1-Ethynyl-2-Fluorobenzene

Hongda Chemical

Specifications

HS Code	776261
Chemical Formula	C8H5F
Molecular Weight	120.12
Appearance	Liquid (usually)
Boiling Point	155 - 157 °C
Density	Data may vary, but around typical aromatic compound densities
Solubility	Soluble in organic solvents like ethanol, ether
Vapor Pressure	Relatively low as a liquid at room temperature
Odor	Aromatic odor characteristic of benzene derivatives

As an accredited 1-Ethynyl-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - ethynyl - 2 - fluorobenzene packaged in a sealed glass bottle.
Storage	1 - Ethynyl - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. As it is likely flammable, store it separately from oxidizing agents. Ideal storage temperature might be around 2 - 8°C to maintain its stability.
Shipping	1 - Ethynyl - 2 - fluorobenzene is shipped in specialized, well - sealed containers to prevent leakage. Transport follows strict chemical safety regulations, ensuring proper handling during transit to avoid any potential hazards.

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General Information

Historical Development

1 - Ethynyl - 2 - Fluorobenzene is an organic compound, and its historical development is worth exploring. In the past, chemical research was still in its infancy, and many substances were yet to be revealed. At that time, organic synthesis techniques were not mature, and few people were interested in such compounds.
However, science has continued to evolve. With the advancement of organic chemistry, chemists have studied benzene derivatives more and more deeply. 1 - Ethynyl - 2 - Fluorobenzene has a unique structure. The alkynyl group and fluorine atom are combined in the benzene ring, which has attracted the attention of the academic community. Early exploration, the synthesis of this compound was difficult, with low yield and many impurities.
However, chemists worked tirelessly to improve the synthesis path. After repeated experiments, new methods were developed, and the yield gradually increased and the purity was also improved. At this point, 1-Ethynyl-2-Fluorobenzene is no longer out of reach, paving the way for subsequent application research and emerging in the fields of materials science and medicinal chemistry.

Product Overview

1 - Ethynyl - 2 - Fluorobenzene is an important compound in organic synthesis. It is a colorless to pale yellow liquid with unique chemical properties. This compound contains ethynyl and fluorine atoms, which give it special reactivity. Ethynyl can participate in a variety of addition reactions, can form carbon-carbon bonds, and expand the structure of molecules. The introduction of fluorine atoms alters the electron cloud distribution of molecules, affecting their physical and chemical properties, such as enhancing the stability and lipophilicity of compounds. In the field of medicinal chemistry, because of its unique structure, it may be used to design and synthesize drug molecules with specific biological activities. By modifying its surrounding structure, it is expected to find new drugs with high efficiency and low toxicity. In the field of materials science, it can be used as a key building block for the construction of special functional materials, providing novel electrical and optical properties for materials.

Physical & Chemical Properties

1 - Ethynyl - 2 - Fluorobenzene is an organic compound with unique physical and chemical properties. Its appearance may be colorless to light yellow liquid with a special odor. In terms of physical properties, it has a certain volatility, and the boiling point depends on factors such as intermolecular forces. It has good solubility in organic solvents, such as ethanol, ether, etc., due to the principle of similar miscibility.
In terms of chemical properties, the alkynyl group in this compound is active and can undergo addition reactions. For example, it is added with electrophilic reagents such as halogens and hydrogen halides to form halogenated styrene derivatives. Fluorine atoms have electron-absorbing properties, which affect the electron cloud density of benzene rings and reduce the electron cloud density of benzene rings. The electrophilic substitution reaction activity is different from that of benzene. It can participate in a variety of organic synthesis reactions and is an important intermediate in organic synthesis, with potential applications in the fields of materials science and medicinal chemistry.

