1-Fluoro-2-Methyl-4-Nitrobenzene

Hongda Chemical

Specifications

HS Code	809618
Chemical Formula	C7H6FNO2
Molar Mass	155.13 g/mol
Appearance	Yellow - brown solid or liquid
Boiling Point	215 - 217 °C
Melting Point	35 - 37 °C
Density	1.32 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Vapor Pressure	Low vapor pressure
Flash Point	94 °C
Odor	Characteristic odor

As an accredited 1-Fluoro-2-Methyl-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - fluoro - 2 - methyl - 4 - nitrobenzene packaged in a sealed glass bottle.
Storage	1 - fluoro - 2 - methyl - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification and handling.
Shipping	1 - fluoro - 2 - methyl - 4 - nitrobenzene, a chemical, must be shipped in accordance with strict hazardous materials regulations. It should be in properly sealed containers, labeled clearly, and transported by carriers licensed for such chemicals.

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General Information

Historical Development

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is an organic compound. Its history can be traced back to the past. At the beginning, the academic community studied the field of organic synthesis and devoted itself to exploring the preparation of new compounds. At that time, the chemical technology was not as exquisite as it is today, and the research on benzene series compounds containing fluorine, methyl and nitro groups was quite limited.
With the passage of time, the chemical theory was gradually improved, and the experimental methods were also constantly innovated. Many chemists have devoted themselves to the study of this compound and tried different synthesis paths. After repeated exploration and improvement, the synthesis method has become more and more mature. First, some scholars successfully prepared the prototype of this compound, but the purity and yield were not ideal. After unremitting efforts were made to optimize the reaction conditions and use more suitable raw materials and catalysts, the synthesis of 1-Fluoro-2-Methyl-4-Nitrobenzene was stabilized, and the yield and purity were also greatly improved, laying the foundation for its subsequent application in chemical, pharmaceutical and other fields.

Product Overview

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is an organic compound with a unique chemical structure. In this compound, fluorine atoms, methyl groups and nitro groups are respectively attached to specific positions in the benzene ring. The introduction of fluorine atoms gives it special chemical activity. The presence of methyl groups affects the spatial configuration and electron cloud distribution of molecules. Nitro groups give molecules a certain polarity, and in many chemical reactions, nitro groups can be used as key reaction check points.
It is widely used in the field of organic synthesis and can be used as an intermediate to participate in the preparation of many complex organic compounds. For example, through a specific reaction, its nitro group can be reduced, and then amino-containing compounds can be derived for synthesis in the pharmaceutical, dye and other industries.
Or use the activity of its fluorine atom to substitution with other reagents to expand the molecular structure and prepare organic materials with different functions.

Physical & Chemical Properties

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is also an organic compound. Its physical and chemical properties can be explored quite a bit. Its state or liquid state has a specific melting boiling point. The melting point is the temperature at which the substance changes from solid to liquid state. The melting point of this compound has its own fixed number. The boiling point is related to the change from liquid to gas state, and it is also an important physical property.
In terms of chemical properties, it contains fluorine, methyl and nitro groups. Fluorine atoms are electronegative, which affects the polarity and reactivity of molecules. Methyl groups are electron-donating groups, which can change the electron cloud density of benzene rings. Nitro groups are strong electron-absorbing groups, which reduce the electron cloud density of the benzene ring, making it more prone to electrophilic substitution reactions, and the substitution check point is also affected by the positioning effect of these groups. Various physicochemical properties are important in the fields of organic synthesis and materials science.

Technical Specifications & Labeling

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is also a chemical product. Its process specifications and identification (commodity parameters) are the key. To make this product, it is necessary to follow precise process regulations. The ratio of raw materials and reaction conditions are fixed. The reaction temperature should be controlled in a certain range, and the duration also needs to be satisfactory, so that the best effect can be obtained.
In terms of identification, its chemical composition and physical properties should be detailed. Such as appearance color, melting point geometry, solubility. And it is necessary to mark the purity and impurity content to clarify its quality. This is the key to process specifications and identification (commodity parameters), which is related to the quality of the product and cannot be ignored.

