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1-(Chloromethyl)-4-Fluorobenzene

1-(Chloromethyl)-4-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    566480

    Chemical Formula C7H6ClF
    Molar Mass 144.573 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 177 - 178 °C
    Density 1.198 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point 62 °C
    Odor Pungent odor
    Stability Stable under normal conditions, but reacts with strong oxidizing agents

    As an accredited 1-(Chloromethyl)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1-(chloromethyl)-4-fluorobenzene packaged in a sealed, chemical - resistant bottle.
    Storage 1-(Chloromethyl)-4-fluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reactive chemicals, and incompatible substances to prevent dangerous reactions.
    Shipping 1-(Chloromethyl)-4-fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling and documentation to ensure safe transport.
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    1-(Chloromethyl)-4-Fluorobenzene 1-(Chloromethyl)-4-Fluorobenzene
    General Information
    Historical Development
    1- (Chloromethyl) -4-Fluorobenzene is an organic compound. It first appeared in the process of scientific research, and it was obtained by chemists who painstakingly studied it. At the beginning, the synthesis method was still simple, but the yield was not abundant.
    After years, various sages have worked tirelessly to explore new paths. Chemists analyze its structure, study its properties, and seek optimization strategies. Then new synthesis methods gradually emerged, and the yield was also improved.
    Today, 1- (Chloromethyl) -4-Fluorobenzene is used in chemical, pharmaceutical and other fields. Remembering the past, from its unfamiliarity at the beginning to its wide use today, its development path has witnessed the progress of chemical technology and the achievements of scholars.
    Product Overview
    1- (chloromethyl) -4-fluorobenzene is also an organic compound. Its color is pure and transparent, and its taste is specific. The melting boiling point has a fixed number, and it has a wide range of uses in chemical industry.
    The preparation of this compound requires specific methods, appropriate agents and strict control. At the time of synthesis, the conditions of each step, such as temperature, pressure, and reaction time, are all important. If it is slightly worse, it will affect the quality and quantity of the product.
    When applied, in the field of medicinal chemistry, it can be used as a raw material for the creation of new drugs and assist in the research of medicinal power. In the field of materials science, it can also participate in the production of special materials, giving materials novelty.
    However, this object is dangerous to a certain extent. When handling it, protective measures should not be ignored. It is necessary to follow the norms to ensure safety and make scientific research go smoothly.
    Physical & Chemical Properties
    1- (Chloromethyl) -4-Fluorobenzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its physical properties, at room temperature, or as a colorless liquid, it has a special odor. Its boiling point and melting point are both characteristics, related to the transformation of its phase state. The boiling point can be determined by the temperature of its gasification; the melting point can be determined by the degree of solidification.
    On its chemical properties, due to the presence of chlorine methyl and fluorine atoms, the activity is different. Chloromethyl can cause the reaction of nucleophilic substitution, and fluorine atoms affect the distribution of electron clouds in molecules, so that this compound has a unique performance in chemical reactions. It can interact with a variety of reagents or form new compounds, which has great potential for application in the field of organic synthesis. Its physical and chemical properties are the basis for exploring many uses of this compound, and are also an indispensable part of chemical research.
    Technical Specifications & Labeling
    1 - (Chloromethyl) -4 - Fluorobenzene is one of the organic compounds. The technical specifications for its preparation, the selection of the first heavy raw materials, need to obtain pure fluorobenzene and chloromethylation reagents, the ratio of the two should be accurately prepared, which is one of the keys. During the reaction process, the temperature control is extremely important, and it must be maintained within a specific range to prevent the growth of side reactions.
    The label of its product must specify the chemical name "1 - (Chloromethyl) -4 - Fluorobenzene", and be accompanied by accurate physical and chemical properties, such as appearance, melting point, boiling point, etc. And must be marked with purity, impurity content and other commodity parameters to prove its quality. In this way, excellent 1- (chloromethyl) -4 -fluorobenzene products can be obtained to meet the needs of all parties.
    Preparation Method
    1- (Chloromethyl) -4-Fluorobenzene is an important compound in organic synthesis. The preparation method, raw materials and production process are very important.
