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1-Fluoro-2,4,6-Trimethylbenzene

1-Fluoro-2,4,6-Trimethylbenzene

Hongda Chemical

Specifications

HS Code

742980

Chemical Formula C9H11F
Molar Mass 138.182 g/mol
Appearance Colorless liquid
Boiling Point 163 - 165 °C
Melting Point −39 °C
Density 0.952 g/cm³
Solubility In Water Insoluble
Vapor Pressure 1.1 mmHg (25 °C)
Flash Point 41 °C
Refractive Index 1.485

As an accredited 1-Fluoro-2,4,6-Trimethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - fluoro - 2,4,6 - trimethylbenzene in 500 - ml glass bottle, tightly sealed.
Storage 1 - fluoro - 2,4,6 - trimethylbenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of materials resistant to corrosion by this chemical. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions. Regularly check storage conditions to ensure its stability.
Shipping 1 - fluoro - 2,4,6 - trimethylbenzene is shipped in specialized, well - sealed containers compliant with chemical transport regulations. Shipment ensures proper protection from environmental factors and potential spills during transit.
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1-Fluoro-2,4,6-Trimethylbenzene 1-Fluoro-2,4,6-Trimethylbenzene
General Information
Historical Development
1 - Fluoro - 2,4,6 - Trimethylbenzene, an organic compound. Tracing back to its origin, at the beginning of the chemical sages studied the technique of organic synthesis, and in the exploration of the method of aromatic hydrocarbon fluorination, they gradually involved this substance. In the past, the development of organic chemistry was not prosperous, and the fluorination reaction was difficult, the conditions were harsh and the yield was not high. However, after years of grinding, the insight into the reaction mechanism became deeper, and the synthesis technology became more exquisite.
At first, only a small amount could be produced, and it was used for basic research to explore its physicochemical properties. After the chemical technology advanced, the reaction conditions were optimized, and the catalyst was improved, so that its yield gradually increased. Nowadays, it is useful in the fields of materials science, medicinal chemistry, etc. It can be used as an intermediate for the synthesis of special materials and new drugs, and it can help the development of related fields. The difficulty of synthesis in the past has been widely used today, which shows the development of chemistry.
Product Overview
1 - Fluoro - 2,4,6 - Trimethylbenzene is an organic compound. Its molecular structure is unique. On the benzene ring, the fluorine atom occupies one place, and the 2,4,6 and 6 positions are occupied by the methyl group.
This compound has specific physical and chemical properties. Appearance may be colorless liquid, with certain volatility. Due to the presence of fluorine atoms, its chemical activity is different from that of ordinary aromatic hydrocarbons. Fluoro has high electronegativity, which causes molecular polarity changes, affecting its solubility, boiling point and other properties.
In the field of organic synthesis, 1 - Fluoro - 2,4,6 - Trimethylbenzene has a wide range of uses. It can be used as a key intermediate to introduce various functional groups through nucleophilic substitution, coupling and other reactions to prepare complex organic compounds, which is of great significance in medicinal chemistry and materials science.
Its preparation may require multi-step reactions, and the target molecular structure can be accurately constructed through specific raw materials and reaction conditions. The synthesis process requires fine control of reaction conditions and impurity removal to ensure product purity and yield.
Physical & Chemical Properties
1 - Fluoro - 2,4,6 - Trimethylbenzene is an organic compound. Its physical properties are unique. It is mostly liquid at room temperature and has a special odor. The boiling point is within a certain range, which is related to the difficulty of gasification. Melting point is also an important indicator, which determines the transition temperature between solid and liquid states.
From the perspective of chemical properties, fluorine atoms in this compound are active and can participate in a variety of substitution reactions. The benzene ring has a conjugated system, which makes it chemically active, which is different from ordinary aliphatic hydrocarbons. The presence of methyl groups at 2,4,6 positions affects the distribution of electron clouds, which in turn changes the reactivity and selectivity.
Its physical and chemical properties make it widely used in the field of organic synthesis. It can be used as an intermediate, participate in the construction of complex organic molecules, and play an important role in medicine, materials and
Technical Specifications & Labeling
1 - Fluoro - 2,4,6 - Trimethylbenzene is an organic compound. It is necessary to specify the technical specifications and labels (commodity parameters) of this product.
