium catalyst in the presence of specific solvents and bases. Palladium acetate catalyst can be selected, toluene can be selected as solvent, and potassium carbonate can be used as base. This method requires precise regulation of catalyst dosage and reaction conditions to achieve efficient synthesis of 1-fluoro-3,4-dimethoxybenzene. Different synthesis methods have their own advantages and disadvantages. In actual operation, the most suitable method should be selected according to factors such as raw material availability, cost, and product requirements.
What are the precautions for storing and transporting 1-Fluoro-3,4-Dimethoxybenzene?
1-Fluoro-3,4-dimethoxybenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can avoid chemical changes caused by excessive temperature, decomposition or other adverse reactions. Dry conditions are indispensable, because if it encounters water vapor, it may undergo reactions such as hydrolysis, which will damage its purity and quality. Well ventilated, it can disperse volatile gases that may escape in time to avoid potential safety hazards caused by accumulation.
Furthermore, keep away from fire and heat sources. This compound is flammable. In case of open flames and hot topics, it is very easy to cause combustion or even explosion. Therefore, fireworks are strictly prohibited in the storage place, and all electrical equipment should be explosion-proof to prevent electric sparks from causing harm.
Because it is a chemical substance, or has certain toxicity and corrosiveness, it must be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. This is because different chemical substances come into contact with each other, or cause violent chemical reactions, resulting in danger.
As for transportation, ensure that the packaging is intact. The packaging material should be strong and protective, capable of resisting vibration, collision and friction, and avoiding material leakage caused by container rupture. During transportation, appropriate temperature and humidity should also be maintained, and it should not be exposed to extreme environments. Transportation vehicles should also be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. Escorts must be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and strictly supervised during transportation to ensure safe transportation.
What is the market price range for 1-Fluoro-3,4-Dimethoxybenzene?
1-Fluoro-3,4-dimethoxybenzene, which is also an organic chemical. As for its market price range, it is difficult to determine with certainty. Because market prices are often influenced by many factors and are volatile.
First, the difficulty of obtaining raw materials has a great impact on their prices. If raw materials are scarce, or it is difficult to collect and refine, the cost will rise and the price will rise. Second, the complexity of the preparation process is also related to the price. Complex processes require more manpower, material resources and technical investment, and the price of finished products will also increase accordingly. Furthermore, the market supply and demand situation is a key factor. If demand is strong and supply is limited, prices will rise; conversely, if supply exceeds demand, prices will tend to fall. In addition, the number of manufacturers and the competitive situation, as well as transportation, storage and other costs, will affect its price.
Because the exact market data is not detailed, it is difficult to directly state its specific price range. For details, you can consult the chemical product trading platform, relevant distributors, or consult the chemical industry information to get the latest and accurate price information.