Technical Specifications & Labeling

1 - Ethynyl - 2 - Fluorobenzene is also an organic compound. Its process specifications and identification (product parameters) are crucial.
The process specifications are related to the preparation method, the raw materials must be carefully selected, and the reaction conditions, such as temperature, pressure, and catalyst dosage, need to be precisely controlled. Too high or too low temperature may cause the reaction to deviate, affecting the purity and yield of the product. The same is true for the pressure, which can make the reaction go smoothly. Small changes in the amount of catalyst will also affect the reaction rate. In terms of
identification (product parameters), its physical properties, such as melting point, boiling point, density, chemical properties cannot be ignored, stability, reactivity, etc., are all important indicators. In this way, users can understand its characteristics, make good use of it in various applications, and ensure product quality and safety.

Preparation Method

1 - Ethynyl - 2 - Fluorobenzene is an important compound in the field of organic synthesis. Its preparation method is related to raw materials and production processes, reaction steps and catalytic mechanisms.
Preparation of raw materials, fluorobenzene and acetylene derivatives are commonly selected. Starting with fluorobenzene, active groups that can react with acetylene groups are introduced through halogenation.
In the reaction step, fluorobenzene halides and acetylene derivatives are first coupled in an alkaline environment with palladium or copper as catalysts. This process requires precise temperature control and reaction time to ensure product purity and yield.
In the catalytic mechanism, the palladium catalyst can activate the halide, make the carbon-halogen bond easy to break, and help the acetylene group to connect smoothly. The copper catalyst can promote the formation of intermediates and accelerate the reaction process. In this way, through exquisite raw material selection, rigorous reaction operation and rational catalytic application, 1-Ethynyl-2-Fluorobenzene can be obtained.

Chemical Reactions & Modifications

There is now a substance named 1-Ethynyl-2-Fluorobenzene. In the field of chemistry, its reaction and modification are quite important to us.
Looking at its chemical properties, this substance participates in various reactions. Its alkynyl group and fluorobenzene structure make the reaction unique. In common reactions, alkynyl groups are active and can interact with electrophilic reagents, but their fluorine atom ortho-sites cause the reaction direction and rate to be different from that of normal substances.
To change its properties, chemical means can be used. Or introduce new groups to change its electron cloud distribution, so that the reaction activity and selectivity are improved. If treated with specific reagents, it can exhibit different reaction paths and obtain completely different products under specific conditions.
The chemical reaction and modification of this substance is still a path to explore, and every step contains deep meaning. Wait for us to study it in detail, so as to understand the mystery and add to the progress of chemistry.

Synonyms & Product Names

1 - Ethynyl - 2 - Fluorobenzene, which is also synonymous with the name of the commodity, is quite related. In the field of chemistry, the names of various substances are complicated, and there are many of the same thing.
Guanfu 1 - Ethynyl - 2 - Fluorobenzene, or those called "o-fluorophenylacetylene", which is named according to its structural characteristics. Neighbors, indicating the relative positions of the two substituents on the benzene ring; fluorine, ethynyl, indicating its functional groups.
Or it may be called "2-fluorophenylacetylene", which also follows the method of structural nomenclature, although slightly simpler than the former, the meaning is also clear. As for the name of the product, due to the different markets and manufacturers, or those with a unique name, they all refer to the same chemical substance. Knowing its synonymous name and the name of the product is the key to research, production, and trade, so as to avoid confusion, so as to communicate smoothly and help all things in chemistry go smoothly.

Safety & Operational Standards

1 - Ethynyl - 2 - Fluorobenzene is a compound commonly used in organic synthesis. Safety and operating standards are of paramount importance during its experimental operation and use.
This compound has certain chemical activity. When storing, be sure to store it in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent chemical reactions caused by temperature, humidity and other factors, causing danger. When taking it, strictly follow the established operating procedures of the laboratory. Experimenters should wear appropriate protective equipment, such as laboratory clothes, protective gloves and goggles, to avoid direct contact with the substance with the skin and eyes. Because once exposed, it may cause irritation and damage to the human body.
During the reaction operation, the temperature, pressure and other conditions of the reaction system need to be precisely controlled. Because its reactivity will change with temperature and pressure changes, a little carelessness may cause the reaction to go out of control and cause a safety accident. And the waste gas and waste liquid generated during the reaction process cannot be discharged at will. The exhaust gas needs to be effectively treated and meet the emission standards before it can be discharged into the atmosphere; the waste liquid should be collected in accordance with regulations and handed over to professional institutions for treatment to prevent pollution to the environment.
In the transportation process, proper packaging and protective measures should also be taken according to its chemical characteristics to ensure the safety of transportation and avoid package damage and leakage due to vibration, collision, etc.
In conclusion, the treatment of 1-Ethynyl-2-Fluorobenzene compounds, from storage, handling to waste disposal, must strictly follow safety and operating practices to ensure the safety of personnel and the environment.

