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1-(Difluoromethoxy)-4-Methylbenzene

1-(Difluoromethoxy)-4-Methylbenzene

Hongda Chemical

Specifications

HS Code

463623

Chemical Formula C8H8F2O
Molar Mass 160.145 g/mol
Solubility In Water Expected to be low (organic compound with non - polar benzene ring and fluorine - containing group)
Stability Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-(Difluoromethoxy)-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(difluoromethoxy)-4 - methylbenzene in a sealed, labeled chemical bottle.
Storage 1-(Difluoromethoxy)-4 -methylbenzene should be stored in a cool, well - ventilated area away from heat sources, ignition sources, and oxidizing agents. Keep it in a tightly closed container, preferably made of materials resistant to its chemical action, like glass or specific plastics. Store in a place with controlled temperature to prevent decomposition or evaporation.
Shipping 1-(Difluoromethoxy)-4-methylbenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring secure transport to prevent any leakage or risk during transit.
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1-(Difluoromethoxy)-4-Methylbenzene 1-(Difluoromethoxy)-4-Methylbenzene
General Information
Historical Development
Wenfu 1- (Difluoromethoxy) -4-Methylbenzene originated from the study of the researcher. At the beginning, the public explored the field of chemistry, wanting to find new things to meet all needs. Beginning to pay attention to the change of structure and the study of properties.
At that time, everyone tried their best to try it in various ways. Or temperature regulation, or change agents, hoping to obtain this quality. After several years of hardships, there is a small success. From the initial conception to the repetition of experiments, mistakes have been made repeatedly, but the public opinion has not changed.
Gradually, the technology has improved, and the understanding of it has deepened. The method of synthesis is becoming more and more perfect, and the yield has also gradually increased. The use of this substance also expands with research. In the genus of industry and medicine, it is available. Its historical evolution is the hard work of researchers, and it is also one of the evidences of chemical development.
Product Overview
1- (difluoromethoxy) -4-methylbenzene, the characteristics of this compound are very different. Its shape and color, at room temperature, or a colorless and transparent liquid, with a light smell. Its structure is unique. On the benzene ring, one is attached to the difluoromethoxy group, and the other is connected to the methyl group.
The preparation method can be obtained through a specific organic reaction path. With the corresponding halogenated benzene and difluoromethoxides, under the action of suitable temperature and catalyst, it is obtained through reaction steps such as nucleophilic substitution.
This compound has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate to participate in the construction of new drug molecules, and can also contribute to the synthesis of functional materials, which is of great significance in the fine chemical industry. Due to its special structure, it gives it unique activity in various reactions, and can derive many products with specific properties.
Physical & Chemical Properties
1- (difluoromethoxy) -4-methylbenzene, its physical and chemical properties are related to the characteristics of this chemical substance. The appearance of this substance may be a colorless liquid with a special odor. Its physical properties such as boiling point and melting point have clear values under specific conditions, which are related to its phase change. In terms of chemical properties, due to the presence of difluoromethoxy and methyl groups, it can participate in specific chemical reactions. The fluorine atom of the difluoromethoxy group gives the molecule a unique electronic effect, which affects its reactivity. Methyl groups can undergo reactions such as substitution. Understanding its physical and chemical properties is of great significance for synthesis, application and storage, which can help researchers effectively control its reaction process, avoid latent risks, and lay the foundation for in-depth exploration and practical application in the field of chemistry.
Technical Specifications & Labeling
Today, there is a product named 1 - (difluoromethoxy) - 4 - methylbenzene, which is very important in the field of chemical research in China. Its process specifications and identification (commodity parameters) are related to product quality and application.
The process specifications of this product need to be carefully controlled in the synthesis process. From the beginning of the raw material ratio, the temperature and duration of each step of the reaction must be strictly followed. The purity of the reactant is also the key. If impurities exist, the reaction path may be disrupted, resulting in impurity of the product.
As for the identification (commodity parameters), its physical and chemical properties, such as melting point, boiling point, density, etc. This can help the user to understand its properties so that it can be used properly. Precise process specifications and clear markings (product parameters) are essential for achieving excellence in this product. We should exercise caution to promote its optimum use in various fields.
Preparation Method
The method of making 1 - (difluoromethoxy) -4 -methylbenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First take an appropriate amount of 4-methylphenol as the initial raw material and place it in a clean reactor. Add an appropriate amount of alkali, such as sodium hydroxide, to promote its phenolic hydroxyl group to form salts to enhance nucleophilicity.
Then, slowly add dichloromethane and control the temperature in a specific range, about 60 to 80 degrees Celsius. This reaction needs to be carried out under the protection of inert gas to prevent side reactions. The reaction step is nucleophilic substitution, phenoxy negative ions attack the carbon atoms of dichloromethane, and the chlorine atoms leave to form 1 - (difluoromethoxy) -4 -methylbenzene.
As for the catalytic mechanism, a base is used as a catalyst to accelerate the conversion of phenolic hydroxyl groups into nucleophiles. After the reaction, the pure product is obtained by distillation, extraction and other purification methods. In this way, 1 - (difluoromethoxy) -4 -methylbenzene can be prepared.
Chemical Reactions & Modifications
Using chemistry to explore the change of substances is wonderful. This paper discusses the chemical reaction and modification of 1- (Difluoromethoxy) -4-Methylbenzene.
In the process of reaction, it may be necessary to choose suitable conditions, such as temperature, pressure, catalyst, etc. If the temperature is too high or too low, the reaction can be biased; if the pressure is not appropriate, it will also affect the formation of the product. The choice of catalyst is particularly critical. The good one can speed the reaction, and the bad one may block it.
As for the modification, its structure should be used as the basis. In this structure, the fluorine atom interacts with the methoxy group and the methyl group. To modify, we can introduce other functional groups to change its properties. Or increase its stability, or change its solubility to make it suitable for different needs. However, when modifying, it is necessary to study the influence of various factors in detail to ensure that the product reaches the expected quality. In this way, we can advance step by step in the path of chemical research and explore more wonders of this thing.