    To prepare this compound, p-fluorotoluene is often used as the initial raw material. Shilling p-fluorotoluene and chlorine under the action of light or initiator undergo free radical substitution reaction. In this step, chlorine gas is active and can replace hydrogen atoms on toluene methyl to generate 1- (Chloromethyl) -4-Fluorobenzene.
    The reaction step is rigorous, the lighting conditions need to be suitable, and the rate of chlorine gas penetration is also exquisite. In order to improve the yield and purity, the reaction temperature and time are often controlled.
    As for the catalytic mechanism, specific catalysts can accelerate the reaction process and have a significant impact on the selectivity of products. By accurately controlling all aspects, high-quality 1- (Chloromethyl) -4-Fluorobenzene can be obtained.
    Chemical Reactions & Modifications
    In the chemical industry, I focus on the change of matter. In 1- (Chloromethyl) -4-Fluorobenzene, I often study the wonder of chemical reaction and modification.
    To observe the chemical reaction, the reagents meet, or warm or pressure, the atoms rearrange, and the new form is bonded. However, it is not easy to achieve the ideal yield. The disturbance of impurities and the control of the rate are all difficult problems. If the catalytic agent is not well selected, the reaction will lag and the yield will be small.
    As for modification, the purpose is to improve its properties. Or increase its stability, or change its dissolution, so as to be suitable for various applications. After clever experiments, adjust its structure, and hope to obtain new properties. Or introduce other groups, change its electron cloud, and the properties are also different.
    We are constantly researching this, and we hope to improve the way of chemical adaptation and modification, so as to make the production of 1- (Chloromethyl) -4-Fluorobenzene purer and more outstanding, so as to benefit all walks of life.
    Synonyms & Product Names
    1- (chloromethyl) -4-fluorobenzene, the synonym and trade name of this substance, is particularly important, related to academic research and industrial application. In the academic world, different literatures or due to habits and research focuses, the synonyms used are different, but they all refer to this specific compound.
    In terms of industry, the trade names set by different manufacturers are also different, aiming to highlight product characteristics or meet market demand. For example, some manufacturers give trade names with their unique synthetic processes to make products more recognizable in the market.
    Synonyms and trade names refer to 1- (chloromethyl) -4-fluorobenzene, which is widely used in the field of organic synthesis and can be used as a key intermediate to synthesize a variety of high-value compounds. It is of great significance to promote chemical research and industrial development. Researchers and practitioners need to clarify their different names in order to accurately communicate and apply.
    Safety & Operational Standards
    1 - (chloromethyl) - 4 - fluorobenzene is also a chemical substance. In its experimental preparation and application, safety and operating standards are of paramount importance.
    All operations involving this chemical must first specify its characteristics. 1 - (chloromethyl) - 4 - fluorobenzene has certain toxicity and irritation. It can cause damage to the human body if it touches the skin, is inhaled or taken by mistake. Therefore, when operating, protective equipment is indispensable. Wear protective clothing, gloves and goggles in front of you to ensure your own integrity.
    The environment of the laboratory also needs to be strictly controlled. Good ventilation must be done to prevent the accumulation of harmful gases. When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources, and must be stored separately from oxidants, alkalis, etc., and must not be mixed with storage to prevent dangerous reactions.
    The operation process is also fixed. When taking it, the action should be slow to avoid spillage. If it is accidentally spilled, emergency measures should be initiated immediately. A small amount of spillage should be mixed with sand, dry lime or soda ash, and then collected in a dry, clean, covered container. If a large amount of spillage is spilled, it needs to build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or a special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
    During the reaction process, temperature, pressure and other conditions must be precisely controlled. Strictly follow the established reaction conditions and operation steps, and cannot be changed without authorization. At the same time, closely monitor the reaction process, detect abnormalities in time and handle them properly.
    Furthermore, after the experiment is completed, the utensils used must be thoroughly cleaned to prevent residual chemicals from affecting the follow-up experiment or causing safety accidents. Discarded chemicals should also follow relevant regulations, be properly disposed of, and should not be discarded at will.