Preparation Method

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is an important chemical substance, and its preparation method involves many factors.
In the selection of raw materials, fluoride, methyl benzene derivatives and nitrogenation reagents should be used as the base. Fluoride needs to be highly active to facilitate the substitution of fluorine atoms; methyl benzene derivatives should ensure structural stability and provide a solid framework for the reaction; nitrogenation reagents need to precisely control the introduction of nitro groups into the check point.
In the preparation process, the methyl benzene derivative is first reacted with the nitrogenation reagent under specific conditions to successfully connect the nitro group to the appropriate position. This step requires strict control of the reaction temperature and time to achieve the best yield. Subsequently, fluoride is introduced to achieve fluorine atom substitution through an ingenious reaction mechanism, which requires strict reaction environment.
The reaction steps are interlocked layer by layer, and the products of each step need to be carefully separated and purified to ensure the purity of the next reaction. And in the whole process, it is necessary to build an efficient catalytic mechanism, select an appropriate catalyst, improve the reaction rate and selectivity, and reduce energy consumption and side reactions. In this way, high-quality 1-Fluoro-2-Methyl-4-Nitrobenzene can be obtained.

Chemical Reactions & Modifications

There is a chemical substance today, named 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene. In the process of chemical reaction and modification, we often study its wonders. The reaction of this compound is related to many chemical principles. The properties of fluorine, methyl and nitro groups affect the reaction trend.
Past investigations have shown that in a specific medium, fluorine atoms can be replaced by other groups due to nucleophilic substitution. Among them, the distribution of the electron cloud of the methyl-p-benzene ring has the effect of modulation, so that the reaction activity and check point are different. The strong electron absorption of nitro groups also affects the reaction path.
If you want to modify it, you can adjust its substituents, change its spatial structure, or introduce new functional groups by chemical means. In this way, this compound may have different properties and have new uses in the fields of medicine and materials. After repeated trials, I hope to be able to understand its reaction law and make good modifications to show its use.

Synonyms & Product Names

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is also a chemical substance. Its synonymous name is often described in the industry.

This thing may be called by another name. Although there are rules to follow in the chemical naming, it is actually used, and the workers and researchers may also give it another name according to their habits and characteristics. Its synonymous name is either based on structural characteristics or derived from synthetic pathways, and each has its own basis.
As for the name of the product, the name chosen by the merchant is also unique in order to recognize its characteristics or meet the needs of the market. This is all for the convenience of understanding and use, so that the industry can quickly distinguish its things. Or there are simple and easy-to-remember words as the trade name, so that the person who hears it knows the meaning.
1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is synonymous with the trade name, which is essential for chemical research, industrial applications, etc., and can help all parties communicate and cooperate smoothly to achieve various research and production services.

Safety & Operational Standards

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is an important chemical substance, which needs to be discussed in detail in terms of its safety and operating practices.
Anyone who handles this substance must do it in a well-ventilated place. This is because the substance may evaporate harmful gases. If the ventilation is not smooth, it will accumulate in the room, which may endanger the health of the operator. And fireworks should be strictly prohibited indoors. It may be flammable. In case of open flames and hot topics, it is easy to cause fires or even explosions, causing major disasters.
When handling, protective measures must not be ignored. Special protective clothing is required to prevent the substance from contacting the skin and prevent it from eroding. You should also wear protective gloves to ensure that your hands are fully protected. As for the eyes, protective glasses are indispensable to prevent substances from splashing in and damaging your eyes.
There are also strict rules for storing this object. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Do not mix with oxidants, food chemicals, etc., to prevent violent chemical reactions and cause danger.
In case of accidental contact with the substance, the contact area should be washed with a large amount of flowing water as soon as possible. If it splashes into the eyes, you need to open the eyelids immediately, rinse continuously, and seek medical attention as soon as possible. If you inhale its volatile gas, you should quickly move to a fresh air place to keep the respiratory tract unobstructed. If necessary, perform artificial respiration, and seek medical attention urgently.
In short, the safety and operating standards of 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene should not be taken lightly, and all procedures should be strictly followed to ensure safety.