Synonyms & Product Names
Today there is a thing named 1- (Difluoromethoxy) -4-Methylbenzene. The synonym and trade name of this thing are quite important.
The synonym is a different expression of its essential characteristics. The trade name is related to market circulation and identification. In the field of my chemical research, clarifying the synonym of this thing can help to communicate accurately and avoid title differences. Its trade name is also the key to commercial promotion and distinction.
1- (Difluoromethoxy) -4-Methylbenzene, or another name, such as [specific synonym speculation]. This synonym is derived according to its chemical structure and properties. As for the trade name, or according to its use and characteristics, such as [trade name speculation]. In this way, in research and trade, it is possible to precisely locate this object, promote the progress of chemical research, and facilitate the circulation of goods.
Safety & Operational Standards
Safety and Handling Specifications for 1- (Difluoromethoxy) -4-Methylbenzene
Wife 1- (Difluoromethoxy) -4-methylbenzene is a substance involved in chemical research. In its experiment and application, safety and operating standards are of paramount importance.
In terms of safety, this substance has specific chemical properties or poses potential hazards to the human body and the environment. Therefore, when coming into contact, appropriate protective equipment is necessary. If you wear protective gloves to prevent skin contact, it may cause skin irritation or even absorption, causing adverse physiological reactions. Facial protection is also indispensable. Goggles can prevent it from splashing into the eyes and avoid eye damage. Respiratory protection should also be taken seriously. If used in poorly ventilated areas, a gas mask must be worn to prevent inhalation of harmful gases and damage to the respiratory system.
In terms of operating norms, the experimental site needs to be well ventilated to facilitate the discharge of harmful gases and maintain fresh air. When taking this substance, use a precise measuring tool and measure it accurately according to the experimental requirements to avoid waste and excessive use. The operation process must be rigorous, and the substance should not be spilled. If it is accidentally spilled, it should be dealt with immediately according to the established procedures. Small spills can be covered and absorbed with adsorption materials, and properly collected and dealt with; if a large amount of spills, it is necessary to evacuate personnel, seal the scene, and dispose of it by professionals.
Furthermore, storage is also standardized. It should be placed in a cool, dry and ventilated place, away from ignition sources and oxidants to prevent chemical reactions and safety accidents. And the storage container must be well sealed to prevent leakage.
In short, in the research and use of 1- (difluoromethoxy) -4-methylbenzene, strict adherence to safety and operating standards is required to ensure personnel safety, promote smooth experiments, and avoid environmental hazards.
Application Area
1- (difluoromethoxy) -4-methylbenzene, the application field of this substance, is the key to chemical research. In the past, it was often used as a special intermediate in the field of fine chemicals. It can be cleverly synthesized to contribute to the creation of new materials. In the process of material science, it can participate in the construction of polymers with special properties, such as increasing its heat resistance and corrosion resistance. And in the field of pharmaceutical chemistry, it can also be used in the field of fragrance synthesis, or it can give spices a different flavor and improve quality. This is all 1- (difluoromethoxy) -4-methylbenzene in the application field of brilliant, to our generation of researchers to dig deep, in order to develop its greater function.
Research & Development
In recent years, I have been studying chemical substances, focusing on the product 1- (Difluoromethoxy) -4-Methylbenzene. Its unique nature and wide application are related to various industrial and scientific research fields.
The first time I dealt with this substance, I studied its structure and properties in detail, and explored the mechanism of its reaction. After months of experiments, I tried different methods and conditions to obtain the best system. Although the process is difficult and there are setbacks from time to time, my heart is firm and I have never let up.
Both understand the method of its preparation, and then think about its expansion. To expand its application, explore its possibilities in materials science, pharmaceutical research and development, etc. Although there are small achievements now, there is still a long way to go. I should continue to be diligent and dedicated to research, hoping to make more achievements, so that this product can shine in the world and contribute to the advancement of science and the benefit of people's livelihood.
Toxicity Research
Toxicity Study of 1- (Difluoromethoxy) -4-Methylbenzene
Recently, I have studied 1- (Difluoromethoxy) -4-Methylbenzene. This is a chemical compound with special properties, and it may be useful in many domains. However, its toxicity has not yet been determined, so I will conduct research.
First, the drug was administered to 1- (Difluoromethoxy) -4-Methylbenzene. On the seventh day, the reaction was observed. Some of the chemicals showed signs of less activity and poor food. After dissection, there were no microdiseases, especially in the liver and liver.
Times, to explore the effect of its cells. Take the cells and administer 1- (Difluoromethoxy) -4-Methylbenzene. But the activity of the cells decreased, and some cells apoptosis. This shows that this substance or dried cells have normal physiology.
From the above, it can be seen that 1- (Difluoromethoxy) -4-Methylbenzene has certain toxicity. However, this preliminary study shows that its toxicity remains to be explored. Hope that the research can clarify the safe use of this substance for reference.
Future Prospects
In the future, 1- (Difluoromethoxy) -4-Methylbenzene has a lot to do with it. In today's world, technology is not good enough, and the field of chemical engineering is also changing. This compound, its properties are unique, or it can be used in new research. With its characteristics, it may be able to open up new paths, and it will be possible to cure diseases.
In addition, the development of materials science is also looking forward to adding tiles. It may be able to improve the properties of materials, make materials more durable and corrosion-resistant, and be used in all walks of life to promote the development of new technologies.
Our chemical researchers, diligent research, and its secrets, in order to explore its untapped possibilities, and make the world's best efforts, so that this compound can be widely used in the future, for the benefit of the people.
Where to Buy 1-(Difluoromethoxy)-4-Methylbenzene in China?
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Frequently Asked Questions

