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1-(Chloromethyl)-3-Fluorobenzene

1-(Chloromethyl)-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code

760731

Chemical Formula C7H6ClF
Molecular Weight 144.57
Appearance Colorless to light yellow liquid
Boiling Point 173 - 175 °C
Density 1.225 g/mL at 25 °C
Flash Point 56 °C
Solubility In Water Insoluble
Refractive Index 1.502

As an accredited 1-(Chloromethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(chloromethyl)-3-fluorobenzene in a tightly - sealed glass bottle.
Storage 1-(Chloromethyl)-3-fluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. It should be in a place with restricted access, following all safety regulations for handling hazardous chemicals.
Shipping 1-(Chloromethyl)-3-fluorobenzene is shipped in accordance with strict chemical transport regulations. It's packed in appropriate containers to prevent leakage, with labels indicating its hazardous nature. Shipments are monitored for safety during transit.
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1-(Chloromethyl)-3-Fluorobenzene 1-(Chloromethyl)-3-Fluorobenzene
General Information
Historical Development
I heard that there was a thing in the past, named 1- (Chloromethyl) -3-Fluorobenzene. Its beginning is the result of the research of various scholars. In the beginning, it only existed in the scriptures, and was investigated by a few wise men.
At that time, people explored its nature in the subtle places, and sought its quality in the subtle places. After several years, the technique has gradually refined before it can be developed. At the beginning of its application, it was still limited to a narrow field, but its potential has already emerged.
After the years passed, the wisdom of scholars became more and more clear, and the skills improved. The use of this thing gradually spread to all industries. Or it can enter the road of medicine, help to cure diseases; or it is the key of chemical industry, promote the birth of new products. From this point of view, it has been hidden and revealed in the passage of time, used by the world, and has become an indispensable material at this time. It is actually the work of learning and the feedback of time.
Product Overview
1- (Chloromethyl) -3-Fluorobenzene is an organic compound. Its color is clear and its taste is specific. It has the properties of halogenated aromatics, chloromethyl and fluorine atoms are attached to benzene rings, and its structure is unique.
This compound is widely used in the field of organic synthesis. It can be used as an intermediate, involved in the synthesis of drugs and materials. Through a specific reaction path, it can combine with a variety of reagents to derive a variety of products.
However, it also has latent risk, high activity of chloromethyl, or the risk of toxicity and irritation. When operating, it must follow safety procedures, take good protection, avoid contact with skin and mucous membranes, and do it in a well-ventilated place. In this way, it is possible to ensure the safety of the experimenter and make the best use of this compound for chemical research and industrial production.
Physical & Chemical Properties
1- (Chloromethyl) -3-Fluorobenzene is also an organic compound. Its physical and chemical properties are crucial to chemical research. This substance may be in a liquid state at room temperature and has a special odor. Looking at its physical properties, the genera of boiling point and melting point affect its morphology in different temperature environments. The boiling point is related to the difficulty of gasification; the melting point is determined by the degree of solid-liquid transformation.
On its chemical properties, chloromethyl and fluorine atoms give it active properties. Chloromethyl chloride, which is easily nucleophilic substitution, reacts with many reagents. Fluorine atoms have strong electronegativity, which affects the distribution of molecular electron clouds, resulting in unique chemical activities. Due to its properties, it can be used as a key intermediate in the field of organic synthesis. Through various reactions, complex organic structures can be constructed, which is an indispensable part of chemical research.
Technical Specifications & Labeling
1- (Chloromethyl) -3-fluorobenzene is also an organic compound. Its process specifications and identification (commodity parameters) are related to the preparation and identification. The preparation method requires precise steps, suitable raw materials, and reaction under specific conditions. When reacting, temperature, pressure, and catalyst are all critical, and there should be no slight mistakes.
In terms of identification, its appearance should be a colorless to slightly yellow liquid with a special odor. Its physical parameters, such as boiling point, melting point, density, etc., are the basis for identification. And on the packaging, its chemical name, molecular formula, warning label, etc. should be clearly marked to inform everyone that it is a chemical substance, so use it with caution. In this way, the process specifications and labels of square 1- (chloromethyl) -3-fluorobenzene are accurate.
