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1-(Chloromethyl)-2,4-Difluorobenzene

1-(Chloromethyl)-2,4-Difluorobenzene

Hongda Chemical

Specifications

HS Code

414225

Chemical Formula C7H5ClF2
Molar Mass 162.564 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 160 - 162 °C
Density 1.324 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 54 °C
Refractive Index 1.475 - 1.477

As an accredited 1-(Chloromethyl)-2,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(chloromethyl)-2,4 - difluorobenzene in a sealed, chemical - resistant bottle.
Storage 1-(Chloromethyl)-2,4-difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions.
Shipping 1-(Chloromethyl)-2,4 -difluorobenzene is a chemical. Shipping requires proper containment in suitable containers. It must follow regulations for hazardous chemicals, with careful handling to prevent spills and ensure safe transportation.
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1-(Chloromethyl)-2,4-Difluorobenzene 1-(Chloromethyl)-2,4-Difluorobenzene
General Information
Historical Development
1- (chloromethyl) -2,4-difluorobenzene is also an organic compound. It first appeared in the academic world and is the result of the evolution of scientific research. In the past, the sages of chemistry studied and searched hard in the field of organic synthesis.
At the beginning, the preparation method was still simple and rudimentary, the yield was quite low, and the purity was difficult to call good. However, the heart of a scholar, perseverance and perseverance, unremitting exploration and concealment. After years of delay, science and technology are improving, and the preparation process is gradually improving. New reagents and new methods emerge one after another, which improves its yield and purity.
This compound is gradually being used in the fields of medicine and materials. In the development of medicine, it is the key to the synthesis of active ingredients; when materials are created, it is also an important angle to improve performance. From the beginning to the rise of 1- (chloromethyl) -2,4-difluorobenzene, it depends on the diligent research of chemists to get on the road of science and move forward steadily, with a brighter future.
Product Overview
1- (chloromethyl) -2,4-difluorobenzene, an organic compound. Its color may be a colorless to slightly yellow liquid with a special odor. The physical properties of this substance, such as boiling point and melting point, vary with accurate experimental determination.
Its chemical properties are active, and the structure of chloromethyl and difluorobenzene rings makes it possible to participate in a variety of chemical reactions. In the field of organic synthesis, it is often used as a key intermediary. It can react with many reagents through a specific reaction path to prepare other fluorine-containing organic compounds.
The method of synthesis may be obtained by a series of reactions such as halogenation and substitution with appropriate starting materials. However, when preparing, it is necessary to pay attention to the reaction conditions, such as temperature, the use of catalysts, etc., to ensure the purity and yield of the product.
Physical & Chemical Properties
1- (chloromethyl) -2,4-difluorobenzene is an organic compound. Its physical and chemical properties are related to the essence of this substance and are quite important. This compound has special physical properties. At room temperature, it may be a colorless liquid, and its taste may be irritating. Looking at its boiling point, it can reach a specific value, due to the force between molecules. Its density is also fixed, reflecting the relationship between its mass and volume.
As for its chemical properties, its chloromethyl group is active, prone to substitution reactions, and can interact with many reagents. The second fluorine atom in the benzene ring affects the distribution of its electron cloud, resulting in its unique chemical activity. In the field of organic synthesis, this compound can be used as a key intermediary, participating in various reactions, and making great contributions to the preparation of organic materials with special structures.
Technical Specifications & Labeling
1 - (chloromethyl) -2,4 -difluorobenzene is an important intermediate in organic synthesis. The technical specifications and identification (product parameters) of its preparation are crucial.
Preparation of this product requires a precise chemical process. First, use a specific reaction raw material, under suitable reaction conditions, such as precise control of temperature, pressure and reaction time, so that the chemical reaction can proceed in an orderly manner. In the meantime, the purity and ratio of the raw material will affect the quality and yield of the product.
In terms of product identification, its chemical structure, purity, impurity content and other parameters need to be detailed. When the purity reaches a specific standard, the impurities must be strictly controlled within the limit. In this way, we can ensure that this product exhibits stable performance and reliable quality in subsequent applications, meeting the needs of different fields.
Preparation Method
To prepare 1 - (chloromethyl) -2,4-difluorobenzene, the raw material and production process, reaction steps and catalytic mechanism are the key.
The raw material is selected, when 2,4-difluorobenzene is used as the base, supplemented by chloromethylating reagents, such as chloromethyl ether. The production process must be operated in a suitable reaction vessel. At the beginning of the reaction step, 2,4-difluorobenzene is mixed with chloromethyl ether in a specific ratio, and an appropriate amount of Lewis acid is added as the catalyst, such as anhydrous zinc chloride. Warm up to a certain temperature and maintain a constant temperature to promote the full reaction of the two. In this process, the chloromethyl of chloromethyl ether replaces the hydrogen atom on the benzene ring to form the The catalytic mechanism of
