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1-(Difluoromethoxy)-3-Nitrobenzene

1-(Difluoromethoxy)-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code

629949

Chemical Formula C7H5F2NO3
Molar Mass 189.116 g/mol
Appearance Typically a colorless to pale - yellow liquid or solid
Boiling Point Data may vary, generally in the range related to its molecular structure's volatility
Melting Point Specific value depends on purity and crystal form
Density A density value based on its mass - volume relationship in a particular state
Solubility In Water Low solubility due to its non - polar aromatic and fluorinated structure
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Varies with temperature, related to its volatility
Flash Point A value indicating the temperature at which it can form an ignitable vapor - air mixture

As an accredited 1-(Difluoromethoxy)-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(difluoromethoxy)-3 -nitrobenzene packaged in a sealed glass bottle.
Storage 1-(Difluoromethoxy)-3-nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions.
Shipping 1-(Difluoromethoxy)-3-nitrobenzene is shipped in specialized, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent spills and maintain safety during transit.
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1-(Difluoromethoxy)-3-Nitrobenzene 1-(Difluoromethoxy)-3-Nitrobenzene
General Information
Historical Development
1- (difluoromethoxy) -3-nitrobenzene is also one of the chemical products. Tracing its historical development, at the beginning, the academic community did not study fluorine-containing compounds in depth, and the synthesis of such substances was difficult.
However, researchers have not stopped exploring, and over the years, organic synthesis technology has gradually improved. For 1- (difluoromethoxy) -3-nitrobenzene, chemists have studied the reaction conditions and raw material ratios many times.
Early attempts, the yield was quite low and there were many impurities. After repeated tests, suitable catalysts and reaction environments were found, which gradually stabilized the synthesis process and improved the yield. From the difficulty of synthesis in the past to today's technology, the preparation process of 1- (difluoromethoxy) -3-nitrobenzene has been continuously improved, and its application in chemical, pharmaceutical and other fields has become more and more extensive. It is one of the major achievements in chemical development.
Product Overview
1- (difluoromethoxy) -3-nitrobenzene, an organic compound. It is a colorless to light yellow liquid with a special gas. The preparation of this compound is often obtained by a specific reaction path. First take a suitable benzene derivative and, under specific reaction conditions, interact with reagents containing difluoromethoxy and nitro groups.
It has a wide range of uses in the field of organic synthesis. It can be used as a key intermediary to prepare a variety of biologically active compounds, or in materials science, to participate in the synthesis of materials with special properties. Its chemical properties are active, and it can act as a reactant in many reactions, substituting and adding reactions with different reagents, and then deriving products with rich structures. Its unique structure endows it with unique application value in specific fields, making it a compound that cannot be ignored in organic chemistry research.
Physical & Chemical Properties
1 - (difluoromethoxy) -3 -nitrobenzene is a chemical research object. Its physical and chemical properties are related to the research. Looking at its physical properties, at room temperature, it may have a specific color and state, such as color or colorless to yellowish, or it may be a liquid, with a certain volatility and a special odor.
In terms of chemical properties, it is active because it contains difluoromethoxy and nitro groups. Nitro is highly oxidizing and can participate in many chemical reactions under specific conditions, such as nucleophilic substitution reactions. The presence of difluoromethoxy also affects its reactivity and selectivity.
The physicochemical properties of this compound lay the foundation for its application in organic synthesis, drug development and other fields. According to its characteristics, researchers can explore new synthesis paths and develop novel uses to promote the development of chemistry and benefit the world.
Technical Specifications & Labeling
1 - (difluoromethoxy) -3 -nitrobenzene is an important chemical product. Its process specifications and identification (product parameters) are crucial.
In the process specification, it is related to the selection of raw materials, and high-purity starting materials need to be selected to ensure a smooth reaction. The reaction conditions are rigorous, and the temperature and pressure are fixed. If the reaction temperature should be controlled within a certain range, the pressure should also meet the standards, so as to ensure the purity and yield of the product.
In terms of labeling, the product parameters need to be clear. From the appearance point of view, it should be in a specific color state. Its purity needs to reach a certain proportion, and the impurity content is strictly limited. And on the packaging, it is necessary to clearly label various parameters, such as chemical structure formula, molecular weight, etc., so that the user can see it at a glance and use it properly according to the specifications to ensure safety and effectiveness.
