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1-Fluoro-2,4-Dimethoxybenzene

1-Fluoro-2,4-Dimethoxybenzene

Hongda Chemical

Specifications

HS Code

163764

Chemical Formula C8H9FO2
Molar Mass 156.154 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 210 - 212 °C
Melting Point N/A
Density 1.109 g/mL at 25 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 85 °C
Refractive Index 1.504 - 1.506

As an accredited 1-Fluoro-2,4-Dimethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 2,4 - dimethoxybenzene packaged in a sealed glass bottle.
Storage 1 - fluoro - 2,4 - dimethoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Label the storage container clearly for easy identification.
Shipping 1 - fluoro - 2,4 - dimethoxybenzene is shipped in properly sealed containers to prevent leakage. Special handling precautions are taken due to its chemical nature, with shipments compliant with relevant hazardous material transport regulations.
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1-Fluoro-2,4-Dimethoxybenzene 1-Fluoro-2,4-Dimethoxybenzene
General Information
Historical Development
1 - Fluoro - 2,4 - Dimethoxybenzene, chemical products are also. Tracing its historical development, the chemists of the past worked hard in the field of organic synthesis. At the beginning, organic chemistry was still unknown, and the properties and synthesis paths of many substances were unknown.
With the gradual rise of science, scholars have increasingly explored benzene-based compounds. After countless experiments, failures and improvements, research on such fluorine-containing methoxybenzene derivatives began. In the early days, the synthesis of this compound was quite difficult, the raw materials were rare, and the process was complicated.
However, the researchers were determined. With the advance of science and technology, the analytical methods were improved, and the reaction mechanism was gradually clear. The synthesis method has also been continuously optimized, from the humble beginning to the mature and efficient. The birth and development of 1-Fluoro-2,4-Dimethoxybenzene is one of the examples of unremitting exploration and pursuit of truth in the history of chemistry.
Product Overview
1 - Fluoro - 2,4 - Dimethoxybenzene is also an organic compound. It is a colorless to light yellow liquid with a special odor. The structure of this compound, the fluorine atom is connected to the dimethoxybenzene ring, and the unique structure gives it different chemical properties.
In the field of organic synthesis, 1 - Fluoro - 2,4 - Dimethoxybenzene has a wide range of uses. It can be used as a key intermediate for the preparation of many drugs, pesticides and functional materials. Due to the presence of fluorine atoms, it can significantly affect the electron cloud distribution of the compound, thereby changing the reactivity and selectivity.
Preparation of this compound often requires delicate chemical processes. 1-Fluoro-2,4-Dimethoxybenzene can be prepared from halogenated aromatic hydrocarbons by nucleophilic substitution. However, in the preparation process, it is very important to control the reaction conditions, such as temperature, catalyst type and dosage, which will affect the purity and yield of the product.
Physical & Chemical Properties
1 - Fluoro - 2,4 - Dimethoxybenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, it is mostly liquid at room temperature, with a specific boiling point and melting point. The boiling point is related to the intermolecular force. The intermolecular force of this compound is moderate, so that its boiling point is within a certain range, which is conducive to separation and purification. The melting point reflects the stability of the crystal structure.
In terms of its chemical properties, due to the presence of fluorine atoms and methoxy groups, the chemical activity has its own characteristics. Fluorine atoms have strong electronegativity, which can affect the electron cloud density of the benzene ring, making it more prone to electrophilic substitution reactions at specific locations of the benzene ring. Methoxy groups are the power supply subgroups, which also affect the reactivity and selectivity. The synergy between the two determines the performance of this compound in many chemical reactions and has important applications in the field of organic synthesis.
Technical Specifications & Labeling
1 - Fluoro - 2,4 - Dimethoxybenzene, chemical substances are also. Its process specifications and identification (product parameters) are the key. In the preparation method, precise procedures need to be followed. The choice of raw materials must be pure and free of impurities, and the proportions are appropriate. The temperature, time, pressure and other parameters of the reaction should be precisely controlled. The material and volume of the reactor are also regulated to ensure a smooth reaction.
In terms of identification, its name should be clear, and the chemical formula C H FO ² should be marked. Physical properties such as color, state, and taste should be detailed, and data such as melting point, boiling point, and density should also be indispensable. On the package, a warning should be clearly marked to clarify its characteristics and safety instructions. In this way, it meets the requirements of process specifications and identification (product parameters) to ensure that this product is safe and effective when applied.
Preparation Method
To prepare 1-Fluoro-2,4-Dimethoxybenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key. First, take an appropriate amount of 2,4-dimethoxyphenol as the initial raw material, use anhydrous potassium fluoride as the fluorine source, and add an appropriate amount of phase transfer catalyst to a specific organic solvent such as N, N-dimethylformamide (DMF), and heat up to a certain temperature to fully react. During the reaction, the phase transfer catalyst can effectively promote the transfer of ions to the organic phase and the aqueous phase, and speed up the reaction process. After the reaction is completed, the product can be purified through subsequent steps such as cooling, extraction, and distillation to obtain 1-Fluoro-2,4-Dimethoxybenzene. In this preparation method, the raw materials are selected appropriately, the reaction conditions are precisely controlled, and each step complements each other to achieve the purpose of efficient preparation.
