1-Fluoro-2-Methoxy-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code	586379
Chemical Formula	C7H6FNO3
Molar Mass	171.126 g/mol
Appearance	Solid (usually a yellowish solid)
Melting Point	Data needed
Boiling Point	Data needed
Density	Data needed
Solubility In Water	Insoluble (expected due to non - polar nature of the benzene ring and hydrophobic groups)
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Flash Point	Data needed
Vapor Pressure	Data needed
Pka	Data needed
Logp	Data needed

As an accredited 1-Fluoro-2-Methoxy-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 1 - fluoro - 2 - methoxy - 3 - nitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage	1 - fluoro - 2 - methoxy - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions. Label the storage container clearly for easy identification.
Shipping	1 - fluoro - 2 - methoxy - 3 - nitrobenzene is shipped in accordance with strict chemical transport regulations. Packed in appropriate containers, it's carefully handled to prevent spills, with shipping routes planned to ensure safe and timely delivery.

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General Information

Historical Development

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene has attracted much attention in the field of organic synthesis. Back in the past, early chemical studies mostly focused on basic elements and simple compounds, but paid little attention to them. With the evolution of science and technology and the refinement of analytical techniques, chemists have been able to explore such complex structures in depth.
At the beginning, the synthesis of 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene was difficult, with low yield and many impurities. However, chemists of successive generations worked tirelessly to improve the synthesis path. First, they explored different reaction conditions, adjusted the ratio of temperature, pressure and reactants, and then tried novel catalysts. After numerous trials and errors.
Today, the method of synthesizing this compound has become mature, the yield has been significantly improved, and it is widely used in medicine, materials and other fields. The hard work of the past has created the results of the present, paving the way for subsequent chemical research and application.

Product Overview

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is an important organic compound. Its appearance is a crystal or liquid with a specific color and a unique odor. This compound is widely used in the field of organic synthesis and is often used as a key intermediate.
The preparation method is achieved by multi-step reaction. Using a specific aromatic hydrocarbon as the starting material, fluorine atoms are introduced through halogenation, methoxylation is added to methoxy groups, and finally nitration is introduced into nitro groups to obtain 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene.
Its properties are stable, and under specific conditions, it can react with many reagents to derive a variety of functional compounds. In the fields of pharmaceutical chemistry and materials science, it has potential application value and can provide key support for the development of new drugs and the creation of new materials.

Physical & Chemical Properties

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is a unique compound. Its physical and chemical properties are of great interest. Looking at its physical properties, at room temperature, this substance is solid, colored or light yellow, with a specific crystal structure. Its melting point and boiling point are key parameters to characterize its physical properties. The melting point is around [X] degrees Celsius, and the boiling point is around [X] degrees Celsius, which is related to its phase transition. As for its chemical properties, due to the presence of fluorine, methoxy, and nitro groups in the molecule, it is endowed with unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of benzene rings and is prone to nucleophilic substitution. The methoxy group has a certain power supply effect on the benzene ring, which affects the selectivity of the reaction check point. Fluorine atoms also play an important role in many reactions due to their high electronegativity, and can participate in various organic synthesis reactions, laying the foundation for the construction of complex organic molecular structures.

Technical Specifications & Labeling

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is an important chemical substance that has attracted much attention in the field of chemical research. Its technical specifications and identification (product parameters) are extremely critical.
When it comes to technical specifications, this substance needs to meet specific purity standards, and the impurity content must be strictly controlled. During the synthesis process, the reaction conditions such as temperature, pressure, and the proportion of reactants need to be precisely controlled. Temperature may affect the reaction rate and product purity, and pressure also plays an important role in the reaction equilibrium.
In terms of identification (product parameters), its chemical structure, molecular weight, melting point, boiling point and other key parameters should be clearly marked. The chemical structure allows researchers to intuitively understand its molecular composition; molecular weight is the basis of many chemical calculations; melting point and boiling point are related to its physical properties and storage and use conditions. These technical specifications and labels (product parameters) provide a solid basis for the research, production and application of 1-Fluoro-2-Methoxy-3-Nitrobenzene.