    In short, in the research and application of 1- (chloromethyl) -4-fluorobenzene, safety and operating standards run through. Only by strictly observing the standards can we ensure the smooth operation of the experiment and ensure the safety of personnel and the harmlessness of the environment.
    Application Area
    1- (Chloromethyl) -4-Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate, helping to form a variety of specific drugs, or treating diseases, or relieving symptoms, and benefiting people's livelihood. In materials science, it also has extraordinary performance. It can participate in the construction of polymer materials through specific reactions, so that the materials have special properties, such as better stability and heat resistance, to meet the needs of different scenarios. In the field of fine chemicals, it is used as a raw material for the synthesis of special chemicals, the products produced, or have a unique aroma, for fragrance blending; or have specific reaction activities, serving other fine synthesis. All of this shows that 1- (Chloromethyl) -4-Fluorobenzene is of great value in various fields, contributing to technological progress and industrial development.
    Research & Development
    In the current study of (1 - (Chloromethyl) -4 - Fluorobenzene), it has great potential in the field of chemical industry. We have carefully investigated its properties and explored its synthesis method. After repeated experiments, we have obtained a wonderful way of synthesis, which can increase its yield and improve its quality.
    In the study, the conditions of the reaction, temperature, pressure, and catalyst are carefully considered. Knowing the change of conditions has a deep impact on the product. And observing its stability in different environments, we hope to be able to clarify the appropriate and taboo for its application.
    Looking to the future, this product is expected to shine in the pharmaceutical and material industries. We should continue to study, expand its application field, promote its development, and make every effort to advance the chemical industry to a higher level.
    Toxicity Research
    The chemical industry is related to people's livelihood, but the investigation of poisons in it cannot be ignored. Today there is 1- (Chloromethyl) -4-Fluorobenzene, and the study of its toxicity is crucial.
    Considering the experiments, this substance may be irritating and can damage the mucosal skin when entering the body. Its volatile gas, if inhaled by the mouth and nose, may damage the lungs. And long-term exposure, there may be teratogenic and carcinogenic risks. Although it is useful in chemical production, its potential harm cannot be ignored.
    We study the toxicity of this substance, and we should carefully investigate its rationale and understand its harm, so as to formulate proper methods to ensure the well-being of practitioners and protect the tranquility of the environment. The use of this material to seek advantages and avoid disadvantages is the right path for chemical research.
    Future Prospects
    Prospects of the future, for 1- (Chloromethyl) -4-Fluorobenzene, there is no way to improve this product. Today's research and development, the field of application of this compound may be beneficial. It can be used in the way of synthesis, or it can provide new solutions for special effects. It is also used in the research and development of materials, or it can become the foundation of new materials and new energy for new materials. There may be problems ahead, such as the difficulty of improving the problem, the control of anti-pollution, etc. However, the scientific researchers will uphold their ambition and will definitely move forward. Unexpected, 1- (Chloromethyl) -4-Fluorobenzene will definitely be able to show its extraordinary use in the field, and add new tiles to the world. This is the scene we are looking forward to.
    Where to Buy 1-(Chloromethyl)-4-Fluorobenzene in China?
    As a trusted 1-(Chloromethyl)-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-(Chloromethyl)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1- (chloromethyl) -4-fluorobenzene?
    1- (cyanomethyl) -4-cyanonaphthalene has a wide range of main uses. In the field of organic synthesis, this compound often acts as a key intermediary. It has a unique structure and strong cyanyl activity. It can interact with various reagents through various chemical reactions to construct various complex and special functional organic molecules.
    In the field of pharmaceutical chemistry, 1- (cyanomethyl) -4-cyanonaphthalene can be used as a starting material for lead compounds. By modifying and optimizing its molecular structure, chemists can create new drug molecules with specific pharmacological activities. Or it can adjust its interaction with biological targets to achieve the purpose of treating specific diseases.
    Furthermore, in the field of materials science, 1- (cyanomethyl) -4-cyanonaphthalene also shows important application value. After appropriate polymerization or compounding with other materials, materials with unique optoelectronic properties can be prepared. Such materials may be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells, contributing to the improvement of device performance.
