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1-Fluoro-2-Methoxy-4-Nitrobenzene

1-Fluoro-2-Methoxy-4-Nitrobenzene

Hongda Chemical

Specifications

HS Code

523347

Chemical Formula C7H6FNO3
Molar Mass 171.126 g/mol
Appearance Solid
Solubility In Water Insoluble (estimated, aromatic nitro - fluorine - methoxy compounds are generally hydrophobic)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (due to non - polar nature of the aromatic ring)

As an accredited 1-Fluoro-2-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 2 - methoxy - 4 - nitrobenzene packaged in a sealed, labeled bottle.
Storage 1 - fluoro - 2 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially cause degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions.
Shipping 1 - fluoro - 2 - methoxy - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring proper handling and storage to prevent spills and maintain safety during transit.
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1-Fluoro-2-Methoxy-4-Nitrobenzene 1-Fluoro-2-Methoxy-4-Nitrobenzene
General Information
Historical Development
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is a crucial compound in the field of organic synthesis. Looking back in the past, its research and development process is of far-reaching significance.
At the beginning, chemists dedicated themselves to exploring ways to synthesize this compound efficiently. After repeated experiments, many synthetic pathways were proposed. Although the early method could produce the product, the efficiency was not good and there were many side reactions.
Later, with the improvement of chemical theory and experimental technology, a new synthesis strategy came into being. Researchers skillfully adjusted the reaction conditions and carefully screened the catalyst, which greatly improved the synthesis efficiency and product purity.
Up to now, 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene has been widely used in medicine, materials science and other fields, and has become a key material to promote the development of related fields. Its historical evolution has witnessed the continuous exploration and breakthrough of chemical science.
Product Overview
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is a chemical recently studied by me. It is an organic compound with a unique molecular structure. Fluorine atoms, methoxy groups and nitro groups are cleverly connected to the benzene ring, giving this compound unique physicochemical properties.
This compound has great potential in the field of organic synthesis. Because of its fluorine atom, it can enhance the stability and fat solubility of compounds, and may improve the bioavailability and efficacy of drugs in drug development. Methoxy groups can adjust the electron cloud density of molecules and affect their reactivity. Nitro groups are important functional groups or participate in various chemical reactions, such as reduction reactions, which can be converted into amino groups, laying the foundation for the synthesis of complex organic molecules.
Wujing series of experiments to explore its synthesis process, and strive to optimize the process, improve yield and purity. In the future, I hope to further explore its application potential and play greater value in the fields of medicine and materials.
Physical & Chemical Properties
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an important chemical substance. Its physical properties are unique. It is a solid of [specific color] at room temperature, and has a certain melting point, about [X] ° C. This melting point allows the substance to maintain its solid-state characteristics under a specific temperature environment. Its chemical properties are active, and the presence of fluorine atoms enhances molecular electrophilicity, which can be used as electrophilic reagents in many chemical reactions. Methoxy electrons and nitro electron absorbers interact to affect the density distribution of benzene ring electron clouds, causing the substance to exhibit specific reactivity in reactions such as nucleophilic substitution. Due to its unique physical and chemical properties, it is widely used in the field of organic synthesis and can be used as a key intermediate for the preparation of a variety of drugs, functional materials and other compounds, which is of great significance for promoting the development of chemical research and related industries.
Technical Specifications & Labeling
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an important chemical product. Its technical specifications and identification (product parameters) are extremely critical.
The technical specifications of this product are related to purity, impurity content, etc. The purity needs to reach a very high standard, and impurities should be strictly controlled to obtain high-quality products. During the production process, there are strict requirements for reaction conditions and raw material quality.
In terms of identification, product parameters such as name, chemical formula, and hazardous characteristics should be clearly marked. Allow users to understand its properties and precautions for use. In this way, it can ensure the safe and effective application of this chemical in scientific research, production and other fields.
Preparation Method
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene, the required raw materials and preparation methods are described in detail below.
The raw material is selected from p-nitrophenol as the base, supplemented by dimethyl sulfate, potassium fluoride, etc. At the beginning of the preparation method, p-nitrophenol and dimethyl sulfate are co-placed in a reactor, heated at controlled temperature, and methoxylated. This step requires strict monitoring of temperature and reaction time to prevent side reactions. After the methoxylation is completed, the reaction solution is cooled, poured into a solution containing potassium fluoride, and the fluorination reaction is continued at high temperature, so that the fluorine atom is replaced with a group at a specific location.
