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1-Fluoro-2-(Methylsulfonyl)Benzene

1-Fluoro-2-(Methylsulfonyl)Benzene

Hongda Chemical

Specifications

HS Code

246434

Chemical Formula C7H7FO2S
Molecular Weight 174.19
Appearance Typically a colorless to pale - yellow liquid
Boiling Point Around 262 - 264 °C
Density Approx. 1.34 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
Flash Point Relatively high, estimated around 110 - 120 °C
Vapor Pressure Low at room temperature

As an accredited 1-Fluoro-2-(Methylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - fluoro - 2 - (methylsulfonyl)benzene packaged in 500 - gram bottles.
Storage 1 - fluoro - 2 - (methylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and contamination. Label the storage container clearly for easy identification.
Shipping 1 - fluoro - 2 - (methylsulfonyl)benzene is shipped in specialized, tightly - sealed containers to prevent leakage. It follows strict chemical transportation regulations, ensuring safe transit due to its chemical nature.
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1-Fluoro-2-(Methylsulfonyl)Benzene 1-Fluoro-2-(Methylsulfonyl)Benzene
General Information
Historical Development
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is also an organic compound. At the beginning of its historical development, scholars delved into the field of chemistry and strived to expand their understanding. At the beginning, it was difficult to explore the properties and preparation methods of this substance.
However, the scientific researchers were unremitting, and after repeated experiments, the synthesis path was gradually clarified. The early synthesis method was complicated and inefficient, and the yield was not high. Years passed, science and technology advanced, and new production methods became more sophisticated, and the yield was improved.
The research on this compound also promoted the development of related fields. Scholars continue to deepen their understanding of its reaction characteristics, contributing to organic synthetic chemistry. Its development is a testament to the wisdom and perseverance of chemical researchers, adding a unique touch to the long river of organic chemistry.
Product Overview
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is an organic compound. It is a colorless to pale yellow liquid with a special odor. In the molecular structure of this compound, the fluorine atom is in the ortho position with the methyl sulfonyl group on the benzene ring.
Because of its unique structure, 1 - Fluoro - 2 - (Methylsulfonyl) Benzene has a wide range of uses in the field of organic synthesis. It is often used as a key intermediate and participates in the construction of many complex organic molecules. Its reactivity can be regulated by the characteristics of functional groups on the benzene ring. Through nucleophilic substitution, electrophilic substitution and other reactions, various functional groups are introduced to prepare compounds with specific structures and functions.
In the fields of medicinal chemistry and materials science, 1 - Fluoro - 2 - (Methylsulfonyl) Benzene has also emerged, providing an important foundation for the development of new drugs and advanced materials. It has significant value in chemical research and industrial production.
Physical & Chemical Properties
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is also an organic compound. Its physical and chemical properties are quite important to chemical researchers.
Looking at its physical properties, at room temperature, this substance is often in a liquid state, with a specific color and taste. Its boiling point and melting point are the keys to characterize its physical state. The boiling point is related to its gasification temperature; the melting point is the point at which it changes from solid to liquid.
As for chemical properties, the presence of fluorine and methyl sulfonyl groups in its structure gives this compound a unique reactivity. Fluorine atoms have strong electronegativity, which can change the distribution of electron clouds in molecules and affect their reactions with other substances. Methylsulfonyl groups also play an important role in many chemical reactions, initiating nucleophilic substitution, electrophilic addition and other reactions. These properties, in the field of organic synthesis, provide a variety of ways and possibilities for the preparation of other compounds, which is an indispensable content of chemical research.
Technical Specifications & Labeling
1 - Fluoro - 2 - (Methylsulfonyl) Benzene, it is also a chemical product. Its technical quality is important (commodity quality) to the general requirements. For example, the quality needs to be high, and the content should be controlled. In the physical quality, melting and boiling can also be determined to meet specific needs.
And (commodity quality), to clarify its chemical formula and molecular weight, so that the user can see at a glance. And the package should not be ignored, so as to ensure the safety of the user. In this way, the technology of 1 - Fluoro - 2 - (Methylsulfonyl) Benzene can be completed and promoted for its use.