Looking at its technical specifications, purity should be the primary consideration. The purity of this product should reach a very high standard, and the impurity content must be strictly controlled. If there are too many impurities, it will affect its effect in various reactions and applications. Its physical properties, such as melting point, boiling point, density, etc., also need to be accurately determined and standardized. Deviations in melting point or boiling point, or suggest differences in product quality.
As for the logo (commodity parameters), the key information such as name, chemical formula, and purity should be clearly marked on the package. It is necessary to indicate the storage conditions, because of its chemical properties or strict storage requirements. Warning labels are also indispensable to indicate its potential hazards, such as whether it is flammable, toxic, etc., so that users can operate carefully to ensure safety. In this way, the technical specifications and labels of this product must be standardized to meet the needs of various uses.
Preparation Method
1 - Fluoro - 2,4,6 - Trimethylbenzene is an organic compound, and the preparation method is very important. In the selection of raw materials, 2,4,6 - trimethylaniline can be used as the starting material. The synthesis process is as follows: First, 2,4,6 - trimethylaniline is mixed with an appropriate amount of hydrofluoric acid, and the sodium nitrite solution is added dropwise at low temperature. In this step, a diazotization reaction occurs to generate a diazonium salt. The reaction process requires strict control of the temperature and dropwise speed to prevent side reactions. Subsequently, the diazonium salt solution is slowly added to the reaction system containing hypophosphoric acid, and a reduction reaction occurs. The diazonium group is replaced by a fluorine atom to obtain 1 - Fluoro - 2,4,6 - Trimethylbenzene. During the whole process, the reaction conditions such as temperature, reactant ratio, reaction time, etc. need to be finely regulated to ensure the purity and yield of the product. During separation and purification, conventional methods such as distillation and extraction can be used to obtain high-purity target products.
Chemical Reactions & Modifications
1 - Fluoro - 2,4,6 - Trimethylbenzene is an organic compound, and there are many things to be studied about its chemical reaction and modification. Its reaction mechanism is complex. Under specific conditions, the activity of fluorine atoms may lead to a series of reactions.
Looking at its chemical modification aims to optimize its properties. The group on the benzene ring can be modified by substitution reaction to change its physical and chemical properties. Or change its solubility, stability, or increase its reactivity to suit different needs.
Furthermore, the reaction conditions have a significant impact on it. Temperature and the choice of catalyst can affect the rate and direction of the reaction. Finding the best reaction conditions is the key to obtaining the ideal product and improving the yield.
To understand the chemical mysteries of 1-Fluoro-2,4,6-Trimethylbenzene, many experiments and detailed investigations are needed to reveal the laws of its reaction and modification, and pave the way for its wider application.
Synonyms & Product Names
1 - Fluoro - 2,4,6 - Trimethylbenzene is an important chemical substance. The investigation of its synonyms and trade names is of great significance in chemical research.
Considering this substance, the synonyms can reflect its different naming angles. Or starting from the structural characteristics, with its fluorine-containing atoms combined with specific methyl positions, there are synonyms described by structure.
As for the trade name, in the market circulation and industrial application, merchants will give it a unique trade name in order to highlight its characteristics and facilitate identification. This substance is used in the chemical industry or as an intermediate to synthesize complex organic compounds. The clarity of its synonyms and trade names helps researchers to communicate accurately, and also helps to accurately locate and apply it in industrial production.
Although the current literature does not provide detailed information on all its synonyms and trade names, continued research and exploration will surely lead to a more comprehensive understanding and contribute to chemical research and industrial development.
Safety & Operational Standards
1 - Fluoro - 2,4,6 - Trimethylbenzene Safety and Operation Specifications
1 - Fluoro - 2,4,6 - Trimethylbenzene is a substance often involved in chemical research. During its experimental operation and use, safety is the first priority, and the operation specifications should not be ignored.
#1. Storage Safety
This substance should be stored in a cool and ventilated warehouse. Keep away from fire and heat sources to prevent it from evaporating or triggering dangerous reactions due to rising temperature. The temperature of the warehouse should not exceed 30 ° C, and the relative humidity should be controlled below 80%. The storage area should be equipped with suitable materials to contain leaks to prevent the spread of accidental leakage. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to avoid danger due to interaction.