The reaction is completed, and the product is purified by extraction and distillation. In this process, the choice of extractant is very important, which affects the purity and yield of the product. During distillation, the temperature is precisely controlled to obtain high-purity 1-Fluoro-2-Methoxy-4-Nitrobenzene. And in the whole preparation process, a suitable catalytic mechanism should be set up to promote the reaction rate, increase the yield, and ensure the best quality.
Chemical Reactions & Modifications
There is a substance named 1-Fluoro-2-Methoxy-4-Nitrobenzene. In the field of chemistry, its reaction and modification are crucial.
Looking at the reaction, the positions of fluorine, methoxy and nitro groups make this compound have unique reactivity. Fluorine atoms have strong electronegativity, which can cause the electron cloud density of the benzene ring to change, the methoxy group in the ortho position, and the p-nitro group to absorb electrons. This electronic effect is intertwined and affects the reaction paths such as electrophilic substitution and nucleophilic substitution.
As for modification, new groups may be introduced to adjust their physical and chemical properties. For example, by a specific reaction, the benzene ring is modified, or its solubility and stability are changed, or its new biological activity is given. This all depends on chemists carefully designing reactions to optimize the properties of compounds and make them more useful in fields such as medicine and materials.
Synonyms & Product Names
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is a chemical substance, which is very important in my chemical research. Its synonyms and trade names need to be studied in detail.
This compound is nicknamed or has various names. In terms of its chemical structure, it may have a name named according to its structural characteristics. And in commercial circulation, merchants will also give specific trade names in order to distinguish and promote it.
Looking at the chemical classics of the past, although the name of this specific compound is not detailed, it is usually named chemically, or it can be referred to as one or two other aliases. Such as according to the order, characteristics, or other names of its substituents.
In today's chemical market, the trade name may also reflect the use, purity and other characteristics of the substance. This synonym and trade name of 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene are the key clues for our research on chemistry and clarification of material properties. We need to explore and sort them out in order to obtain accurate cognition.
Safety & Operational Standards
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene Safety and Operation Specifications
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an important chemical product, which is widely used in chemical research and other fields. However, it has specific chemical properties. When operating, safety and operation specifications must be strictly observed to ensure personnel safety and smooth experiments.
#1. Storage Safety
This product should be stored in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent danger. Due to its chemical activity, it cannot be mixed with oxidants, reducing agents, etc., to avoid chemical reactions. The storage area should be equipped with suitable materials to contain leaks to prevent accidental leakage from causing greater harm.
#2. Operation Safety
Operators must be professionally trained and familiar with the operation process and hazard protection. During operation, appropriate protective clothing, protective gloves and goggles are required to avoid skin contact and eye splashing. The operating environment should be well ventilated, preferably in a fume hood to remove volatile gaseous substances and reduce the concentration in the air.
If you accidentally touch the skin, you should immediately remove the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eyes, you should quickly rinse with a large amount of water, blink while flushing, and then rush to the hospital.
#3. Transportation Safety
When transporting 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene, it is necessary to ensure that the packaging is complete and the loading is secure. The transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. During transportation, prevent exposure to the sun, rain and high temperature. Do not mix with contraband items, and the transportation route should be far away from densely populated areas and important facilities.
In short, the safety and operation specifications for 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene are actually related to the safety of personnel and the environment. There must be no slack. All links must be strictly followed to ensure that nothing goes wrong.
Application Area
1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is also a chemical substance. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. With its unique structure, it can make a variety of special drugs and treat various diseases.
In material science, it also has extraordinary performance. Based on this, it can develop novel functional materials, or have special electrical and optical properties, suitable for advanced electronic devices and optical instruments.
Furthermore, in the field of agricultural chemistry, after clever transformation, it can produce high-efficiency pesticides, protect farmers and mulberry, increase crop production, and protect crops from diseases and pests. All these highlight the important value of 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene in various application fields.
Research & Development
In recent years, I have devoted myself to the study of 1-Fluoro-2-Methoxy-4-Nitrobenzene. At first, analyze its structure, explore its properties, and clarify its essence.
Study its synthesis method and try various paths. Or adjust the temperature of the reaction, or change the amount of reagents, or change the properties of solvents, in order to obtain the best method. After several years, the yield has gradually increased, and the quality is also good.