Preparation Method
There is currently a method for preparing 1 - Fluoro - 2 - (Methylsulfonyl) Benzene, which is described in detail below.
Raw materials and production process: Starting with benzene, through sulfonation, benzene sulfonic acid is obtained, and then it is co-heated with dimethyl sulfate to form methyl benzene sulfonate. Subsequently, a fluorinating agent is used to replace it with a fluorine atom easily sulfonate group, and then 1 - Fluoro - 2 - (Methylsulfonyl) Benzene is obtained.
Reaction steps: First, benzene is co-heated with concentrated sulfuric acid, and the temperature is moderately controlled to promote the sulfonation reaction. After forming benzene sulfonic acid, cool down, add dimethyl sulfate, and then heat up. When the ester is formed, a fluorinating agent is applied, stirred in a timely manner, and the temperature is controlled to promote fluorination.
Catalytic mechanism: During sulfonation, sulfuric acid is the energy barrier to promote and reduce the reaction. When fluorination is replaced, or a phase transfer catalyst is used to make the two phases more miscible, increase the activity of the fluorinating agent, and improve the effect of the reaction.
Chemical Reactions & Modifications
There is now a substance named 1 - Fluoro - 2 - (Methylsulfonyl) Benzene. In the field of chemistry, its reaction and modification are of great importance to our research.
The reaction of this compound requires detailed investigation of its structure. The position of the fluorine atom and the methyl sulfonyl group has a great influence on the reaction path. Fluorine, with strong electronegativity, can change the density of the electron cloud at the ortho position, and the activity of nucleophilic or electrophilic reactions is unusual.
And methyl sulfonyl group, with electron-absorbing properties, also tends to react with the surrounding atoms. When modifying, or introduce new groups to adjust its physical and chemical properties. It can be substituted by nucleophilic substitution, and the fluorine atom can be used as his group to change its polarity and reactivity.
If you want to get better properties, you must understand the reaction mechanism and observe that changes in conditions, such as temperature and solvent, have an impact on the product. After repeated research and testing, it is expected that the reaction can be controlled, and an ideal modified product can be obtained to develop its functions in the fields of medicine and materials.
Synonyms & Product Names
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is especially important in the field of my chemical research. Its synonymous name and the name of the commodity are also meaningful.
The name of a chemical substance often has multiple expressions. The names of synonyms are different, so they refer to the same substance instead of different names. As for the name of the commodity, it involves the needs of the market and commerce.
1 - Fluoro - 2 - (Methylsulfonyl) Benzene, or it is called fluoromethylsulfonyl benzene and the like, which is a synonymous name. And among the shops, merchants or take different names to sell it, but in fact, it is all this thing. We chemical researchers, in all kinds of names, should be carefully discerned, so that in our research, there is no risk of misuse, and we can clearly express our meaning in academic and commercial exchanges, so as not to be confused. In this way, we can find the right path of chemical research, and move forward steadily in exploring the mysteries of matter.
Safety & Operational Standards
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is an important chemical product. It is necessary to elaborate on the safety and operation specifications of this product.
In terms of safety, this chemical substance may pose certain potential hazards. It may have different degrees of effects on human health, such as contact with the skin, or cause skin irritation, allergic reactions; if it is not carefully entered into the eyes, it may also damage the eye tissue. Inhalation of its volatile aerosol, or irritation to the respiratory tract, and even harm the function of the lungs. Therefore, during the operation, safety measures are essential.
Operators should wear appropriate protective clothing, such as chemical-resistant work clothes and protective gloves, to ensure that the skin does not come into direct contact with the substance. Eye protection is also very important. You need to wear protective glasses or a mask to prevent accidental splashing. And the operation should be carried out in a well-ventilated environment. It is best to equip professional ventilation equipment to discharge volatile gases in time and reduce the concentration of harmful substances in the air.
