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1-Fluoro-2-Nitrobenzene

1-Fluoro-2-Nitrobenzene

Hongda Chemical

Specifications

HS Code

656810

Chemical Formula C6H4FNO2
Molar Mass 141.1 g/mol
Appearance Yellow liquid
Boiling Point 207 - 208 °C
Melting Point 1 - 2 °C
Density 1.335 g/cm³
Flash Point 83 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Odor Pungent odor

As an accredited 1-Fluoro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - fluoro - 2 - nitrobenzene in 500 - ml glass bottle, tightly sealed.
Storage 1 - fluoro - 2 - nitrobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container to prevent vapor release. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Adhere to proper labeling for easy identification and ensure compliance with safety regulations.
Shipping 1 - fluoro - 2 - nitrobenzene is a hazardous chemical. Shipping requires compliance with strict regulations. It must be packaged in appropriate containers, labeled clearly, and transported by carriers approved for handling such substances.
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1-Fluoro-2-Nitrobenzene 1-Fluoro-2-Nitrobenzene
General Information
Historical Development
1 - Fluoro - 2 - Nitrobenzene is an organic compound, and its historical development is very interesting. In the past, chemists studied the way of organic synthesis, paying particular attention to aromatic compounds containing fluorine and nitro groups.
At that time, the technology of organic synthesis was just beginning to take off, and scholars devoted themselves to exploring the preparation of novel compounds. After repeated experiments and exquisite ideas, the method of synthesizing 1 - Fluoro - 2 - Nitrobenzene was gradually obtained. At first, the synthesis steps were cumbersome and the yield was not abundant, but chemists persevered and continuously improved the process.
With the passage of time, the chemical theory has become increasingly refined, and the synthesis technology has also been greatly improved. The profound understanding of the reaction mechanism has led to the emergence of new methods, and the synthesis of 1-Fluoro-2-Nitrobenzene has become more efficient and accurate, paving the way for its application in many fields.
Product Overview
1 - Fluoro - 2 - Nitrobenzene is an organic compound with unique properties. In terms of appearance, it is a colorless to light yellow liquid with a special odor. This substance has a wide range of uses in the chemical industry.
As far as its preparation is concerned, it is often obtained through a specific chemical synthesis path. Using benzene as the starting material, nitro groups are introduced through nitration reaction, and then halogenation reaction, fluorine atoms are introduced to obtain 1 - Fluoro - 2 - Nitrobenzene.
Its chemical properties are active, and the presence of nitro groups makes it oxidizing to a certain extent. Fluorine atoms affect the electron cloud distribution and reactivity of molecules. In organic synthesis, it can be used as a key intermediate to participate in many reactions, such as nucleophilic substitution reactions, to construct more complex organic molecular structures, and has important application value in the fields of medicine, pesticides, and materials science.
Physical & Chemical Properties
1 - Fluoro - 2 - Nitrobenzene is an organic compound. It is a colorless to light yellow liquid with a special odor. Its boiling point is about 187 to 188 degrees Celsius, and its melting point is -27 degrees Celsius. The density is about 1.32 g/cm ³, which is insoluble in water, but soluble in organic solvents such as alcohols and ethers.
In terms of its chemical properties, the presence of fluorine atoms and nitro groups gives this compound a unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, and electrophilic substitution reactions are difficult to occur, while nucleophilic substitution reactions are easier to carry out. Although fluorine atom has strong electronegativity, it can participate in various substitution reactions under certain conditions because of its small atomic radius and large C-F bond energy with benzene ring, which shows its important value in the field of organic synthesis and is a key intermediate in many organic synthesis reactions.
Technical Specifications & Labeling
1 - Fluoro - 2 - Nitrobenzene is an important chemical in organic synthesis. Its process specifications and identification (product parameters) are extremely critical. In terms of process specifications, the synthesis of this product requires precise control of the reaction conditions. The reaction temperature should be maintained at a specific range, too high or too low will affect the yield and purity. The raw materials used must meet high purity standards, and the presence of impurities can cause side reactions.
