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What are the chemical properties of 1-Ethenyl-3-Fluorobenzene?
1-Vinyl-3-fluorobenzene, an organic compound. Its molecular structure contains a fluorine atom and a vinyl group attached to a styrene ring. The chemical properties of this compound are unique and closely related to the properties of the styrene ring, fluorine atom and vinyl group.
First of all, the styrene ring is aromatic, the electron cloud is uniformly distributed, stable and can participate in electrophilic substitution reactions. In the case of electrophilic reagents, the styrene ring can provide electron pairs to form a sigma complex, which is then rearranged to lose protons and form substitution products. In 1-vinyl-3-fluorobenzene, the electron cloud of the styrene ring is changed by the influence of fluorine atoms and vinyl groups, resulting in slightly different reactivity from that of benzene.
Fluorine atoms have strong electronegativity, and the electron-withdrawing induction effect is significant. This effect reduces the electron cloud density of the benzene ring, weakens the activity of electrophilic substitution reaction, and affects the ortho and para-site localization effects. Usually, electrophilic reagents are more likely to attack the meta-site, because fluorine atoms absorb electrons, so that the density of the meta-site electron cloud is relatively high.
Vinyl contains carbon-carbon double bonds, which are unsaturated and can undergo addition reactions. It is common to react with bromine water or carbon tetrachloride solution of bromine, and the double bond is opened, and the bromine atom is added to the double-bond carbon to form a dibromo substitute. Under the action of the catalyst, it can also be added with hydrogen, hydrogen halide, etc. And the vinyl can undergo polymerization reaction, and the double bond is opened to
In addition, in 1-vinyl-3-fluorobenzene, there is a conjugation effect between the styrene ring and the vinyl group, which affects the distribution and stability of the molecular electron cloud, and then affects its chemical properties. The conjugation system reduces the molecular energy, enhances the stability, and changes the reactivity and selectivity at the same time.
In short, the properties and interactions of 1-vinyl-3-fluorobenzene-phenyl ring, fluorine atom and vinyl group show a variety of chemical properties and have important application value in organic synthesis and other fields.
What are the physical properties of 1-Ethenyl-3-Fluorobenzene?
1-Vinyl-3-fluorobenzene is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, clear and transparent, as pure as autumn water, without obvious impurities and suspended solids. This appearance feature is particularly critical when initially identifying and observing its state.
times and boiling points are about a certain temperature range, and the specific value will vary slightly due to experimental conditions, but roughly within this range. The characteristics of boiling point play a decisive role in the separation and purification of the compound. To obtain pure 1-vinyl-3-fluorobenzene from the mixed system, it can be achieved by distillation and other means according to its boiling point.
In addition, the melting point is also a specific value. Determination of the melting point helps to distinguish the purity of the compound. If there are few impurities, the melting point should approach the theoretical value; if there are more impurities, the melting point will shift, or decrease, or the melting range will become wider.
In terms of density, it has its specific value. This density characteristic is of great significance when it comes to liquid-liquid separation, mixing, etc. By knowing its density, it can be judged that it floats or sinks in the mixed liquid, and it can assist in the design of the separation scheme.
The solubility cannot be ignored. In organic solvents, such as common ethanol and ether, it often has a certain solubility and can dissolve with it to form a uniform solution. However, in water, the solubility is poor and it is difficult to miscible with water. This difference in solubility is an important consideration in the process of extraction and the construction of the reaction system.
In addition, 1-vinyl-3-fluorobenzene has a certain volatility and will slowly evaporate in the air. Its vapor pressure varies at different temperatures, which affects its behavior in the gas phase. During storage and use, it is necessary to consider its volatilization characteristics and take appropriate sealing measures to prevent its escape.
What are the main uses of 1-Ethenyl-3-Fluorobenzene?
1-Vinyl-3-fluorobenzene, this is an organic compound with unique chemical properties and diverse uses. In the field of organic synthesis, it is often used as a key intermediate. Because its molecules contain vinyl and fluorine atoms, they are endowed with special reactivity and properties, and can be used for a variety of chemical reactions, such as addition and substitution, to construct complex organic molecular structures. For example, in the synthesis of new drug molecules, its vinyl can undergo addition reactions with other compounds containing specific functional groups, introducing key structural fragments, laying the foundation for the development of new drugs.
