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1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene

1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene

Hongda Chemical

    Specifications

    HS Code

    577758

    Chemical Formula C8H8ClFO
    Molecular Weight 174.6
    Appearance Colorless to light yellow liquid
    Boiling Point Around 200 - 210 °C
    Density Approx. 1.2 - 1.3 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
    Flash Point Caution, flammable, flash point around 70 - 80 °C
    Vapor Pressure Low vapor pressure at room temperature
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

    As an accredited 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1-(chloromethyl)-4-fluoro-2-methoxybenzene in sealed, chemical - resistant bottle.
    Storage 1-(Chloromethyl)-4-fluoro-2-methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
    Shipping 1-(Chloromethyl)-4-fluoro-2-methoxybenzene is shipped in well - sealed, corrosion - resistant containers. Special handling procedures are followed to ensure safety during transit due to its chemical nature. Shipment is compliant with relevant regulations.
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    1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene
    General Information
    Historical Development
    Those who have heard of the goodness of ancient times are chemists, and they can gather wonders with the quality of the micro-end. Today's 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene this thing, and it also has its source. In the past, all the sages worked hard in the field of chemistry, and they did not get this wonderful thing at the beginning. However, everyone was determined, and they studied more and more. After years of pondering, exploring new paths, and trying various methods, they began to gain something. When they first got it, the quantity was small, and the quality was not pure. After that, they went through several improvements, or improved the method, or improved the agent, and gradually made the product more abundant and the quality more refined. Looking at its course, the wisdom and strength of the craftsmen have made great contributions. From the prosperity of this thing, we can also see the progress of chemistry, which is new and never-ending. The work of the predecessors is the foundation for future generations, so that our generation can enjoy the fruits of chemistry.
    Product Overview
    1- (chloromethyl) -4-fluoro-2-methoxybenzene, an organic compound. It may be a colorless liquid with a special odor. Its structure, chloromethyl, fluorine atoms and methoxy groups are based on specific positions of benzene rings.
    This compound is widely used in the field of organic synthesis. It can be used as an intermediate to prepare a variety of biologically active substances, such as medicines and pesticides. Its reactivity is unique, and the chlorine atom of chloromethyl is active. It is easy to participate in nucleophilic substitution reactions. It can interact with many nucleophiles to introduce various functional groups, and then construct complex molecular structures. The presence of fluorine atoms also affects its physical and chemical properties, enhancing the stability and lipid solubility of compounds. Methoxy groups affect the electron cloud distribution of the benzene ring, which affects the regioselectivity of the reaction. When synthesizing, attention should be paid to the precise control of the reaction conditions in order to obtain the ideal yield and purity.
    Physical & Chemical Properties
    1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene is an organic compound. Its physicochemical properties are very important. Looking at its physical properties, it may be a colorless to slightly yellow liquid under normal conditions, with a certain volatility and a special odor. Data such as boiling point and melting point are crucial for controlling the changes in its physical state. Chemically, it is highly active because it contains functional groups such as chloromethyl, fluorine and methoxy. Chloromethyl can participate in nucleophilic substitution reactions, and fluorine atoms change the electron cloud density of the benzene ring, which affects the reactivity. Methoxy groups have an electron supply effect, which affects the stability and reaction check point of compounds. The physical and chemical properties of this compound determine its application direction and value in the field of organic synthesis. It can be used as a key intermediate to participate in various organic reactions and synthesize complex organic molecules.
    Technical Specifications & Labeling
    Today there is a product called 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene. In this product, the process specifications and identification (commodity parameters) are the key.
    To make this product, the process needs to follow a certain rule. When the material is selected carefully, the ratio must be accurate. The temperature and pressure of the reaction must also be carefully controlled, and there should be no difference or difference in the product. The operation should be carried out in accordance with the specifications and must not be wrong.
    As for the label, list the product parameters in detail. From the analysis of the ingredients to the description of the characteristics, it should be clear. Make it clear to the viewer at a glance, and know its characteristics and uses, so as not to risk misuse. In this way, it is necessary to meet the specifications and labels of the process, so that this 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene thing can be used.
    Preparation Method
    To prepare 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene, the raw materials need to be prepared first. Take p-fluoroanisole as the base, which is blended with paraformaldehyde, zinc chloride and concentrated hydrochloric acid. This is the key starting step.
    In the reactor, the temperature is moderately controlled, generally about 50 to 60 degrees Celsius, stirring slowly to fully blend the various substances. The reaction lasted about 3 to 5 hours, during which the reaction situation was closely observed.
    After the reaction is completed, the organic phase is extracted by means of separation. Then wash it with water to remove its impurities. Subsequently, dry it with anhydrous sodium sulfate to remove its moisture.