In terms of operating specifications, when taking the chemical, be sure to use a precise measuring tool, and strictly use the amount required for experiment or production to avoid waste and danger caused by excessive use. The weighing process needs to be carried out on a smooth and clean table to ensure the accuracy of the data. When mixing or reacting, follow the established reaction conditions and steps step by step. Pay close attention to the temperature, pressure and other parameters of the reaction process. If there is any abnormality, take corresponding measures immediately.
When storing, 1 - Fluoro - 2 - (Methylsulfonyl) Benzene should be placed in a cool, dry and ventilated place, away from fire and heat sources, and away from direct sunlight. At the same time, it should be stored in categories with other chemicals to prevent mutual reaction. Only by strictly adhering to safety and operating practices can the safety and effectiveness of this product during use be guaranteed.
Application Area
1 - Fluoro - 2 - (Methylsulfonyl) Benzene is an important chemical substance. Its application field is quite wide. In the field of organic synthesis, it is often used as a key intermediate. It can interact with a variety of reagents through specific reaction pathways to build complex organic molecular structures.
In the field of materials science, it can participate in the preparation of materials with special properties. For example, by polymerizing with specific polymer monomers, the material is endowed with unique electrical and optical properties.
In pharmaceutical chemistry research, this compound may exhibit potential biological activity. After structural modification and optimization, it may be developed into new drugs for the treatment of diseases.
In conclusion, 1 - Fluoro - 2 - (Methylsulfonyl) Benzene has significant value in multiple application fields, and more potential uses need to be explored and explored.
Research & Development
Today there is a thing named 1 - Fluoro - 2 - (Methylsulfonyl) Benzene. Our generation has been studying this thing for a long time, and we have worked very hard on its research and development.
At the beginning, it was a lot of trouble to explore its properties and structure. However, everyone worked together, according to ancient methods and new techniques, and gradually understood its quality. After many tests, we know the rules of its reaction, and we have also gained results in the method of synthesis.
At present, the use of this thing is becoming more and more widespread. In the field of medicine, it can be used as a medicine guide to help with the effect of medicine; in the field of chemical industry, it is an essential material for the production of other things.
We should continue the past and deepen our research. Seek better methods to control it, and expand its use. I hope this thing will be in the future, for the progress of the world, and make more contributions, so that the road of research and development will be wider and wider, and it will be used by everyone.
Toxicity Research
Since modern times, the art of chemistry has advanced day by day, and all kinds of new things have been produced. Today, there is 1-Fluoro-2- (Methylsulfonyl) Benzene, which is gradually emerging in the chemical industry. However, the study of its toxicity is crucial.
When studying its toxicity, you must use rigorous methods to observe its changes in the living body. Or take all kinds of experimental organisms, such as rats and insects, feed and touch it with an appropriate amount of this substance, and observe its physiological signs. If you see it languishing, lose diet, or even damage to organs, you can know its toxicity.
Furthermore, explore its diffusion and degradation in the environment. If it does not melt for a long time, it may cause ecological harm by tossing and turning between water and soil. Therefore, the toxicity of 1-Fluoro-2 - (Methylsulfonyl) Benzene is a top priority at present, which is related to the health of living beings and the safety of the environment.
Future Prospects
Prospects of the future, in 1 - Fluoro - 2 - (Methylsulfonyl) Benzene, this product is possible. Its characteristics are unique, and in the field of chemical engineering, it can be the foundation for exploring new paths.
In today's world, science and technology are changing, and chemical research is also taking steps. 1 - Fluoro - 2 - (Methylsulfonyl) Benzene or its special research, in the field of materials, to help the production of new materials with special properties, to solve the problem of production. Or in the field of materials, to spawn new materials with special properties, to meet the needs of all walks of life.
Our explorers, our heart and insight into its secrets. In the next few days, I will definitely be able to make 1 - Fluoro - 2 - (Methylsulfonyl) Benzene a bright pearl that has not yet been developed and used by the world. It is my hope that I will be able to achieve this.
Where to Buy 1-Fluoro-2-(Methylsulfonyl)Benzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-2-(Methylsulfonyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2- (Methylsulfonyl) Benzene?