Application Area

1 - Ethynyl - 2 - Fluorobenzene is a unique chemical substance. Its application field is quite wide. In the field of pharmaceutical research and development, because of its unique molecular structure, it may be able to help create new drugs, providing the possibility to overcome difficult diseases. In the field of materials science, it can be used as a synthetic raw material for special functional materials, endowing materials with specific physical and chemical properties, such as enhancing the stability and functionality of materials. In the field of organic synthesis, this substance may be used as a key intermediate to construct more complex organic molecular structures and expand the variety and properties of organic compounds. Its potential applications in many fields open up new paths for chemical research and industrial production, and researchers need to explore in depth to explore its potential value and function.

Research & Development

In recent years, I have devoted myself to the study of 1-Ethynyl-2-Fluorobenzene. Its unique nature and potential in the field of organic synthesis.
At the beginning, its structure was analyzed, the wonder of its chemical bonds was explored, and the reason for its reactivity was revealed. Then, various reaction conditions were tested, hoping to obtain the optimal method to increase its yield and improve its purity.
Although the process is difficult, every small achievement is exciting. After repeated attempts, the selection of catalysts, temperature control, and solvent preparation have all been achieved. This result may pave the way for the mass production and wider application of this substance. In the future, I hope to be able to push this research to a new level, so that 1-Ethynyl-2-Fluorobenzene can be used in industry and scientific research, adding a touch of brilliance to the academic and industry, and promoting the progress and development of related fields.

Toxicity Research

1 - Ethynyl - 2 - Fluorobenzene is a common chemical in organic synthesis. In terms of toxicity research, its effect on organisms should be carefully investigated.
Ancient scholars, when studying chemical substances, must pay attention to their toxicity. If this 1 - Ethynyl - 2 - Fluorobenzene enters the organism, it may disturb its physiological order. Test it in animals, observe the changes in behavior and physiological indicators after eating this compound. Observe whether it has signs of drowsiness, abnormal diet, or whether there are any damage to organs.
and observe its effect on cells. In vitro cell experiments, explore whether it can cause cell lesions and apoptosis. The study of toxicity is related to the safety of living beings and is also the basis for chemical applications. Detailed investigation of the toxicity of 1-Ethynyl-2-Fluorobenzene can provide evidence for future use, protection, and use of this chemical appropriately to avoid its harm and promote its benefits.

Future Prospects

1 - Ethynyl - 2 - Fluorobenzene is also an organic compound. Looking at its future prospects, the potential is particularly considerable.
This compound may emerge in the field of materials science. Its unique molecular structure makes it possible to produce new materials with excellent performance. In electronic components, it can help improve its electrical and thermal conductivity, paving the way for the lightness and efficiency of future electronic devices.
In medical chemistry, there are also infinite possibilities. With its special chemical properties, it may be able to develop special new drugs to overcome difficult diseases and benefit the common people.
Furthermore, in chemical synthesis, it can be used as a key intermediate to expand novel synthesis paths and enrich the means of organic synthesis.
Although there may be challenges ahead, over time, 1-Ethynyl-2-Fluorobenzene will surely shine, create a new situation in various fields, and contribute to the progress and development of mankind.

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Frequently Asked Questions

As a leading 1-Ethynyl-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-Ethynyl-2-Fluorobenzene?

