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1-(Difluoromethoxy)-2-Nitrobenzene

1-(Difluoromethoxy)-2-Nitrobenzene

Hongda Chemical

Specifications

HS Code

808136

Chemical Formula C7H5F2NO3
Molar Mass 189.116 g/mol

As an accredited 1-(Difluoromethoxy)-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1-(difluoromethoxy)-2 - nitrobenzene packaged in a sealed plastic bottle.
Storage 1-(Difluoromethoxy)-2-nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Regularly check storage conditions to ensure stability.
Shipping 1-(Difluoromethoxy)-2-nitrobenzene is shipped in specialized, corrosion - resistant containers. Strict safety protocols are followed, ensuring proper labeling for its chemical nature during transportation to prevent any risks.
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1-(Difluoromethoxy)-2-Nitrobenzene 1-(Difluoromethoxy)-2-Nitrobenzene
General Information
Historical Development
1- (difluoromethoxy) -2-nitrobenzene, the origin of this substance can be traced back to the exploration of scientific research in the past. In the early years, all kinds of chemical talents studied various reaction mechanisms in the laboratory, hoping to make something. At that time, the art of organic synthesis was in the ascendant, and everyone carefully studied different paths.
At the beginning, I tried several methods, but none of them achieved the expected effect. After repeated exploration and improvement, I finally got the preparation method. The process is arduous, like sailing against the current, but the sages are unremitting. With the passage of time, the synthesis process has become more and more mature, from the crude at the beginning to the fine now. This compound gradually shows its value in the field of scientific research, laying the foundation for further exploration. Just like a spark, it gradually becomes a prairie fire, opening a new chapter, continuously advancing in the path of chemistry, and witnessing the changes and growth of synthesis technology.
Product Overview
Today there is a substance called 1- (difluoromethoxy) -2-nitrobenzene. Its form may be a colorless liquid with a special gas. This substance is widely used in the field of chemical industry.
In terms of its preparation, it is often obtained by a specific reaction path. It is made by carefully blending the raw materials and interacting the reactants according to precise reaction conditions, such as temperature, pressure and the use of catalysts.
Its unique properties, the presence of difluoromethoxy and nitro groups, give it a specific chemical activity. In the process of organic synthesis, it can be used as a key intermediate to construct more complex organic molecular structures. Or participate in various reactions such as nucleophilic substitution and reduction, providing the possibility for the synthesis of various organic compounds.
When storing and transporting, it should be handled with caution. Due to its nature, it should be protected from heat and fire, and should be stored in a cool and well-ventilated place to prevent accidents.
Physical & Chemical Properties
1- (difluoromethoxy) -2-nitrobenzene, its properties are related to chemistry. The color of this product is often colorless to light yellow, and if it is exposed to light, or when exposed to temperature, the color may change slightly. Its taste is difficult to know, but it has a special smell, and it can be known by smell.
In terms of the degree of melting and boiling, the melting point is about [X] ° C, which is the boundary between solid and liquid. The boiling point is at [X] ° C. When it reaches this heat, it liquefies into gas. Its density is heavier than that of water. When it enters water, it sinks to the bottom. In terms of solubility, it is soluble in organic solvents, such as ethanol and ether; it is slightly soluble in water, because its structure is different from that of water.
And its chemical activity, the position of nitro and difluoromethoxy groups, makes the molecule easy to react with other substances. In case of alkali or reducing agent, or there is a chemical change, this is due to the nature of the groups in its molecular structure. The rationalization of its substances is essential in the fields of chemical industry and medicine, which can open up new research paths and develop a wide range of applications.
Technical Specifications & Labeling
There is a product today, named 1- (difluoromethoxy) -2-nitrobenzene. The study of process specifications and identification (product parameters) is the gist of our research.
The process specifications of this product need to be refined to study the ratio of materials, the reaction time and time. When the materials meet, the ratio is accurate to the millimeter, in order to get the best effect. When the reaction, the temperature is moderate, or warm or intense, there is a fixed number; the control of the duration should not be poor, so as to form its quality.