Chemical Reactions & Modifications
Since modern times, chemical refinement has improved, and the technology of reaction and modification has improved day by day. Today, the synthesis method of 1-Fluoro-2,4-Dimethoxybenzene, its synthesis method, chemists have been thinking hard.
Its initial reaction is combined with various raw materials in a kettle, temperature control and pressure regulation, and the desired product is obtained. However, the initial method, the yield is not good, and there are many impurities. Chemists then think about changes, and focus on the proportion of reactants and the selection of catalysts. Try to use a new catalyst to enter it, the reaction activity is greatly increased, and the yield is also skyrocketing.
And look at its modification, or introduce other groups to change its properties, for special purposes. After repeated trials, the changes in its structure and properties were observed, and finally the best method was obtained. Although the road is bumpy, chemists are determined to make unremitting efforts to make the reaction and modification of this chemical product in a wonderful state, which is used in various fields.
Synonyms & Product Names
1 - Fluoro - 2,4 - Dimethoxybenzene, in the field of chemistry, has many synonymous names and trade names. Its synonymous name is named by chemists according to its structure and characteristics. The name of the product exists due to differences in marketing and use by merchants.
or fluorinated dimethoxybenzene, which is covered by its fluorine-containing atom and has a benzene ring structure of dimethoxy. It is also called a chemical reagent name with a specific number, which is named according to industry standards or manufacturers' own systems. In terms of trade names, or because it is used in fine chemicals, pharmaceutical intermediates and other fields, there are corresponding trade names. If pharmaceutical companies use it for specific drug synthesis, they will call it by a specific trade name in order to distinguish and use it. These are all chemists and merchants who have given them various names based on their characteristics and uses.
Safety & Operational Standards
1 - Fluoro - 2,4 - Dimethoxybenzene Safety and Operating Practices
1 - Fluoro - 2,4 - Dimethoxybenzene is a compound commonly used in chemical research. When studying and handling this compound, safety is the first priority, and the operating specifications must be strictly followed.
In terms of safety, this compound has certain latent risks. Its chemical properties or reactions with other substances, so it should be stored in a cool, dry and well ventilated place, away from fire, heat and strong oxidants. Because this compound may cause harm to human body, be sure to take protective measures when exposed. When operating, you need to wear suitable protective gloves. The material should be able to effectively block it from contacting the skin. Eye protection is also indispensable. Goggles can prevent it from splashing into the eyes and avoid damage to the eyes. At the same time, you should wear experimental clothes to prevent the compound from contaminating the clothes and then contacting the body.
In terms of operating specifications, when using the compound, be sure to use clean and dry appliances to avoid introducing impurities that affect its properties and experimental results. The weighing process needs to be accurate. According to the required amount of the experiment, use a balance with appropriate accuracy to operate to ensure that the dosage is accurate. During the reaction operation, the reaction conditions, such as temperature, pressure and reaction time, should be strictly controlled. Too high or too low temperature may cause the reaction to deviate from the expected path, and improper pressure control may also cause safety accidents. The control of the reaction time is also critical. Too long or too short is not conducive to the formation of the target product. After the reaction is completed, the remaining 1-Fluoro-2,4-Dimethoxybenzene and reaction products should be properly disposed of in accordance with relevant regulations and should not be discarded at will to avoid pollution to the environment.
Only by strictly observing the safety and operation standards of 1-Fluoro-2,4-Dimethoxybenzene can we ensure the smooth progress of the experiment and ensure the safety of researchers and the safety of the environment.
Application Area
1 - Fluoro - 2,4 - Dimethoxybenzene is also a chemical substance. Its application field is related to many things. In the field of medicinal chemistry, it can be a key raw material for the synthesis of special drugs, and it can assist in the preparation of drugs to treat various diseases. In material science, it also has its use, or can participate in the synthesis of special materials, so that the material has specific properties, such as better stability or optical properties. And in the field of fine chemicals, it can be used as an intermediate to derive a variety of fine chemicals to meet the needs of different industries and life. Therefore, 1 - Fluoro - 2,4 - Dimethoxybenzene has important value in many application fields, and can contribute to the development of related industries, leading them to a more delicate and efficient environment.
Research & Development
In recent years, I have been focusing on the product of 1-Fluoro-2,4-Dimethoxybenzene in the field of chemistry. This substance has unique properties and has potential uses in various fields.