Preparation Method
To prepare 1 - (chloromethyl) -3 -fluorobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
First take an appropriate amount of 3-fluorotoluene as the initial raw material, which is the basis for the reaction initiation. In a suitable reaction kettle, add an appropriate amount of initiator, such as benzoyl peroxide, which can effectively induce the reaction. Introduce chlorine gas, and under light or heating conditions, the two undergo free radical substitution reaction. Light or heating provides energy for the reaction, so that the chlorine gas molecules are split into chlorine radicals, and then replaced with hydrogen atoms on the methyl group in 3-fluorotoluene.
The reaction steps are rigorous and orderly, and the rate of chlorine gas entry needs to be precisely controlled. Too fast or too slow will affect the purity and yield of the product. And the reaction temperature should be maintained at a certain range. If it is too high, it is easy to cause side reactions to occur, and if it is too low, the reaction rate will be slow.
As for the catalytic mechanism, the initiator decomposes to produce free radicals, which prompts the reaction to initiate, and the subsequent free radical chain reaction continues to advance until the reaction is completed. After the reaction is completed, the product is separated and purified by distillation, extraction and other means to obtain high-purity 1- (chloromethyl) -3 -fluorobenzene.
Chemical Reactions & Modifications
The wonders of chemistry are endless changes, new substances are born, and their properties are also different. The chemical reaction and modification of 1- (Chloromethyl) -3-Fluorobenzene compound are worth studying.
In the process of reaction, nucleophilic substitution is often used. Halogenated hydrocarbons are active and can meet with many nucleophilic reagents, such as alcohols and amines, to generate new products, and the structure changes as a result. Or by eliminating the reaction, dehalogenating hydrogen, forming unsaturated bonds, and developing different chemical activities.
When it comes to modification, he can be introduced. With the properties of aromatic rings, it can be replaced, and different groups are added to adjust its physical and chemical properties. Such as adding polar groups to increase solubility; adding conjugate structures to improve optical properties. This is the path of optimization, making 1- (Chloromethyl) -3-Fluorobenzene more possible in the field of materials and medicine, and opening up a new chapter for chemical research and application.
Synonyms & Product Names
1 - (chloromethyl) -3 -fluorobenzene, the synonym and trade name of this substance are quite important. In the field of chemistry, synonyms can help to express accurately, and trade names involve market circulation.
As far as synonyms are concerned, or due to differences in regions and customs, there are different names. This 1 - (chloromethyl) -3 -fluorobenzene, or other chemical naming expressions, all refer to the same substance, which is commonly used by chemical researchers for communication.
As for trade names, it is related to commercial operations. Different manufacturers produce this substance, or give unique trade names according to their own marketing strategies and product characteristics. This trade name is convenient for market identification and promotion, making it easy for customers to distinguish products from different sources.
In short, the synonymous heavy chemistry professional exchange, commodity fame and profit market operation, both in the research and application of 1- (chloromethyl) -3 -fluorobenzene, each has its own function.
Safety & Operational Standards
1 - (chloromethyl) -3 -fluorobenzene, this chemical substance is in the experiment, and its safety and operation standards are of paramount importance.
All experiments involving this substance, the operator must first wear complete protective gear. Wearing special laboratory clothes can prevent chemical substances from splashing and eroding the clothes; wearing protective goggles can protect the eyes from accidental splashing; and the choice of gloves should be based on the specific experimental situation, choose suitable materials to prevent chemical substances from penetrating.
The operating environment should be well ventilated. Set up a fume hood and ensure its normal operation, which can disperse the harmful gases generated in the experiment in time, make the experimental space fresh air, and reduce the risk of inhalation by the operator.
When taking 1- (chloromethyl) -3 -fluorobenzene, be careful. Measure the required dose with a precise measuring tool to avoid excess or deficiency. When pouring, the bottle body is inclined moderately and the rate is uniform, beware of liquid splashing. If it is added to the reaction system, it should be injected slowly and stirred at the same time to make full fusion and avoid adverse reactions caused by excessive local concentration.
