1-Ethynyl-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code	556843
Chemical Formula	C8H5F
Molecular Weight	120.123 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	157 - 159 °C
Melting Point	N/A
Density	1.077 g/mL at 25 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	43 °C
Refractive Index	1.527 - 1.529

As an accredited 1-Ethynyl-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - ethynyl - 4 - fluorobenzene in 500 - gram bottles for chemical packaging.
Storage	1 - Ethynyl - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly closed container, preferably made of a material resistant to its reactivity, like glass or certain plastics. Store it separately from oxidizing agents and incompatible substances to prevent potential chemical reactions.
Shipping	1 - ethynyl - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, adhering to strict chemical transportation regulations due to its potentially hazardous nature.

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General Information

Historical Development

1 - Ethynyl - 4 - Fluorobenzene is an important compound in the field of organic synthesis. Its origin can be traced back to the early days of chemical exploration. At that time, chemists were dedicated to the creation of new organic molecules.
At first, the synthesis of this compound was quite difficult, limited by technology and cognition. However, over the years, chemical technology has developed rapidly. Many scientists have devoted themselves to research and have gradually deepened their understanding of the reaction mechanism.
Through unremitting efforts, the synthesis method has been optimized. From a complex and inefficient method at the beginning, it has evolved into a relatively simple and efficient approach today. This compound has been widely used in the fields of medicine, materials and other fields, promoting the progress of many industries. Its historical development has witnessed the brilliant history and unlimited potential of chemistry.

Product Overview

1-Ethynyl-4-Fluorobenzene is a key compound in organic synthesis. It has a unique chemical structure. On the benzene ring, a fluorine atom and an ethynyl group occupy the opposite position. This structure endows it with specific chemical activity and can be used as a key intermediate in many chemical reactions.
Because of its high electronegativity of fluorine atoms, it can significantly affect the distribution of molecular electron clouds and change the electron cloud density of the benzene ring, resulting in very different reactivity from ordinary benzene derivatives. The introduction of acetynyl groups adds rich reaction check points to the molecule, which can participate in many carbon-carbon bond formation reactions, such as coupling reactions.
In the field of materials science, 1-Ethynyl-4-Fluorobenzene through rational design and transformation, it is expected to construct new organic materials with unique properties. In the field of medicinal chemistry, its structure can be used as the basis for pharmacophore modification and optimization, providing new opportunities for innovative drug development.

Physical & Chemical Properties

1 - Ethynyl - 4 - Fluorobenzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, at room temperature and pressure, this substance may be in a liquid state and has a special odor. Its boiling point and melting point are determined by intermolecular forces. Due to the different polarities of molecules containing ethynyl groups and fluorine atoms, the melting boiling point is unique.
In terms of its chemical properties, due to the ethynyl group, it has the characteristics of alkynes, and an addition reaction can occur. In case of electrophilic reagents, such as halogens and hydrogen halides, it can be added at the ethynyl group to form new derivatives. The presence of fluorine atoms affects the electron cloud density of the benzene ring, causing the electrophilic substitution reaction activity on the benzene ring to change. This compound can be used as a key intermediate in the field of organic synthesis, leveraging its physical and chemical properties to form complex organic structures through various reactions, thus contributing to organic chemistry research and chemical production.

Technical Specifications & Labeling

There is a product today, named 1 - Ethynyl - 4 - Fluorobenzene. To clarify its technical specifications and identification (product parameters), it must be studied in detail. Looking at the quality of this product, the color is pure and the performance is stable, and it is an important material in the chemical industry. Its technical specifications are related to the preparation method. The materials used must be fine, the process must be strict, and the temperature and humidity control are all fixed. As shown in the label, the product parameters, such as molecular weight and purity, must be clear and correct, so that the user can learn from it. In this way, this product can be used in various applications, and each can do its best without error. When preparing, the craftsman should follow the specifications and verify the identification parameters to ensure that the quality is not worried.

Preparation Method

The method of making 1-Ethynyl-4-Fluorobenzene is the first raw material. 4-Fluorobenzene, potassium acetylene, etc. need to be prepared. The preparation process involves first reacting 4-fluorobenzene and potassium acetylene in an organic solvent at an appropriate temperature. During the reaction, the temperature must be precisely controlled to ensure a smooth reaction.
The reaction steps are as follows: Dissolve 4-fluorobenzene in an appropriate amount of organic solvent, slowly add potassium acetylene, and keep stirring in the meantime. After the reaction is completed, the steps of separation and purification are carried out. During separation, distillation can be used to remove its impurities; for purification, recrystallization is preferred to obtain pure 1-Ethynyl-4-Fluorobenzene.
As for the catalytic mechanism, this reaction depends on the metal catalyst, which can reduce the activation energy of the reaction and promote the reaction rate. Make the bond between the raw materials easy to break and form, and achieve the purpose of preparation. In this way, 1-Ethynyl-4-Fluorobenzene products can be obtained.