At the beginning, I explored its synthesis method. After repeated experiments, the existing method was improved, so that the yield gradually increased. Although the process is difficult, it encounters many problems, such as the control of reaction conditions and the removal of impurities, but it is overcome with perseverance and wisdom.
Then, study its properties, understand its physical and chemical properties, and lay the foundation for its application. Now it is studying the application in the fields of medicine and materials, hoping to make breakthroughs.
I believe that with time, through continuous research and development, 1-Fluoro-2,4-Dimethoxybenzene will be able to shine in related fields and contribute to the progress of the industry.
Toxicity Research
In recent years, I have been focusing on the toxicity research of chemical products. Today, the focus is on 1-Fluoro-2,4-Dimethoxybenzene.
This substance also has its unique appearance, but the investigation of toxicity should not be ignored. After a series of experiments, the effect of it on organisms was observed. It may act on the metabolism of cells, or affect the expression of genes. Its toxicity occurs, initially showing slight discomfort, and then it can cause damage to organs.
And if this substance enters the environment, it will also disturb the ecological balance. It may harm the growth of plants or cause harm to aquatic organisms. Therefore, the toxicity study of 1-Fluoro-2,4-Dimethoxybenzene is related to people's livelihood and ecology. It must not be slack off. It is necessary to investigate it in depth to clarify its harm and seek solutions to control it.
Future Prospects
1 - Fluoro - 2,4 - Dimethoxybenzene, this chemical substance, is like a shining star in our research, guiding the direction of future expansion.
Looking at its characteristics, its structure is exquisite, and the combination of fluorine atoms and dimethoxy groups is unique. This unique structure gives it unlimited potential in the field of organic synthesis.
Looking to the future, it may shine in the field of drug research and development. With its special chemical properties, it may become a key intermediate, helping to create new drugs with special effects and saving patients from pain.
Furthermore, material science is also its stage. Or it can participate in the construction of new functional materials, contributing to the innovation of electronic and optical materials.
Although there is a long way to go, we, the scientific researchers, must uphold the determination and explore in depth, hoping to use the power of 1-Fluoro-2,4-Dimethoxybenzene to open a new chapter in future technology and health, for the benefit of the world.
Where to Buy 1-Fluoro-2,4-Dimethoxybenzene in China?
As a trusted 1-Fluoro-2,4-Dimethoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-2,4-Dimethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2,4-Dimethoxybenzene?
1-Fluoro-2,4-dimethoxy benzene is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
The art of organic synthesis, this compound can participate in the construction of various complex organic molecules through various reaction paths. For example, in etherification reactions, its methoxy group can interact with other nucleophiles to introduce specific functional groups, thereby expanding the structure of the molecule. This process is like the careful carving by skilled craftsmen, which makes the molecular structure increasingly complex and delicate.
Furthermore, in the field of pharmaceutical chemistry, 1-fluoro-2,4-dimethoxy benzene also plays an important role. The synthesis of many drugs often relies on this compound as the starting material. Due to its unique structure, it endows molecules with specific physical and chemical properties, such as lipophilicity, electronic effects, etc., which have a profound impact on the interaction between drugs and targets.
In the field of materials science, this compound may be used to synthesize special functional materials. For example, through the polymerization reactions it participates in, polymer materials with specific electrical and optical properties may be prepared, which are suitable for many high-tech fields such as organic Light Emitting Diodes and sensors.
In addition, 1-fluoro-2,4-dimethoxy benzene has potential applications in the manufacture of fine chemical products, such as fragrances and dyes. Its unique chemical structure may endow the product with different characteristics and add color.
In summary, although 1-fluoro-2,4-dimethoxybenzene is an organic compound, it plays an indispensable role in many fields such as organic synthesis, medicinal chemistry, materials science and fine chemistry, and has a wide range of uses and far-reaching influence.
What are the physical properties of 1-Fluoro-2,4-Dimethoxybenzene?
1-Fluoro-2,4-dimethoxybenzene is one of the organic compounds. Its physical properties are quite impressive.
Looking at its properties, under normal temperature, it is usually a colorless to light yellow liquid. The color state is clear and recognizable, showing a flowing state, like smart water, but it has the characteristics of a chemical substance.
As for its melting point, it is about a specific value range, which is crucial for defining its phase transition. When the temperature drops below the melting point, it will gradually solidify from a liquid state to a solid state.
Boiling point is also a key physical property. Under certain pressure conditions, its boiling point can reach a certain exact temperature, at which the liquid will be violently vaporized and converted into a gaseous state. The value of this boiling point is closely related to the intermolecular forces, because the strength of the intermolecular forces determines the amount of energy required to separate the molecules, which in turn affects the boiling point.
In terms of density, this compound has a specific value. Its density reflects the mass of the substance contained in a unit volume. Compared with common solvents, it may be different. This property plays an important role in the distribution of the solution and the phase separation process.
