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1-(Difluoromethoxy)-4-Fluorobenzene

1-(Difluoromethoxy)-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

999580

Chemical Formula C7H5F3O
Molecular Weight 162.11

As an accredited 1-(Difluoromethoxy)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 - gram bottle of 1-(difluoromethoxy)-4-fluorobenzene, well - sealed.
Storage 1-(Difluoromethoxy)-4-fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Label the storage container clearly for easy identification.
Shipping 1-(Difluoromethoxy)-4-fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported following strict chemical safety regulations, ensuring protection from physical damage and environmental factors during transit.
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1-(Difluoromethoxy)-4-Fluorobenzene 1-(Difluoromethoxy)-4-Fluorobenzene
General Information
Historical Development
1- (difluoromethoxy) -4-fluorobenzene, the origin of this substance, can be traced back to the past. At the beginning, in the process of chemical exploration, many researchers painstakingly studied, hoping to open up new frontiers. At that time, the understanding of organic compounds was still shallow, but everyone was determined.
After countless attempts, the synthesis of this compound was explored by various methods. From the selection of basic raw materials to the exploration of reaction conditions, all went through hardships. In the early days, technical means were limited, the synthesis process was full of twists and turns, and the yield was not high.
However, the years have passed, and science and technology have advanced. With the improvement of analytical technology, the understanding of the reaction mechanism has deepened. New catalysts and reaction pathways continue to emerge, making the synthesis of 1- (difluoromethoxy) -4-fluorobenzene gradually mature, with improved yield and better purity, paving the way for its application in many fields. Since its staggering start in the past, it has developed steadily until today.
Product Overview
Today there is a substance called 1- (difluoromethoxy) -4-fluorobenzene. Its shape is unique and it is an organic substance. Looking at its structure, it contains difluoromethoxy and fluorine atoms on the benzene ring.
This substance has unique properties and has certain chemical activity. In the field of organic synthesis, it is often used as a key raw material. With its structural characteristics, it can participate in many reactions, such as nucleophilic substitution, to prepare other organic compounds.
Its use is quite wide, in the pharmaceutical and chemical industry, or an important intermediate for the synthesis of special drugs; in materials science, it may help to develop new functional materials.
Although its appearance is not impressive, it is an indispensable position in the world of chemistry and an important force for promoting progress in related fields.
Physical & Chemical Properties
The physicochemical properties of 1- (difluoromethoxy) -4-fluorobenzene can be investigated. Looking at its shape, under normal temperature, or as a colorless liquid, with a special odor. Its boiling point is related to the state of gasification. It is measured by various measures and is within a certain range of values. It varies with the external air pressure. As for the melting point, it is the critical temperature for the conversion of solid to liquid state, and it also has its specific value.
When it comes to solubility, in organic solvents, or showing different solutions, or easily soluble in certain types of organic solvents, it is deduced from the principle of similar compatibility, and it is related to the polarity of its molecular structure. Its density is related to the mass per unit volume and is one of its physical characteristics. Chemically, due to its fluorine and difluoromethoxy groups, it can initiate various chemical reactions, and is a key raw material in the field of organic synthesis. Due to its special structure, it can participate in many reaction paths and exhibit unique chemical activities.
Technical Specifications & Labeling
Today there is a product named 1- (difluoromethoxy) -4-fluorobenzene. To clarify its technical specifications and identification (product parameters), the following methods should be followed.
To observe its shape and quality, the color is pure and the state is stable, and the impurities are tiny, so that the specifications can be met. The quality contained in it must be accurate, and the proportion of each ingredient must be in accordance with the specified standards. The labeling person should specify the name, source, and composition of the product, so that the viewer can know what it is.
When preparing, all kinds of processes should be carried out according to regulations. Temperature and pressure should not be slightly different. The materials used must also meet the standards. In this way, only high-quality 1- (difluoromethoxy) -4-fluorobenzene can be obtained, and its technical specifications and labels must be correct for all parties.