Preparation Method

To prepare 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene, the raw materials and production process are the key. First, take an appropriate amount of o-methoxy nitrobenzene as the raw material, which is the starting material. Use anhydrous potassium fluoride as the fluorinating agent, and mix it evenly in a specific organic solvent, such as dimethyl sulfoxide. Heat up to about 120 - 150 degrees Celsius, maintain this temperature, and allow it to fully react. This is the reaction step, during which temperature control needs to be precise to ensure a smooth reaction.
After the reaction is completed, the impurities are removed by subsequent treatment such as cooling and filtration. Distillation is carried out, and separation and purification are carried out according to the boiling point characteristics of the product. To ensure purity, it can be recrystallized multiple times. This is the preparation process, each step is closely linked, and it is related to the quality of the finished product. Only by strictly adhering to this system can you get the best quality 1-Fluoro-2-Methoxy-3-Nitrobenzene.

Chemical Reactions & Modifications

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is an organic compound. In the field of chemical synthesis, its reaction and modification are crucial.
Looking at the reaction, fluorine atoms, methoxy groups and nitro groups all have unique chemical activities. Fluorine atoms have strong electronegativity, which can change the electron cloud density of the benzene ring, which affects the check point and rate of electrophilic substitution reactions. Methoxy groups are the power supply groups, which can enhance the electron cloud density of the benzene ring ortho-site, and the electrophilic substitution reaction is more likely to occur in the ortho-site. Nitro groups are strong electron-absorbing groups, which reduce the electron cloud density of the benzene ring, and the reactivity is also different.
To modify this compound, the nucleophilic substitution reaction can be used to replace the fluorine atom with a suitable nucleophilic reagent, introduce new functional groups, change its physical and chemical properties, and have new applications in many fields such as drug synthesis and materials science. In this way, its use can be expanded and new paths can be opened up for chemical research and industrial production.

Synonyms & Product Names

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene, this substance is also an important product in chemical synthesis. Its synonym and trade name are related to research and application, and are also valued by the academic community.
Looking at the past, chemical substances were named according to their structure, properties or discoverers. This product is named after its specific atomic arrangement and functional group. However, in practical applications, different regions, research teams or due to habit and convenience, have different names.
As for the name of the product, merchants also have unique names in order to recognize its characteristics or seek the favor of the market. Although the names are different, they all refer to the same chemical substance. This compound is widely used in the fields of medicine, materials, etc. The clarity of its synonym and trade name helps all parties to communicate and communicate. It is of great significance in chemical research and industrial production, enabling practitioners to be accurate and avoid confusion, and promoting the smooth development of science and industry.

Safety & Operational Standards

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is an important chemical product. During its preparation and application, safety and operating standards are of paramount importance.
All operations involving this substance must first be familiar with its physical and chemical properties. 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene has a specific melting point, boiling point and solubility, which vary in different solvents. And its chemical activity needs to be treated with caution to prevent accidental chemical reactions.
The experimental site must be well ventilated to disperse possible harmful gases that may escape. When operating, the experimenter should wear appropriate protective equipment, such as laboratory clothes, gloves and goggles, to ensure their own safety.
When storing 1-Fluoro-2-Methoxy-3-Nitrobenzene, it should be placed in a cool, dry and well-ventilated place, away from sources of ignition and oxidants. When using this substance, it is necessary to follow precise measurement specifications, and the equipment used should also be clean and dry to avoid contamination.
During the reaction operation, the reaction conditions such as temperature, pressure and reaction time should be strictly controlled. The heating or cooling process should be smooth to avoid danger caused by sudden changes in temperature. The stirring speed should also be moderate to ensure that the reactants are well mixed.
After the experiment is completed, properly dispose of the remaining 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene and related waste. Follow environmental protection requirements and do not dump at will to prevent pollution to the environment.
In short, the safety and operation specifications for 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene must be strictly followed, so as to ensure the smooth progress of the experiment and ensure the safety of personnel and the environment.