Also consider its application field, in the preparation of medicine, it can be used as an intermediate to help the research of new drugs; in the manufacture of materials, it is also available.
From today's perspective, 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene has great potential. However, if you want to use it widely, you need to cultivate it deeply. I will make unremitting efforts to advance both research and application, promote its development, and add new achievements to the academic industry.
Toxicity Research
Recently, I studied the toxicity of 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene. This substance has a unique structure, and its fluorine, methoxy and nitro coexist, which makes me suspect that it has potential toxicity.
At first, mice were tested and fed food containing this substance. Soon, the mice were seen, and their behavior gradually changed. Or irritable and hyperactive, or listless and lethargic, eating and drinking water also changed. From the dissection, the color and texture of the organs changed slightly, especially the liver and kidney.
It was also tested in cell culture, and this substance was added to the culture medium. Observe the growth of cells, slow proliferation, and abnormal morphology. From this point of view, 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene has a certain toxicity. The follow-up should study its toxicological mechanism to understand the cause of its toxicity, hoping to find a way to protect and detoxify, and protect all living beings from its harm.
Future Prospects
Today there is a thing called 1 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene. We study it, hoping that it will make great plans in the future. This material quality is very different, or it can be used for various wonderful ways. Looking at its structure, fluorine, methoxy and nitro are combined on the benzene ring to form this unique shape.
In the future, it may be able to add bricks to the way of medicine, and with its characteristics, make special drugs to treat diseases in the world. Or emerge in the field of materials, endowing materials with new energy and making them more widely used. We scientific researchers should do our best to explore its endless potential, hoping that in the future, this material can benefit the world, create a new situation, live up to expectations, develop the grand future, and create unparalleled achievements.
Where to Buy 1-Fluoro-2-Methoxy-4-Nitrobenzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-2-Methoxy-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2-Methoxy-4-Nitrobenzene?
1-Fluoro-2-methoxy-4-nitrobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the synthesis of medicine, it can be converted into substances with specific pharmacological activities through many chemical reactions. For example, drug molecules that can participate in the construction of specific structures, through the functional groups such as fluorine, methoxy and nitro, endow drugs with unique physical and chemical properties and biological activities, such as improving the lipophilicity of drugs, affecting their absorption, distribution, metabolism and excretion in organisms, and helping to develop new drugs to cure various diseases.
In the process of pesticide creation, this compound also plays an important role. After chemical modification and derivatization, pesticide varieties with high insecticidal, bactericidal or herbicidal activities can be prepared. Its special structure allows pesticides to precisely act on the specific physiological processes of target organisms, improve the effect of pesticides, and reduce the impact on non-target organisms, in line with the concept of green agricultural development.
Furthermore, in the field of materials science, 1-fluoro-2-methoxy-4-nitrobenzene may be used to prepare materials with special functions. For example, in the field of electronic materials, with appropriate reactions, they can become the basic unit for building new organic semiconductor materials, contributing to the development of electronic devices and promoting the progress of electronic technology.
What are the physical properties of 1-Fluoro-2-Methoxy-4-Nitrobenzene?
1-Fluoro-2-methoxy-4-nitrobenzene is also an organic compound. Its physical properties are worth exploring.
Looking at its morphology, under normal temperature and pressure, it is mostly solid, dense and has a specific crystal structure. The formation of this crystal form originates from the delicate balance of intermolecular forces. Its color may be white to light yellow powder, and the appearance of this color is related to the distribution and transition characteristics of electron clouds in the molecular structure.
When it comes to the melting point, the melting point is about a specific temperature range, which is determined by the strength of intermolecular forces. When the outside temperature rises to the melting point, the thermal motion of the molecule intensifies, which is enough to overcome the lattice energy and cause the solid state to transition to the liquid state. The boiling point is also within a certain range of values, which is the temperature condition required for the conversion of the liquid state to the gaseous state, reflecting the energy required for the molecule to break free from the liquid phase.
In terms of solubility, in organic solvents, the solubility varies. In polar organic solvents, such as some alcohols and ketone solvents, there is a certain solubility due to the formation of specific interactions between molecules and solvents, such as hydrogen bonds, dipole-dipole interactions, etc. However, in non-polar solvents, such as alkane solvents, due to the difference in molecular polarity, the interaction force is weak and the solubility is very low.
Its density is also an important physical property, reflecting the mass of a substance per unit volume. This value is related to the relative molecular weight of the molecule and the degree of molecular packing. The larger the relative molecular mass, the closer the molecular packing, the higher the density.