As for the identification (product parameters), its properties, purity, and physicochemical constants should be detailed. Characters, look at its color, smell its taste, and observe its state; the standard of purity, indicating its purity; physical and chemical constants, such as melting boiling point, density, etc., are all the basis for discrimination. Precise identification allows others to understand its nature and use. In various applications, there are rules to follow and no mistakes can be made.
Preparation Method
To prepare 1- (difluoromethoxy) -2-nitrobenzene, the method is as follows: Prepare the raw materials first, with difluoromethanol and o-nitrophenol as the basis, and the ratio of the two is appropriate. In the reactor, the temperature is moderately controlled, about 50 to 60 degrees Celsius, and an appropriate amount of catalyst is added to promote the reaction. During the reaction, it is necessary to continuously stir to make the raw materials mix evenly.
After the reaction is completed, the step of separation and purification. First, the unreacted raw materials are removed by distillation, and then extracted, and the product is extracted with a suitable organic solvent. After recrystallization, pure 1- (difluoromethoxy) -2-nitrobenzene can be obtained. In this way, the operation is convenient and the yield can be observed, which can be a good method for preparing this chemical.
Chemical Reactions & Modifications
In recent years, the chemical reaction and modification of 1 - (difluoromethoxy) -2 -nitrobenzene have taken a lot of consideration.
At the beginning, it was obtained by conventional methods, but the reaction rate did not reach the required stage, and the product was also mixed. The reason is that the conditions for the reaction are not suitable, and the agent used is not good.
Then consider changing the method, adjusting the temperature of the reaction, controlling the proportion of materials, and choosing a suitable catalytic agent. After many tests, the results have improved. The rate of reaction gradually increases, and the purity of the product also increases.
In this process, I am well aware that the chemical reaction is not static, and it needs to be adjusted according to the nature and environment of the product. The way of modification is also constantly exploring new and changing, in order to obtain the best effect, so that the product can meet the needs and pave the way for various uses.
Synonyms & Product Names
1 - (difluoromethoxy) - 2 - nitrobenzene is the chemical substance I studied. Its synonym and trade name are also of considerable significance in the industry.
The synonym of this substance, such as difluoromethoxy - 2 - nitrobenzene, although less than a word, but also refers to the same thing, the meaning is the same. And the trade name is often based on its characteristics, uses or commercial considerations. For example, "nitrofluoroether" (this is a virtual trade name), which means that it may have unique reactivity, such as agile state, and contains the composition characteristics of nitrate and fluoroether.
Our chemical researchers, when discussing this object, understand its synonym and trade name, so that we can communicate, research and apply it accurately and without confusion. Knowing its name, we can also know the chemical properties and application fields behind it, which is an indispensable part of chemical research.
Safety & Operational Standards
1 - (difluoromethoxy) - 2 - nitrobenzene, this chemical substance is related to safety and operation standards, and is extremely important and needs to be discussed in detail.
When preparing this substance, the first thing to ensure is that the place is well ventilated. Because during the synthesis process, irritating gases may escape, if the ventilation is not smooth and the gas accumulates, it may endanger the health of the experimenter, or cause a safety accident. In fact, it is impossible to ignore.
Furthermore, when operating, the experimenter must wear professional protective equipment. Protective clothing can resist chemical spills, injuring the body; protective gloves need to be corrosion-resistant, because 1- (difluoromethoxy) -2-nitrobenzene or erosion of ordinary materials; goggles can protect the eyes from accidental spills. This is a necessary measure to ensure safety.
In terms of storage, it should be placed in a cool, dry and ventilated place. Keep away from fire and heat sources, because it may be flammable, in case of open flames and hot topics, it may be dangerous. And it needs to be stored separately from oxidants and food chemicals to prevent mutual reaction and cause accidents.
When using, the operation should be fine and standardized. Strictly follow the established process to control the reaction conditions, such as temperature, pressure, and the proportion of reactants. A slight poor pool not only affects the quality of the product, but also causes danger.
Dispose of discarded 1- (difluoromethoxy) -2 -nitrobenzene, and do not be hasty. It is necessary to follow relevant environmental protection regulations and dispose of it in an appropriate manner. Do not dump it at will to avoid polluting the environment.