Application Area

1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is an important chemical substance. It has a wide range of application fields and can be used as a key intermediate in the synthesis of specific drugs to deal with certain diseases. For example, drugs that have inhibitory effects on specific pathogens, the structural properties of this compound enable it to participate in complex reactions and build effective drug molecules.
In the field of materials science, it may be used to prepare special functional materials. Because of its fluorine, nitro and other groups, it endows materials with unique electrical and optical properties. If materials with special photoelectric conversion properties are prepared, they can be applied to optoelectronic devices to improve device efficiency.
In the field of organic synthetic chemistry, it is often an important starting material. With its active chemical properties, a series of valuable organic compounds can be derived through many reactions, such as nucleophilic substitution, which greatly expands the boundaries of organic synthetic chemistry and provides a material basis for the development of many fields.

Research & Development

In recent years, I have been focusing on the study of 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene in the field of chemistry. Its unique properties and the states it presents in various reactions are thought-provoking.
Initially, it took a lot of trouble to analyze its structure. With various instruments, the arrangement of its atoms and the connection of bonds were observed in detail. To clarify its spatial structure is the basis for subsequent research.
Then investigate its reaction mechanism. Try different reagents and conditions to observe its changes. Observe that when it encounters nucleophiles, it may be substituted or added, depending on the situation. And temperature and solvent genus also have a huge impact on the reaction.
Thinking about the application of this substance. In the synthesis of medicine, it is expected to become a key intermediate, which will help in the production of special drugs; in the field of materials, it may be able to give materials new properties and make them more suitable for needs.
Although the road of research and exploration is full of thorns, every gain is inexplicable. I hope that in the future, I can better understand its nature and use it widely, for the advancement of chemistry and the benefit of mankind, and exhaust my wisdom.

Toxicity Research

There is a substance named 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene. I am a chemical researcher, specializing in the toxicity of this substance.
Looking at its molecular structure, fluorine, methyl and nitro coexist. Nitro is often toxic and can disturb the normal metabolism of organisms. And fluoride-containing compounds also have special effects on biological systems.
Experimentally observed, this substance was applied to the tested organisms. Not long after, the physiological state of the tested organisms changed. Its growth rate was slow, or there was an abnormality in behavior. Biochemical indicators were also abnormal, such as changes in the activity of some enzymes.
In summary, 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene is toxic. The toxicological mechanism should be investigated in detail to clarify its potential harm to ecology and human body, and provide evidence for protection and treatment strategies.

Future Prospects

In the future world, the technology of chemical engineering will become more and more prosperous. Today, there is 1 - Fluoro - 2 - Methyl - 4 - Nitrobenzene, and its use is good. I will study its properties and hope to make good use of it.
In the future, it may be possible to make a large-scale display of its color in the field of engineering, assist in the research of special effects, and save the world. Or in the world of materials, the research of new materials, adding more tiles to make the material special, and it is necessary to use it.
And the research of new materials, the synthesis method will be more delicate, and the cost can be reduced. In this way, the more easily accessible it is, the more widely used it will be, for the benefit of people, so that the unseen scene will be new and exciting.

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Frequently Asked Questions

As a leading 1-Fluoro-2-Methyl-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2-Methyl-4-Nitrobenzene?

1-Fluoro-2-methyl-4-nitrobenzene has a wide range of uses. In the field of organic synthesis, it is often a key raw material to produce many important compounds.
First, in the process of pharmaceutical synthesis, it can be used as an intermediate to participate in the construction of drug molecules. Due to its special chemical structure, it can endow drugs with specific biological activities or improve the pharmacokinetic properties of drug absorption, distribution, and metabolism. For example, in the synthesis of some antibacterial drugs or anti-tumor drugs, 1-fluoro-2-methyl-4-nitrobenzene can be introduced into the molecular framework of drugs through a series of reactions, laying the foundation for the realization of drug activity.
Second, in the field of pesticides, it also plays an important role. It can be converted into pesticide components such as insecticides and fungicides by reaction. Its structure can interact with specific targets in pests or pathogens, interfere with their physiological and biochemical processes, achieve the effect of controlling pests and diseases, help agricultural harvests, and ensure crop yield and quality.
Furthermore, in the field of materials science, it can be used to prepare special polymer materials. By polymerizing with other monomers, its unique structure is introduced into the polymer chain to give the material special properties, such as improving the material's heat resistance, chemical corrosion resistance, or giving the material specific optical and electrical properties, to meet the needs of different fields for special properties of materials.
In addition, in the synthesis of dyes, 1-fluoro-2-methyl-4-nitrobenzene can be used as a starting material to build a chromophore through a multi-step reaction, which imparts rich colors and good dyeing properties to dyes. It is widely used in textile, printing and dyeing industries to make fabrics colorful.

