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What are the physical properties of 1-Fluoro-2-Methylbenzene?
1-Fluoro-2-methylbenzene, also known as o-fluorotoluene, is one of the organic compounds. This substance has unique physical properties, so let me tell you one by one.
Looking at its properties, under room temperature and pressure, 1-fluoro-2-methylbenzene is a colorless and transparent liquid. Its appearance is plain, but it contains its own characteristics. Its smell is quite special, with a fragrant smell, but it is different from the common fragrance. It is slightly irritating. Although this smell is not pungent or intolerable, it cannot be ignored.
When it comes to boiling point, the boiling point of 1-fluoro-2-methylbenzene is about 115 ° C to 117 ° C. At this temperature, it transforms from liquid to gaseous state, and the molecular motion intensifies, breaking free from the liquid phase. The value of the boiling point is affected by the intermolecular force, which determines the phase transition of 1-fluoro-2-methylbenzene in this temperature range.
In terms of melting point, it is about -57.3 ° C. When the temperature drops below the melting point, the thermal motion of the molecules weakens, and the arrangement of each other tends to be regular, and the substance solidifies from liquid to solid. This melting point indicates that 1-fluoro-2-methylbenzene solidifies at a relatively low temperature, and the daily ambient temperature is mostly higher than this, so it is usually a liquid state.
In terms of density, the density of 1-fluoro-2-methylbenzene is less than that of water, about 0.991g/cm ³. This property makes it float on the water surface when mixed with water, and the two are stratified. Due to the different way of intermolecular accumulation from water, the mass per unit volume is different.
Solubility is also an important physical property. 1-fluoro-2-methylbenzene is insoluble in water. Because it is an organic compound, the molecular polarity is weak, while water is a polar molecule. According to the principle of "similar miscibility", the two are difficult to miscible. However, in organic solvents, such as ethanol, ether, etc., 1-fluoro-2-methylbenzene has good solubility, and can be mixed with each other because it is compatible with the forces between organic solvent molecules.
In addition, 1-fluoro-2-methylbenzene is volatile and will gradually evaporate in the air, which is caused by the thermal movement of molecules to escape some molecules from the liquid surface. And because it is a flammable liquid, it is very easy to burn in case of open flames and hot topics. When using and storing, special attention should be paid to fire and explosion protection to ensure safety.
What are the chemical properties of 1-Fluoro-2-Methylbenzene?
1-Fluoro-2-methylbenzene is also an organic compound. It has various chemical properties, which are described in detail as follows:
First, its substitution reaction. Because the benzene ring has a fluorine atom and a methyl group, the two have different effects on the electron cloud density of the benzene ring. The methyl group is the power supply group, which increases the electron cloud density of the ortho and para-position, and the electrophilic substitution reaction is prone to occur in the ortho and para-position. For example, with bromine in the catalysis of iron bromide, the bromine atom tends to replace the ortho and para-position of the methyl group. Although the fluorine atom has an electron-sucking induction effect, its lone pair electrons are conjugated with the benzene ring, and there is a electron supply conjugation effect. The
times and addition reactions. The unsaturation of the benzene ring makes 1-fluoro-2-methylbenzene can be added to hydrogen and the like. In the presence of suitable catalysts such as nickel, the benzene ring can be gradually hydrogenated under heating conditions to form saturated alicyclic compounds.
Furthermore, it has an oxidation reaction. Methyl can be oxidized. In case of strong oxidants such as acidic potassium permanganate solution, methyl can be oxidized to carboxyl groups to give 1-fluoro-2-benzoic acid.
It also reacts with metal-organic reagents. If reacted with magnesium, Grignard reagents can be obtained. This Grignard reagent has strong nucleophilic properties and can react with many electrophilic reagents containing carbonyl groups. It has a wide range of uses in organic synthesis.
1-fluoro-2-methylbenzene The presence of fluorine and methyl is rich in chemical properties and plays an important role in organic synthesis and other fields. It can be converted into other organic compounds through various reactions.
What are the main uses of 1-Fluoro-2-Methylbenzene?
1-Fluoro-2-methylbenzene, also known as o-fluorotoluene, is a crucial raw material in organic synthesis and is widely used in many fields.
First, in the field of pharmaceutical synthesis, this compound is a key intermediate. It can be converted into compounds with specific pharmacological activities through a series of chemical reactions, and then used to create various drugs. For example, in the synthesis path of some antibacterial drugs, the reaction steps involved in 1-fluoro-2-methylbenzene play a decisive role in the construction of the core structure of drug molecules, laying the foundation for the development of new antibacterial drugs.
Second, in the field of pesticides, 1-fluoro-2-methylbenzene also plays an important role. Using it as a starting material, a variety of high-efficiency pesticides can be synthesized. Such pesticides can effectively control crop diseases and pests, and improve crop yield and quality. For example, the preparation of some pesticides, 1-fluoro-2-methylbenzene, after ingenious chemical modification, the generated products have highly targeted and killing effects on specific pests, and have relatively little impact on the environment, which meets the needs of modern green agriculture development.