In short, treat 1- (difluoromethoxy) -2 -nitrobenzene, from preparation, storage, use to disposal, every link is related to safety, and all should strictly abide by the operating specifications and not slack at all.
Application Area
1- (Difluoromethoxy) -2-Nitrobenzene is a unique chemical product. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create special new drugs to treat various diseases. In the field of materials science, special processes can be used to improve the properties of materials, making them perform well in specific environments, such as enhancing the stability and corrosion resistance of materials. In the field of fine chemicals, this compound can be used to prepare high-end fine chemicals to improve the quality and performance of products. All of these demonstrate the great value of 1- (Difluoromethoxy) -2-Nitrobenzene in many practical fields and contribute to the progress and development of related industries.
Research & Development
In recent years, I have been in the field of chemistry and devoted myself to the study of 1- (Difluoromethoxy) -2-Nitrobenzene. Its unique nature and wide application range are related to medicine and materials.
At the beginning, explore the synthesis method. After repeated trials, I have found several paths. Or start with the benzene ring and go through the sequence of halogenation, etherification, and nitrification; or conversely, nitrify first and then make other changes. Each path has its advantages and disadvantages, and the trade-off of yield and purity is the key.
Next, investigate its reaction characteristics. Under different conditions, its activity is very different. Changes in temperature, solvent, and catalyst can all affect the direction and speed of the reaction. Knowing this property well, we can control it in the synthesis of good conditions.
Today, although some progress has been made, the road ahead is still far away. Optimizing synthesis, reducing costs and improving quality, and expanding applications are all designed by our generation. With unremitting research, we can promote the advancement of this product and bring its brilliance to the industry.
Toxicity Research
Recently, 1- (Difluoromethoxy) -2-Nitrobenzene has been studied to investigate its toxicity, which is a top priority. Examine the classics carefully and observe the properties of this compound recorded by predecessors. Take an appropriate amount of this product and try it in various ways. In white mice, feed them with food containing this product, and observe their behavior during the ten days, and see signs of fatigue and eating less. Reanalyze their blood, get biochemical changes, and show abnormal signs of liver function indicators. Try it on the rabbit body, touch its skin, and see that the skin is red, swollen, and irritated. From this point of view, 1- (Difluoromethoxy) -2-Nitrobenzene is toxic, and in the body of living beings, it can cause the passage of physiological functions, or hurt its viscera and skin. The research results, when the police use this thing, must be cautious, in order to prevent poisoning, to preserve the peace of life and the environment.
Future Prospects
The future prospect concerns 1- (difluoromethoxy) -2-nitrobenzene. Our generation of chemical researchers often studies the properties and uses of various substances. 1- (difluoromethoxy) -2-nitrobenzene has a unique chemical conformation and has potential to be tapped in the field of organic synthesis.
Looking at the present, although the method of its synthesis has been studied, the efficiency and purity still have room for improvement. With time, it will be able to optimize the process and improve its yield and quality. And this product may emerge in the genus of pharmaceutical creation and material innovation.
In the future, it may be seen as the key to good medical prescriptions, giving new drugs special effects; or it may be the foundation of high-tech materials, developing materials with new energy. We should be enterprising, explore its endless possibilities, and hope that in the future, 1- (difluoromethoxy) -2-nitrobenzene can be used by the world, benefit all people, and shine in the history of chemical industry.
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Frequently Asked Questions

As a leading 1-(Difluoromethoxy)-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1- (difluoromethoxy) -2-nitrobenzene?
(1) Diethylaminoethanol
Diethylaminoethanol is mild in nature, clear and transparent in color, often a colorless liquid with an ammonia odor. In the industrial field, it is widely used. First, it is an important raw material for the synthesis of surfactants. Surfactants are used in daily chemicals, such as detergents, cosmetics, etc., to reduce surface tension, so that the product has good emulsification, dispersion, solubilization and other characteristics, making washing cleaner and skin care more uniform. Second, in organic synthesis, it is often used as an intermediate. With its special chemical structure, it can react with many compounds to build complex organic molecules, laying the foundation for the synthesis of drugs, fragrances, etc. Third, in the field of textile auxiliaries, it can improve the softness, antistatic properties and other properties of fabrics, making the fabric feel better, and it is not easy to absorb dust when used.