What are the physical properties of 1-Fluoro-2-Methyl-4-Nitrobenzene?

1-Fluoro-2-methyl-4-nitrobenzene, this is an organic compound. Its physical properties are quite important, let me talk about them one by one.
First words Appearance, at room temperature, it is often colorless to light yellow liquid. Viewed clear, or slightly colored, depending on the purity. This color is closely related to purity. Those who are pure are light in color, and those who contain impurities are slightly darker.
Second, the smell has a special aromatic smell, but this smell is not pleasant and irritating. If people smell it, there may be discomfort in the nasal cavity and respiratory tract, so be careful when touching it.
As for the boiling point, it is about a specific temperature range, and the exact value is affected by environmental factors. Roughly speaking, at a certain temperature range, at this temperature, the substance changes from liquid to gaseous state. The characteristics of boiling point are crucial in chemical operations such as separation and purification. It can be purified by distillation and other methods according to the difference in boiling point.
Melting point is also a key physical property. At a certain low temperature, the substance solidifies from liquid to solid. The determination of melting point helps to identify the purity of the substance. If the purity is high, the melting point is close to the theoretical value; if the purity is low, the melting point is deviated.
In terms of density, compared with water, its density is different. This property is of great significance when it involves operations such as liquid-liquid separation. According to different densities, the substance can be stratified with other liquids such as water, and then separated.
Solubility is also an important property. It has a certain solubility in common organic solvents, such as ethanol and ether, and can be soluble with them. However, in water, the solubility is poor, which is caused by the polarity difference between the molecular structure of the organic substance and water. This difference in solubility can be used in the process of organic synthesis, extraction, etc., to select a suitable solvent for reaction or separation. The physical properties of 1-fluoro-2-methyl-4-nitrobenzene are diverse, and they are all key considerations in the fields of chemical industry and scientific research, which are related to many operations and applications.

What is the chemistry of 1-Fluoro-2-Methyl-4-Nitrobenzene?

1-Fluoro-2-methyl-4-nitrobenzene has unique chemical properties. Its fluorine atom, due to its strong electronegativity, causes the electron cloud density of the benzene ring to change. In the nucleophilic substitution reaction, the fluorine atom can be used as a leaving group to open a path for the reaction. The methyl group is attached to the benzene ring, showing a electron-giving effect, which slightly increases the density of the ortho and para-potential electron clouds, but its effect is weaker than that of the nitro group. Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, greatly reduces the activity of the electrophilic substitution reaction of the benzene ring, and at the same time decreases the density of the ortho and para-potential electron clouds even more, and the mes
In many reactions, 1-fluoro-2-methyl-4-nitrobenzene exhibits characteristics. For example, during nucleophilic substitution, the position of the fluorine atom is more susceptible to attack by nucleophilic reagents due to the influence of nitro electron absorption. Due to the deviation of the benzene ring electron cloud by the nitro group, the carbon attached to the fluorine atom is partially positively charged, and the nucleophilic reagent is easy to combine with it, and the fluorine ion leaves. Another example is electrophilic substitution. Under the action of nitro, the reaction mainly proceeds in the meso-site, because the density of the meso-site electron cloud is relatively higher than that of the ortho and para-site.
In addition, the physical properties of the compound are also related to its chemical properties. Its molecular polarity is enhanced The increase of polarity causes the intermolecular force to increase, and the melting point, boiling point or increase; the solubility in polar solvents is better than that in non-polar solvents.
In short, 1-fluoro-2-methyl-4-nitrobenzene coexists with fluorine, methyl and nitro groups, and has unique chemical properties. It has important uses in organic synthesis and other fields. Its reactivity and check point selectivity provide many possibilities for organic chemistry research and practice.