In terms of identification, the name, molecular formula, molecular weight and other basic parameters should be clearly marked on the product packaging. Hazard warning labels should also be indicated, because they are toxic and corrosive to a certain extent, which is related to user safety. Accurate process specifications and identification (product parameters) are fundamental to ensuring the quality and safety of 1-Fluoro-2-Nitrobenzene.
Preparation Method
1 - Fluoro - 2 - Nitrobenzene is an important compound in organic synthesis, and its preparation method is crucial.
Raw materials and production process: The main raw materials are o-nitrochlorobenzene and anhydrous potassium fluoride. In the reactor, an appropriate amount of organic solvent, such as cyclosulfone, is added, which can improve the reaction efficiency. Heat up to a certain temperature, usually between 180-220 ° C, and stir to fully contact the raw materials for the reaction.
Reaction steps: The chlorine atom of o-nitrochlorobenzene is affected by the nucleophilic substitution reaction and is replaced by the fluoride ion in potassium fluoride. This reaction process requires strict control of temperature and reaction time, about 5-8 hours, to ensure complete reaction. Catalytic mechanism: The addition of appropriate amounts of catalysts, such as quaternary ammonium salts, can accelerate the nucleophilic attack of fluoride ions, reduce the activation energy of the reaction, make the reaction easier, and improve the yield and purity of 1-Fluoro-2-Nitrobenzene.
Chemical Reactions & Modifications
1 - Fluoro - 2 - Nitrobenzene is also an organic compound. Its chemical reaction can be explored. In various reactions, the change of nucleophilic substitution is particularly significant. Fluorine atoms are active and often replaced by nucleophilic reagents. Because fluorine has strong electronegativity, the ortho-nitro group enhances the electron attraction of the benzene ring, making it easier for fluorine to leave.
As for its modification, the reaction conditions, such as temperature and solvent changes, can be modified to adjust its activity and selectivity. Increasing the temperature often promotes the reaction to accelerate, but if it is too high, it may increase side reactions. The polarity of the solvent also has a significant impact. Polar aprotic solvents are conducive to nucleophilic substitution, which can increase the nucleophilicity of the reagent and make the reaction smooth. Therefore, it is of great value to investigate the chemistry of 1 - Fluoro - 2 - Nitrobenzene in organic synthesis.
Synonyms & Product Names
1 - Fluoro - 2 - Nitrobenzene, also known as o-fluoronitrobenzene. In the field of chemical industry, its name is also often used as an alias. There are many different ways to address chemical products.
o-fluoronitrobenzene, which is often a key material in the process of chemical synthesis. With its characteristics, it can be used in the preparation of many fine chemicals. Or in the pharmaceutical synthesis industry, it is an important intermediate; or in the preparation of dyes, it is a key starting material.
The science of chemical industry, to distinguish between one heavy thing and more. In addition to its original name, o-fluoronitrobenzene, its synonyms are also well known to the industry. This is all due to the inheritance and exchange of chemical processes, and various laws and titles may be different in various places, but they all refer to this thing. Synonyms, like the codes of chemical classics, are familiar to the industry, so that they can travel smoothly on the road of research and development and production, be accurate and correct, and achieve the delicacy of chemical industry.
Safety & Operational Standards
1 - Fluoro - 2 - Nitrobenzene is an important chemical substance. There are many strict regulations to be followed for its laboratory operation and safety.
In terms of operating environment, the laboratory must be well ventilated to prevent the accumulation of harmful gases. Due to its certain toxicity and volatility, if the air is not circulated, it is easy for the operator to inhale excessive and damage health.
When using this substance, appropriate protective equipment should be worn. Protective gloves should be worn, and the material should be able to resist the erosion of 1 - Fluoro - 2 - Nitrobenzene to avoid contact with the skin, otherwise it may cause skin irritation and even poisoning. At the same time, wear protective glasses to prevent the substance from splashing into the eyes and causing serious damage to the eyes.