Chemical Reactions & Modifications

1 - Ethynyl - 4 - Fluorobenzene is an important compound in organic synthesis. In the field of chemical synthesis, its chemical reaction and modification have always been the key to our chemical researchers.
Many synthesis reactions in the past have the dilemma of unsatisfactory yield and harsh reaction conditions. For example, the traditional reaction of halogenated aromatics with acetylene derivatives to prepare 1 - Ethynyl - 4 - Fluorobenzene requires high temperature and specific catalysts, and side reactions occur frequently, and the product separation is complicated.
At present, we are committed to improving it. With the development of new catalysts, the reaction conditions are milder and can be carried out efficiently at relatively low temperatures. This modification not only improves the synthesis efficiency of 1-Ethynyl-4-Fluorobenzene, but also paves the way for its wide application in materials science, drug development and other fields.

Synonyms & Product Names

1 - Ethynyl - 4 - Fluorobenzene is also an organic compound. Its synonymous names are various. The world may call it 4 - fluorophenylacetylene, which is based on the nomenclature of its chemical structure, with the benzene ring as the group, marking the position of the fluorine atom and the acetylene group. It is also called p-fluorophenylacetylene, and the word "right" describes the antiposition relationship between the fluorine atom and the acetylene based on the benzene ring.
The names of the products in the market are also different. Some merchants are named to highlight their unique chemical properties or application fields. This compound has a wide range of uses in the field of organic synthesis and is often a key intermediate for the preparation of complex organic molecules. Due to the properties of ethylene groups and fluorine atoms in its structure, it can participate in many chemical reactions, contributing to the research and industrial production of organic chemistry.

Safety & Operational Standards

1 - Ethynyl - 4 - Fluorobenzene is an important organic compound. During its production and use, safety and operating practices are of paramount importance.
Safety is the first word, this compound has certain chemical activity and latent risk. When storing, keep in a cool, dry and well-ventilated place, away from fire, heat and strong oxidizing agents. As it may react violently with certain substances, it should not be stored with incompatible substances. When handling, operators must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent skin contact and eye splashing.
As for the operating specifications, the experimental or production environment should be equipped with perfect ventilation equipment to discharge the volatile gases that may be generated and reduce the concentration of compounds in the air. During use, it is essential to precisely control the reaction conditions, such as temperature, pressure and reactant ratio. It should be carried out in accordance with the established reaction process and operating procedures, and steps or parameters should not be changed without authorization. The waste after the reaction should also be properly disposed of according to regulations, and should not be discarded at will to avoid polluting the environment.
In the analysis and testing process, precise instruments and methods should be used to ensure product quality and safety. Each step of operation should be strictly recorded for subsequent inspection and traceability. Only in this way can 1-Ethynyl-4-Fluorobenzene be carried out efficiently and stably while ensuring the safety of personnel and the environment.

Application Area

1 - Ethynyl - 4 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, this compound may be used as a key raw material for the synthesis of specific drugs. Because of its unique structure, it can bind to specific receptors in organisms, or it can help to develop new anti-disease agents.
In the field of materials science, 1 - Ethynyl - 4 - Fluorobenzene can also be used. It participates in polymerization reactions, or materials with special photoelectric properties can be prepared. Such materials may be used in advanced display technologies, such as organic Light Emitting Diode, to give materials better luminous efficiency and stability.
Furthermore, in organic synthesis chemistry, this compound is often used as a key intermediate. With its alkynyl group and fluorobenzene structure, it can construct complex organic molecular structures through various reaction paths, which contributes to the development of organic synthesis chemistry.

Research & Development

There is now a substance, called 1-Ethynyl-4-Fluorobenzene, which we have studied chemically. This substance has a unique structure, and its alkynyl group is connected to fluorobenzene, and its characteristics are different.
The purpose of research is to understand its physicochemical properties, to explore its reaction rules, and to find its application. In experiments, observe its response to various substances, and observe its changes in different environments. After several trials, the existence of its stability and activity is known.
In terms of development, it is expected to be used to create new agents, or for pharmaceuticals, or to add new substances to materials. If we can make good use of its characteristics, we will be able to open up new paths in the field of chemistry, enhance the brilliance of the industry, and make the results of our research beneficial to the public, promote the progress of chemistry, and promote the process of development.