Preparation Method
To prepare 1- (Difluoromethoxy) -3-Nitrobenzene, the raw materials, production process, reaction steps and catalytic mechanism are as follows. First, take an appropriate amount of 3-nitrophenol as the starting material, and put it into the reactor in a certain ratio with difluorobromomethane. Add an appropriate amount of potassium carbonate as a base, acetonitrile as a solvent, and heat it up to 60-70 ° C. At this temperature, potassium carbonate promotes the deprotonation of the hydroxyl group of 3-nitrophenol to form phenoxy anions, which undergo nucleophilic substitution with difluorobromomethane. When the reaction duration is over, the reaction process is monitored by TLC. After the reaction is completed, the reaction solution is cooled and salts such as potassium carbonate are filtered off. The filtrate was distilled under reduced pressure to remove acetonitrile, and the residue was separated and purified by column chromatography to obtain the target product 1- (Difluoromethoxy) -3-Nitrobenzene. In this process, potassium carbonate efficiently promoted the nucleophilic substitution reaction and improved the yield and purity of the product.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance named 1- (Difluoromethoxy) -3-Nitrobenzene. In chemical research, its reaction and modification are very critical.
Looking at this compound, in order to understand its chemical properties, it is necessary to investigate the mechanism of its reaction. In the past, many scholars have devoted themselves to exploring the reaction path between it and other substances, hoping to obtain the best reaction conditions, so that its yield can be improved and its purity can be better.
When reacting, problems are often encountered. For example, the reaction rate is slow, or side reactions are clustered, resulting in impure products. In order to solve this dilemma, scholars have tried their best to change the reaction temperature, adjust the ratio of reactants, or find a better catalyst.
There are also many considerations in terms of modification. It is hoped that by modifying its structure, it can have new properties, or enhance its stability, or increase its activity. In this way, it can broaden its application in chemical, pharmaceutical and other fields.
In short, the chemical reaction and modification of 1- (Difluoromethoxy) -3-Nitrobenzene still need unremitting research by scholars to achieve a good environment and contribute to the development of chemistry.
Synonyms & Product Names
1 - (difluoromethoxy) - 3 - nitrobenzene, in the field of my chemical research, its namesake and trade name are quite important.
The material of chemistry has many names, and there are many people who have the same thing and different names. 1 - (difluoromethoxy) - 3 - nitrobenzene, or has another name, its name may change due to the focus of research and the practice of the industry. The trade name is related to the easy circulation of the market, and it is the number of its logo in the market.
On the occasion of research and development, it is necessary to carefully investigate its namesake, so that all the explanations are unified and not confused. The trade name should also be clear, so as to connect the way of business. The identification of the two is of great benefit to the practice of chemistry and the prosperity of the industry. Only by clarifying the same name and business name can we travel freely in the path of chemical research and industrial management, avoid the disturbance of fallacies, and promote the smooth development.
Safety & Operational Standards
1- (difluoromethoxy) -3-nitrobenzene, this chemical substance is crucial to safety and operating standards.
At the beginning of preparation, all raw materials must be carefully selected to check their purity and ensure that they meet the required standards before they can be put into use. The place of operation must be spacious, bright and well ventilated to drain harmful gases and avoid accumulation. All utensils used should be clean and intact. Wash and dry in a suitable way in advance to prevent impurities from mixing in and causing random reactions.
When operating, all steps must follow precise procedures. The order of feeding materials, the speed and urgency are all fixed. If there are reagents that are highly corrosive or toxic, such as some reagents used in the preparation of 1- (difluoromethoxy) -3-nitrobenzene, they must be taken with special equipment, and the operator should also use protective equipment, such as corrosion-resistant gloves, anti-goggles, anti-virus masks, etc., to protect themselves. The reaction temperature and time must be strictly controlled, and the temperature should be adjusted with precise temperature control equipment to monitor on time to ensure that the reaction is carried out as expected.