After the experiment is completed, the residual 1- (chloromethyl) -3 -fluorobenzene should not be discarded at will. According to relevant regulations, it should be sorted and stored in a specific container for centralized and proper disposal. Experimental equipment should also be washed in time to remove residual chemicals for next use.
Storage of 1 - (chloromethyl) -3 - fluorobenzene should be dry, cool, and away from fire and heat sources. Due to its certain chemical activity, improper storage is prone to danger. The container must be well sealed to prevent volatile leakage.
In short, in the research and use of 1 - (chloromethyl) -3 - fluorobenzene, strict safety and operating standards should be adhered to to ensure the smooth operation of the experiment and the safety of the operator.
Application Area
1- (chloromethyl) -3-fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediary. With this material, a variety of specific drugs can be made, treating various diseases and saving patients from pain. In the field of materials science, it also has extraordinary uses. Based on it, new materials can be developed, which are specific and suitable for a variety of scenarios. For example, in electronic devices, it helps to improve its performance; in optical materials, it increases its optical effect. Although this compound is of fine quality, it is indispensable in many application fields, just like masonry in large buildings. It is of great help to the progress of science and technology and the improvement of people's livelihood.
Research & Development
In recent years, my research on the organic compound 1- (Chloromethyl) -3-Fluorobenzene has been in depth. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, I explored its synthesis path, but it has been subject to many twists and turns. The traditional method, or the yield is not up to expectations, or the impurities are difficult to remove. I and my colleagues repeatedly experimented and improved the process, and finally obtained a method, which can improve the yield and control the impurities.
Then, study its reactivity. After many experiments, it was found that it can react with a variety of reagents under specific conditions to generate products with novel structures. This discovery opens up a new path for organic synthesis.
Looking forward to the future, we hope to further expand its application based on this. Or for the preparation of new materials, or to assist in drug research and development. Unremitting research can promote the development of this compound and contribute to the field of chemistry.
Toxicity Research
The toxicity study of 1- (Chloromethyl) -3-Fluorobenzene
Recently, our research methods for chemical products focus on 1- (Chloromethyl) -3-Fluorobenzene. The toxicity investigation of this product is the most important in the field of chemical research.
At the beginning, the first time, the product was used to reduce the toxicity of the product, and the reverse effect was found. This product was given to mice, and the rats were usually stunted, and the function of the liver and the liver was normal.
However, the cytolysis of the cytoplasm. Take the cytoplasm and administer 1- (Chloromethyl) -3-Fluorobenzene. But the growth of the cells was blocked and the proliferation was slow. Some cells are even modified in shape, and the integrity of the membrane is also broken.
Therefore, 1- (Chloromethyl) -3-Fluorobenzene is toxic. During work and use, care must be taken to prevent its leakage and prevent organisms and environments from being harmed by it. Before it is done, more in-depth research is needed to clarify its toxicology in order to prevent it and resolve it.
Future Prospects
The future prospect concerns (1 - (Chloromethyl) -3 - Fluorobenzene) this thing. Our generation has been studying this thing for several years. Looking at its current state, although there are small achievements, the road ahead is still long.
We want to make it shine in the field of medicine, hoping to contribute to the elimination of diseases. We also hope to emerge in the field of materials and pave the way for the creation of new materials. Or develop its strengths in the field of electronics, helping electronic devices to be more refined and more clever.
Although the current difficulties are many, the obstacles of technology and the constraints of cost are all obstacles. However, we are unswerving and firmly believe that with time, we will be able to overcome all kinds of problems. At that time, (1 - (Chloromethyl) -3 - Fluorobenzene) will be as bright as a pearl, blooming endless light in the vast world of the future, becoming the pride of our scientific research, used by the world, and blessing all people.
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Frequently Asked Questions

As a leading 1-(Chloromethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (chloromethyl) -3-fluorobenzene?
The main uses of (monomethoxy) -3-chlorobenzene are related to many fields. In the field of medicinal chemistry, it is a key intermediate for the synthesis of various drugs. Due to the special chemical structure of this compound, it can endow the prepared drugs with specific pharmacological activities. For example, it can be integrated into the molecular structure of drugs through a series of chemical reactions to develop drugs with antibacterial and anti-inflammatory effects.
