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1-(Difluoromethoxy)-4-Iodobenzene

1-(Difluoromethoxy)-4-Iodobenzene

Hongda Chemical

Specifications

HS Code

404867

Chemical Formula C7H5F2IO
Molecular Weight 286.015
Appearance Typically a colorless to light - yellow liquid (usually predicted based on similar aromatic compounds)
Boiling Point Data may vary, but likely in a range relevant to aromatic ethers with halogen substituents, e.g., around 200 - 250 °C (estimated)
Density Estimated to be greater than 1 g/cm³, likely around 1.8 - 2.0 g/cm³ based on similar halogen - containing aromatic compounds
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate due to its non - polar aromatic nature
Solubility In Water Insoluble in water as it is a non - polar organic compound
Flash Point Relatively high due to the presence of halogen atoms, estimated around 80 - 100 °C
Vapor Pressure Low at room temperature, typical for a non - volatile organic compound with halogen and ether functional groups

As an accredited 1-(Difluoromethoxy)-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(difluoromethoxy)-4-iodobenzene in a sealed, labeled chemical container.
Storage 1-(Difluoromethoxy)-4-iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
Shipping 1-(Difluoromethoxy)-4-iodobenzene is shipped in sealed, corrosion - resistant containers. Care is taken to ensure proper labeling. Shipments follow strict regulations for handling hazardous chemicals to prevent spills and ensure safety during transit.
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1-(Difluoromethoxy)-4-Iodobenzene 1-(Difluoromethoxy)-4-Iodobenzene
General Information
Historical Development
The technology of chemical industry is changing with each passing day, and the research of matter is also new. The origin of the 1- (Difluoromethoxy) -4-Iodobenzene mentioned today is also the origin of all the sages in the field of chemistry, thinking and exploring. At the beginning, everyone did not know its nature and production method. However, as the years went by, the craftsmen worked hard, either in the conditions of the reaction or in the selection of raw materials, and tried it repeatedly.
Gradually obtained exquisite methods, so that the preparation of this material became more and more perfect. Its application is also gradually widening, and it has emerged in the fields of medicine and materials. From ignorance of the unknown to skilled use, the development of this substance is like a star, shining from the dim light. The difficult exploration of the past has laid the foundation for the brilliance of the present, and in the future, it will become more and more prosperous, adding splendid chapters to the history of chemical industry.
Product Overview
1- (difluoromethoxy) -4-iodobenzene is an organic compound. It may be a colorless liquid with a special odor. In this compound, the fluorine atom is connected to the methoxy group, and the iodine atom is located in the benzene ring, which gives it specific chemical properties.
In the field of organic synthesis, 1- (difluoromethoxy) -4-iodobenzene is often a key intermediate. The introduction of fluorine can change the polarity and stability of molecules, while iodine atoms are active and easily participate in many nucleophilic substitution reactions, such as interacting with nucleophilic reagents containing carbon, nitrogen, oxygen, etc., to construct new carbon-carbon, carbon-heteroatom bonds, and assist in the synthesis of a variety of complex organic molecules. It has great potential in drug research and development, materials science, etc., and is an important object for organic chemistry research.
Physical & Chemical Properties
1- (difluoromethoxy) -4-iodobenzene is also an organic compound. Its physical properties are unique, and it is mostly a colorless liquid at room temperature, with certain volatility. The boiling point is suitable for a specific temperature, which is related to various physical factors such as the attractive force between molecules. Its solubility is slightly soluble in organic solvents such as ethanol and ether. Due to the principle of similar compatibility, those whose molecular structures are similar to organic solvents are more easily soluble.
On its chemical properties, iodine atoms are active and can be involved in the reaction of nucleophilic substitution. The benzene ring has a conjugated structure, which makes its chemical properties different from others. The existence of difluoromethoxy also changes the distribution of its electron cloud, which affects the reaction activity. When encountering nucleophiles, iodine atoms are often the reaction check point and can be replaced to derive new compounds. They are widely used in the field of organic synthesis. They are important intermediates for the preparation of complex organic molecules. With their physicochemical properties, they can expand the way of organic synthesis and explore the unknown chemical world.