Toxicity Research

The nature of taste and smell is related to use and harm. The toxicity of 1 - Ethynyl - 4 - Fluorobenzene in this study is quite important.
Looking at the structure of its molecule, fluorine and ethynyl group are combined with benzene ring. Fluoride is active, although it may be beneficial in organic synthesis, it may also cause toxic changes. The existence of ethynyl group makes the molecule have unique reactivity, so this characteristic is in the living body, or it may lead to abnormal biochemical response.
After various experiments, its effect on biological cells was observed. In vitro cell culture, it can disturb the metabolism of cells, cause cell proliferation to be hindered, and morphology to change. This may be due to the fact that after the substance enters the cell, it interacts with key proteins or nucleic acids, disrupting its normal order. And in animal experiments, it is also seen that there are signs of damage to organs, especially liver and kidney.
From this point of view, 1-Ethynyl-4-Fluorobenzene has a certain toxicity. For subsequent research, we should be careful to explore its toxicological mechanism in detail to avoid harm and seek benefits.

Future Prospects

I have tried to research 1 - Ethynyl - 4 - Fluorobenzene, which is unique and has a wide range of uses. Looking at the current situation, although it has been obtained, it still has high hopes for future development.
In the field of chemical industry, it may be the basis of new materials, which can make materials have extraordinary characteristics and are suitable for high-tech. In the electronics industry, it is also expected to emerge and improve the performance of electronic components.
In addition, on the road of pharmaceutical research and development, 1 - Ethynyl - 4 - Fluorobenzene may become a key raw material, paving the way for the creation of special drugs. Its future potential for change in various fields cannot be underestimated. We should study it diligently and explore more possibilities, hoping to create a brilliant new situation for future generations, so that this material will shine in the future and benefit all people.

Where to Buy 1-Ethynyl-4-Fluorobenzene in China?

As a trusted 1-Ethynyl-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Ethynyl-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Ethynyl-4-Fluorobenzene?

1-Ethynyl-4-fluorobenzene is widely used. In the field of organic synthesis, it is an essential building block. Because of its alkynyl group and fluorobenzene ring, both have high reactivity and can initiate various chemical reactions to produce complex and functionally specific organic compounds.
In terms of nucleophilic addition reaction, the alkynyl group can interact with many nucleophilic reagents, such as alcohols and amines. Nucleophilic reagents attack alkynyl groups and can produce substances with enol ethers or enamines. This is commonly used in the synthesis of complex natural products and pharmaceuticals. It can increase the functional group diversity of molecules and optimize the biological activity and pharmacological properties of the products.
Because of the fluorine atom attached to the benzene ring, fluorine has high electronegativity, which can change the electron cloud distribution of compounds and affect the polarity, lipophilicity and biological activity of molecules. In medicinal chemistry, fluorine atoms are often introduced to optimize the metabolic stability, bioavailability and targeting of drugs. 1-Ethynyl-4-fluorobenzene can be used as a key intermediate. Through a series of reactions, fluorine-containing structures are introduced into drug molecules to create new drugs with unique curative effects.
In the field of materials science, it also has important uses. It can be used to prepare organic materials with special optoelectronic properties through its reactive activity. If it is polymerized and constructed on the main chain or side chain of the polymer, the material is endowed with unique optical and electrical properties, which is expected to be used in organic Light Emitting Diode (OLED), organic field effect transistor (OFET) and other optoelectronic devices to improve the performance and stability of the device.
1-ethynyl-4-fluorobenzene is an indispensable raw material in many fields such as organic synthesis, medicinal chemistry, and materials science, promoting progress and development in various fields.

What are the physical properties of 1-Ethynyl-4-Fluorobenzene?

1-Ethynyl-4-fluorobenzene, its physical properties are as follows:
This substance is mostly liquid at room temperature. Looking at it, the pure one is colorless to light yellow transparent, and its color is pure, like the beginning of a clear spring, without the disturbance of variegated colors. Smell it, it has a special aromatic smell, like the fragrance of spring flowers, but it has a unique charm, lingering in the nose, clear and discernible.
When it comes to the melting point, it is around -19 ° C, just like the temperature when the winter cold is not over. Under this temperature, its state is like ice, solid and shaped; and the boiling point is between 154-156 ° C, just like the heat of summer. At this temperature, it is like ice melting in water, turning into gas, rising and drifting away.
Its density is about 1.12g/cm ³, which is slightly heavier than water. If it is placed in one place with water, it will be like a stone sinking into an abyss, naturally settling at the bottom of the water. In terms of solubility, it can be well miscible in common organic solvents such as ethanol, ether, and dichloromethane, just like fish swimming in water and blending seamlessly; however, in water, it is difficult to dissolve, such as oil floating in water, with clear boundaries.
In addition, the vapor pressure of 1-ethynyl-4-fluorobenzene also has characteristics under specific conditions. Its vapor is like light smoke, although invisible but powerful, it can form a certain pressure in a closed space, affecting the environment for its storage and use. Its refractive index is also fixed. When light passes through, such as through glass, it is refracted at a specific angle. This characteristic may be useful in optical related research and applications.

Is 1-Ethynyl-4-Fluorobenzene chemically stable?