    Again, in the preparation of fine chemical products, 1- (cyanomethyl) -4-cyanonaphthalene can be used to synthesize special dyes, fragrances and high-performance coatings. It can endow the product with unique color, aroma or excellent physical and chemical properties, meeting the special needs of different industries for fine chemical products.
    From this perspective, 1- (cyanomethyl) -4-cyanonaphthalene occupies an important place in many fields such as organic synthesis, medicinal chemistry, materials science and fine chemistry due to its own structural characteristics. It is actually an organic compound with a wide range of uses and important value.
    What are the physical properties of 1- (chloromethyl) -4-fluorobenzene?
    The physical properties of (monomethylamino) -4-bromobenzene are as follows:
    This is an organic compound, and it is mostly solid at room temperature and pressure. Looking at its color, or white to light yellow crystalline powder, this color state characteristic is quite meaningful for identifying and preliminarily judging its purity.
    Its melting point is within a specific range. Specifically, due to different experimental conditions and measurement methods or slight differences, it is roughly around [X] ° C. Melting point is an important physical constant, which can be used to identify the compound and can also help to judge its purity. If the sample purity is high, the melting point range is narrow; if it contains impurities, the melting point is reduced and the melting range is widened.
    As for the boiling point, at normal pressure, or near [X] ° C. The determination of boiling point requires consideration of external pressure factors, and pressure changes will cause the boiling point to change accordingly. The boiling point characteristics of this compound are of great significance in the process of separation and purification. It can be separated from other substances by means of distillation and other means according to the difference in boiling point.
    In terms of solubility, it shows a certain solubility in organic solvents, such as ethanol and acetone. It can be soluble in such organic solvents, which provides convenience for its organic synthesis reaction and subsequent processing steps. In water, the solubility is relatively poor, and this characteristic determines its behavior and application scenarios in aqueous systems.
    Density is also one of the key parameters of physical properties, and its density is about [X] g/cm ³. Density data is indispensable when it comes to solution preparation, reaction material measurement, etc., which helps to accurately control the ratio of reaction conditions to materials.
    In addition, (monomethylamino) -4-bromobenzene is volatile to a certain extent. Although the volatility is not strong, it is still necessary to consider its volatilization characteristics under specific environments and conditions, and store and handle it properly to prevent losses due to volatilization or safety issues.
    Is 1- (chloromethyl) -4-fluorobenzene chemically stable?
    The physical properties of 1 - (methoxy) -4 -bromobenzene are quite stable. Looking at this compound, the methoxy group has the effect of electron supply, which can increase the electron cloud density of the benzene ring. Although the bromine atom has an electron-absorbing effect, its conjugation effect cannot be ignored. The two coexist on the benzene ring and interact, resulting in the compound being relatively stable under common conditions.
    The lone pair electrons of the oxygen atom in the methoxy group can form a conjugated system with the benzene ring, resulting in a more uniform electron cloud distribution, which helps to enhance the stability of the molecule. Although the bromine atom has the induction of electron absorption due to its strong electronegativity, the electron cloud density of the benzene ring decreases, but its p-orbital forms a p-π conjugate with the π-orbital of the benzene ring, which compensates for the decrease in electron cloud density to a certain extent.
    In general chemical environments, 1- (methoxy) -4-bromobenzene is not prone to spontaneous violent chemical reactions. In common acid-base media, without specific catalytic conditions, its structure is difficult to change significantly. That is, in the case of mild oxidizing or reducing agents, without special activation steps, the compound can maintain its own structural integrity.
    This stability is due to the balance of electronic effects in the molecule. The electronic effects generated by the methoxy group and the bromine atom are mutually restricted to build a relatively stable electronic structure, so that 1- (methoxy) -4-bromobenzene exhibits good chemical stability under normal conditions.
    What are the preparation methods of 1- (chloromethyl) -4-fluorobenzene?
    In order to prepare 1 - (cyanomethyl) - 4 - cyanonaphthalene medicine, there are three methods, which are described as follows.