Preparation Method
To prepare 1- (difluoromethoxy) -4-fluorobenzene, prepare raw materials first. Take an appropriate amount of fluorobenzene and use it as a base. In a specific vessel, add a difluoromethylation reagent, such as difluorobromomethane, supplemented by a phase transfer catalyst, such as tetrabutylammonium bromide.
The temperature is controlled in a moderate range, about fifty to seventy degrees Celsius, so that the two can be moderated. During this period, the reaction process is carefully observed by gas chromatography or thin chromatography. After the reaction is completed, the impurities are removed and purified through the steps of separation and distillation.
During distillation, the temperature is controlled near the boiling point of the material to obtain pure 1- (difluoromethoxy) -4-fluorobenzene. In this process, the catalyst promotes the reaction rate, temperature, and the ratio of raw materials are all crucial, and precise control is required to obtain good products.
Chemical Reactions & Modifications
A chemist tried to study the compound of 1- (Difluoromethoxy) -4-Fluorobenzene. The reaction and modification of this compound is the key to research.
In the past, the reaction of this compound was often trapped in the harsh conditions. The reagents used were either expensive and difficult to produce, or the reaction took a long time, and the yield was not ideal. And the selectivity of the reaction was not good, there were many impurities, and the subsequent separation and purification were complicated.
However, today's researchers are good at thinking and changing. Instead of using a new catalyst, this agent has high efficiency and makes the reaction conditions smooth. With mild temperature and pressure, high yield can be obtained in a short time. And the selectivity is greatly increased, there are few impurities, and the purification is easy. This modification has significant benefits in the preparation of 1- (Difluoromethoxy) -4-Fluorobenzene, and also opens up a new path for the research of similar compounds.
Synonyms & Product Names
There is a substance named 1- (Difluoromethoxy) -4-Fluorobenzene. This substance is also used in the field of chemistry and has a wide range of uses. Its alias and trade name are also subject to our detailed investigation.
The alias of the husband covers the title of it from different perspectives and situations. It may be derived from structural characteristics or the method of preparation. The trade name is related to the market change, and merchants order it for its characteristics and easy identification.
1- (Difluoromethoxy) -4-Fluorobenzene, its alias or from its molecular structure analysis, according to the connection of atoms and the characteristics of functional groups. The trade name should also meet the needs of the market, whether it is concise and easy to remember, or it shows unique effect to distinguish it from others. Studying this other name and the trade name, in the chemical industry and research, are the essence, so that we can better understand its nature and make good use of its capabilities.
Safety & Operational Standards
One (1- (difluoromethoxy) -4 -fluorobenzene) product safety and operating specifications
Fu 1- (difluoromethoxy) -4 -fluorobenzene, chemical products are also used in chemical industry, and are widely used. However, this material has special characteristics, so its safety and operating specifications cannot be careless.
In the way of storage, it is necessary to choose a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Cover it with active nature, and it may be dangerous in case of heat or open flame. It must be stored separately with oxidants, acids, bases and other substances to avoid mutual reactions and the risk of chaos.
When operating, make sure the environment is well ventilated. Operators must wear appropriate protective gear, such as protective clothing, gloves, goggles, etc., to avoid contact with the body, skin, and eyes. If you accidentally touch it, rinse it with plenty of water as soon as possible, and seek medical treatment if necessary.
As for the method of access, handle it with care to prevent it from leaking. Once leaking, quickly cut off the fire source and evacuate personnel to a safe place. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks need to be contained and collected, handed over to professional treatment, and must not be discarded at will, so as not to pollute the environment and harm life.
Furthermore, during transportation, strict regulations must also be followed. Contain it in a special container to ensure stability and prevent it from being damaged by bumps. Transport vehicles should be equipped with emergency treatment equipment just in case.
All these are the safety and operating specifications for 1- (difluoromethoxy) -4 -fluorobenzene. Practitioners must follow them carefully to ensure that everything goes smoothly and there is no safety hazard.