During operation, the movement should be steady and careful. Due to its active chemical nature, improper operation or dangerous reactions. For example, do not mix with strong oxidants at will, otherwise it may cause violent chemical reactions or even explosions. When configuring relevant solutions, add reagents in a specific order and proportion to precisely control the reaction conditions.
After the experiment is completed, the remaining 1-Fluoro-2-Nitrobenzene and related wastes must not be discarded at will. It needs to be collected in accordance with regulations and handed over to professional institutions for treatment to avoid polluting the environment.
In conclusion, when operating 1 - Fluoro - 2 - Nitrobenzene, strict safety and operating practices must be followed to ensure the safety of personnel and the smooth progress of experiments, as well as the safety of the environment.
Application Area
1 - Fluoro - 2 - Nitrobenzene is an important chemical substance with a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of specific drugs. Due to the unique electronic effect of fluorine and nitro groups on the benzene ring, it can endow drugs with specific biological activities, helping them better act on human targets and achieve the purpose of treating diseases.
In the field of materials science, this compound can participate in the preparation of special functional materials. Its structural properties make the obtained materials have good stability and unique optical properties, etc., and may have extraordinary performance in optical device manufacturing.
Furthermore, in organic synthetic chemistry, 1-Fluoro-2-Nitrobenzene is often used as a starting material. Through various chemical reactions, complex organic molecular structures are constructed, paving the way for the synthesis of new organic compounds and promoting the continuous development of the field of organic chemistry.
Research & Development
1 - Fluoro - 2 - Nitrobenzene is a crucial compound in the field of organic synthesis. Our researchers have made significant progress in its preparation process after long-term research. In the past, the preparation process of this compound was complicated and the yield was not ideal.
However, today is different from the past. After repeated experiments and careful improvement, we have developed a new synthesis path. This path is concise and efficient. By precisely regulating the reaction conditions, such as temperature and catalyst dosage, the yield can be greatly improved.
Looking to the future, 1 - Fluoro - 2 - Nitrobenzene has broad application prospects in many fields such as medicine and materials. Our researchers should persevere, deeply explore its performance and application, and strive to promote the further development of related industries, making modest contributions to academia and industry, and making this compound shine brighter.
Toxicity Research
The toxicity of 1 - Fluoro - 2 - Nitrobenzene is a key issue in chemical research. Looking at this substance, its molecular structure is unique, and the combination of fluorine and nitro groups may cause special chemical activity.
After various experiments, it may react differently in organisms. Taking mice as a test, micro-exposure, the fur is slightly abnormal at first, and gradually slows down, which may indicate that it has an impact on the nervous system. Tested with plants, it was found that the growth rate of plants slowed down and the leaf color was also abnormal, which seemed to interfere with the physiological metabolism of plants.
However, toxicity studies are not achieved overnight, and the effects of different doses and exposure times need to be investigated in detail, as well as the state of degradation and transformation in the environment, in order to obtain the full picture of its toxicity and provide a solid basis for future application and prevention.
Future Prospects
The future prospect concerns the product of 1-Fluoro-2-Nitrobenzene. This chemical product has great potential in our scientific research. If its synthesis method can be refined, it will definitely increase the yield and optimize the quality. When the process is mature, it may be widely used in medical creation to add strength to the cure of various diseases; it can also be devoted to material research and development to open up new fields. Its application prospects are like the beginning of the stars, although it is not dazzling, it has already emerged. With time, scientific researchers will be able to explore its endless possibilities, such as sailing through the waves and sailing to a wider scientific ocean, creating extraordinary achievements, and shining brightly on the future scientific and technological stage for the benefit of all people.
Where to Buy 1-Fluoro-2-Nitrobenzene in China?
As a trusted 1-Fluoro-2-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-fluoro-2-nitrobenzene?