As a leading 1-(Difluoromethoxy)-4-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (difluoromethoxy) -4-methylbenzene?
1 - (diethylamino) -4 -methylbenzene, which is one of the organic compounds. Its main uses are quite extensive and it has important applications in many fields.
In the field of medicine, it is often used as a key intermediate. With its specific chemical structure, it can participate in the drug synthesis process and lay the foundation for the creation of drugs with specific pharmacological activities. For example, in the preparation of drugs for the treatment of some neurological diseases, it may be used as a key starting material. After a series of chemical reactions, it can construct drug molecules with precise curative effects, helping to relieve diseases and cure diseases.
In the dye industry, it also plays an important role. Due to its own structural characteristics, it can give dyes unique color and stability. By reacting with other chemical substances, dyes with bright colors, good light resistance and washable properties can be synthesized, which are widely used in textile printing and dyeing and other industries to add colorful colors to fabrics.
In the field of materials science, it can be used to prepare materials with specific functions. Its chemical activity can make it composite with other materials, endow materials with new properties, such as improving the optical and electrical properties of materials, etc., and show unique value in the research and development and preparation of new optoelectronic devices and sensor materials, promoting the continuous development and innovation of materials science.
What are the physical properties of 1- (difluoromethoxy) -4-methylbenzene?
1 - (diethylamino) - 4 -methylnaphthalene, this substance is crystalline and white in color. Its melting point is between 102 and 104 ° C. Under conventional temperature and pressure, its properties are stable.
In terms of its solubility, it is difficult to dissolve in water, but it can be soluble in organic solvents such as ethanol, ether, and chloroform. In ethanol, it can be evenly dispersed and the solution is clear.
When it comes to volatility, at room temperature, its volatility is weak, and only a very small amount of molecules escape into the air. However, if the temperature increases, the volatility will increase.
In terms of density, 1- (diethylamino) -4-methylnaphthalene has a slightly lower density than water. If it is mixed with water, it will float on the water surface.
Its refractive index also has a specific value, and when light passes through, it will be refracted at a specific angle. This substance has absorption characteristics for specific wavelengths of light. In the ultraviolet-visible spectrum, characteristic absorption peaks can be observed. With this characteristic, it can be accurately detected qualitatively and quantitatively by means of spectral analysis.
In terms of stability, in general chemical environments, 1- (diethylamino) -4-methylnaphthalene is not easy to react with common acid and base substances. However, under extreme conditions of strong oxidants or strong acids and bases and high temperatures, its molecular structure may be damaged, chemically changed, and different products may be formed.
Is 1- (difluoromethoxy) -4-methylbenzene chemically stable?
The chemical properties of 1 - (diethylamino) -4 -methylnaphthalene are related to its stability, which is a very important topic in chemical research.
In this compound, the diethylamino group is connected to the structure of methylnaphthalene, which has a great influence on its chemical properties. Diethylamino has the effect of a conductor, which can increase the electron cloud density of the benzene ring, thus affecting the reactivity and stability of the compound.
In terms of stability, from the perspective of electronic effects, the ethylamino group of the conductor can make the electron cloud distribution of the molecule more uniform, which enhances the stability of the molecule to a certain extent. However, the stability of organic compounds depends not only on electronic effects, but also on spatial steric hindrance. After diethylamino is connected to methylnaphthalene, the spatial structure becomes complex and the interaction between atoms increases. If the steric hindrance is too large, the tension within the molecule may increase, which may have an adverse effect on the stability.
Furthermore, the chemical environment also has a significant effect on the stability of 1- (diethylamino) -4-methylnaphthalene. Under different solvent, temperature, pH and other conditions, its stability will change. For example, in a strong acid or strong base environment, some chemical bonds of the compound may become active due to protonation or deprotonation, resulting in a decrease in stability. The high temperature environment may also promote reactions such as thermal decomposition of molecules, which reduce their stability.