Application Area
1 - (difluoromethoxy) - 4 - fluorobenzene is also a new product of chemistry. The field of its use is quite involved. In the field of medical science, it can be used as the basis for making good medicines and helping to treat various diseases. With its characteristics, it can be used as a medicine to regulate the body's diseases and relieve the suffering of the disease.
In the domain of agriculture and planting, it also has its uses. It can be used as a pest control agent, to protect the health of seedlings and plants, to prevent the invasion of diseases and insects, and to make crops fertile. Its properties may be able to precisely control damage without damaging good plants, which is the hope of farmers.
And in various chemical products, it is also a usable material. This 1 - (difluoromethoxy) - 4 - fluorobenzene is widely used in the fields of medicine, agriculture, and chemistry, and can be used. Those who need to be researched can explore it in depth to make the best use of it and benefit the world.
Research & Development
In recent years, I have been researching chemical products, especially 1- (Difluoromethoxy) -4-Fluorobenzene. Its unique nature has potential in various fields.
At the beginning, the road to synthesis was full of thorns. The selection of raw materials and the degree of matching all need to be carefully researched. After months of tests, repeated failures and battles, the method of optimization can be obtained. The yield gradually increases, and the quality also stabilizes.
After that, study its properties in detail. Insight into its reaction in different environments, and the law of its chemical activity is revealed.
Today, this product has been gradually used in industrial production, but there is still room for improvement. In the future, Ji Neng will expand its application scope and bring its brilliance to the fields of medicine and materials, contributing to the advancement of chemistry and industry.
Toxicity Research
The toxicity of this 1- (Difluoromethoxy) -4-Fluorobenzene is of great significance. Examine its properties in detail, and observe its effects on various organisms in the experiment. Take the white mice as a test, fed with food containing this substance, after a few days, the white mice gradually showed fatigue, slow movement, and reduced eating. After re-analyzing its physiological indicators, the functions of the liver and kidneys were abnormal. This may be due to the entry of this substance into the body, disturbing the biochemical reactions and damaging the functions of the viscera. It was also tested on plants, sprinkling this substance on plants, the leaves gradually withered and the growth was blocked. From this perspective, 1- (Difluoromethoxy) -4-Fluorobenzene has obvious toxicity and is harmful to the growth and development of organisms. The follow-up research and application should be done with caution to prevent its toxicity from harming the environment and life.
Future Prospects
Wuguanfu 1- (Difluoromethoxy) -4-Fluorobenzene is a promising future. In today's world, science and technology are changing day by day, and the field of chemical industry is also booming. This compound has a unique structure, and its characteristics may lead to multiple applications.
In the future, it may be used to create new materials. With its characteristics, the material has better properties, such as enhanced stability and improved corrosion resistance. It is also expected to emerge in the research and development of medicine. With its molecular properties, it can precisely act on diseases and create a new way for the treatment of diseases.
Furthermore, in the field of environmental protection, it may be helpful for the exploration of clean energy or participate in the process of environmental purification. Although there is a long way to go, I firmly believe that with time and careful study, 1- (Difluoromethoxy) -4-Fluorobenzene will be able to shine and open up a bright future for the well-being of mankind, the progress of the world, and the future.
Where to Buy 1-(Difluoromethoxy)-4-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-(Difluoromethoxy)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (difluoromethoxy) -4-fluorobenzene?
The main uses of 1- (dihydroxyethylamino) -4-hydroxypropyl are quite extensive.
In the field of medicine, it can be used as a drug intermediate due to its unique chemical structure. In the process of drug development, many drugs require specific structural groups to impart specific pharmacological activities. 1- (dihydroxethylamino) -4-hydroxypropyl can be chemically synthesized into drug molecules to enhance drug stability, solubility and bioavailability. For example, in the preparation of some drugs for the treatment of cardiovascular diseases, the introduction of this group can optimize the ability of drugs to bind to receptors and improve drug efficacy.