is that Lewis acid activates chloromethyl ether, enhances its electrophilicity, and makes the benzene ring more prone to electrophilic substitution reaction with it. In this way, the purpose of preparing 1- (chloromethyl) -2,4-difluorobenzene can be achieved through delicate regulation of raw materials, processes, steps and catalysis.
Chemical Reactions & Modifications
To taste the industry of chemical industry, if you want to be subtle, you must focus on the reaction and modification. Today there is 1- (Chloromethyl) -2,4-Difluorobenzene, and the reaction path of its synthesis is related to the yield and purity, which cannot be studied carefully.
The reaction method used in the past may have defects, resulting in impure products, and the yield is not good. In order to improve, the reaction conditions, such as temperature and catalyst selection, should be carefully observed. If the temperature is high, the reaction speed may cause side reactions to occur; if the temperature is low, although there are few side reactions, it takes a long time and the yield is low.
The catalyst is also the key, and the good agent can promote the reaction, improve the rate and selectivity. Furthermore, the purity and ratio of raw materials have an impact. The way of modification can start with the molecular structure and introduce groups to change its properties and increase its wide application. In this way, the properties of this chemical may be better and it will shine in the industrial process.
Synonyms & Product Names
1 - (chloromethyl) -2,4-difluorobenzene, this substance is widely used in the field of organic synthesis. Its synonymous name, or 2,4-difluorobenzyl chloride. In the chemical industry, the two refer to the same substance.
In the past, chemists investigated this compound and found that it has a unique structure and characteristics. Because it contains chloromethyl and difluorophenyl groups, it shows different activities in many chemical reactions.
In the industrial preparation route, it is obtained through a variety of processes and reactions. As a chemical raw material, it plays a significant role in the synthesis of fine chemicals, pharmaceutical intermediates, etc. In the process of drug development, 1- (chloromethyl) -2,4-difluorobenzene (i.e. 2,4-difluorobenzyl chloride) is a key intermediate, which helps to synthesize many specific drugs and makes great contributions to human health.
Safety & Operational Standards
1 - (chloromethyl) - 2,4 -difluorobenzene is also a chemical product. Its safety and operation regulations are of paramount importance in the industrial industry, and it is related to the health and smooth operation of everyone.
This product is specialized, and it must be operated in accordance with safety regulations between use and production. The method of storage must be placed in a dry and common place, avoiding open fires and hot topics. The reservoir must be firm and sealed to prevent its leakage and risk. It must not be mixed with strong oxygen agents and strong alkalis, so as to avoid the danger of melting.
As for the process of operation, the operator wears special protective clothing, anti-chemical gloves and masks to avoid skin contact and air absorption. The operation should be wide-open, and the row should be installed to decontaminate the gas. When taking it, handle it with care, do not damage the device and discharge the medicine. If there is a leak, cut off the source immediately, swarm people in the place, and prohibit fire. When a small amount of leakage, cover it with sand or inert material and collect it in a special device. A large amount of leakage will be contained in the embankment, and then treated.
At the time of transportation, there are also strict regulations. The package must be in accordance with the standard, and the quality and danger of the product should be marked. Protection from exposure, rain and shock during transportation.
In short, 1 - (chloromethyl) - 2,4 - difluorobenzene safety and operating regulations, all practitioners should be careful not to neglect, in order to ensure the safety of the industry and people.
Application Area
1- (chloromethyl) -2,4-difluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help form new drugs, treat various diseases, and increase the health of patients. In material science, it can make special functional materials, endow materials with new qualities, such as excellent stability and conductivity, etc., for high-tech products. In pesticide chemistry, it is also an important raw material, which can make high-efficiency and low-toxicity pesticides, protect crops, and increase their yield. This compound is widely used in many fields, and is actually an important role in scientific research and industrial production.
Research & Development
Since modern times, the art of chemistry has advanced day by day, and various compounds have emerged in an endless stream. In this case, the research and development of 1- (Chloromethyl) -2,4-Difluorobenzene is related to many fields.
To study this compound, it is necessary to clarify its physicochemical properties at the beginning. Explore its structure and know its reaction rules in order to advance on the road of synthesis. When experimenting, it is crucial to strictly observe the reaction conditions, temperature, pressure, and ratio of reagents.
The development direction can be used to create new drugs, and with its unique structure, it may emerge in the field of medicine; or it may add bricks to materials science and give materials new energy. However, the road to research is not smooth, and problems must be encountered. Those who need scientific research should make unremitting efforts to promote the research and development of 1- (Chloromethyl) -2,4-Difluorobenzene with wisdom and perseverance, so that it can be used by the world and benefit the world.