In the field of materials science, 1-vinyl-3-fluorobenzene also has important applications. Can participate in polymerization reactions to prepare polymer materials with special properties. Due to the high electronegativity of fluorine atoms, fluoropolymers often have excellent chemical corrosion resistance, low surface energy and good thermal stability. This compound is used as a monomer to synthesize polymers, or can be used to make high-performance coatings, plastics and other materials. For example, coated on metal surfaces, with its corrosion resistance, it can effectively protect metals from external environment erosion; applied to electronic device packaging materials, using good thermal stability to ensure stable operation of devices in high temperature environments.
Furthermore, in the fine chemical industry, 1-vinyl-3-fluorobenzene can be used as a raw material for the synthesis of fine chemicals such as special fragrances and dyes. With its unique molecular structure and appropriate chemical modification, compounds with unique aroma or color can be synthesized to meet the needs of fine chemicals in different fields. For example, in the fragrance industry, novel aroma compounds are synthesized for the preparation of high-end perfumes; in the dye industry, dyes with bright colors and high fastness are prepared for use in textile printing and dyeing industries.
What are the preparation methods of 1-Ethenyl-3-Fluorobenzene?
The preparation method of 1-vinyl-3-fluorobenzene is now described by you.
One method can be started from 3-fluorobenzaldehyde. Shilling 3-fluorobenzaldehyde reacts with Phospho-Yellide reagent through Wittig, which is a common method for forming carbon-carbon double bonds in organic synthesis. The carbonyl group of the aldehyde group in 3-fluorobenzaldehyde interacts with Phospho-Yellide reagent, and the carbonyl oxygen binds to Phospho-Yellide phosphorus, and then a elimination reaction occurs to form a carbon-carbon double bond, resulting in 1-vinyl-3-fluorobenzene. The reaction conditions are relatively mild, but the preparation of phosphine Yelid reagent may be a little more complicated. It is necessary to first react halogenated hydrocarbons with triphenylphosphine to obtain quaternary phosphonium salts, and then treat quaternary phosphonium salts with strong bases to obtain phosphine Yelid reagent.
The second method can use 3-fluorobrobenzene as raw material. First, 3-fluorobrobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to prepare Grignard's reagent 3-fluorophenyl magnesium bromide. Grignard's reagent has strong nucleophilicity, and then reacts with ethynyl halides (such as ethynyl bromide) to introduce vinyl, and then 1-vinyl-3-fluorobenzene However, this process requires strict anhydrous and oxygen-free conditions. Due to the easy decomposition of Grignard's reagent in contact with water or oxygen, the experimental operation requirements are quite high.
Another method can be started from 3-fluoroaniline. The 3-fluoroaniline is first reacted by diazotization, and the 3-fluoroaniline is treated with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is unstable, and then the diazonium salt and vinyl borate are coupled under the action of a suitable catalyst (such as palladium catalyst), and 1-vinyl-3-fluorobenzene can also be obtained. This method relies on high-efficiency catalysts, and the diazotization reaction requires precise control of temperature to prevent the decomposition of diazonium salts from
1-Ethenyl-3-Fluorobenzene What are the precautions in storage and transportation?
For 1-vinyl-3-fluorobenzene, many precautions need to be paid attention to during storage and transportation.
This substance has a certain chemical activity, and when storing, the first environment should be selected. It should be placed in a cool and ventilated place, away from fire and heat sources. It is easy to cause chemical reactions or be dangerous due to heat. The temperature of the warehouse where it is located should not be too high, usually not exceeding 30 ° C.
Furthermore, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. This is because of its chemical properties. When it encounters the above substances, it is easy to react violently and endanger safety.
Storage containers also need to be carefully selected, and well-sealed containers should be used to prevent leakage. At the same time, regular inspections of storage facilities should be carried out to check whether the containers are damaged or leaking.
When transporting, there are also many precautions. Transportation vehicles must have corresponding qualifications and should be equipped with necessary emergency treatment equipment and protective equipment. During transportation, the speed should not be too fast. Avoid violent operations such as sudden braking and sharp turns to prevent the container from being damaged due to vibration and collision.
When loading and unloading, operators should be careful, light loading and unloading, and do not drop or drag. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the surrounding people, isolate the leakage area, and choose appropriate treatment methods according to the leakage situation.
In short, 1-vinyl-3-fluorobenzene must be operated in strict accordance with regulations throughout the storage and transportation process to ensure safety and prevent accidents.