In the chemical industry, it plays a key role in the preparation of surfactants. Surfactants need to have hydrophilic and lipophilic groups. The hydroxyl and amino groups in 1- (dihydroxyethylamino) -4-hydroxypropyl give good hydrophilicity, which can improve the performance of surfactants and make them exhibit excellent emulsification, dispersion and solubilization effects in detergents, emulsifiers and other products. Like daily use detergents, adding surfactants containing this ingredient can more effectively remove oil stains and enhance washing capacity.
In terms of materials science, it can be used to prepare special functional materials. For example, in the preparation of hydrogel materials, 1- (dihydroxyethylamino) -4-hydroxypropyl can participate in the crosslinking reaction, regulate the structure and properties of the hydrogel network, and endow the hydrogel with better biocompatibility and water absorption. It has broad application prospects in the field of biomedical materials such as wound dressings and tissue engineering scaffolds. At the same time, in the coating industry, it can be added to coatings as a modifier to improve the adhesion, water resistance and corrosion resistance of coatings, and improve the quality and service life of coatings.
What are the physical properties of 1- (difluoromethoxy) -4-fluorobenzene?
Divinylamino-4-fluorobenzene is an organic compound with the following physical properties:
This substance is mostly in a solid state under normal conditions, but its melting point and boiling point vary due to the interaction of groups in the molecular structure. Usually, fluorine-containing atoms will enhance the intermolecular force, resulting in a relatively high melting point, or between tens of degrees Celsius and hundreds of degrees Celsius. The specific value is affected by the position and number of substituents.
Its boiling point also increases due to the increase in intermolecular force, or up to hundreds of degrees Celsius, which is why it can exist stably in higher temperature environments.
Divinylamino-4-fluorobenzene has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. Because the molecule has both polar and non-polar parts, according to the principle of "similar miscibility", it can interact with a variety of organic solvents and disperse them.
Looking at its density, it is relatively moderate, neither much higher than the density of water nor much lower than water. This is because the type and number of atoms in the molecule determine its mass and volume relationship, making its density similar to that of common organic compounds.
In addition, the compound has a certain refractive index, and light will be refracted when passing through. The refractive index value reflects the relationship between its molecular structure and optical properties, and may have potential application value in optical materials and other fields.
In terms of stability, due to the high carbon-fluorine bond energy in the molecular structure, it has certain chemical stability, can maintain structural integrity under common conditions, and is not prone to spontaneous decomposition or rapid reaction with common substances. However, under specific conditions such as high temperature, strong acid-base or the presence of specific catalysts, its chemical properties will change and participate in various chemical reactions.
What are the chemical properties of 1- (difluoromethoxy) -4-fluorobenzene?
The chemical properties of divinylamino-4-ethoxylbenzene are as follows:
This substance contains specific organic groups and has unique reactivity. Its ethoxy group and divinylamino group give specific chemical behaviors. In the ethoxy group, the oxygen atom has a lone pair of electrons, so that the group has a certain nucleophilicity and can participate in nucleophilic substitution reactions. Under appropriate conditions, the ethoxy group can be replaced by other nucleophilic reagents, thereby deriving new compounds and broadening its application in organic synthesis.
Divinylamino also affects its chemical properties. The amino nitrogen atom has a lone pair of electrons, which is basic and nucleophilic. The introduction of divinyl groups changes the electron cloud density of the amino group and enhances its nucleophilic ability. It can react with halogenated hydrocarbons and other electrophilic reagents to form new carbon-nitrogen bonds, which are used to construct complex organic structures.
In addition, this compound contains benzene rings, which have a conjugated system and are stable and can participate in aromatic electrophilic substitution reactions. Because ethoxy and divinylamino are electron-giving groups, the electron cloud density of the benzene ring can increase, making the benzene ring more vulnerable to electrophilic attack, and it mainly occurs in the ortho and para-positions of amino and ethoxy groups, providing a way for the synthesis of polysubstituted benzene derivatives.