Toxicity Research
Since modern times, chemical refinement has improved, and various substances have changed with each passing day. Today there is 1- (Chloromethyl) -2,4-Difluorobenzene, which is gradually emerging in the field of chemical industry. However, the study of its toxicity still needs to be investigated in detail.
The study of the toxicity of husband is related to the well-being of everyone, and it is necessary to be careful. The nature of this product may involve the entry of skin touch and respiration. It is necessary to explore its reaction in different environments and observe its impact on the biological body. Observe whether it damages the viscera and disturbs the flow of qi and blood.
Although research may have started at present, there is still a long way to go. We must carefully investigate the mystery of the toxicity of 1- (Chloromethyl) -2,4-Difluorobenzene with scientific methods and a rigorous heart, so as to guide the future use, avoid its harm and pursue its benefits, and live up to the mission of scientific research.
Future Prospects
The future outlook concerns 1- (Chloromethyl) -2,4-Difluorobenzene, and the future can be described as bright. Looking at the field of chemistry today, this compound is becoming more and more useful. In pharmaceutical research and development, it can be a key intermediate, help create new agents, cure diseases, or solve the pain of many patients, making health promising. In materials science, it may participate in the synthesis of new materials, endowing materials with specific properties, such as better stability, conductivity, etc., making material applications more diverse.
Our chemical researchers should be enterprising and unremitting in their exploration. The method of refined synthesis can improve the yield, reduce its cost, and make its production more efficient and economical. Expand the scope of application and explore potential uses to make this compound shine in various fields in the future. Over time, 1- (Chloromethyl) -2,4-Difluorobenzene will surely contribute to technological progress and social development, and become the cornerstone of future brilliance.
Where to Buy 1-(Chloromethyl)-2,4-Difluorobenzene in China?
As a trusted 1-(Chloromethyl)-2,4-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-(Chloromethyl)-2,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (chloromethyl) -2,4-difluorobenzene?
The main purpose of 1- (methoxy) -2,4-dienol is to play an important role in the synthesis of polymers. In the field, it is often used in the synthesis of polymers. Because of its specific activity, it can be modified to synthesize compounds with specific biological activities, such as some compounds used in the treatment of inflammation, tumors and other diseases.
In terms of productivity, 1- (methoxy) -2,4-dienol can be used for the synthesis of polymers, herbicides, etc. Its chemical properties can help it inhibit the growth of crop diseases and pests, or dry grass production, so as to ensure the health of crops and increase the yield.
In the field of materials, this compound also has its application. It may be used as a raw material to synthesize polymer materials with specific properties, such as polymers with special optical and chemical properties. By rationalizing the reaction and introducing it into the polymer, new properties can be given to the material to meet the needs of different work.
In addition, in the study of synthetic synthesis, 1- (methoxy) -2,4-dienol is a synthesizer with low value. Chemicals can use its active function to develop the properties of various molecules and expand the performance research of chemical compounds. Therefore, 1- (methoxy) -2,4-dienol, due to its specialization, plays an important role in many fields such as engineering, engineering, materials and chemical synthesis, which promotes the development of the phase field.
What are the physical properties of 1- (chloromethyl) -2,4-difluorobenzene?
1 - (methoxy) - 2,4 - dibromobenzene is an organic compound with the following physical properties:
It is mostly solid at room temperature, and has a certain melting point and boiling point due to the influence of intermolecular forces and relative molecular weights. The melting point or in a specific range, the specific value varies according to the purity of the substance; the boiling point is related to the intermolecular forces and relative molecular weights. The relative molecular mass is large, and the intermolecular forces are strong, so the boiling point is high.
The compound is insoluble in water. Because it is an organic molecule, there are no large numbers of groups that can form hydrogen bonds with water molecules in the structure. Water is a polar molecule. According to the principle of "similar miscibility", the polarity difference makes it insoluble in water. However, it is easily soluble in common organic solvents, such as ethanol, ether, chloroform, etc. Organic solvents are mostly non-polar or weakly polar, and are compatible with the intermolecular forces of 1- (methoxy) -2,4-dibromobenzene, which is conducive to mutual dissolution.
1- (methoxy) -2,4-dibromobenzene has a certain density, which is greater than that of common organic solvents. In organic synthesis and other operations, if delamination is involved, it will be in the lower layer. At the same time, the compound is volatile, but the volatility is not strong. Due to the existence of a certain force between molecules, it needs a certain amount of energy to overcome the intermolecular force to escape the system. In addition, it may also have a specific odor, but the odor description is more subjective and usually has a special odor similar to aromatic hydrocarb
What are the synthesis methods of 1- (chloromethyl) -2,4-difluorobenzene?
There are several common methods for the synthesis of 1- (cyanomethyl) -2,4-dibromobenzene:
One is a halogenation reaction. With benzene as the initial raw material, methyl is introduced into the benzene ring through a Foucault alkylation reaction, and then a specific halogenating agent, such as bromine, is brominated at the 2,4 position of the benzene ring under the catalysis of a suitable catalyst, such as iron powder or iron tribromide, to obtain 2,4-dibromotoluene. Then, using specific reagents and conditions, the methyl is converted to cyanomethyl, such as halogenation of the methyl by halogenation reaction, and then nucleophilic substitution reaction with cyanyl reagents such as sodium cyanide, so that the target product 1 - (cyanomethyl) - 2,4 - dibromobenzene can be obtained.
The second is to react with a compound containing cyanomethyl as the starting material. Select a suitable phenolic compound, first protect the phenolic hydroxyl group to prevent it from interfering in the subsequent reaction. After that, brominate the benzene ring with a brominating agent to achieve bromine substitution at the 2,4 positions. After the bromination is completed, the protective group of the phenolic hydroxyl group is removed, and after a series of conversion reactions, 1- (cyanomethyl) -2,4-dibromobenzene is finally obtained.
The third is the reaction involving organometallic reagents. For example, by preparing an organolithium reagent containing a benzene ring or a Grignard reagent, it is reacted with a halogenated hydrocarbon or a carbonyl compound containing a cyanomethyl structural unit to form a carbon-carbon bond, thereby realizing the synthesis of 1- (cyanomethyl) -2,4-dibromobenzene. During the reaction process, it is necessary to precisely control the reaction conditions, such as reaction temperature, reaction time, and the dosage ratio of reagents, to ensure that the reaction can proceed smoothly in the direction of the target product, while improving the yield and purity of the product.
What are the precautions for 1- (chloromethyl) -2,4-difluorobenzene during storage and transportation?
1 - (cyanomethyl) - 2,4 -dibromonaphthalene in storage and transportation, need to pay attention to many key matters. This is an organic compound, special properties, a little careless will cause disaster.
First, pay attention to the storage environment. It is advisable to choose a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flames and hot topics, it is easy to cause combustion, endangering the safety of the surrounding. Too high temperature or too much humidity may cause chemical reactions, affecting the quality and stability.
Second, the packaging must be tight. Suitable packaging materials need to be selected to prevent the intrusion of water vapor, oxygen, etc. Damaged packaging can make substances come into contact with the outside world, or cause deterioration, and may also leak, posing a threat to the environment and the human body.
Third, be careful when handling. Load lightly and unload lightly to avoid collisions and falls to prevent packaging damage. Because it may be fragile, improper handling can easily cause packaging to break and cause material leakage.
Fourth, during transportation, follow relevant regulations and standards. Select compliant transportation tools and methods to ensure transportation safety. At the same time, transportation personnel should be familiar with the characteristics of the transported substances and emergency treatment methods, and can respond quickly in case of emergencies.
Fifth, obvious warning signs should be set in the storage area to remind personnel to pay attention to safety. And it should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment to deal with possible fires and leakage accidents in a timely manner.
Only by paying full attention to the above matters can we ensure the safety of 1- (cyanomethyl) -2,4-dibromonaphthalene during storage and transportation, avoid accidents, and ensure the safety of personnel and the environment.
What is the market price of 1- (chloromethyl) -2,4-difluorobenzene?
Today, there is a question about the market price of 1- (methoxy) -2,4-dibromobenzene. The price of a good often depends on factors such as supply and demand, manufacturing costs, quality, and the wide and narrow market.
On its supply and demand, if the market is prosperous and the production is small, the price will rise; if the demand is small and the supply is large, the price will be depressed. If the demand for 1- (methoxy) -2,4-dibromobenzene is greatly increased by various industries, and the producer fails to respond quickly, the price should be high.
Manufacturing costs are also a major factor. The production of this compound requires raw materials, labor, equipment, energy, etc. If the price of raw materials increases, or the cost of labor increases, the consumption of equipment is large, and the price of energy is expensive, the cost will rise, and the price will also rise. On the contrary, if the production technology is advanced and the cost is reduced, the price may be reduced.
The quality is also related to the price. The quality of 1- (methoxy) -2,4-dibromobenzene, with less impurities and high purity, is more suitable for users, and the price is higher than the quality.
Furthermore, the market is wide and narrow. In Guangzhou City, the audience is large, and the sales volume is expected to increase significantly. Although the price may be slightly lower, it adds up to a lot, and the benefits can be viewed; in the narrow city, the audience is small, and the price may need to be slightly higher to ensure its profits.
From this perspective, it is difficult to determine the market price of 1- (methoxy) -2,4-dibromobenzene. It is necessary to comprehensively consider the above factors before a more accurate decision can be made. However, in order to know the real-time price, it is also necessary to observe the chemical raw material market and consult the production and marketing merchants to know the details.