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What are the main uses of 1-Cyclopentyl-2- (Trifluoromethyl) Benzene?
1-Cyclopentyl-2- (trifluoromethyl) benzene, this is an organic compound with a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. With its unique structure, it can participate in a variety of chemical reactions, such as nucleophilic substitution reaction, electrophilic substitution reaction, etc. Through nucleophilic substitution, the check point of the connection between cyclopentyl and benzene ring can be introduced into other functional groups, laying the foundation for the construction of more complex organic molecules. During electrophilic substitution, the hydrogen atom on the benzene ring can be replaced by other groups, enriching the structure and properties of compounds, and assisting in the synthesis of organic materials with specific functions. For example, it may play an important role in the synthesis of optoelectronic materials.
In the field of medicinal chemistry, or with potential biological activity. Due to the presence of trifluoromethyl, this group can significantly change the physical and chemical properties of the compound, such as increasing fat solubility, which is conducive to drug penetration through biofilms and improving bioavailability. Scientists may use this as a starting material, through a series of chemical modifications and screening, to develop new drugs for the treatment of specific diseases.
In terms of materials science, this compound may be used to prepare polymer materials with special properties. Introduce it into polymer systems as a monomer or additive. With the characteristics of trifluoromethyl, it imparts excellent properties such as chemical resistance and low surface energy to the material, and is used to manufacture high-performance materials required in aerospace, electronic devices and other fields.
In summary, 1-cyclopentyl-2 - (trifluoromethyl) benzene has shown important uses in many fields such as organic synthesis, medicinal chemistry, and materials science due to its unique structure, providing a key material basis and research direction for the development of various fields.
What are the physical properties of 1-Cyclopentyl-2- (Trifluoromethyl) Benzene?
1-Cyclopentyl-2- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite impressive.
Looking at its properties, under normal circumstances, it is mostly a colorless to light yellow liquid, clear and transparent. Its smell is slightly special aromatic, although not rich, it is also clearly recognizable.
As for the melting point, it is about -40 ° C. The characteristics of this low temperature make it difficult to solidify in ordinary environments. The boiling point is roughly between 200 and 210 ° C. A higher temperature is required to gasify it.
Its density is heavier than that of water, about 1.2 g/cm ³. When put into water, it will sink to the bottom of the water. In terms of solubility, this substance is insoluble in water, and its molecular structure is mostly non-polar, and the interaction with water molecules is weak. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it can dissolve well. Due to the principle of similar compatibility, the non-polar or weakly polar characteristics of organic solvents are compatible with 1-cyclopentyl-2 - (trifluoromethyl) benzene.
Furthermore, its refractive index is also an important physical property, about 1.48 - 1.50, which reflects the degree of refraction of light passing through the substance, and is of great reference value when identifying and analyzing this compound.
All these physical properties are key elements for the understanding and study of 1-cyclopentyl-2 - (trifluoromethyl) benzene, and are of great significance in many fields such as organic synthesis and materials science.
What are the synthesis methods of 1-Cyclopentyl-2- (Trifluoromethyl) Benzene?
There are several ways to synthesize 1-cyclopentyl-2 - (trifluoromethyl) benzene. One is the Suzuki-Miyaura coupling reaction between aryl halides and cyclopentyl boronic acid. This reaction requires the participation of palladium catalysts and bases, and is carried out in an appropriate solvent. In aryl halides, the activity of halogen atoms is very critical, usually iodine has the highest activity, followed by bromine, and chlorine has relatively low activity. Base agents such as potassium carbonate and sodium carbonate can adjust the pH of the reaction system and promote the smooth occurrence of the reaction. Solvents such as dioxane and toluene can provide a suitable environment for the reaction.