1-Fluoro-2- (methylsulfonyl) benzene has many main uses. In the field of organic synthesis, it can be called a key raw material. Due to its unique chemical structure, it can participate in various delicate reactions to construct various complex and functional organic molecules.
In the process of pharmaceutical research and development, this compound plays an important role. Or it can be used as a starting material for the synthesis of specific drugs. By ingenious reaction steps, other key groups are introduced to create drug molecules with the effect of treating specific diseases. The structural characteristics of fluorine atoms and methylsulfonyl groups may endow drugs with unique biological activity, lipophilicity and metabolic stability, which helps to improve drug efficacy.
In the field of materials science, 1-fluoro-2- (methylsulfonyl) benzene is also useful. Or it can be used to prepare polymer materials with special properties, such as as as functional monomers in polymerization reactions, introducing special functional groups, giving materials excellent properties such as chemical resistance, good thermal stability or unique electrical properties, so as to meet the needs of different fields for special properties of materials.
In addition, in the preparation of fine chemical products, this compound is often used as an important intermediate. It can be converted into various fine chemicals through a series of reactions, such as special flavors, additives, etc., to meet the needs of people for high-quality and diverse fine chemical products.
What are the physical properties of 1-Fluoro-2- (Methylsulfonyl) Benzene?
1-Fluoro-2- (methylsulfonyl) benzene, which is mostly liquid at room temperature, looks clear and colorless, with a specific aromatic odor. Its boiling point is quite high, about 250-260 ° C. Due to the strong interaction forces between molecules, such as dipole-dipole force and van der Waals force, more energy is required to overcome such forces in order to make it boil.
The density of this substance is greater than that of water, about 1.3-1.4 g/³ cm, so when placed in water, it will sink to the bottom. Its solubility is slightly special, and it can be well miscible in organic solvents such as dichloromethane, chloroform, and toluene. Because these organic solvents are similar in structure to 1-fluoro-2- (methylsulfonyl) benzene, according to the principle of "similar miscibility", the two are easily miscible; however, in water, its solubility is extremely small, and it is difficult to form effective interactions due to the large difference between molecular polarity and water molecules.
In terms of stability, 1-fluoro-2- (methylsulfonyl) benzene is quite stable under conventional environmental conditions and is not prone to spontaneous chemical reactions. However, under specific conditions, such as high temperature, strong oxidants or strong bases, its chemical properties become active. Due to the presence of fluorine atoms and methyl sulfonyl groups, the electron cloud density of benzene ring changes, and nucleophilic substitution reactions are more likely to occur. When encountering nucleophilic reagents, fluorine atoms may be replaced. The sulfur atoms in methyl sulfonyl groups have higher valence states and have certain oxidation properties. Under suitable conditions, they can participate in redox reactions.
Is 1-Fluoro-2- (Methylsulfonyl) Benzene Chemically Stable?
The stability of the chemical properties of 1-fluoro-2- (methylsulfonyl) benzene is related to many aspects. In this compound, the fluorine atom has strong electronegativity, which can change the electron cloud density distribution of the benzene ring, which has a great impact on its chemical activity. Fluorine atoms can cause the electron cloud density of the benzene ring to decrease, and the electrophilic substitution reactivity may change. However, because the methylsulfonyl group also has electron-withdrawing properties, the interaction between the two makes the reactivity complicated.
Methylsulfonyl is a strong electron-withdrawing group, which can enhance the polarity of molecules, in chemical reactions, or make the benzene ring more vulnerable to nucleophilic reagents. In this way, 1-fluoro-2 - (methylsulfonyl) benzene may exhibit unique activities in nucleophilic substitution reactions.
When it comes to stability, under general conditions, 1-fluoro-2 - (methylsulfonyl) benzene is still stable. In case of extreme conditions such as high temperature, strong acid, strong base or strong oxidant, its structure may change. At high temperature, the chemical bond can obtain enough energy to break; in the environment of strong acid and strong base, or lead to acid-base catalytic reaction, causing molecular structure rearrangement or decomposition; strong oxidant or oxidize some groups in the molecule, causing its chemical properties to change.