#2. Operating Specifications
When operating, be sure to exercise strict caution. Experimenters wear protective gloves and goggles in front of appropriate protective clothing to prevent skin contact and eye splashing. Operate in a well-ventilated environment, preferably in a fume hood to ensure that the volatile gas can be discharged in time and will not accumulate in the air.
When taking the substance, the utensils used must be clean and dry to prevent impurities from mixing and affecting its properties or causing adverse reactions. The measurement process should be accurate, and the dosage should be strictly controlled according to the experimental requirements. If it is accidentally spilled, the operation should be stopped immediately, and irrelevant personnel should be quickly evacuated to start emergency treatment procedures. In the case of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite and collected in a closed container; if a large amount of leakage needs to be constructed embankment or excavated for containment, transferred to a tanker or a special collector with an explosion-proof pump, recycled or transported to a waste treatment site for disposal.
#3. Emergency disposal
If you accidentally come into contact with the skin, you should immediately take off the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eyes, you need to immediately lift the eyelids, rinse with flowing water or normal saline for more than 15 minutes, and seek medical attention quickly. If inhaling the volatile gas of this substance, you should quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and seek medical attention.
In short, in the research and use of 1-Fluoro-2,4,6-Trimethylbenzene, strict adherence to safety and operating standards can ensure the smooth operation of the experiment, and ensure the safety of personnel and the environment is not damaged.
Application Area
1 - Fluoro - 2,4,6 - Trimethylbenzene is also an organic compound. Its application field involves many aspects of chemical industry. In the field of material synthesis, it can be used to make special materials. Because of its unique structure, it gives different properties to the material and helps the material to have better stability and adaptability. In pharmaceutical chemistry, it also has its place. It can be used as an intermediate in drug synthesis. After delicate reactions, it is converted into molecules with specific pharmacological activities, which contributes to the research and development of new drugs. In the fragrance industry, it may be able to participate in the preparation of fragrances due to its special smell and chemical properties, adding a unique charm to the aroma. All these show the important value of 1 - Fluoro - 2, 4, 6 - Trimethylbenzene in various application fields, which is an ingredient that cannot be ignored in chemical research.
Research & Development
There is a substance today, named 1 - Fluoro - 2, 4, 6 - Trimethylbenzene. I am a chemical researcher and have studied it for a long time.
The study of this substance is related to many aspects. Its structure is unique, and the arrangement of fluorine atoms and methyl groups affects its physical and chemical properties. After repeated experiments, its reaction under different temperatures, humidity and pH levels was observed.
During the research process, problems arose frequently. The precise control of the reaction conditions is like dancing on the tip of a needle. However, we did not give up, and after unremitting exploration, we finally achieved some results.
Looking forward to its development, the use may be extremely extensive. In the field of material synthesis, or as a key raw material, new materials with excellent performance can be obtained. In pharmaceutical chemistry, it may also be an opportunity for innovative drug research and development. With time and continued research, it will be able to play a greater role and contribute to scientific and technological progress and people's well-being.
Toxicity Research
Recently, I studied the toxicity of 1 - Fluoro - 2,4,6 - Trimethylbenzene in my laboratory. Looking at its molecular structure, fluorine atoms are connected to benzene rings, and methyl groups are attached to them.
Test it with various substances and observe its reaction. See it under specific conditions, or combine with other substances, or cause changes in properties. After many tests, it is known that if this substance enters the body, it may disturb the order of physiology and damage the ability of organs.
In the environment, it is not good. It may stay in water and soil, or float in the air, causing harm to the surroundings. Although its amount is not abundant, it has accumulated for a long time and should not be underestimated.
We should be careful and study its detoxification method to prevent its spread, so as to protect the well-being of all beings and maintain the tranquility of the environment.
Future Prospects
The promise of the future can be seen. Today there is 1 - Fluoro - 2,4,6 - Trimethylbenzene, which is very powerful in the field of chemical transformation. We are researching it, hoping to explore its depth and expand its use.
This material property is unique, or it can be used in new research to cure world diseases. Or in the field of materials, to help new materials grow, and to improve our utensils. The law of its inversion, we can reverse it and make it clear.