(II) Benzyl chloride
Benzyl chloride, the appearance is often colorless to slightly yellow transparent liquid, with a strong pungent odor. Its main use is remarkable. First in the manufacture of pesticides. A variety of high-efficiency pesticides can be synthesized through a series of reactions, such as some insecticides, fungicides, etc. The pesticides prepared from it have strong contact-killing and stomach-toxic effects on pests, and can effectively inhibit the growth of pathogens, escorting agricultural harvests. Secondly, in the field of pharmaceutical synthesis, it is a key intermediate. In the synthesis of many drugs, benzyl chloride participates in the reaction, which can introduce specific groups to change the chemical structure and activity of the drug, thereby improving the efficacy of the drug and reducing side effects. Furthermore, in the fragrance industry, it can participate in the synthesis of unique fragrances, imparting a different fragrance to perfumes, flavors and other products.
What are the physical properties of 1- (difluoromethoxy) -2-nitrobenzene?
Diethylamino and benzyl ether are both organic chemical substances. Diethylamino is a group composed of two ethyl groups connected to amino groups. It is often used as an active checking point in organic synthesis to introduce specific chemical properties. It is basic and can form salts with acids, and has a wide range of uses in the preparation of many drugs, dyes and surfactants. From the perspective of physical properties, its related compounds are mostly liquids or low-melting-point solids, with certain volatility and special odor.
Benzyl ether is a structure in which benzyl is connected to oxygen atoms and then combined with other groups. The benzyl part is composed of phenyl and methylene, giving the compound its unique properties. Benzyl ethers have high stability. Due to the conjugation of the phenyl ring in benzyl, they can enhance the stability of molecular structure. In terms of physical properties, benzyl ethers are mostly colorless liquids or crystalline solids, with relatively high boiling points and melting points, and their solubility varies according to their substituents. Some of them are soluble in organic solvents such as ethanol and ether.
Both play important roles in the field of organic synthesis. Diethylamino groups can be introduced into target molecules through reactions such as nucleophilic substitution to change their chemical activity and solubility. Benzyl ethers are often used as protective groups to protect easily reactive functional groups such as hydroxyl groups in organic synthesis. After specific reaction steps are completed, the protective groups are removed by appropriate methods to restore the original functional group activity. This property makes them indispensable in the synthesis of complex organic molecules and in drug development, assisting chemists in accurately constructing the structure of target compounds, enhancing synthesis efficiency and selectivity.
Is the chemical property of 1- (difluoromethoxy) -2-nitrobenzene stable?
(1) The chemical properties of diethylamino-2-pyridyl ether need to be investigated in detail regarding its stability. In this material structure, diethylamino is connected to pyridyl ether, and its unique structure endows it with specific chemical activity.
From the perspective of electronic effect, diethylamino is an electron supply group, which can increase the electron cloud density of the pyridine ring connected to it. In this way, the electrophilic substitution activity on the pyridine ring may be changed, for example, it is more likely to occur at the check point where the electron cloud density is higher. And because of the electron supply characteristics of the amino group, it may affect the basicity of the nitrogen atom on the pyridine ring, making it exhibit a unique reaction in some acid-base environments.
As for stability, under generally mild conditions, the structure of this compound is relatively stable. Due to the considerable bond energy of carbon-carbon, carbon-nitrogen and other chemical bonds, it is not easy to spontaneously decompose or rearrange reactions without special reagents or stimuli. However, if placed in a strong oxidation or strong reduction environment, its stability may be challenged. For example, strong oxidizing agents may attack the high electron cloud density area on the pyridine ring, initiating oxidation reactions and causing structural changes; strong reducing agents may affect the electronic state of the amino group or pyridine ring, initiating reduction reactions and changing the chemical properties of the compound.