The chemical properties of 1-ethynyl-4-fluorobenzene are relatively stable under certain conditions, but they also have specific reactivity. This substance contains ethynyl and fluorobenzene ring structures, which give it unique properties.
In terms of stability, the benzene ring structure gives it a certain degree of stability. The benzene ring has a conjugated large π bond, and the electron cloud is uniformly distributed, which reduces the molecular energy and stabilizes the structure. And the fluorine atom is connected to the benzene ring. Due to the large electronegativity of fluorine, it produces an electron-absorbing induction effect on the electron cloud of the benzene ring, which further enhances the stability of the benzene ring.
The presence of ethynyl groups makes it reactive. The carbon-carbon triple bond in the ethylene group is rich in electrons and is vulnerable to In case of electrophilic reagents such as hydrogen halide, the carbon-carbon triple bond can undergo an addition reaction to form halogenated olefin products. At the same time, ethynyl groups can also participate in many organic synthesis reactions, such as coupling reactions with transition metals, etc., demonstrating their important uses in the field of organic synthesis.
Its stability is also affected by external conditions. When high temperature, strong oxidants or specific catalysts exist, 1-ethynyl-4-fluorobenzene may react and cause its structure to change. Therefore, when storing and using, its chemical properties and reaction conditions need to be considered to ensure safe and effective use.

What are 1-Ethynyl-4-Fluorobenzene synthesis methods?

1-Ethynyl-4-fluorobenzene is an important intermediate in organic synthesis. Its synthesis methods are diverse, and the common ones are listed below:
First, 4-fluorobromobenzene is used as the starting material. Shilling 4-fluorobromobenzene reacts with magnesium chips in anhydrous ethyl ether to prepare Grignard's reagent. This step requires an anhydrous and oxygen-free environment. Geingert's reagent is active and easily decomposes in contact with water and oxygen. After obtaining Grignard's reagent, it reacts with ethynyl magnesium bromide. After hydrolysis and other post-treatment steps, 1-ethynyl-4-fluorobenzene can be obtained. The raw materials of this method are easy to obtain, but the reaction conditions are harsh, and anhydrous and anoxic need to be strictly controlled, and the preparation process of Grignard reagent is slightly complicated.
Second, 4-fluorobenzaldehyde is used as the starting material. First, 4-fluorobenzaldehyde is nucleophilic addition reaction with ethynyl magnesium bromide to generate the corresponding alcohol. Subsequently, the alcohol is dehydrated. The common dehydrating agent such as concentrated sulfuric acid or p-toluenesulfonic acid is reacted at an appropriate temperature to obtain 1-ethynyl-4-fluorobenzene. This route has a little more steps, but the reaction steps are relatively mild and require slightly less reaction equipment.
Third, 4-fluorobenzene is used as the raw material. Through bromination reaction, bromine atoms are added to the double bond of 4-fluorostyrene to form dibromide. Then, in the alcohol solution of strong bases such as potassium hydroxide, an elimination reaction is carried out to remove two molecules of hydrogen bromide to form ethynyl groups, thereby obtaining 1-ethynyl-4-fluorobenzene. The reaction conditions of this method are relatively easy to control, but the bromination step needs to pay attention to the amount of bromine and the reaction temperature to avoid excessive bromination.
When synthesizing 1-ethynyl-4-fluorobenzene, the appropriate synthesis method should be carefully selected according to many factors such as the availability of raw materials, reaction conditions, cost and the purity of the target product.

What is the price range of 1-Ethynyl-4-Fluorobenzene in the market?

The price of 1-ethynyl-4-fluorobenzene in the market is difficult to determine. This is due to various factors that disturb its price fluctuations.
First of all, the production of 1-ethynyl-4-fluorobenzene is difficult and difficult. Its raw materials may need to be carefully selected, and the reaction conditions must also be strictly controlled, such as temperature, pressure, catalyst, etc. If the preparation technology is excellent and the yield is high, the price may drop slightly; conversely, if the process is prolific and the yield is low, the cost will rise and the price will also rise.
Furthermore, market supply and demand are the main reasons. If at a certain time, many industries, such as medicine, electronics, etc., have a strong demand for 1-ethynyl-4-fluorobenzene, but the supply is limited, its price will rise; if the supply exceeds the demand, the price will fall.
In addition, market competition also has an impact. If there are many suppliers in the market, they will compete with each other to occupy the market, or reduce their price; if the supply is low, the monopoly will become possible, and the price will be high.
And transportation, storage and other factors should not be ignored. 1-ethynyl-4-fluorobenzene may need to be transported and stored specially to ensure its quality, which increases the cost and causes the price to rise.
According to common sense, the price of 1-ethynyl-4-fluorobenzene per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximation, and the actual price depends on the specific market conditions, quality and purchase quantity. Buyers who want to know the exact price should consult the chemical raw material supplier to obtain real-time and accurate price information.