Not yet, hope to be able to precisely control its synthesis method, reduce its cost, and improve its efficiency. In this way, it can be widely used in all walks of life, for the benefit of the world. And work together with colleagues to gather the wisdom of others, with the hope of improving its overall picture as soon as possible, and developing the possibility of its limitations, so as to create a grand scene that has not yet been created.
Where to Buy 1-Fluoro-2,4,6-Trimethylbenzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-2,4,6-Trimethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-2,4,6-Trimethylbenzene?
The use of 1-fluoro-2,4,6-trimethylbenzene is quite important. This compound is often used as a key intermediate in the field of chemical synthesis.
In the process of organic synthesis, it can involve a variety of reactions. In terms of nucleophilic substitution reaction, fluorine atoms are quite active and can be replaced by many nucleophilic reagents. From this, other organic compounds are derived, and their structures and properties are changed accordingly, which are suitable for different needs.
In the field of materials science, 1-fluoro-2,4,6-trimethylbenzene is also useful. After a specific reaction, it can be introduced into the structure of polymer materials, thereby improving the properties of materials. For example, it can enhance the stability of the material, so that it can better maintain its inherent properties in different environments; or it can adjust the solubility of the material to make it better in specific solvents, which is convenient for the processing and application of the material.
In the field of pharmaceutical chemistry, it has also made a name for itself. Due to its unique molecular structure, it can become the basic module for building drug molecules. Through appropriate chemical modification and reaction, the obtained compound can be endowed with specific biological activity, providing the possibility for the development of new drugs. By rationally designing the reaction route and integrating it into the molecular structure of the drug, it may improve the pharmacological properties of the drug, such as improving the efficacy of the drug and reducing side effects, which will contribute to the development of the pharmaceutical industry.
In summary, 1-fluoro-2,4,6-trimethylbenzene plays an important role in many fields such as chemical synthesis, materials science, and medicinal chemistry, and is an indispensable compound in the field of organic chemistry.
What are the physical properties of 1-Fluoro-2,4,6-Trimethylbenzene?
1-Fluoro-2,4,6-trimethylbenzene is also an organic compound. Its physical properties are quite important and are described here.
Looking at its properties, under normal temperature and pressure, 1-fluoro-2,4,6-trimethylbenzene is mostly a colorless and transparent liquid with a clear appearance, just like a clear spring, without special turbidity or precipitation.
As for its boiling point, it is about 170-172 ° C. At this temperature, the substance changes from liquid to gaseous state, and the force between molecules overcomes external pressure to change its shape. The characteristics of boiling point are crucial in the process of separation and purification, and can be distinguished from other substances according to this.
In terms of melting point, it is about -27 ° C. When the temperature drops to Si, 1-fluoro-2,4,6-trimethylbenzene solidifies from liquid to solid, and the molecular arrangement tends to be ordered from disorder.
The density is about 0.958g/cm ³, which is slightly lighter than water. If it is placed in one place with water, it will float on the water surface. This characteristic is also the main point of identification.
The solubility is also considerable. It is insoluble in water, but it is well miscible in organic solvents such as ethanol, ether, acetone, etc. This is because of the principle of similarity and compatibility. Its molecular structure is similar to that of organic solvents, so it is mutually friendly.
In addition, 1-fluoro-2,4,6-trimethylbenzene has a certain volatility and can be slowly dissipated in the air. Its vapor is slightly heavier than air and can be deposited in lower places. And it is flammable, and there is a risk of combustion and explosion in case of open flames and hot topics. When using and storing, it must be treated with caution.
Is 1-Fluoro-2,4,6-Trimethylbenzene chemically stable?
The stability of the chemical properties of 1-fluoro-2,4,6-trimethylbenzene is a problem that chemistry students often explore. In this compound, the benzene ring is a stable conjugated system, and its electron cloud distribution is uniform, which endows the benzene ring with special stability. The substitution of methyl and fluorine atoms makes the properties of this compound change.
methyl is a power supply group, which pushes the electron cloud to the benzene ring through induction and superconjugation effects, which can increase the electron cloud density on the benzene ring. Although this change affects the electron cloud distribution of the benzene ring, due to the strong stability of the benzene ring conjugated system, the power supply action of methyl is not enough to greatly shake its fundamental structure, and has a limited impact on the overall stability.