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And wolfberry is the dry and ripe fruit of the nightshade plant Ningxia wolfberry. Wolfberry has a sweet taste, flat nature, and belongs to the liver and kidney meridians. It is widely used in the field of health care. It is often used as medicine in traditional Chinese medicine to nourish the liver and kidney. For symptoms such as soreness of waist and knee, dizziness, and vision loss caused by deficiency of liver and kidney yin, wolfberry has a good conditioning effect. In daily diet, people often use wolfberry for soup, such as wolfberry red dates and black chicken soup, which not only tastes delicious, but also has the effect of nourishing qi and blood; or add wolfberry when making tea, such as wolfberry chrysanthemum tea, which can clear the liver and eyesight, and is suitable
In summary, glutinous rice grains are mainly used for food seasoning and beverage production, bringing unique flavor and certain health effects; wolfberry focuses on health care, and plays a role in nourishing the liver and kidney in traditional Chinese medicine and daily diet therapy, both of which are important elements in traditional life and health culture.
What are the physical properties of 1-fluoro-2-nitrobenzene?
Lead and mercury are common substances, each with unique physical properties.
Lead has a soft texture, is a silver-gray metal, and has good ductility. Its density is quite high, about 11.34 grams per cubic centimeter. This property allows lead to be used in many fields, such as manufacturing shot balls, with its high density to achieve specific motion effects. The melting point of lead is relatively low, 327.5 ° C. It is easy to melt into a liquid state under heating conditions. This property makes it widely used in the casting field and can be cast into various lead products. Although the conductivity of lead is not as good as that of copper, aluminum and other metals, it still has a certain conductivity. It is also used in some occasions where conductivity requirements are not high and other special properties are required. In addition, lead has good corrosion resistance and can resist the attack of many chemicals. It is often used in the manufacture of chemical equipment liners, battery shells, etc., to protect equipment from corrosion.
Mercury is commonly known as mercury. It is liquid at room temperature and pressure, which is its remarkable physical property. Mercury has high surface tension, rolls in a spherical shape, and shines like silver beads. Its density is also high, about 13.59 grams/cubic centimeter, which is higher than that of lead. Mercury has an extremely low melting point of -38.87 ° C and a boiling point of 356.6 ° C. This wide range of liquid characteristics makes it important for applications in thermometers, sphygmomanometers and other instruments, and can accurately indicate values with temperature changes. Mercury has good electrical conductivity and is used in some electronic components such as electrical switches and rectifiers. However, mercury is volatile and will slowly evaporate into mercury vapor at room temperature. Mercury vapor is toxic and requires extreme caution when used and handled.
Is 1-fluoro-2-nitrobenzene chemically stable?
Guanfu River and choline, the chemical properties of the two are related to the change of things and the reason of things, and have been studied by the world. Let's discuss it today to clarify whether its nature is stable or not.
The river, the convergence of water, Haohao soup. Its main component is water, and its chemical properties are relatively stable. Water is formed by the combination of hydrogen and oxygen, and its molecular structure is H2O O. Under normal temperature and pressure, water is liquid and its properties are peaceful. If it does not encounter special conditions such as high temperature and strong electricity, it rarely initiates violent chemical changes. For example, in rivers, water often coexists with sand, gravel, soil, etc., which is only a physical mixture, and there are few chemical reactions that cause its essence to change drastically. This is because the chemical bonds of hydrogen and oxygen in water molecules are stable, and considerable energy is required from the outside world to break them.
As for choline, it is an organic compound containing nitrogen. Its structure has a quaternary ammonium base part, which gives choline a certain chemical activity. Choline is easily soluble in water, in aqueous solution, or in an ionic state due to ionization. Encounters with many chemical reagents, or can initiate reactions. In case of acid, the quaternary ammonium base part of choline may undergo ion exchange reaction with hydrogen ions in the acid; in case of some oxidants, because the valence of some atoms in the structure is variable, it may also be oxidized. Compared with water, choline has more active chemical properties and is slightly less stable.
To sum up, the chemical properties of water, the main component of the river, are quite stable, while choline is relatively active due to its special structure, and its stability is inferior to water. The difference in chemical properties between the two stems from the characteristics of their internal atomic composition and chemical bonds. This is the wonder of the chemical world and the key to exploring the nature and laws of matter.