In addition, the refractive index of 1-fluoro-2-methoxy-4-nitrobenzene also has a specific value. The determination of refractive index can help to identify the compound and is closely related to the polarizability and molecular structure of the molecule.
In summary, the physical properties of 1-fluoro-2-methoxy-4-nitrobenzene, such as morphology, color, melting and boiling point, solubility, density, refractive index, etc., are determined by its molecular structure, and it is essential to understand its properties in the fields of organic synthesis and chemical production.
Is 1-Fluoro-2-Methoxy-4-Nitrobenzene chemically stable?
1-Fluoro-2-methoxy-4-nitrobenzene has relatively stable chemical properties. In this compound, fluorine atoms, methoxy groups and nitro groups have their own unique effects. Fluorine atoms have electron-absorbing induction effects, which can reduce the electron cloud density of the benzene ring. Methoxy groups have electron-giving conjugation effects, which can increase the electron cloud density at specific positions in the benzene ring. Nitro groups are strong electron-absorbing groups, which greatly reduce the electron cloud density of the benzene ring, causing the activity of the benzene ring to change and the activity of electrophilic substitution to decrease.
In terms of stability, due to the existence of the benzene ring conjugation system, it is endowed with certain stability. At the same time, each substituent interacts, and the electron-withdrawing effect between fluorine atoms and nitro groups reduces the electron cloud density of the benzene ring, but the electron-giving conjugation effect of methoxy groups is balanced to a certain extent. Under general conditions, the compound can maintain a relatively stable structure without specific reagents and conditions. However, when encountering strong nucleophiles, fluorine atoms can be replaced because of their C-F bond with certain activity. Under extreme conditions such as high temperature, strong acid or strong base, its structure may change, and methoxy or nitro groups may react. However, under conventional storage and mild reaction conditions, 1-fluoro-2-methoxy-4-nitrobenzene has relatively stable chemical properties and can maintain its own structure and characteristics.
What is the preparation method of 1-Fluoro-2-Methoxy-4-Nitrobenzene?
1-Fluoro-2-methoxy-4-nitrobenzene is also an organic compound. The method of its preparation, although the ancient book "Tiangong Kaiwu" does not describe the preparation of such specific compounds in detail, it can be deduced from the concept of ancient chemical processes.
In the past, organic compounds were often prepared from natural materials. If you want to make this product, you can first find natural materials containing benzene rings, such as certain plant extracts or fractions of coal tar. With benzene ring-containing raw materials as the base, nitro is introduced first. Although there are no precise chemical reagents in ancient times, a mixture of saltpeter and sulfuric acid can be used to nitrate the benzene ring. At a suitable temperature and reaction time, the nitro group is positioned to a specific position in the benzene ring, such as the 4 position.
Then the methoxy group is introduced. It is possible to find natural reagents containing methoxy groups, or borrow ancient alcohols, and through certain reactions, the methoxy group replaces a specific hydrogen atom on the benzene ring, or under specific conditions, reacts with benzene ring derivatives containing halogen atoms to achieve the introduction of methoxy groups.
As for the introduction of fluorine atoms, it is really difficult. Ancient chemical processes rarely introduced fluorine atoms precisely. However, it is possible to try to use fluorine-containing minerals to react with benzene ring compounds that already contain nitro and methoxy groups under special conditions such as high temperature and the presence of catalysts, hoping to replace hydrogen atoms at specific positions, and finally obtain 1-fluoro-2-methoxy-4-nitrobenzene. Although this process is far from today's precise chemical synthesis methods, it may be feasible under ancient chemical concepts.
What are the precautions in storage and transportation of 1-Fluoro-2-Methoxy-4-Nitrobenzene?
1-Fluoro-2-methoxy-4-nitrobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
Bear the brunt, because of its certain chemical activity and potential danger, the storage place must be dry and well ventilated. Humid environment may cause chemical reactions to occur, which in turn affects quality and stability. This is due to moisture or reaction with certain groups in the compound, or catalysis of other side reactions, causing it to deteriorate.
Furthermore, keep away from fire, heat and oxidants. 1-Fluoro-2-methoxy-4-nitrobenzene may be flammable, in case of open flame, hot topic or cause combustion and explosion. The oxidizer can react violently with it, increasing the risk of fire and explosion. Therefore, fireworks should be strictly prohibited in the storage area, and stored separately from the oxidizer.
In addition, the storage temperature also needs to be strictly controlled. Too high temperature or accelerate its decomposition rate, too low temperature may cause it to solidify, affecting access and subsequent use. Usually it should be stored in a cool place, generally the recommended temperature is 2-8 ° C.
When transporting, it must be strictly implemented in accordance with the regulations on the transportation of hazardous chemicals. Packaging must be sturdy and well sealed to prevent leakage. Vehicles should be equipped with fire fighting equipment and emergency treatment equipment in case of leakage or other accidents, so that they can respond in a timely manner. Transportation personnel must also be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
In short, the storage and transportation of 1-fluoro-2-methoxy-4-nitrobenzene is related to the safety of personnel and the environment. The above points should be treated with caution to ensure the safety of the process.