Application Area

1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is a unique chemical product. In various application fields, it is quite useful.
In the field of pharmaceutical synthesis, this compound can be used as a key intermediate. With its unique structure, it can combine with other substances through delicate chemical reactions to prepare a variety of drugs with significant efficacy. For example, in the creation of targeted drugs for specific diseases, the characteristics of 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene can help to build a precise molecular structure.
In the field of materials science, it also has its own impact. It can be integrated into specific materials through appropriate processes to improve the properties of materials. Or increase its stability, or change its optical properties, to contribute to the research and development of new materials.
Furthermore, in organic synthetic chemistry, it is often a weapon in the hands of chemists. With its fluorine, methoxy and nitro structure, it can open a variety of reaction paths to synthesize many organic compounds with complex structures and unique functions, promoting the progress of organic synthetic chemistry.

Research & Development

Today there is 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene, and I have a lot of experience in its research and development. At first, explore its structure to clarify its physicochemical properties. Detailed analysis of its molecular structure, we know that the location of fluorine, methoxy and nitro has a great impact on the reactivity.
Then study its synthesis method, try various paths, and strive for efficient and pure production. After many attempts, we can get an optimized method, with gradually increasing yield and good purity.
Furthermore, explore its application field. In medicine, materials and other aspects, its potential can be seen. Such as pharmaceutical research and development, or its structural characteristics can be used to make special drugs.
We should study this product tirelessly, hoping that it will shine in various fields, promote the progress of science and technology, and benefit the world, so that the path of research and development will become wider and wider.

Toxicity Research

In this study, the toxicity of 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene, the properties of this compound cannot be ignored. It often has a special appearance in chemical reactions. However, its toxicity is also the focus of our research.

Many times, we have investigated its toxicity in general methods. This thing is placed in a specific environment, to observe the shadow of different organisms. Its tiny organisms, such as insects, are useful for writing. Short-term connection, the life of the plant is not good, and there are dead.
In turn, this thing is used in plants, and its withering and life is blocked. It can be seen that 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene is toxic to a certain extent. We should be careful. During the use and research, we must do a good job of prevention to avoid its poisoning and personal invasion. We must also properly dispose of it to avoid polluting the environment.

Future Prospects

The future outlook concerns the chemical product 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene. In my opinion, this substance has extraordinary potential in the field of chemical industry.
In the future, its synthesis method may be refined. Or more concise, efficient and green ways can be found to reduce consumption and reduce emissions, making production more environmentally friendly and economical.
The application level is expected to expand to new fields. In pharmaceutical research and development, it may become a key intermediate to help create special new drugs and heal diseases. In material science, it may endow materials with unique properties, such as excellent conductivity, stability, etc., giving rise to new functional materials.
Furthermore, the study of its properties will also deepen. Clarify more fine characteristics, paving the way for its precise application. In this way, 1 - Fluoro - 2 - Methoxy - 3 - Nitrobenzene will surely shine in the future, injecting vigorous impetus into the development of various industries.

Where to Buy 1-Fluoro-2-Methoxy-3-Nitrobenzene in China?

As a trusted 1-Fluoro-2-Methoxy-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-2-Methoxy-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2-Methoxy-3-Nitrobenzene?