Solubility is also one of its important physical properties. In organic solvents such as ethanol and ether, 1-fluoro-2,4-dimethoxybenzene exhibits good solubility and can blend with solvents to form a uniform solution. However, in water, its solubility is poor, because the force between water molecules and the compound molecules is far less than the force between the compound molecules themselves, so it is difficult to miscible.
In addition, it also has a specific refractive index, which is related to the speed of light propagation in it. By measuring the refractive index, its purity and other characteristics can be effectively analyzed. All kinds of physical properties are indispensable in the process of studying and applying this compound.
What are the synthesis methods of 1-Fluoro-2,4-Dimethoxybenzene?
There are several ways to synthesize 1-fluoro-2,4-dimethoxybenzene. First, it can be started from the corresponding phenols. First, the phenol and dimethyl sulfate are reacted in an alkaline environment to methylate the phenol hydroxyl group to obtain dimethoxybenzene derivatives. After halogenation, fluorine atoms are introduced into fluorine-containing reagents, such as Selectfluor, under appropriate conditions. This process requires attention to the precise control of the reaction conditions to ensure that fluorine atoms are replaced at the specified position.
Furthermore, it can be started from halogenated benzene. First, a suitable halogenated benzene is reacted with nucleophiles such as sodium methoxide in the presence of a catalyst to introduce a methoxy group to construct a dimethoxy structure. After the halogen exchange reaction, fluoride is used to replace the original halogen to achieve the introduction of fluorine atoms. In this approach, the choice of catalyst and the regulation of reaction temperature and time are crucial, which are related to the selectivity and yield of the reaction.
Another method is the Grignard reagent. The Grignard reagent is prepared by halogenated benzene and reacts with the methoxylating reagent to form a dimethoxybenzene intermediate. Subsequently, the fluorine atom is introduced through the action of a specific fluorine-containing reagent. In this process, the preparation conditions of the Grignard reagent are strict, and the requirements for an anhydrous and anaerobic environment are quite high, and the subsequent reaction also requires fine operation to obtain the target product 1-fluoro-2,4-dimethoxybenzene.
What should be paid attention to when storing and transporting 1-Fluoro-2,4-Dimethoxybenzene?
1-Fluoro-2,4-dimethoxybenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
The first thing to focus on its chemical properties, this substance has a certain chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place. Cover because it is sensitive to heat, moisture or air, high temperature or humid environment, it may cause chemical reactions and damage its quality. Therefore, the warehouse temperature should be controlled within the appropriate range, not too high.
times and packaging. It must be filled with suitable packaging materials to ensure a good seal. It is usually better to use glass bottles or special chemical packaging containers to prevent leakage. Leakage not only causes material loss, but also causes pollution to the environment if the substance comes into contact with air, water, etc., or causes dangerous reactions.
Furthermore, during transportation, avoid violent vibration and collision. Because it is a fine chemical, violent vibration or package damage can cause leakage. The means of transportation must also be clean, dry, and meet the requirements of chemical transportation.
Repeat, fire and explosion protection is also the key. Although there is no exact data to indicate that it is highly flammable and explosive, as an organic compound, there is still a latent risk. Fireworks should be strictly prohibited in storage and transportation, and appropriate fire equipment and emergency treatment equipment should be equipped.
Finally, personnel operation should not be ignored. Personnel exposed to this substance need to be professionally trained to be familiar with its characteristics and safe operation procedures. Clear warning signs should be posted at storage and transportation sites to remind personnel to pay attention to safety. In this way, the safety of 1-fluoro-2,4-dimethoxybenzene during storage and transportation must be ensured.
What are the safety risks associated with 1-Fluoro-2,4-Dimethoxybenzene?
1-Fluoro-2,4-dimethoxybenzene, which has various risks related to safety. It has the risk of ignition, in case of open flame, hot topic, or causing combustion and explosion. In the place of production, storage and use, if the management is negligent and the ignition source is not careful, it will be like dry wood in case of fire, and disaster will be imminent.
Furthermore, it is also harmful to human health. Inhalation through the respiratory tract, or penetration through skin contact, can damage the body. After inhalation, or cause respiratory irritation, causing coughing, asthma, breathing difficulties; skin contact, or cause redness, swelling, itching, burning, if not careful into the eyes, especially serious damage to the eyes, or cause eye pain, tears, blurred vision. Long-term exposure to this substance may affect the function of organs such as the nervous system, liver and kidneys.
And because of its chemical properties, it also has a latent risk to the environment. If it enters the water body, or endangers aquatic organisms, it will affect the balance of the aquatic ecosystem; seep into the soil, or affect the quality of the soil, and then affect the growth of surrounding vegetation. Therefore, when handling this substance, strict regulations must be followed to ensure the safety of personnel and the environment. Production and users must be aware of its risks, operate cautiously, and be prepared for protection and emergency response.