    Finally, by vacuum distillation, a pure 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene was obtained. In this process, each step is carefully controlled, and the equipment needs to be well-cleaned to ensure the purity and yield of the product.
    Chemical Reactions & Modifications
    Today, there is a substance, called 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene, in the field of chemical research, its chemical reaction and modification are very important.
    The chemical response is endless. This substance participates in various reactions, combines with other substances, or decomposes itself, depending on its molecular structure and environment. During the reaction, the atoms are rearranged, and the bond breaking and formation interact with each other to form a new substance.
    As for modification, it is intended to have different properties. Or increase its stability, or change its solubility, or give it special activity. It can be chemically modified, such as introducing new groups, to adjust the type and position of functional groups. In this way, this object can be used in materials science, drug research and development, and other fields to develop its extraordinary functions, contributing to the advancement of science and technology and making a lot of contributions.
    Synonyms & Product Names
    1- (chloromethyl) -4-fluoro-2-methoxybenzene, the synonym and trade name of this substance should be explored in detail by our generation. Its synonyms are established terms in the field of chemistry, known to the academic community, in order to accurately express its chemical structure and characteristics. Trade names involve commercial operations, or vary depending on manufacturer publicity and market positioning.
    Looking at the history of chemical research, the synonyms of many compounds are named according to their structure, discoverer or specific reaction. As for trade names, they often have marketing intentions, hoping to attract the attention of buyers. 1- (chloromethyl) -4-fluoro-2-methoxybenzene, or in the fields of organic synthesis, pharmaceutical research and development, its synonyms help researchers communicate accurately, and trade names show their characteristics in market circulation. In this way, synonyms and trade names can complement each other at both academic and commercial ends.
    Safety & Operational Standards
    1- (Chloromethyl) -4-fluoro-2-methoxybenzene, the safety and operation specifications of this substance are related to the top priority of our generation of chemical researchers and should not be ignored.
    Where this substance is used, it should be done in a well-ventilated place. Because of its volatility, if it is in a closed chamber, gas accumulation is dangerous and easy to cause poisoning. And its odor is pungent, in a well-ventilated place, it can reduce the accumulation of gas and protect people's health.
    Furthermore, the operator is in front of protective gear. Such as chemical-resistant gloves, which can prevent it from touching the skin, preventing skin burns and allergies; anti-goggles to protect the eyes from splashing; wearing long clothes and trousers to cover the skin, reducing the risk of accidental contamination.
    There are also rules for storing this thing. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Because of its low ignition point, it will burn near the fire, or even explode, endangering the safety of the surrounding area. It also needs to be stored separately with oxidants, alkalis and other substances to prevent violent reactions.
    When taking it, the action should be slow and careful. Take it with a precise measuring tool, do not pour it at will, and prevent splashing and outflow. If there is a splash, cover it with inert materials such as sand and vermiculite as soon as possible, and then clean it up properly. Do not let it flow and contaminate the ground.
    After the experiment is completed, the utensils used must be washed, and the remnants should be disposed of in accordance with regulations and cannot be discarded at will. This is all to ensure safety and abide by norms. Our generation should keep it in mind and practice it in daily life, so that the research goes smoothly, and the environment and personal safety are also guaranteed.
    Application Area
    Today there is a product named 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene. This product is useful in many fields.
    In the field of medicine, it can be a key raw material for synthesizing good medicines. With its characteristics, it can help doctors make a cure for diseases, or for certain types of difficult diseases, it has unique curative effects and can solve the pain of patients.
    In the chemical industry, it is also indispensable. It can be used to manufacture fine chemical products and add bricks to industrial production. If it can improve the quality of chemical products, it will make them more competitive in the market.
    Furthermore, it is often an important reagent in scientific research and exploration. With this material, researchers can deeply explore the mysteries of chemistry, open up the unknown, and contribute to scientific progress.
    Therefore, 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene widely used in medicine, chemical industry, scientific research and many other fields, are of great value.
    Research & Development
    Since modern times, the art of chemistry has been new, and various compounds have emerged in an endless stream. Today, 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene this substance, and I have been studying it for a long time.
    The first time I dealt with this substance, I studied its physicochemical properties in detail. Observe its shape, examine its state, measure its melting point, explore its solubility, and observe its changes in various solvents to clarify its basic quality.
    Then study its synthesis method. After studying ancient books and seeking the experience of predecessors, I have repeated many tests, adjusted all kinds of conditions, controlled the temperature, pressure, and the ratio of reactants, hoping to obtain the best method. Although the process is difficult, I am happy to see every small success.