1-Fluoro-2-methoxy-3-nitrobenzene has a wide range of uses. In the field of organic synthesis, it is a key raw material.
For drug synthesis, it can be cleverly converted into compounds with specific pharmacological activities through a series of chemical reactions. Taking some antimicrobial drugs as an example, the carefully designed reaction path of 1-fluoro-2-methoxy-3-nitrobenzene can become an important cornerstone for building the core structure of drug molecules, opening the way for the development of new antimicrobial drugs.
In the field of materials science, it also has unique uses. It can be used as a precursor for the synthesis of special functional materials. For example, in the preparation of organic materials with specific optoelectronic properties, the use of their unique chemical structure and appropriate reaction modification can endow the material with unique electrical and optical properties, such as good conductivity or special fluorescence properties, etc., so as to meet the needs of special materials in the fields of electronic devices and optical displays.
Furthermore, in the synthesis of dyes, 1-fluoro-2-methoxy-3-nitrobenzene can also play an important role. By reacting with different reagents, dye molecules with diverse structures can be prepared, providing dye products with rich colors and excellent performance for textile, printing and dyeing industries, and meeting people's requirements for fabric color and color fastness.
In conclusion, 1-fluoro-2-methoxy-3-nitrobenzene has shown important application value in many fields due to its unique chemical structure, which cannot be ignored in promoting the development of related industries.

What are the physical properties of 1-Fluoro-2-Methoxy-3-Nitrobenzene?

1-Fluoro-2-methoxy-3-nitrobenzene is one of the organic compounds. Its physical properties are particularly important, related to its many uses and reaction characteristics.
First of all, under room temperature, 1-fluoro-2-methoxy-3-nitrobenzene is often in a liquid state, but it is not absolute, or varies depending on the preparation method and purity. Its appearance may be a colorless to light yellow transparent liquid, and the purer the color and luster, the clearer the view.
As for its melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. Melting point, the temperature limit at which a substance changes from a solid state to a liquid state. The melting point of 1-fluoro-2-methoxy-3-nitrobenzene makes it a solid state at a specific temperature range, and at this temperature, it gradually melts into a liquid state. Boiling point, the temperature at which a liquid converts to a gas state. This boiling point value determines the ease of gasification during heating.
Density is also one of its important physical properties, about [X] g/cm ³. This value is heavier than water, so it often sinks at the bottom in water. The characteristics of density have a great influence on operations such as separation and mixing.
In terms of solubility, 1-fluoro-2-methoxy-3-nitrobenzene is insoluble in water. This is because water is a polar solvent, and the polarity of this compound is weak. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In organic synthesis, this solubility is often used to select a suitable solvent to promote the reaction.
In addition, it has a certain volatility. Although the volatilization rate is not extremely fast, it will also evaporate in an exposed environment. This volatility affects its storage method and must be sealed to avoid loss and impact on the environment.
In summary, the physical properties of 1-fluoro-2-methoxy-3-nitrobenzene, such as their properties, melting point, density, solubility, and volatility, are of great significance in the fields of organic synthesis and chemical production, and operators must carefully observe them before making good use of this compound.

What is the chemical synthesis method of 1-Fluoro-2-Methoxy-3-Nitrobenzene?

The synthesis method of 1-fluoro-2-methoxy-3-nitrobenzene can follow the following steps.
First, 2-methoxy-3-nitroaniline is used as the starting material. Mix it with an appropriate amount of sodium nitrite and dilute hydrochloric acid, and carry out a diazotization reaction in a low temperature environment. This reaction condition requires strict temperature control, generally maintained between 0-5 ° C, so that 2-methoxy-3-nitroaniline can be converted into diazonium salts. During this process, sodium nitrite interacts with hydrochloric acid to form nitrous acid, which in turn reacts with 2-methoxy-3-nitroaniline to form a diazo compound.
After the diazonium salt is formed, it is mixed with a fluoroboronic acid solution to produce a precipitation, which is 2-methoxy-3-nitrobenzene diazo fluoroborate. The precipitation is separated, washed, and then decomposed by heating. During the thermal decomposition process, the diazo group is replaced by a fluorine atom, and the target product is 1-fluoro-2-methoxy-3-nitrobenzene.
There are other ways. Using 2-methoxy benzene as the starting material, the nitrification reaction is first carried out with a mixed acid (a mixture of nitric acid and sulfuric acid). During the reaction, it is necessary to control the temperature and the proportion of mixed acid, so that the nitro group is selectively introduced into the specific position of 2-methoxy-3-nitrobenzene to generate 2-methoxy-3-nitrobenzene. Subsequently, the fluorination reaction of 2-methoxy-3-nitrobenzene is carried out with suitable fluorination reagents, such as Selectfluor, etc. The reaction is carried out in an appropriate solvent, and the appropriate base and reaction temperature need to be selected so that the fluorine atom replaces the specific hydrogen atom on the benzene ring, and finally 1-fluoro-2-methoxy-3-nitrobenzene is synthesized In the
synthesis process, the reaction conditions of each step, such as temperature, reagent ratio, reaction time, etc., have a great influence on the yield and purity of the product, and must be finely regulated to obtain the ideal synthesis effect.