Fluorine atoms, although highly electronegative, are electron-withdrawing groups, which can reduce the electron cloud density of benzene rings through induction effects. However, it has certain particularities, because the solitary pair electrons of fluorine atoms can form p-π conjugation with benzene rings, and this conjugation can increase the stability of benzene rings to a certain extent.
Overall, the chemical properties of 1-fluoro-2,4,6-trimethylbenzene have certain stability. However, under specific reaction conditions, such as strong oxidizing agents, strong reducing agents, or extreme conditions such as high temperature and high pressure, its stability may be challenged. Because the substituents on the benzene ring can change the electron cloud density at various positions on the benzene ring, some positions are more prone to electrophilic substitution, nucleophilic substitution and other reactions. Although its chemical properties are relatively stable, it is not absolutely immutable. In a suitable chemical environment, various chemical changes can still occur, showing its unique chemical activity.
What are the preparation methods of 1-Fluoro-2,4,6-Trimethylbenzene?
The preparation method of 1-fluoro-2,4,6-trimethylbenzene is generally as follows.
First, it can be prepared by the electrophilic substitution reaction of aromatic hydrocarbons. Take 2,4,6-trimethylbenzene as the substrate and react with fluorine-containing electrophilic reagents under appropriate reaction conditions. Commonly used electrofluorinated reagents, such as Selectfluor, etc. In the reaction, the fluorine atom of the electrophilic reagent attacks the benzene ring and replaces the hydrogen atom on it, thereby generating 1-fluoro-2,4,6-trimethylbenzene. This reaction needs to be carried out in a suitable solvent, such as dichloromethane, and the reaction temperature and time need to be controlled to improve the yield and purity of the product.
Second, prepared by halogen exchange reaction of halogenated aromatics. First obtain 1-chloro (or 1-bromo) -2,4,6-trimethylbenzene, and then make it halogen exchange with fluorinated reagents. Commonly used fluorinating reagents include potassium fluoride, etc. This reaction usually needs to be carried out in a polar aprotic solvent, such as dimethyl sulfoxide (DMSO), and a phase transfer catalyst needs to be added to promote the reaction. The phase transfer catalyst can make the fluorinated reagents of inorganic salts have better solubility and reactivity in the organic phase, thereby improving the reaction rate and yield.
Third, prepared by the Grignard reagent method. First prepare 2,4,6-trimethylphenylmagnesium halide (Grignard reagent), and then react with suitable fluorine-containing reagents. For example, react with fluorocarbons or trifluoromethanesulfonates to form the target product 1-fluoro-2,4,6-trimethylbenzene. This reaction needs to be carried out under anhydrous and oxygen-free conditions, because Grignard reagents are extremely active and will react quickly in contact with water or oxygen and fail. During the reaction process, conditions such as reaction temperature and proportion of reactants need to be precisely controlled to ensure the smooth progress of the reaction and the quality of the product.
What are the precautions for storing and transporting 1-Fluoro-2,4,6-Trimethylbenzene?
1-Fluoro-2,4,6-trimethylbenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First storage environment. This substance should be stored in a cool and ventilated warehouse, away from fire and heat sources, to prevent it from evaporating or causing danger due to excessive temperature. The temperature of the warehouse should be controlled within a specific range, generally not exceeding 30 ° C. Because of its flammability, it should be stored separately from oxidizing agents and acids, and should not be mixed to prevent chemical reactions from causing fires or explosions. At the same time, the warehouse should be equipped with suitable materials to contain leaks so that they can be dealt with in time if they accidentally leak.
Second and transportation safety. When transporting, it is necessary to ensure that the container does not leak, collapse, fall or damage. The means of transportation should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid sun exposure. Highway transportation should be carried according to the specified route, and do not stop in residential areas and densely populated areas. When transporting by railway, it is strictly forbidden to slip away. Loading and unloading personnel should handle lightly to prevent damage to packaging and containers.
Furthermore, safety protection cannot be ignored. Storage and transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods, and be equipped with necessary personal protective equipment, such as gas masks, protective gloves, etc., to avoid contact with the substance to cause harm to the body. In the event of a leak, personnel from the contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency responders should wear self-contained positive pressure breathing apparatus and anti-toxic clothing to cut off the source of the leak as much as possible, ventilate reasonably, and accelerate the spread to properly dispose of it to ensure the safety of personnel and the environment from pollution.