What are the synthesis methods of 1-fluoro-2-nitrobenzene?
To prepare 1-alkyne and 2-cyanopyridine, there are many ways to synthesize them.
One of them can be through nucleophilic substitution reaction. Select an appropriate halogenated hydrocarbon, if you want to obtain 1-alkyne, the halogenated hydrocarbon one-terminal alkynyl group, and the reagent containing the active group, in a suitable solvent, under the catalysis of a base, the halogenated atom is replaced to form a 1-alkyne compound. As for 2-cyanopyridine, halogenated pyridine can be selected, and cyanide reagents, such as potassium cyanide, can be used. With the assistance of a phase transfer catalyst, the halogenated atom is replaced by a cyano group, so 2-cyanopyridine is obtained. In this process, it is necessary to pay attention to the reaction temperature, the strength and dosage of alkali, because these factors have a great influence on the reaction rate and product purity.
Second, metal-organic reagents are used. When preparing 1-alkynes, alkynyl-based reagents can react with suitable halogenated compounds. First, alkynyl-based reagents, such as alkynyl lithium or alkynyl magnesium reagents, are prepared, and then nucleophilic substitution occurs with halogenated hydrocarbons to generate 1-alkynes. Synthesis of 2-cyanopyridine, pyridine-based metal reagents can be used to react with cyanylating reagents. In this method, the preparation conditions of metal reagents are strict, the requirements for anhydrous and oxygen-free environments are high, and the
Third, through addition reaction. For 1-alkynes, unsaturated hydrocarbons can be obtained by addition of alkynyl-containing reagents. For example, alkenes and acetylene are added under the action of specific catalysts to form 1-alkynes. Synthesis of 2-cyanopyridine can be made by taking advantage of the unsaturation of the pyridine ring and the cyanide-containing reagents under the guidance of catalysts. The key to this approach lies in the choice of catalyst, and different catalysts have a significant impact on the selectivity and activity of the reaction.
In addition, the target molecule can be gradually constructed from common raw materials through multi-step reactions. For example, starting from simple hydrocarbons, through halogenation, substitution, addition and other series of reactions, 1-alkyne is obtained; pyridine derivatives are used as starting materials, and 2-cyanopyridine is synthesized through functional group conversion and cyano group introduction. Although this method has complicated steps, it can flexibly select raw materials and optimize the reaction route according to actual needs.
What should be paid attention to when storing and transporting 1-fluoro-2-nitrobenzene?
Mercury and cyanomercury are safe for storage and storage. Please pay attention to the following things:
The first priority is safety. Mercury is a toxic and heavy metal, and it is toxic. Its evaporation and inhalation can cause serious damage to the mind, digestion and immunity. Cyanomercury is also toxic, and it is a huge hazard to the human environment. Therefore, when operating both, you must follow safety procedures and wear protective clothing, gloves, gas masks, etc., to prevent skin contact and inhalation.
Furthermore, store it properly. Mercury should be kept in a sealed container to prevent damage. A small amount of water can be added to cover it to form a water seal. Cyanomercury should be stored in dry, dry, and well-connected places, and can be used to prevent fire, gas and oxidation. Due to its activity, in case of specific substances or pieces, it is easy to react biochemically and cause dangerous accidents.
In terms of production, according to the phase method, the combined method should be used. Mercury and cyanomercury are all dangerous chemical products, and it is necessary to have a suitable location to support them. The container should be firmly sealed to ensure that it is clear that it is dangerous, and that the contents and dangerous characteristics are clear. On the way, control the degree and temperature of the parts to avoid shocks and collisions, and avoid leakage caused by container breakage.
Once there is a leakage, it is urgent to report immediately. Evacuate the crowd around the area and set a warning. Manage the situation to prevent the leakage of mercury, and sprinkle sulfur powder to generate mercury sulfide, reduce toxicity, and then collect it carefully. Cyanomercury leakage, according to its chemical characteristics, chemical treatment, treatment of waste residue, according to the dangerous waste disposal.