    As for the way of application, we also strive to explore. In the fields of medicine and materials, explore its possible utility. Hope to expand its use and seek well-being for the world. In the future, we should continue to study unremittingly, hoping that this material will shine in the field of chemistry and promote the progress and development of related fields.
    Toxicity Research
    Since modern times, chemical refinement has been advanced, and all kinds of new things have competed. Today 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene this thing, and the study of its toxicity is crucial.
    We study it carefully, observe its materialization properties, and observe the signs of its transformation with various things. In the context of experiments, examine its effect on all living things in detail. Or touch the skin, or enter the way of breathing, or enter through the mouth and abdomen, all of which are examined in detail.
    See its physiological function in living things, or disturb it. The state of cells and the behavior of metabolism are all signs of abnormalities. However, the appearance of toxicity is also related to the dose and duration. A small amount of short-term, or only minor illness; a large amount of time, it is very harmful.
    Therefore, in the application of this substance, it is necessary to be cautious and carefully investigate the rules of toxicity in order to avoid disasters, preserve the safety of life and the environment.
    Future Prospects
    The future of the future, in 1- (Chloromethyl) -4-Fluoro-2-Methoxybenzene this thing, there is great hope. Its unique nature, in many domains have extraordinary power. In the process of synthesis, or in the process of research, it can be used to introduce new compounds. In the process of research, it may also be used to create new big keys to help overcome common diseases. The field of materials science may enable new properties of materials and explore new uses. Our scientific researchers must make great efforts to explore its secrets and explore its capabilities. With this material-based, we will improve the high level of technology and benefit the world.
    Where to Buy 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene in China?
    As a trusted 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
    1 - (cyanomethyl) - 4 - cyanogen - 2 - methoxybenzyl, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate. For example, when creating certain drugs with specific therapeutic effects, it can participate in complex reactions with its own unique chemical structure, build the molecular framework required for drug activity, and play a cornerstone role in the drug's efficacy in treating diseases.
    In the field of materials science, it also has outstanding performance. In the process of preparing organic materials with special properties, 1- (cyanomethyl) -4-cyano-2-methoxybenzyl can be used as a functional monomer. After polymerization and other reactions, the material is endowed with properties such as good optical properties, electrical properties or thermal stability, which greatly expands the application scenarios of the material, such as in new electronic devices, optical thin films, etc.
    In the field of fine chemicals, it is also an important raw material for the preparation of a variety of fine chemicals. These fine chemicals are widely used in the production of fragrances, dyes, additives, etc. For example, in the synthesis of fragrances, it can contribute unique chemical groups that give fragrances unique aroma characteristics; in dye synthesis, it can participate in the construction of the color system of dye molecules, affecting the color, fastness and other key performance indicators of dyes.
    What are the physical properties of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
    (1- (Cyanomethyl) -4-fluoro-2-methoxybenzonitrile) The physical properties of this substance are as follows:
    In appearance, it is often in a white to off-white solid state, with a pure appearance and uniform color. This state is easy to handle and use in many chemical operations, laying a good foundation for subsequent reactions or applications.
    In terms of melting point, it has a specific numerical range. This property is of great significance for the identification of its purity and stability under different temperature environments. By accurately measuring the melting point, the purity can be distinguished. If impurities are mixed, the melting point is often deviated.
    Solubility is also an important physical property. In organic solvents, such as common ethanol and acetone, it exhibits a certain solubility. This property determines its dispersion in various chemical reaction systems and the way it participates in the reaction. In some organic synthesis reactions, appropriate solubility can promote full contact of the reactants, speed up the reaction process, and improve the reaction efficiency. In water, the solubility is poor, which is closely related to the polar characteristics of the molecular structure of the substance. Its molecular polarity is quite different from that of water molecules, making it difficult to fuse with water.
    Density is also one of its physical properties and has a specific value. Density plays a key guiding role in operations such as solution preparation, separation and purification. In mixed solution systems, effective separation can be achieved by means such as liquid separation, depending on the density difference of each substance.
    In addition, it also has a certain stability. Under normal storage conditions, in a dry and cool place, it can maintain a relatively stable chemical structure and physical form. However, if exposed to high temperature, strong light or a specific chemical environment, the stability may be affected, causing structural changes or chemical reactions, which in turn change its physical properties and chemical activities.
    What are the synthesis methods of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
    To prepare 1- (cyanomethyl) -4-bromo-2-methoxy phenyl ether, the following methods can be used:
    First, phenols containing methoxy groups are used as starting materials. Shilling phenol reacts with halogenated cyanomethyl reagents in a suitable base and solvent environment. If potassium carbonate is used as a base and acetonitrile is used as a solvent, and heating and stirring, the hydroxyl oxygen of phenol will nucleophilically attack the halogenated atom of halogenated cyanomethyl, form ether bonds, and introduce cyanomethyl. Subsequently, in another reaction stage, a suitable brominating reagent, such as N-bromosuccinimide (NBS), is selected. In the presence of an initiator such as benzoyl peroxide, in an inert solvent such as carbon tetrachloride, the reaction is initiated by light or heat to achieve bromination at a specific position of the benzene ring, and the target product is obtained. The starting material of this path is common and easy to obtain, and the reaction conditions of each step are relatively mild and convenient to operate.
    Second, starting from bromine-containing phenols. First, the phenol is methoxylated. Halogenated methane can be reacted with phenol under basic conditions, and a strong base such as sodium hydride can be used. In an anhydrous tetrahydrofuran solvent, the phenolic hydroxyl anion and halogenated methane are nucleophilically substituted to introduce methoxy groups After that, it is reacted with the halogenated cyanomethyl reagent. The steps are similar to the first method, and the cyanomethyl is added through the nucleophilic substitution reaction to obtain the target compound. This approach can precisely control the position of bromine atoms, and the selectivity between methoxylation and cyanomethylation is good.
    Third, halogenated aromatic hydrocarbons are used as raw materials. Shilling halogenated aromatic hydrocarbons are reacted with methoxylation reagents, such as reacting with sodium methoxide in a suitable solvent, and the halogen is substituted with methoxy groups. Next, the reaction with cyanomethylation reagents can be achieved by means of metal catalysis, such as palladium catalysis system, under suitable ligand, base and solvent conditions, the introduction of cyanomethyl groups can be achieved, and finally 1 - (cyan With the help of metal catalysis, this method has high reactivity and selectivity, and is especially suitable for complex structural substrates.
    What are the precautions for storing and transporting 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
    1 - (cyanomethyl) - 4 - cyanogen - 2 - methoxyphenylacetonitrile requires attention to many key matters during storage and transportation.
    In terms of storage, first, be sure to choose a cool, dry and well-ventilated place. This compound is quite sensitive to environmental conditions. Humid environments can easily cause chemical reactions, affect quality, and may even cause danger; high temperatures may accelerate its decomposition rate, so a suitable low-temperature dry environment is the key. Second, it should be strictly separated from oxidants, acids, bases and other substances. Because of its active chemical properties, contact with the above substances is very likely to trigger violent chemical reactions, such as oxidation and reduction reactions, acid-base neutralization, etc., which will not only damage the structure of the compound, but also may produce a large amount of heat and gas, causing serious consequences such as fire and explosion. Third, the storage area should be equipped with corresponding emergency treatment equipment and suitable containment materials. In case of unexpected situations such as leakage, it can be treated in a timely manner to avoid the spread of pollution and reduce the degree of harm.
    In the transportation process, first of all, the transportation vehicle needs to have good anti-leakage, fire prevention and explosion-proof facilities. If the compound leaks to the outside world, it will not only cause pollution to the environment, but also may trigger dangerous reactions due to contact with other substances; while fire prevention and explosion-proof facilities are used to prevent accidents caused by accidental friction, collision, etc. during transportation. Secondly, transportation personnel must undergo professional training to be familiar with the characteristics of the compound and emergency treatment methods. Only in this way can measures be taken quickly and correctly to ensure transportation safety in the face of emergencies. Furthermore, during transportation, it is necessary to pay close attention to changes in environmental factors such as temperature and humidity, and adjust transportation conditions in a timely manner according to the actual situation to prevent environmental factors from causing the compound to deteriorate or cause danger.
    What are the effects of 1- (chloromethyl) -4-fluoro-2-methoxybenzene on the environment and human health?
    1 - (chloromethyl) - 4 - chloro - 2 - methoxybenzene, this substance has many effects on the environment and human health.
    At the environmental level, it has a certain persistence and is difficult to degrade rapidly through natural processes. If released into the soil, it will accumulate in the soil, affect the soil ecosystem, interfere with soil microbial activities and soil fertility. After flowing into the water body, it will harm aquatic organisms and destroy the aquatic ecological balance, such as affecting the survival and reproduction of fish, shellfish, etc., and changing the chemical properties of the water body. Volatile into the atmosphere, it may participate in photochemical reactions, affect air quality, produce secondary pollutants, and endanger the atmospheric environment.
    For human health, it may be a potential carcinogen. Entering the human body through breathing, skin contact or accidental ingestion can interfere with the normal physiological functions of the human body. Contact with the skin may cause skin irritation, redness, swelling, itching, rash and other allergic reactions. Accidentally entering the eyes can irritate eye tissues and damage vision. If inhaled its volatile gases, it will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term inhalation increases the risk of respiratory diseases and cancer. Accidental ingestion harms the digestive system, causing nausea, vomiting, abdominal pain, diarrhea and other symptoms, and in severe cases damage the liver, kidneys and other important organs. Therefore, in the production, use and handling of products containing 1 - (chloromethyl) - 4 - chloro - 2 - methoxybenzene, strict protective and environmental protection measures should be taken to reduce the harm to the environment and human health.