In the field of materials science, (monomethoxy) -3-chlorobenzene also has important uses. It can be used as a raw material for the preparation of high-performance polymer materials. By ingeniously designing the polymerization reaction, (monomethoxy) -3-chlorobenzene can effectively improve the properties of polymers, such as enhancing their heat resistance, mechanical strength and chemical stability. These high-performance polymer materials are widely used in high-end technology industries such as electronics and aerospace.
Furthermore, in the field of organic synthesis chemistry, (monomethoxy) -3-chlorobenzene is often used as a basic building block for building complex organic molecules. Due to its methoxy and chlorine atoms, both are highly reactive functional groups, which can participate in a variety of organic reactions such as nucleophilic substitution and coupling reactions, so as to realize the diversified construction of organic molecules, providing rich choices for organic synthesis chemists to explore the synthesis paths of novel organic compounds.
In summary, (monomethoxy) -3-chlorobenzene plays an indispensable role in many fields such as medicine, materials and organic synthesis, and is of great significance to promote scientific research and industrial development in related fields.
What are the physical properties of 1- (chloromethyl) -3-fluorobenzene?
(1 - (methoxy) -3 -fluorobenzene) is an organic compound with the following physical properties:
This substance is mostly liquid at room temperature and has a certain volatility. Its boiling point is affected by the intermolecular force. Due to the presence of fluorine atoms and methoxy groups in the molecule, the intermolecular force changes, and the approximate boiling point is within a certain range, but the specific value will vary depending on the exact structure and experimental conditions.
In terms of solubility, the compound contains fluorine atoms, which are more electronegative atoms, and methoxy groups, which have a certain polarity. Therefore, in polar organic solvents such as ethanol and acetone, it often has good solubility and can be mutually soluble with these solvents in a certain proportion; while in non-polar solvents such as n-hexane, the solubility is relatively poor.
Compared with water, its density will vary depending on the composition and structural characteristics of the molecule. Generally, it is equivalent to the density of common organic liquids, and may be slightly greater or less than the density of water, depending on the precise molecular structure and measurement conditions.
In addition, the appearance of (1- (methoxy) -3 -fluorobenzene) is usually a colorless transparent or slightly colored liquid, and the smell has a certain particularity, similar to the smell of some aromatic compounds, but it is different from the smell of ordinary aromatic hydrocarbons due to the presence of fluorine atoms and methoxy groups. Its refractive index is also in a specific range due to the characteristics of molecular structure. Refractive index is one of the characteristic constants of substances and can be used to identify and analyze the compound.
What are the chemical properties of 1- (chloromethyl) -3-fluorobenzene?
1 - (cyanomethyl) - 3 - cyanopyridine is an organic compound, and its chemical properties are of great interest. Let me explain in detail for you.
Among this compound, cyanyl (-CN) is the key functional group. The cyanyl group has a high activity and has a significant polarity due to the existence of carbon-nitrogen triple bonds. This polarity makes 1 - (cyanomethyl) - 3 - cyanopyridine participate in many chemical reactions.
Hydrolysis is one of them. Under acidic or alkaline conditions, cyanyl groups can be hydrolyzed. In acidic media, cyanyl groups are gradually converted to carboxyl groups (-COOH), first to form amide intermediates, and then further hydrolyzed to carboxylic acids. Although the hydrolysis mechanism under basic conditions is different, carboxylic salts are eventually formed, and corresponding carboxylic acids can be obtained after acidification. This hydrolysis property makes 1- (cyanomethyl) -3 -cyanopyridine an important raw material for the synthesis of carboxyl-containing compounds.