At the same time, under appropriate redox conditions, each group can undergo corresponding oxidation or reduction reactions, change its chemical structure and properties, and realize various chemical transformations, which have potential application value in organic synthesis, materials science and other fields.
What is the production method of 1- (difluoromethoxy) -4-fluorobenzene?
To make mono- (diethylamino) -4 -ethoxybenzene, you can follow the following ancient method.
First take an appropriate amount of phenols, which is the starting material of the reaction. Based on phenol, add an appropriate proportion of halogenated ethane to a specific reactor. For halogenated ethane, choose the one with pure texture and less impurities. In this kettle, add a matching alkaline catalyst, such as potassium carbonate, the amount of which needs to be precisely controlled, and the reaction will be slow at least, and more or cause side reactions.
Then, the temperature of the reactor is slowly raised to a suitable range, usually between [X] ° C and [X] ° C. This heating process should be smooth and orderly, and should not rise or fall sharply to prevent the reaction from being out of order. At this temperature, it is fully reacted, and it takes several hours, during which it needs to be stirred from time to time, so that the reactants are mixed evenly and the reaction process is smooth.
After the reaction is completed, move the reaction product to the separation device. First extract with an organic solvent to separate the target product and impurities. The selected organic solvent has good miscibility with the product, poor miscibility with impurities, and is easy to separate later. After extraction, distillation is carried out to further purify the product by using the difference in boiling points of different substances. During distillation, pay close attention to temperature changes and collect fractions in a specific boiling point range. This is the product of preliminary purification.
Then, diethylamine is used as another key reactant. In another clean reaction vessel, mix the preliminarily purified product with diethylamine in a certain proportion. This ratio is crucial and affects the purity and yield of the product. Then add an appropriate amount of acid binding agent, such as triethylamine, to promote the forward progress of the reaction and reduce the generation of side reactions.
In this container, adjust the temperature to about [X] ° C, and continue the reaction number. After the reaction is completed, it goes through a series of post-processing operations, such as washing and drying. The solvent used for washing can effectively remove impurities without damaging the product. The drying process, either using a desiccant or using a reduced pressure drying method, can make the product moisture content meet the standard.
After these steps, the product of mono- (diethylamino) -4 -ethoxylbenzene can be obtained. However, during the preparation process, all conditions need to be carefully controlled, and a slight difference will affect the quality and quantity of the product.
What are the precautions for using 1- (difluoromethoxy) -4-fluorobenzene?
Diethyl ether acetylene, also known as 1- (diethoxymethyl) -4-ethynylbenzene, has many points to pay attention to during use.
First, it is necessary to pay attention to its flammable characteristics. Diethyl ether acetylene is a flammable substance that is easily flammable in case of open flames and hot topics. Therefore, in the storage and use site, it is necessary to strictly prohibit fireworks and keep away from potential ignition sources such as fire sources and heat sources. The site should be equipped with complete fire prevention facilities and fire extinguishing equipment, and personnel should also be familiar with fire extinguishing methods so that they can respond quickly in the event of a sudden fire.
Second, pay attention to its toxic effects. The substance may have certain toxicity to the human body and can invade the human body through inhalation, ingestion or skin contact. Therefore, personal protective measures should be taken during the operation, such as wearing suitable gas masks, protective gloves and protective glasses, to prevent direct contact with the skin and eyes, and at the same time ensure that the operation site has good ventilation conditions to reduce the concentration of harmful substances in the air.
Third, storage conditions are quite critical. It should be stored in a cool and ventilated warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials, so that in the event of a leak, it can be properly handled in a timely manner.
Fourth, the transportation link should not be ignored. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidants, acids, alkalis, edible chemicals, etc. During transportation, it should be protected from exposure to the sun, rain and high temperature. Stopovers should be kept away from fire, heat sources and high temperature areas.
Operating diethyl ether acetylene must strictly follow relevant safety operating procedures and precautions to ensure personnel safety and environmental safety.