Technical Specifications & Labeling
1- (difluoromethoxy) -4-iodobenzene, the process specifications and identification (product parameters) of this substance are very important. Its process specifications are related to the preparation method, from the selection of raw materials to the control of reaction conditions, all need to be accurate. The raw materials must be pure, and the reaction temperature, duration, and pressure are all fixed, with a difference of one cent, or the product may be inaccurate.
On the label, the name is clear and clear, and the molecular formula and molecular weight are accurately identified. Appearance and properties are truthfully described, such as color and smell. Safety labels are also indispensable to warn of potential hazards, such as toxicity and explosion risks. This is essential to ensure product quality and use safety, and is related to the success or failure of subsequent applications. It must not be taken lightly.
Preparation Method
To prepare 1- (Difluoromethoxy) -4-Iodobenzene, the method is as follows: Prepare the raw materials first. When taking an appropriate amount of benzene-containing compounds and reagents with difluoromethoxy groups, the proportions of the two need to be accurately weighed. The reaction process is to slowly mix the raw materials in a temperature-controlled reactor and apply moderate stirring to make the two blend. The reaction step is to promote the interaction between molecules, gradually form new bonds, and form intermediate products. After purification, the impurities are removed by a purification mechanism to purify the product. The purification method can be used by distillation to divide the pure heteroaryl according to its boiling point difference; the chromatographic method can also be applied to obtain the pure 1- (Difluoromethoxy) -4-Iodobenzene according to its different adsorption properties. Therefore, this compound can also be obtained.
Chemical Reactions & Modifications
The chemical reaction and modification of 1- (difluoromethoxy) -4-iodobenzene are important topics in chemical research. In our chemical research, the reaction characteristics of this compound are crucial. Its chemical reaction, or involving nucleophilic substitution, is easy to be attacked by nucleophilic reagents due to the reactivity of iodine atoms, resulting in the formation of new derivatives.
However, the optimization of its reaction conditions needs to be investigated in depth. Such as temperature and the choice of solvent will affect the yield and selectivity of the reaction. To improve the reaction effect, new catalysts can be tried to change the kinetic path of the chemical reaction.
As for modification, in order to expand its application field, the difluoromethoxy group can be modified. Or introduce other functional groups to give it new physical and chemical properties, such as changing its solubility and stability, hoping to find new uses in materials science, medicinal chemistry and other fields.
Synonyms & Product Names
Today there is a product called 1- (difluoromethoxy) -4-iodobenzene. This product is quite important in the field of my chemical research. Although it has no common name in the world, it is well known to researchers in the industry.
From the name of chemistry, this is called precision to clarify the structure and composition of its molecules. Although it does not have a catchy nickname, it is on the table of experiments and research rooms. It participates in various reactions with its essence and is an important corner for synthesizing new products and exploring mechanisms.
Our chemists are accompanied by various substances every day. Although 1- (difluoromethoxy) -4-iodobenzene is not a common name known to the market, it has left an indelible mark on the path of science with its unique chemical properties, promoting the art of chemistry and moving forward step by step.
Safety & Operational Standards
1- (difluoromethoxy) -4-iodobenzene, this chemical substance is related to safety and operating standards, and is essential.
In terms of safety, its characteristics need to be clarified. This substance may have specific chemical activity and latent risk. When storing, be sure to keep it in a cool, dry and well-ventilated place, away from fire and heat sources to prevent danger. Because of its violent reaction with certain substances, it should be avoided to co-store with strong oxidants, strong acids, strong bases, etc.