When storing, 1- (difluoromethoxy) -3-nitrobenzene should be placed in a cool and dry place to avoid heat, moisture, and strong light. And when placed separately from flammable, explosive, and oxidizing substances to prevent accidental reactions. The container must be well sealed, with clear name, purity, date and other information for easy inspection.
When transporting, the regulations of hazardous chemicals must be followed. Choose suitable packaging materials, such as those with buffer and leak-proof functions. Transport vehicles should also be equipped with emergency equipment, such as fire extinguishers, adsorption materials, etc. Transport personnel must be professionally trained to know the characteristics of the transported objects and emergency disposal methods.
All of these are the requirements for the safety and operation of 1- (difluoromethoxy) -3-nitrobenzene. Compliance with them can ensure smooth experimentation and production, protect personnel safety, and avoid environmental harm.
Application Area
1 - (difluoromethoxy) - 3 - nitrobenzene is also a chemical product. Its application field is quite extensive. In the field of medicine, it can be used as an intermediate to help the research and development of new drugs. With its unique structure, or can participate in specific reactions, it lays the foundation for the synthesis of drug molecules with special curative effects.
In the field of materials, this compound can also be used. Or can optimize the properties of materials, such as improving their stability and solubility. Make materials exhibit unique properties in electronic, optical and other aspects to meet the needs of different scenarios.
Furthermore, in the field of fine chemicals, 1 - (difluoromethoxy) - 3 - nitrobenzene may be a key raw material to help synthesize high-value-added fine chemicals and meet the needs of industry and life. All of these are manifested in many application fields and contain unlimited potential. It needs to be further explored by researchers to develop its great use.
Research & Development
Since modern times, the art of chemistry has become increasingly refined, and the research of various compounds has become a common practice. Today, there is 1- (Difluoromethoxy) -3-Nitrobenzene, which is the object of our dedicated research.
We have carefully observed its physical properties and chemical properties, explored its synthesis method, and studied the influence of changing conditions on its yield and purity. After repeated experiments and detailed analysis of the data, we have initially obtained the best way to synthesize. However, if you want to achieve perfection, you still need to make progress.
At the application end, we will test its potential in the fields of medicine and materials, hoping to open up new avenues and contribute to the advancement of science and technology and the benefit of people's livelihood. Although the road ahead is long, we are determined to achieve scientific breakthroughs through the research of this product, promote the prosperity of the industry, and seek far-reaching benefits for the development of future generations.
Toxicity Research
The nature of taste and smell is related to people's livelihood, and the study of toxicity is particularly important. Today there is 1- (Difluoromethoxy) -3-Nitrobenzene, and the study of its toxicity should not be ignored.
View its chemical properties, the genus of fluorine and nitro, or the risk of cryptotoxicity. Fluoride, although there may be changes in the physical state, may be involved in excess, which may damage the human body. Nitro enters the body, or disturbs the transportation of qi and blood, and the ability of the viscera.
From an experimental point of view, when small animals touch it, or show discomfort, and stop abnormally, the physiological signs also change. Loss of fur, diet or loss, and even weakness of vitality.
And this thing should not be careless in the environment. Its decomposition path and transmission path need to be carefully investigated. Or sewage soil, or dye the air, endangering all spirits.
Therefore, the study of the toxicity of 1- (Difluoromethoxy) -3-Nitrobenzene requires public wisdom, probing its subtleties, and understanding its harm in order to maintain the well-being of the people and the environment.
Future Prospects
The future development is related to (1 - (Difluoromethoxy) -3 - Nitrobenzene). Our generation of chemical researchers holds great hope for this product. It has extraordinary potential in many fields. Looking at the progress of today's chemical industry, the technology is new and the exploration is endless.
We hope that in the field of medicine, it can add new paths to cure diseases and save people. Or it can help develop special drugs to solve the suffering of patients. In terms of materials, we hope it will become a high-quality raw material, which can be tough, durable and have special properties to meet the needs of construction, electronics and other industries.
Although there may be thorns in the road ahead, scientific exploration is fearless and difficult. We will do our best to study technology and optimize the process. In the near future, (1 - (Difluoromethoxy) -3 - Nitrobenzene) will surely shine, contributing to human well-being and social progress, and developing infinite possibilities.