And its solubility in organic solvents is also related to stability. Good solubility or make the molecule more easily dispersed, contact with other substances, stability or slightly reduced; if the solubility is poor, the intermolecular interaction is strong, stability or slightly increased.
In summary, the stability of the chemical properties of 1-fluoro-2- (methyl sulfonyl) benzene is not absolute, depending on environmental conditions and encountered substances. Under common mild conditions, it can maintain certain stability; however, under extreme conditions or the action of specific reagents, its structure and properties may change significantly.
What are the synthesis methods of 1-Fluoro-2- (Methylsulfonyl) Benzene?
For 1-fluoro-2 - (methylsulfonyl) benzene, there are various ways to synthesize it. First, it can be started from halogenated aromatics. First, halogenated benzene is taken, and a halogen exchange reaction is carried out with an appropriate fluorine source, under suitable reaction conditions with a catalyst, so that the halogen atom can easily become a fluorine atom to obtain a fluorobenzene derivative. Next, a methyl sulfonyl group is introduced. Methylsulfonyl chloride is often used as a reagent to react with fluorobenzene derivatives in the presence of bases. The base can bind the acid and promote the reaction to the right, resulting in the target product 1-fluoro-2 - (methylsulfonyl) benzene.
Furthermore, it can be started from benzene derivatives. If there is a benzene with a suitable substituent, a sulfonyl group is first introduced through a sulfonation reaction, and the reaction conditions are adjusted to position the sulfonyl group at the desired position. Subsequently, the sulfonyl group of the resulting sulfonated product is converted into a methyl sulfonyl group, which may require a multi-step reaction and is achieved by intermediate conversion. After that, a fluorine atom is introduced, and a halogen atom exchange or other suitable fluorination reaction means is used to obtain 1-fluoro-2- (methyl sulfonyl) benzene.
or from other aromatic compounds. For example, fused aromatic hydrocarbons such as naphthalene and anthracene, through appropriate ring opening and functionalization reactions, the structure of the target molecule is gradually constructed, and fluorine atoms and methyl sulfonyl groups are introduced in sequence to achieve the purpose of synthesizing 1-fluoro-2- (methyl sulfonyl) benzene. However, this path may be complicated, and the reaction steps and conditions need to be carefully planned to avoid unnecessary side reactions and improve the yield and purity of the target product.
What are the precautions for 1-Fluoro-2- (Methylsulfonyl) Benzene during storage and transportation?
1-Fluoro-2 - (methylsulfonyl) benzene is an organic compound. During storage and transportation, many matters need to be paid careful attention.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. This is because it is afraid of heat and moisture, high temperature is prone to chemical reactions, humid environment or deterioration of substances. The warehouse temperature should be controlled within a suitable range, and it should not be too high to prevent its stability from being damaged.
Furthermore, it needs to be properly separated from other chemicals. Because of its specific chemical properties, if it is co-stored with oxidizing, reducing substances and alkalis, or causes severe reactions, it will cause danger. Therefore, objects with different chemical properties should be stored separately according to the class to prevent interaction.
Packaging is also critical. It is necessary to ensure that the packaging is intact, and the packaging materials used must be adapted to its characteristics and have good sealing to prevent leakage. If the packaging is not good, the substance will evaporate or leak, which will not only damage itself, but also endanger the surrounding environment and personal safety.
When transporting, it must be handled gently. Due to its sensitivity, rough loading and unloading can easily cause package damage and cause leakage. Transport personnel should be professionally trained to be familiar with its characteristics and emergency treatment methods.
Transport vehicles also need to be clean, dry and free of residual impurities. If the transportation vehicle has transported other substances and inappropriate substances remain, or reacts with 1-fluoro-2- (methylsulfonyl) benzene. At the same time, avoid high temperatures and open flames during transportation, choose a safe route, and stay away from densely populated and important facilities to ensure safety. In this way, storage and transportation are guaranteed.