1- (cyanomethyl) -3 -cyanopyridine can also participate in nucleophilic substitution reactions. The carbon atoms on the cyanomethyl group are slightly positively charged due to the electron-withdrawing action of the cyanyl group and are vulnerable to attack by nucleophilic reagents. Nucleophilic reagents such as alcohols and amines can replace some groups on the cyanomethyl group to form new carbon-heteroatom bonds, which is of great significance in organic synthesis to introduce specific functional groups
Furthermore, its cyanyl group can participate in the addition reaction. For example, with compounds containing active hydrogen, such as water, alcohols, etc., under appropriate catalytic conditions, the cyanyl group can be added to generate products such as cyanoalcohols and aminonitriles. Such addition reactions provide an effective way for the synthesis of polyfunctional compounds.
1- (cyanomethyl) -3 -cyanopyridine has active chemical properties due to the presence of cyanyl groups. It is widely used in the field of organic synthesis and can be used in various reactions to construct various organic compounds. It has contributed greatly to the development of organic synthetic chemistry.
What are the synthesis methods of 1- (chloromethyl) -3-fluorobenzene?
To prepare 1 - (methoxy) - 3 - bromobenzene, there are several ways to synthesize it:
First, m-bromophenol is used as the starting material. First, it reacts with halomethane in an alkaline environment, such as potassium carbonate as the base, acetonitrile as the solvent, m-bromophenol interacts with iodomethane, phenolic hydroxyl groups will undergo nucleophilic substitution reaction with halomethane, phenoxy negative ions attack the carbon atom of halomethane, and the halogen ions leave to form the product of methoxy substitution 1 - (methoxy) - 3 - bromobenzene. The raw material of this route is relatively easy to obtain, the reaction conditions are relatively mild, and the operation is convenient.
Second, start from 3 - bromophenamine. The amino group is first converted into a diazonium salt through a diazotization reaction. Sodium nitrite and hydrochloric acid are reacted with 3-bromoaniline at low temperature (usually 0-5 ° C) to form a diazonium salt. Then methanol is added, and the diazonium group is replaced by a methoxy group to obtain the target product 1- (methoxy) -3-bromobenzene. Although this process is a little complicated, the diazotization reaction has high selectivity and can introduce methoxy groups accurately.
Third, isobromoanisole is used as the raw material. If isobromoanisole can be obtained directly, it can be properly transformed into functional groups. For example, the bromination of m-bromoanisole with a brominating agent (e.g. N-bromosuccinimide, NBS) under certain bromination reaction conditions, such as in a suitable catalyst and solvent system, can introduce bromine atoms at specific positions in the benzene ring to generate 1- (methoxy) -3-bromobenzene. This approach requires attention to the selectivity of the reaction to ensure that bromine atoms are introduced to the desired position.
What should I pay attention to when storing and transporting 1- (chloromethyl) -3-fluorobenzene?
Mercury (mercury) is a highly toxic substance, and it needs to be carefully treated in many aspects during storage and transportation.
In terms of storage, the first seal is heavy. Because it is highly volatile, if the seal is not good, mercury vapor will escape, which is a great hazard to human health and the environment. It is often held in thick-walled glass containers or metal containers, tightly sealed to prevent leakage. And mercury has a high density, and the container needs to be strong to withstand its weight and not break.
Furthermore, the storage temperature is also particular. It should be placed in a cool and ventilated place, protected from high temperature and direct sunlight. Due to the increase in temperature, the evaporation of mercury will increase, and the suitable temperature is between 15 ° C and 25 ° C.
The humidity of the storage environment cannot be ignored. Excessive humidity may cause mercury corrosion and accelerate the damage of the container, so the environment should be kept dry.
As for transportation, safety packaging is the top priority. Use special mercury transportation containers with buffers and fixtures inside to avoid mercury leakage due to shaking and collisions during transportation. And there should be obvious warning signs on the outside of the container, such as "highly toxic" and "careful leakage", so that transporters and related personnel can understand its danger.
The choice of transportation means is also critical. Choose a smooth and small vibration to reduce mercury impact. During transportation, close monitoring is required to ensure that the temperature and humidity are suitable and the packaging is not damaged.
In addition, transportation personnel must be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of mercury. In the event of a leak, they can respond quickly and correctly to reduce the harm.
When storing and transporting mercury, every step from container selection, environmental control to packaging and transportation and personnel training is crucial, so as to ensure the safe storage and transportation of mercury and avoid irreparable damage to people and the environment.