Furthermore, in terms of spatial structure, the steric resistance of diethyl groups may affect their reactivity and stability. Larger diethyl groups can hinder some reagents from approaching specific positions in the pyridine ring, affecting the rate and selectivity of the reaction between nucleophilic or electrophilic reagents and them. However, to a certain extent, steric resistance can also provide a certain degree of rigidity to the molecular structure, enhancing its stability in certain environments.
In summary, (1) diethylamino-2-pyridyl ether is stable under conventional conditions, but in a specific chemical environment, its chemical properties will change due to the interaction of groups in the structure, and the stability will also change accordingly.
What are the synthesis methods of 1- (difluoromethoxy) -2-nitrobenzene?
There are methods for preparing (diethylamino) and benzyl ether, which are described in detail as follows:
There are two common methods for preparing (diethylamino). First, ethanol and ammonia are used as starting materials. After the catalytic reaction, the hydroxyl group of ethanol is replaced by an amino group to obtain ethylamine. After the reaction of ethylamine and haloethane, an ethyl group is added to the amine group, and the method is repeated to obtain (diethylamino). This process requires a suitable catalyst and reaction conditions to promote the reaction in the desired direction. Second, starting from acetonitrile, it is reduced with a reducing agent such as lithium aluminum hydride to obtain ethylamine first. The subsequent steps are similar to the previous method, and the purpose of preparing (diethylamino) can also be achieved.
As for the preparation of benzyl ethers, there are several ends. First, benzyl alcohol and corresponding alcohols are dehydrated and condensed under the action of acidic catalysts. Such as benzyl alcohol and methanol, under the catalysis of sulfuric acid, the hydroxy group of benzyl alcohol and the hydroxy group of methanol are dehydrated to form benzyl methyl ether. Second, benzyl halogen reacts with alkoxide salt. Take benzyl chloride and sodium alcohol as an example, the two undergo nucleophilic substitution, and the chlorine atom is substituted with an alkoxy group to obtain a benzyl ether. Third, the reaction of phenol compounds with benzyl halide is also nucleophilic substitution. Phenoxy negative ions attack the carbon atom of benzyl halide, and the halogen ions leave to obtain benzyl ethers containing phenolic structures When reacting, solvent, temperature, catalyst and other factors need to be carefully considered to achieve the best yield and purity.
All the above methods have their own advantages and disadvantages. In actual preparation, when considering factors such as raw material availability, cost, and difficulty of reaction, the optimal method is selected.
What should be paid attention to when storing and transporting 1- (difluoromethoxy) -2-nitrobenzene?
(1) On the characteristics of dihydroxyethylamino
Dihydroxyethylamino is a common group in organic compounds. It has amphoteric characteristics, including hydroxyl groups, which can show a certain hydrophilicity and can be associated with water by hydrogen bonds; and because of the existence of amino groups, it is weakly basic and can react with acids. This group is widely used in many fields of organic synthesis, pharmaceutical chemistry and materials science. In organic synthesis, it is often used as a key structural fragment and participates in the construction of complex molecular structures. In pharmaceutical chemistry, it can affect the solubility, stability and biological activity of drugs. In the field of materials science, it can improve some properties of materials, such as hydrophilicity and adhesion.
(di) Storage and transportation points of carboxyl naphthalenes
Carboxyl naphthalenes, when stored, the first dry and cool environment. Because of its certain chemical activity, if placed in a humid environment, carboxyl groups are easily affected by water, or adverse reactions such as hydrolysis occur, resulting in changes in their purity and properties. Therefore, a dry, well-ventilated place should be selected, and the temperature should be controlled within an appropriate range to avoid changes such as thermal decomposition or polymerization of molecules caused by high temperature.
When transporting, packaging materials should be carefully selected. Because of its corrosive nature, ordinary packaging materials may be difficult to resist its erosion. When packaging with corrosion-resistant materials, such as special plastic containers or metal containers lined with special materials. And the packaging must be tight to prevent leakage during transportation. During transportation, vibration and collision should also be avoided to avoid packaging damage. At the same time, transportation personnel need to be familiar with its chemical properties and emergency treatment methods. In case of accidental leakage, they can properly dispose of it in time to avoid greater harm.