In terms of operating specifications, operators should be professionally trained and strictly abide by the operating procedures. The operation site should be equipped with corresponding fire equipment and leakage emergency treatment equipment. When operating, appropriate protective equipment should be worn, such as protective glasses, protective gloves, protective clothing, etc., to prevent it from coming into contact with the skin and eyes. In case of accidental contact, rinse immediately with a large amount of water and seek medical treatment in time. During use, pay attention to the ventilation of the operating environment to avoid inhaling its volatile gases. In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area and isolated to strictly restrict access. Emergency responders should wear self-contained positive pressure respirators and anti-acid and alkali work clothes. Do not let leaks come into contact with combustible substances, and cut off the source of leaks as much as possible to prevent them from flowing into restricted spaces such as sewers and drainage ditches. In the event of a small leak, it can be mixed with sand, dry lime or soda ash, or it can be rinsed with a large amount of water, diluted with washing water, and placed in the wastewater system. In the event of a large leak, build a dike or dig a pit for containment, cover it with foam to reduce the vapor hazard, and transfer it to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal. In this way, the safety of 1- (difluoromethoxy) -4-iodobenzene during storage and use can be ensured.
Application Area
Today, there is a product named 1- (Difluoromethoxy) -4-Iodobenzene, which is widely used in the field of chemical industry. In the process of pharmaceutical creation, it can be a key raw material, help synthesize special drugs, cure various diseases, and save patients from pain.
In the context of material research and development, it can add material specificity. Or increase its stability, make it last longer; or change its optical properties, to suit the needs of optical instruments.
In the industry of fragrance production, it can also emerge, giving a different fragrance and intoxicating people. This compound has extraordinary potential in various application fields, and is indispensable for chemical research and development.
Research & Development
Today, there is a product named 1- (difluoromethoxy) -4-iodobenzene. In the field of chemical research in China, its research and development is quite critical.
We studied its properties in detail and explored the method of its synthesis. After many attempts, we used specific reagents and suitable conditions to make the reaction proceed in an orderly manner. Observe the reaction process, observe the quality and quantity of the product, and strive to optimize the synthesis path, hoping to obtain higher yield and purer products.
In the study, its application potential in different fields is also considered. Or it can be used to create new materials, giving materials different properties with its unique structure; or it can become a key intermediate in the road of drug development, laying the foundation for the birth of new drugs.
We uphold the heart of research and make unremitting explorations, with the aim of researching and developing this product, contributing to the advancement of chemistry and science and technology, and exploring new frontiers in the future.
Toxicity Research
I have heard that the name of 1- (Difluoromethoxy) -4-Iodobenzene is in the chemical species, and it is also a subject of our attention. We are engaged in toxicity research and investigate the characteristics of this substance in detail.
Toxicity research is related to the safety of living beings and the harmony of all things in the world. This 1- (Difluoromethoxy) -4-Iodobenzene has a unique molecular structure, but its effect in living bodies is unknown. Or observe its effect on cells, see if it damages the structure of cells, or disrupts their metabolic order. After it enters the organism, it is transmitted through what route and accumulates in which organ.
We analyze the toxicity of this substance with scientific method and rigorous attitude. Or use animal experiments to observe the change of its symptoms; or use cell culture to study its microscopic transformation. Expect to get the real fruit, Ming 1- (Difluoromethoxy) -4-Iodobenzene toxicity is detailed, for the world to use this thing, prepare a safe policy, keep all things safe, and avoid disasters.
Future Prospects
The vision of the future, in 1- (Difluoromethoxy) -4-Iodobenzene, this thing is like a shining star, guiding us forward. Its unique nature, exquisite, in the field of transformation, strength.
In the field of research and development, or it can be a new cornerstone, its special manufacturing, precise effect on the focus, and the treatment of patients. In the field of materials science, it is also expected to give birth to new materials. With its characteristics, it can enhance the properties of materials and be used in high-tech.
Our chemical researchers, upholding the ambition to study the secrets of this compound. With the wisdom of the first, the technology of integration, explore more possibilities. It is hoped that with unremitting efforts, 1- (Difluoromethoxy) -4-Iodobenzene will be widely used in the future, promoting human well-being and technological progress.
Where to Buy 1-(Difluoromethoxy)-4-Iodobenzene in China?