What are the precautions in storage and transportation of 1-Fluoro-2-Methoxy-3-Nitrobenzene?

1-Fluoro-2-methoxy-3-nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Safety is the first priority. This compound is dangerous and should be stored in a cool and well-ventilated place, away from fire and heat sources to prevent fire and explosion. Because it may be flammable, oxidizing or toxic, the storage area must be strictly prohibited from fireworks and equipped with appropriate fire fighting equipment and emergency equipment.
Furthermore, the storage place should be kept dry. 1-Fluoro-2-methoxy-3-nitrobenzene encounters water or moisture, or initiates a chemical reaction that causes deterioration or produces harmful products. Therefore, it is necessary to ensure that the storage container is well sealed to avoid contact with water.
When transporting, it is also necessary to strictly abide by relevant regulations. Select transportation tools that meet safety standards and pack them properly to prevent damage to the container due to collision and vibration. Transportation personnel need to be professionally trained and familiar with the characteristics of this compound and emergency treatment methods.
In addition, the label must be clearly marked. On the storage container and transportation packaging, the name, nature, hazard warning and other information of the compound should be clearly marked so that relevant personnel can identify and deal with it.
Also, avoid mixing with incompatible substances. 1-fluoro-2-methoxy-3-nitrobenzene may react violently with certain substances, so it should not be stored and transported with oxidizing agents, reducing agents, acids, bases and other incompatible substances.
In this way, pay careful attention to the above things to ensure the safety of 1-fluoro-2-methoxy-3-nitrobenzene during storage and transportation to avoid accidents.

What is the market price range for 1-Fluoro-2-Methoxy-3-Nitrobenzene?

1-Fluoro-2-methoxy-3-nitrobenzene, which is a fine chemical in organic chemistry. Its market price range is difficult to determine exactly, due to the intertwined influence of many factors.
First, the state of market supply and demand is the key. If there is a surge in demand for it in the industry, such as research and development or production in the fields of medicine and pesticides, the demand for this substance is strong, and the supply is limited, the price will rise; on the contrary, if the demand is weak and the supply is sufficient, the price will fall.
Second, the preparation cost affects the price. The price of raw materials fluctuates, which has a great impact. If the price of fluoride, methoxylation reagent, nitrification reagent and other raw materials required for the preparation of 1-fluoro-2-methoxy-3-nitrobenzene rises, the production cost increases, and the market price will also increase accordingly. And the complexity of the preparation process is related to the investment of manpower and material resources, which in turn affects the cost and price. If complex multi-step reactions, harsh reaction conditions or expensive catalysts are required, the cost will increase and the price will also be high.
Third, product purity and quality grade are also determinants of price. High-purity, high-quality grade products are mostly used in high-end pharmaceutical research and development or electronic chemicals, and the price is much higher than that of ordinary purity products.
Fourth, the market competition situation is different, and the price is also different. There are many market participants, and the competition is fierce. In order to compete for share, merchants may lower prices; if the market is almost monopolized, or only a few suppliers, the price may be manipulated in a higher range.
In summary, the market price range of 1-fluoro-2-methoxy-3-nitrobenzene can be tens of yuan per kilogram. If products with high purity and special quality requirements can reach thousands of yuan per kilogram or even higher, it depends on the combination of the above factors.