Furthermore, it can be achieved by Fu-g alkylation reaction. Using 2 - (trifluoromethyl) benzene as the substrate, cyclopentyl halide or cyclopentene as the alkylation reagent, under the action of Lewis acid catalysts such as aluminum trichloride, titanium tetrachloride, etc., the cyclopentyl group is connected to the benzene ring. This reaction condition needs to be strictly controlled. Because Lewis acid has high activity, it is easy to initiate side reactions such as polyalkylation.
Or by the Grignard reagent method. First prepare cyclopentyl Grignard reagent, which can be obtained by reacting cyclopentyl halide with magnesium in anhydrous ethyl ether or tetrahydrofuran. Subsequently, it is reacted with 2 - (trifluoromethyl) benzaldehyde or the corresponding carbonyl compound, and through the hydrolysis step, 1-cyclopentyl-2 - (trifluoromethyl) benzene is finally obtained. This method requires strict reaction environment and requires anhydrous and anaerobic conditions to prevent Grignard's reagent from decomposing in contact with water or oxygen.
The above methods have their own advantages and disadvantages. In actual synthesis, the choice should be made carefully according to many factors such as the availability of raw materials, the difficulty of reaction conditions and the purity of the target product.
What are the precautions for 1-Cyclopentyl-2- (Trifluoromethyl) Benzene in storage and transportation?
1-Cyclopentyl-2 - (trifluoromethyl) benzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound may have certain reactivity and should be placed in a cool, dry and well-ventilated place. Due to high temperature and humidity, it is easy to cause chemical reactions and damage the quality. If it is heated, or the molecular structure changes, and even triggers decomposition reactions, it must not be prevented. Its storage place must also be kept away from fire, heat sources, and must not be mixed with oxidants, acids, bases and other substances. Such substances may react violently with 1-cyclopentyl-2- (trifluoromethyl) benzene, resulting in danger. Furthermore, the storage container must be tightly sealed to prevent its volatilization and escape. First, to avoid loss, and second, to prevent its diffusion in the air, endangering the environment and personal safety.
Times and transportation. When transporting, the selected packaging material must be solid and durable, and can effectively resist vibration, collision and friction. And the packaging should be in accordance with relevant regulations, posted clearly and clearly hazard signs to warn transporters and other relevant personnel. Transportation vehicles should also be equipped with good ventilation equipment. If there is a leak on the way, the volatile gas can be dissipated in time to reduce the danger. During transportation, drivers and escorts must always pay attention to the status of the goods and must not leave their posts without authorization. Once any abnormalities are detected, such as leaks, odors, etc., corresponding measures should be taken immediately, such as evacuating the crowd, sealing the scene, and promptly reporting to the relevant departments.
In short, the storage and transportation of 1-cyclopentyl-2- (trifluoromethyl) benzene is related to safety and quality. All links must not be slack, and relevant norms and requirements must be strictly followed to ensure foolproof.
What is the market price of 1-Cyclopentyl-2- (Trifluoromethyl) Benzene?
There is a question today about the market price of 1-cyclopentyl-2- (trifluoromethyl) benzene. However, the market is unpredictable, and this price is difficult to determine.
To know the details, you can observe it from various paths. First, the supply and demand of the market is the key. If there are many people who need this product, but there are few suppliers, the price will increase; conversely, if the supply exceeds the demand, the price will be reduced.
Second, the difficulty of its production also depends on the price. If the production requires rare materials, and the process is complicated, requiring more manpower and material resources, the cost will be high, and the price will not be low.
Third, the competition in the market also has an impact. If there are many such products and the price is good, the price of this product is a contentious market, or its price can be reduced.
Fourth, changes in the current situation, such as the issuance of decrees and trade regulations, can make the price fluctuate. If taxes are increased, the cost will increase, and the price may rise; conversely, if there is a supportive policy, the price may be reduced.
As for the actual price, you can visit the chemical material merchants and ask them for quotations. You can also observe the recent transaction price of the online chemical trading platform for reference. However, the market changes rapidly, and the price varies from time to time. It is necessary to observe in real time to obtain a more accurate price.