As a trusted 1-(Difluoromethoxy)-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-(Difluoromethoxy)-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1- (difluoromethoxy) -4-iodobenzene?
The main uses of diethyl ether amino-4-chloroquinoline, which is chloroquine, are as follows:
Chloroquine is a good medicine for anti-malaria. The malaria pathogen is Plasmodium, which is transmitted to the human body through mosquito bites. Chloroquine can enter the body of Plasmodium, interfere with its nucleic acid metabolism and protein synthesis, and then inhibit the growth and reproduction of Plasmodium, which can effectively control the onset of malaria symptoms. Whether it is vivax malaria, three-day malaria, or oval malaria, it has a good effect. It can also quickly relieve symptoms and reduce the mortality rate of falciparum malaria.
In addition to anti-malaria, chloroquine is also used in autoimmune diseases. Such as rheumatoid arthritis, this disease is caused by the immune system disorder attacking its own joint tissue. Chloroquine can regulate the immune response, reduce inflammation, relieve joint pain and swelling, delay the progress of joint damage, and improve the quality of life of patients. Another example is systemic lupus erythematosus, the patient's immune system is abnormally active, attacking multiple organs and systems. Chloroquine can regulate immunity, inhibit inflammation, improve skin erythema, joint pain and other symptoms, reduce disease recurrence, and help stabilize the disease.
In addition, chloroquine has also shown a certain role in certain infectious diseases. When targeting specific viral infections, chloroquine can modify the intracellular environment and interfere with the invasion and replication process of the virus. Although it cannot be used as a single specific antiviral drug, it can play an auxiliary role in the combination treatment plan and cooperate with other drugs to improve the therapeutic effect.
What are the physical properties of 1- (difluoromethoxy) -4-iodobenzene?
Diethyl ether amino (the expression here may be wrong, speculated to be diethylaminoethyl) - 4-chlorobenzoic acid (speculated to be miswritten "polychlorobenzene") is an organic compound, its physical properties are as follows:
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions, which is conducive to identification and distinction. When it is in the solid state, the texture is relatively delicate, and it feels creamy when touched by hand, just like fine sand.
When it comes to melting point, it is in the range of 100-104 ° C. When it is heated and the temperature rises to this range, the compound gradually melts from a solid state to a liquid state. This melting point characteristic is of great significance in many fields such as organic synthesis and drug purification. For example, in the pharmaceutical process, the purity can be judged by the melting point. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
In terms of boiling point, under specific pressure conditions, its boiling point is in a specific temperature range (because no precise conditions are given, it is difficult to specify the specific value). The boiling point is the key temperature point for the transformation of a compound from a liquid state to a gas state. During the separation and purification process, it can be separated from other substances by means of distillation according to the difference in boiling points.
Solubility is also an important physical property. The compound is slightly soluble in water, because its molecular structure contains hydrophobic groups, and the interaction between water molecules is weak, so it is difficult to dissolve. However, it is soluble in organic solvents such as ethanol and ether. In organic synthesis experiments, this solubility is often used to select suitable solvents for reaction, recrystallization, etc. to achieve the desired experimental effect. For example, using ethanol as a solvent can improve the dispersion of the compound in the reaction system and promote the reaction.
What are the chemical properties of 1- (difluoromethoxy) -4-iodobenzene?
Diethylaminoethoxyethanol, also known as 2- (diethylamino) ethoxyethanol, has the following properties:
This substance is a colorless to light yellow transparent liquid at room temperature, with a special odor. From the volatile point of view, it has a certain volatility. In terms of solubility, it can be miscible with various organic solvents such as water, alcohol, ether, etc., showing good solubility.
In terms of chemical activity, diethylaminoethoxyethanol molecules contain hydroxyl groups and amino groups, which make it have certain reactivity. Hydroxyl groups can participate in esterification reactions, and under specific conditions, can react with acids to form corresponding ester compounds. The amino groups show a certain alkalinity and can neutralize with acids to form salts. At the same time, this alkalinity also makes it useful as an acid binding agent in some organic synthesis reactions, which contributes to the smooth progress of the reaction.