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Frequently Asked Questions

As a leading 1-(Difluoromethoxy)-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (difluoromethoxy) -3-nitrobenzene?
The main use of 1 - (diethylamino) - 3 -pyridylbenzene is its important role in the field of chemical research.
In terms of research, this compound is often used as an important chemical compound. Its special chemical properties make it possible to synthesize multiple compounds. For example, in the research and synthesis process of some anti-tumor compounds, 1 - (diethylamino) - 3 -pyridylbenzene can be used as a starting material to gradually produce molecules with specific biological activities from a series of reactions. Because of the diethylamino-pyridylbenzene part in the product, it can interact with specific target proteins in biology, and the drug can be used for therapeutic effects.
In the field of chemical research, it is also an important synthetic method. Chemists can use its active functionalities to perform multiple chemical reactions such as nuclear substitution, even, etc., to synthesize a series of chemical compounds with special chemical properties. These newly synthesized compounds cannot be made of chemical-rich substances, and may exhibit special chemical properties in the field of materials, such as for materials with special optical properties.
In addition, in some research studies, 1 - (diethylamino) - 3 - pyridylbenzene can be used to build cellular models or chemical models to explore the disease management of related diseases and the role of chemical substances.
What are the physical properties of 1- (difluoromethoxy) -3-nitrobenzene?
1 - (diethylamino) - 3 -cyanopyridine, this physical property is quite unique. Its properties are often crystalline, with pure white matter. It looks like finely crushed agaris, and under light, it shines slightly.
When it comes to the melting point, it is about a specific range, just like when ice melts warm, it has a fixed transition point. This temperature is crucial for judging its purity and characteristics. When heated to this temperature, the crystal quietly conforms to fate and gradually converts from a solid state into a liquid state.
Furthermore, its solubility is also characteristic. In water, it is only slightly soluble, just like raindrops falling on lotus leaves, most of it remains on the surface, and only a little is integrated into it. However, organic solvents, such as ethanol and acetone, can be better miscible with each other, just like a wanderer returning home, naturally integrating into the suitable environment. This property has become a key basis for many chemical operations, such as separation and purification.
Its stability should not be underestimated. Under normal conditions of normal temperature and pressure, and without the intrusion of special chemical reagents, it can maintain its own structure intact, just like a hermit, holding on to itself in tranquility. But if the environment suddenly changes, the temperature is too high, or it encounters strong oxidants, strong acids and alkalis, etc., its molecular structure may change like a mantle, triggering chemical reactions and generating other substances.
These physical properties are indispensable factors in the field of chemical production and drug research and development. In chemical production, according to its melting point and solubility, a reasonable process can be designed to achieve efficient preparation; in drug development, its stability and solubility in different solvents are related to the dosage form design and efficacy of the drug. It is like a precision gear, silently pushing forward in the giant wheel of science.
What are the chemical properties of 1- (difluoromethoxy) -3-nitrobenzene?
1 - (diethylamino) - 3 -pyridyl indole, this is a class of organic compounds. Its chemical properties are unique and it has important applications in many fields.
From the structural point of view, the compound contains diethylamino and pyridyl indole structural units. In diethylamino, the nitrogen atom has lone pair electrons, which endows it with a certain alkalinity. Under appropriate conditions, it can react with acids to generate corresponding salts. Moreover, because diethylamino is the power supply group, it will affect the distribution of the molecular electron cloud, increasing the density of the electron cloud connected to it, so that the region is more prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. Electrophilic reactions are more likely to unfold at specific locations in the benzene ring.
Pyridyl indole part, the presence of pyridyl ring changes the original electron cloud distribution of indole. Pyridyl ring has certain aromatic and basic properties, and can participate in the reaction as an electron receptor in some reactions. Indole structure is a key structural fragment of many bioactive molecules and drugs, endowing compounds with potential biological activity.
In terms of chemical reactivity, 1- (diethylamino) -3 -pyridyl indole can participate in a variety of organic synthesis reactions. For example, based on the reactivity of the indole ring, Fu-gram alkylation or acylation reactions can occur, introducing other functional groups at specific positions of the indole ring, expanding the molecular structure complexity and providing the possibility for the preparation of compounds with more specific functions. At the same time, nitrogen atoms on the pyridine ring can participate in coordination chemistry to form complexes with metal ions, which may have potential applications in the field of catalysis. Metal complexes may exhibit unique catalytic properties for catalyzing specific organic reactions.