    One is the nucleophilic substitution method. Select halogenated naphthalenes and cyanide reagents, such as sodium cyanide, potassium cyanide, etc., in an appropriate organic solvent, add a catalyst and heat it up. In this reaction, the halogen atom activity of halogenated naphthalenes is very important, and the reaction is easy to progress if the activity is high. The commonly used halogenated naphthalenes have 4 - halogenated naphthalenes, and the cyanide reagent needs to be excessive to promote the complete reaction. Organic solvents can be selected from polar aprotic solvents such as dimethyl sulfoxide, N, N - dimethylformamide, Catalysts such as cuprous iodide can speed up the reaction rate. The advantage of this method is that the raw materials are easy to obtain, and the reaction conditions are not extremely harsh; however, there are also deficiencies. If there are many side reactions, it is slightly difficult to separate the product.
    The second is the oxidation cyanidation method. Taking 4-methylnaphthalene as the starting material, 4-naphthalaldehyde is oxidized to obtain 4-naphthalene formaldehyde, and then reacts with cyanide reagents, such as hydrocyanic acid or its salts, in an alkaline environment, and then reacts in a series of conversions to obtain the target. Oxidation of 4-methylnaphthalene can use oxidizing agents such as potassium permanganate, potassium dichromate, etc., to control the reaction conditions to obtain 4-naphthalaldehyde. In The advantages of this approach are high atomic utilization rate and pure product; the disadvantages are that the oxidation step conditions are stricter, and hydrocyanic acid is highly toxic, so the operation needs to be careful.
    The third is the transition metal catalysis method. Naphthalene and cyanide reagents are used as raw materials to react under the action of transition metal catalysts. Commonly used transition metals such as palladium and nickel, etc., the ligand cooperates with the metal to activate the substrate and promote the introduction of cyanide groups. This method has good selectivity, can accurately prepare the target product, and the reaction conditions are relatively mild. However, the high cost of transition metal catalysts makes it difficult to separate and recover the catalysts after the reaction, which limits its application.
    The above methods to prepare 1- (cyanomethyl) -4-cyanonaphthalene have their own advantages and disadvantages, and the practical application needs to be weighed according to factors such as raw material availability, cost, and product purity.
    What are the precautions for storing and transporting 1- (chloromethyl) -4-fluorobenzene?
    There are many things to pay attention to when storing and transporting haloalkyl-4-haloether.
    First, heat protection is essential. Haloalkyl-4-haloether is more sensitive to heat, and high temperature is easy to cause decomposition, polymerization and other reactions, which will damage the quality, or even cause safety risks. Therefore, when storing, it should be found in a cool and ventilated place, away from heat sources such as heating and fire. During transportation, it is also necessary to pay attention to the ambient temperature. During extremely hot seasons, necessary cooling measures may be taken, such as the use of refrigerated trucks for transportation.
    Second, moisture prevention cannot be ignored. Haloalkyl-4-haloether may react with water, causing deterioration. The warehouse must be kept dry, and the humidity should be controlled within an appropriate range. The packaging must have good moisture resistance. If the packaging is damaged and it is exposed to water vapor, it is likely to affect its chemical properties and stability.
    Third, avoid contact with incompatible substances. Haloalkyl-4-haloether may have violent chemical reactions with certain oxidants, strong bases, active metals, etc. When storing, it should be stored separately from such substances, and the principle of "compatibility" of chemical substances should be followed to prevent dangerous interaction. When transporting, it should not be transported with the above incompatible substances.
    Fourth, the packaging should be firm and compliant. Select suitable packaging materials to ensure that they can withstand certain pressure and vibration, and prevent the package from breaking due to collision and turbulence during transportation, and the leakage of haloalkyl-4-haloether. The packaging should be clearly marked with warning signs and relevant information for easy identification and handling.
    Fifth, follow relevant regulations and operating procedures. Whether it is storing or transporting haloalkyl-4-haloether, it must be strictly implemented in accordance with national and local hazardous chemical management regulations. Operators should be professionally trained to be familiar with its characteristics and emergency treatment methods, so as to ensure the safety and stability of haloalkyl-4-haloether during storage and transportation.