What are the preparation methods of 1-Fluoro-2-Methyl-4-Nitrobenzene?

There are several methods for preparing 1-fluoro-2-methyl-4-nitrobenzene.
First, o-methylaniline is used as the starting material. First, o-methylaniline is diazotized to form a diazonium salt at low temperature and under the action of sodium nitrite and hydrochloric acid. Subsequently, fluoroborate acid is added to form a fluoroborate precipitation. After separation, drying, and thermal decomposition, 1-fluoro-2-methylbenzene can be obtained. Then, mixed acid (concentrated sulfuric acid and concentrated nitric acid) is used to nitrate 1-fluoro-2-methylbenzene. According to the positioning rules of benzene ring substituents, methyl is an ortho-para-site group, and fluorine also has a certain positioning effect. Finally, 1-fluoro-2-methyl-4-nitrobenzene can be obtained. The steps of this method are relatively clear, and the control of reaction conditions should be paid attention to during the diazotization and thermal decomposition process to ensure the yield and purity.
Second, 2-methyl-4-nitroaniline is used as the raw material. The diazotization reaction is also carried out first to generate diazonium salts. After that, suitable fluorinated reagents, such as potassium fluorocuprate, are selected to carry out fluorination reaction to directly obtain 1-fluoro-2-methyl-4-nitrobenzene. The key to this path lies in the complete degree of diazotization reaction and the activity and selectivity of fluorinated reagents. The reaction parameters such as temperature, time, and reagent dosage need to be carefully regulated to achieve the ideal preparation effect.
Third, 1-chloro-2-methyl-4-nitrobenzene is used as the starting material. Halogen atom exchange reaction is used to react with fluorine sources such as potassium fluoride in specific solvents such as DMF. This reaction requires suitable catalysts, such as crown ethers, to enhance the activity of fluoride ions and accelerate the reaction process. During the reaction process, the progress of the reaction should be closely monitored, and the reaction conditions, such as temperature, reaction time, and proportion of reactants, should be adjusted to optimize the reaction and obtain the target product 1-fluoro-2-methyl-4-nitrobenzene.
The above preparation methods have their own advantages and disadvantages. In practical application, it is necessary to choose carefully according to many factors such as raw material availability, cost, and product quality requirements.

1-Fluoro-2-Methyl-4-Nitrobenzene what are the precautions during use

1-Fluoro-2-methyl-4-nitrobenzene is a chemical commonly used in organic synthesis. During use, many precautions need to be kept in mind.
Those who bear the brunt must be fully protected. This compound is toxic and irritating to a certain extent, and contact with the human body can cause harm. Therefore, when using, appropriate protective equipment must be worn, such as protective gloves, goggles, protective clothing, etc., to prevent skin and eye contact. If accidentally touched, rinse with plenty of water as soon as possible and seek medical treatment in a timely manner.
Furthermore, because of its volatility, it is suitable to use it in a well-ventilated place or operate in a fume hood, so as to avoid the accumulation of harmful gases and reduce the risk of inhalation. Fireworks should also be strictly prohibited in the operation room, because they are flammable, and the risk of combustion and explosion may be caused by open flames and hot topics.
Storage should not be taken lightly. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions.
When taking and weighing, the action should be precise and careful to avoid leakage. If there is any leakage, appropriate measures should be taken immediately to clean it up to prevent its spread and pollution of the environment.
In addition, the waste generated during use should not be discarded at will, and should be properly disposed of in accordance with relevant regulations to protect the environment and public health.
In short, when using 1-fluoro-2-methyl-4-nitrobenzene, it is necessary to strictly follow the safety operating procedures and be careful to ensure personal safety and the smooth progress of experiments or production.