1-Ethynyl-2-fluorobenzene is one of the organic compounds. Its physical properties are worth exploring.
When it comes to appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This color and state can be an important characterization in the observation and operation of many organic synthesis reactions.
Its boiling point is related to the temperature node where the substance changes from liquid to gaseous state. The boiling point of 1-ethynyl-2-fluorobenzene makes it possible to realize the transformation of its phase state under a specific temperature environment, which is of great significance in separation and purification operations.
Melting point is also a key physical property. The value of the melting point, which defines the critical temperature at which a substance melts from a solid state to a liquid state, affects its physical form under different temperature conditions, and has implications for the control of the ambient temperature for storage and use.
Density is the mass of a substance per unit volume. The density of 1-ethynyl-2-fluorobenzene provides basic data for studies such as the stratification phenomenon of mixed solutions and the space occupied by substances.
In terms of solubility, it may have a certain solubility in organic solvents such as ethanol, ether, etc. This property is convenient for it to be used as a reactant or intermediate in organic synthesis reactions, and to create a suitable reaction environment with the help of suitable solvents to promote the progress of the reaction.
In addition, the physical properties such as vapor pressure and refractive index of the substance also have their own uses. Vapor pressure is related to the volatilization ability of the substance, which affects its behavior in the gas phase environment; refractive index can be used for analytical work such as purity detection. All these physical properties are related to each other, and are of great value in the research, production and application of 1-ethynyl-2-fluorobenzene.

What are the main uses of 1-Ethynyl-2-Fluorobenzene?

1-Ethynyl-2-fluorobenzene is a crucial compound in organic synthesis. Its main uses cover a wide range of fields.
In the field of medicinal chemistry, this compound is a key synthetic building block. Through delicate chemical reactions, it can be ingeniously integrated into the molecular structure of drugs, thus endowing drugs with specific biological activities and pharmacological properties. For example, when developing innovative drugs for specific diseases, the unique chemical properties of 1-ethynyl-2-fluorobenzene can help chemists build a unique molecular framework, greatly enhance the affinity between drugs and targets, enhance efficacy, and open up a new path for drug development to overcome difficult diseases.
In the field of materials science, it also plays an indispensable role. It can be used as a starting material for the synthesis of high-performance materials, and materials with special optical, electrical or mechanical properties can be prepared through carefully designed polymerization reactions or other chemical transformations. For example, in the preparation of organic optoelectronic materials, the introduction of this compound can effectively adjust the electronic transport properties and luminescence properties of materials, laying a solid foundation for the manufacture of efficient organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
In addition, in the field of fine chemicals, 1-ethynyl-2-fluorobenzene is also often used to synthesize various fine chemicals, such as special fragrances, additives, etc. Due to its unique chemical structure, it can endow products with unique properties and qualities to meet the diverse needs of fine chemicals in different industries.
In summary, 1-ethynyl-2-fluorobenzene plays a pivotal role in many fields of modern chemical synthesis and industrial production, and has made outstanding contributions to promoting technological progress and innovative development in related fields.

What are 1-Ethynyl-2-Fluorobenzene synthesis methods?

The synthesis method of 1-ethynyl-2-fluorobenzene, through the ages, chemists have explored many paths. First, using o-fluorobrobenzene as the starting material, it is first reacted with magnesium chips to make Grignard reagent, that is, o-fluorophenyl magnesium bromide. This reaction needs to be carried out in anhydrous ether and other inert solvents, and the reaction temperature and stirring rate must be strictly controlled to prevent side reactions from occurring. Then, it is reacted with acetynyl magnesium bromide, and through a series of complex nucleophilic substitution reactions, 1-ethynyl-2-fluorobenzene can be obtained. This process requires fine control of the reaction conditions in order to improve the yield and purity of the product.
Furthermore, it can be started from o-fluorobenzaldehyde. First, it is reacted with lithium ethynyl reagent at low temperature to form the corresponding alcohol intermediate. This step requires careful operation in a low temperature environment to ensure that the reaction proceeds in the desired direction. Then, the alcohol intermediate is dehydrated by suitable dehydration reagents, such as concentrated sulfuric acid or phosphorus trioxide, etc., to obtain the target product 1-ethynyl-2-fluorobenzene. However, the dehydration process needs to pay attention to the reaction temperature and time to avoid overreaction or carbonization.
In addition, a coupling reaction strategy catalyzed by transition metals can also be used. Using o-fluoroiodobenzene and acetylene as substrates, the reaction occurs in a suitable base and solvent system in the presence of transition metal catalysts and ligands such as palladium and copper. For example, using tetra (triphenylphosphine) palladium as a catalyst and potassium carbonate as a base, heating the reaction in N, N-dimethylformamide solvent. This method can easily synthesize 1-ethynyl-2-fluorobenzene due to the high efficiency and selectivity of transition metal catalysts, but the cost of the catalyst and the post-treatment steps of the reaction also need to be considered.
The above methods have their own advantages and disadvantages. Chemists will carefully choose the most suitable synthesis path according to actual needs and conditions.