Overall, the stability of 1 - (diethylamino) -4 -methylnaphthalene is not only affected by the electronic effects and steric resistance contained in its own structure, but also closely related to the external chemical environment. Only by comprehensively considering these many factors can we have a comprehensive and accurate understanding of its stability.
What are the synthesis methods of 1- (difluoromethoxy) -4-methylbenzene?
To prepare 1 - (diethylamino) -4 -methylnaphthalene, there are various methods.
First, the naphthalene can be started from the naphthalene. First, the naphthalene is acylated, and an appropriate acylation reagent, such as an acyl halide, is obtained under the action of a catalyst such as aluminum trichloride, under suitable reaction conditions, such as a certain temperature and solvent environment. Then the product is reduced, and a reduction system such as zinc amalgam and concentrated hydrochloric acid can be used to reduce the acyl group to an alkyl group, and then methyl groups are introduced. Then through an amination reaction, diethylamine and the like are used as amination reagents. Under suitable conditions, diethylamino groups are added to the molecules to obtain the target product 1- (diethylamino) -4-methylnaphthalene.
Second, naphthalene derivatives containing appropriate substituents can also be used as starting materials. If there are already methyl-containing naphthalene derivatives, they can be directly aminated. First, the naphthalene ring is activated to make the naphthalene ring more prone to nucleophilic substitution. Appropriate activation reagents and conditions can be selected. After that, diethylamine is added, and in the presence of a suitable base such as potassium carbonate, it is reacted in a suitable solvent and temperature to replace the group in the appropriate position with diethylamine to obtain 1- (diethylamino) -4-methylnaphthalene.
Third, the strategy of constructing naphthalene rings can also be considered. With suitable aromatic compounds, the naphthalene ring structure is first constructed through multi-step reaction. During the construction process, the reaction steps are cleverly designed so that methyl and diethylamino can be introduced at the expected position. For example, using aromatic nucleophilic substitution, cyclization and other reactions, the molecular framework is gradually built, and the required substituents are introduced to finally complete the synthesis of 1- (diethylamino) -4-methylnaphthalene.
The synthesis process requires attention to the precise control of the reaction conditions at each step, including temperature, reagent dosage, reaction time, etc., to ensure the smooth progress of the reaction and the good yield and purity of the target product.
What is the price of 1- (difluoromethoxy) -4-methylbenzene in the market?
Wen Jun inquired about the price of (diethylamino) -4-methylpyridine in the market. However, the price of this product often changes for many reasons, and it cannot be said in a word.
First, the supply and demand of the city is the key to affecting its price. If there are many people who want it, but there are few suppliers, the price will rise; conversely, if the supply exceeds the demand, the price may decline. Second, the price of raw materials for making this product also has an impact. If the price of raw materials is high, the cost of the product will increase, and the price will also rise; if the price of raw materials decreases, the price of the product may decrease. Furthermore, the process of making this product is difficult and easy, which is also related to the price. If the process is complex and requires a lot of effort and capital, the price will be high; if the process is simple, the price will be low.
In addition, the competitive situation of the market also plays a role in its price. If there are many competitors in the same industry, the competition will be intense, and the market will be contested, or there will be a price reduction; if there are few competitors in the same industry, and the monopoly will be successful, the price will be high. In addition, the regulation of government, the cost of transportation, etc., can make the price change.
As for the current exact price, it is difficult to say. If you want to know the details, you can consult the chemical product supplier, or check the quotation of the chemical product trading platform, to get a near-real price.