In terms of stability, the substance is relatively stable under conventional storage and use conditions. However, if it is exposed to high temperature, open flame or strong oxidant environment, there is a risk of chemical reaction or even combustion and explosion. Therefore, during storage and use, it must be strictly avoided from contact with these dangerous environments or substances to ensure safe operation. In addition, it may be corrosive to some metal materials, so when choosing storage containers and equipment, it is necessary to fully consider the corrosion resistance of the material to prevent safety issues such as leakage due to corrosion.
What is the preparation method of 1- (difluoromethoxy) -4-iodobenzene?
The preparation method of (diethylamino) -4-pyridine formaldehyde is as follows:
First take an appropriate amount of pyridine, place it in a reactor, add a certain amount of catalyst, and under suitable temperature and pressure conditions, introduce an appropriate amount of formaldehyde gas to react. This reaction aims to make pyridine and formaldehyde undergo a nucleophilic addition reaction. The nitrogen atom on the pyridine ring has a certain nucleophilicity and can attack the carbonyl carbon atom of formaldehyde, thereby introducing an aldehyde group at the No. 4 position of pyridine to form a preliminary product of 4-pyridine formaldehyde.
Next, for the 4-pyridine formaldehyde product, diethylamine is added. In a suitable organic solvent environment, such as toluene, under the condition of heating and the presence of a catalyst, the aldehyde group of 4-pyridyl formaldehyde undergoes a condensation reaction with diethylamine. The carbonyl group of the aldehyde group dehydrates and condensates with the amino group in diethylamine to form a carbon-nitrogen double bond, and finally produces (diethylamino) -4-pyridyl formaldehyde.
During the reaction process, the proportion of each reactant needs to be precisely controlled to ensure that the reaction proceeds in the direction of generating the target product. At the same time, conditions such as temperature, pressure, and reaction time need to be strictly controlled. Excessive temperature may lead to an increase in side reactions and affect the purity of the product; if the temperature is too low, the reaction rate will be slow, and the reaction may even be unable to proceed effectively. The regulation of pressure is also critical. Appropriate pressure helps the reactants to fully contact and promote the smooth progress of the reaction. The reaction time also needs to be accurately controlled. If it is too short, the reaction will be incomplete, and if it is too long, it may lead to problems such as overreaction or product decomposition. After the reaction, a series of separation and purification methods, such as distillation, extraction, recrystallization, etc., are required to obtain high-purity (diethylamino) -4-pyridine formaldehyde products.
What are the precautions for storing and transporting 1- (difluoromethoxy) -4-iodobenzene?
Carbon disulfide is also a flammable and toxic chemical. When storing and transporting it, many matters must be paid attention to.
The first one concerns storage. It must be in a cool, well-ventilated place, away from fires and heat sources. Because it is extremely flammable, open flames and hot topics can cause ignition and explosion. The storage temperature should be controlled at no more than 30 ° C. It should be stored separately from oxidizing agents, amines, alkali metals, etc., and must not be mixed to prevent severe chemical reactions. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials for emergencies.
Times and transportation. When transporting, make sure that the container does not leak, collapse, fall, or damage. The exhaust pipe of the means of transportation shall be equipped with a fire retardant device, and it is strictly forbidden to use mechanical equipment and tools that are prone to generating sparks for loading and unloading. Road transportation should be carried on the prescribed route, and do not stop in residential areas and densely populated areas. When transporting by rail, it should not be slipped away. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When transporting by ship, it should be avoided from direct sunlight, away from heat and fire sources, and should be stacked in isolation from other goods, and should not be transported in the same cabin as food, medicine, etc.
In short, the storage and transportation of carbon disulfide can cause serious disasters if it is not careful. Practitioners must be familiar with relevant safety knowledge and strictly abide by operating procedures to ensure the safety of personnel and the environment.