In terms of physical properties, the solubility of the compound is affected by the polar groups in its structure. Diethylamino has a certain polarity, while pyridine ring and indole ring are non-polar aromatic structures. Under the synthesis, it may have good solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide, etc., which is conducive to separation and purification as a reaction substrate or product in organic synthesis operations.
In short, 1 - (diethylamino) -3 -pyridyl indole has diverse chemical properties due to its special chemical structure, and may have broad application prospects and research value in many fields such as organic synthesis, medicinal chemistry and materials science.
What is the production method of 1- (difluoromethoxy) -3-nitrobenzene?
To make 1 - (diethylamino) - 3 - cyanobenzene, you can follow the following ancient methods:
The first raw material, take an appropriate amount of benzene as the group, and prepare diethylamine, cyanide reagents, etc., all things need to be pure and the amount is correct, this is the basis of the preparation.
First make the benzene substitution reaction. In a suitable device, control the temperature at a suitable temperature, add benzene and an appropriate amount of halogenated reagents, often with brominated or chlorinated agents, to promote the formation of halogenated benzene. In this step, you need to pay attention to the reaction situation. If the temperature is too high, it will be by-product of impurities, and if it is low, the reaction will be delayed. After the reaction is completed,
times, place halogenated benzene and diethylamine in the reaction kettle. Add an appropriate amount of base, such as potassium carbonate or the like, as an acid binding agent. Heat up to a suitable degree, so that the two perform nucleophilic substitution reaction. In the meantime, stir evenly to make the reaction sufficient. After the reaction is completed, extract, distillation, etc. to remove impurities and purify to obtain 1- (diethylamino) benzene.
Then introduce a cyanide group into it. Use 1- (diethylamino) benzene as the substrate, and select a suitable cyanide reagent, such as cuprous cyanide, etc. In a specific solvent, such as N, N-dimethylformamide, heating and stirring, so that the cyano group can smoothly replace the hydrogen at a specific position of the benzene ring to form 1- (diethylamino) -3-cyanobenzene. Finally, through recrystallization, column chromatography and other fine purification methods, the pure product is obtained to meet all needs. Every step is about success or failure, and strict procedures must be followed to obtain good products.
What are the precautions for using 1- (difluoromethoxy) -3-nitrobenzene?
When using 1 - (diethylamino) -3 -pyridyl chromone, many things should be paid attention to.
First, this substance has specific chemical activity, and when using it, you must follow the standard operating procedures. Do not touch it with your bare hands to prevent it from coming into contact with the skin, causing skin allergies or other damage. When operating, wear appropriate protective gloves and preferably protective clothing to protect yourself.
Second, this substance may react with other chemicals under certain conditions. Therefore, during storage and use, it should be strictly avoided to mix with unknown chemicals at will. Before use, it is necessary to understand the chemical properties of other reagents with it in detail, and confirm in advance whether the two will have adverse reactions, such as violent reactions, toxic gases, etc.
Third, the preservation of 1- (diethylamino) -3 -pyridylchrone is also very critical. It needs to be stored in a dry, cool and well-ventilated place, away from fire and heat sources. Because it may be flammable or sensitive to temperature, improper storage environment or danger. At the same time, it should be sealed and stored to prevent it from reacting with moisture, oxygen and other components in the air, which will affect its chemical properties and quality.
Fourth, when using 1 - (diethylamino) -3 - pyridyl chromone in the experiment or production process, the relevant places should be equipped with complete ventilation facilities. If there is gas generated during operation, good ventilation can discharge it in time to avoid the accumulation of harmful gases in the air, so as to ensure the safety of the operator's breathing.
Fifth, the amount of 1 - (diethylamino) -3 - pyridyl chromone used must be precisely controlled. Excessive use may not only cause waste of resources, but also lead to unexpected side reactions, which may adversely affect the quality and yield of the final product. Before use, the appropriate dosage should be determined by accurate calculation according to the experimental purpose or production requirements.