Third, in the field of materials science, 1-fluoro-2-methylbenzene can be used as a raw material for the synthesis of special functional materials. Polymer materials with unique properties can be prepared by polymerization or blending with other compounds. For example, some materials with excellent optical properties or thermal stability, the participation of 1-fluoro-2-methylbenzene gives the material a special structure and properties, which meets the strict requirements of high-performance materials in the fields of electronics and optics.
In addition, 1-fluoro-2-methylbenzene is also involved in the fine chemical industry such as fragrances and dyes. In the synthesis of fragrances, its participation can give the fragrance a unique aroma; in the preparation of dyes, it helps to build special chromophore groups and improve the color and stability of dyes. In summary, 1-fluoro-2-methylbenzene has shown irreplaceable value in many fields due to its unique chemical structure, promoting the continuous development and progress of various related industries.
What are the preparation methods of 1-Fluoro-2-Methylbenzene?
1-Fluoro-2-methylbenzene, also known as o-fluorotoluene, is prepared by the following methods.
One is halogenation. With o-toluidine as the starting material, through diazotization reaction, o-toluidine is converted into a diazonium salt. Subsequently, the diazonium salt is reacted with fluoroborate acid to form a fluoroborate precipitation. After separation, drying, and then thermal decomposition, o-fluorotoluene can be obtained. In this process, the diazotization reaction needs to be handled carefully, and the reaction temperature and pH should be strictly controlled, otherwise it is easy to produce side reactions and affect the purity and yield of the product. The chemical reaction is roughly as follows: o-toluidine first reacts with sodium nitrite and hydrochloric acid to form diazonium salt, and then the diazonium salt reacts with fluoroboronic acid, and finally thermally decomposes to obtain o-fluorotoluene.
The second is the direct fluorination method. Toluene is used as the raw material and reacts directly with fluorine gas in the presence of a specific catalyst. Although the reaction process is simple, the fluorine gas activity is extremely high, the reaction is violent, the selectivity is difficult to control, and it is easy to generate by-products such as polyfluorinated substitutes. Therefore, the reaction equipment and process conditions are strict, and parameters such as reaction temperature, pressure, and fluorine gas inlet rate need to be precisely adjusted to improve the yield and purity of o-fluorotoluene.
The third is the hal Using o-chlorotoluene or o-bromotoluene as the substrate, and metal fluorides, such as potassium fluoride, under the action of suitable solvents and catalysts, the halogen exchange reaction occurs. This reaction condition is relatively mild and convenient to operate. However, it is crucial to choose a high-efficiency catalyst and a suitable solvent. For example, the use of crown ether compounds as catalysts can enhance the activity of metal fluorides and improve the reaction efficiency and selectivity. At the same time, the reaction process needs to be fully stirred to ensure that the substrate is fully in contact with metal fluorides to promote the reaction.
All the above preparation methods have advantages and disadvantages. In practical application, the appropriate method needs to be carefully selected according to factors such as specific needs, raw material availability, cost considerations and equipment conditions.
What 1-Fluoro-2-Methylbenzene need to pay attention to when storing and transporting
1-Fluoro-2-methylbenzene is an organic compound. During storage and transportation, many things need to be paid attention to to ensure safety.
First, when storing, be sure to choose a cool and well-ventilated place. This is because it is volatile to a certain extent, high temperature will increase volatilization. If it is in a closed environment, it may accumulate to dangerous concentrations, causing safety hazards. A cool environment can effectively reduce its volatilization rate. Well ventilated can disperse volatile gases in time to avoid gas accumulation.
Second, keep away from fire and heat sources. 1-Fluoro-2-methylbenzene is a flammable substance that can cause combustion and explosion in case of open flame and high heat energy. Even a little spark may trigger a serious accident, so fireworks are strictly prohibited in storage and transportation sites, and all electrical equipment, lighting facilities, etc. should have explosion-proof functions.
Third, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed in storage and transportation. Due to its active chemical properties, contact with oxidants may cause severe oxidation reactions or even explosions; contact with acids and alkalis may cause chemical reactions, cause deterioration of substances, and may produce harmful gases, threatening personnel and the environment.
Fourth, storage containers must be tightly sealed. In order to prevent leakage, because the volatile gas will not only pollute the environment, but also damage human health, such as irritating the respiratory tract, nervous system, etc. In the event of a leak, personnel in the contaminated area should be quickly evacuated to a safe area, isolated, and strictly restricted access. Emergency personnel need to wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and cut off the source of leakage as much as possible.
Fifth, during transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In summer, it is best to transport in the morning and evening to prevent sun exposure. During the journey, follow the prescribed route and do not stop in residential areas and densely populated areas.
Only by strictly following the above precautions can we ensure the safety of 1-fluoro-2-methylbenzene during storage and transportation, avoid accidents, and protect people's lives and the environment.