1-Ethynyl-2-Fluorobenzene What are the precautions in storage and transportation?

1-Ethynyl-2-fluorobenzene is an organic compound. During storage and transportation, many matters must not be ignored.
First word storage. This material is lively, flammable and has a certain chemical activity. It should be stored in a cool and ventilated warehouse, away from fire and heat sources. The storage temperature should not exceed 30 ° C. Because of its flammability, it will react violently with oxidants, acids, alkalis and other substances, so it must be stored separately, and mixed storage should not be avoided. Warehouse lighting, ventilation and other facilities should be explosion-proof, with switches located outside the warehouse, and equipped with corresponding varieties and quantities of fire-fighting equipment. At the same time, leakage emergency treatment equipment and suitable containment materials should be prepared to prevent accidents.
Times and transportation. During transportation, the packaging must be complete and the loading should be safe. During transportation, ensure that the container does not leak, collapse, fall or damage. This compound is a dangerous chemical, and the transportation vehicle should follow the specified route and do not stop in residential areas and densely populated areas. The transportation enterprise needs to have the corresponding qualifications, and the transportation personnel should be familiar with its dangerous characteristics and emergency treatment methods, and carry the necessary emergency protective equipment. When loading and unloading, the operator should load and unload lightly to prevent damage to the packaging and containers, and avoid direct contact of the substance with the human body. In case of inadvertent contact, corresponding first aid measures should be taken quickly according to different situations. In this way, the safety of 1-ethynyl-2-fluorobenzene during storage and transportation can be guaranteed, and disasters can be avoided.

What is the market outlook for 1-Ethynyl-2-Fluorobenzene?

1-Ethynyl-2-fluorobenzene is also an organic compound. Its market prospect is related to many factors, so let me tell you one by one.
From the perspective of the chemical industry, this compound is quite useful in the field of synthesis. In the creation of new materials, it may be a key intermediate. Due to the rapidly advancing materials science, the demand for compounds with specific structures and properties is increasing. The ethynyl group and fluorine atom of 1-ethynyl-2-fluorobenzene endow it with unique reactivity and can participate in various organic reactions, helping material scientists to produce new materials with outstanding properties. For example, those with special electrical and optical properties may have broad applications in electronic devices, optical instruments and other industries. Therefore, the demand for chemical synthesis may be one of the major driving forces for its market growth.
Furthermore, the field of medicinal chemistry cannot be ignored. Fluorinated compounds are playing a growing role in drug development because they can change the metabolic stability and fat solubility of compounds. The structure of 1-ethynyl-2-fluorobenzene may provide the possibility for the synthesis of specific drugs. With the increasing investment in pharmaceutical research and development, the demand for novel structural blocks is also rising. If breakthroughs can be made in this field, the demand for pharmaceutical companies will be prosperous, and their market prospects will be brighter.
However, there are also challenges. The process of preparing this compound may need to be refined to reduce costs and improve yield. High costs are unfavorable for large-scale marketing activities. And the chemical market is highly competitive, and similar or alternative compounds are also competing for share. Only by leading technology and controllable costs can we gain a firm foothold in the market.
In summary, the market prospects of 1-ethynyl-2-fluorobenzene coexist with opportunities and challenges. With technological progress and process improvement, it is expected to bloom in the fields of chemical industry and medicine, and open up a broad market space.