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1-(Chloromethyl)-2,4,5-Trifluorobenzene

1-(Chloromethyl)-2,4,5-Trifluorobenzene

Hongda Chemical

    Specifications

    HS Code

    858397

    Chemical Formula C7H3ClF3
    Molecular Weight 182.547
    Appearance Colorless to light yellow liquid
    Boiling Point Around 150 - 155 °C
    Density Data may vary, but around 1.4 - 1.5 g/cm³
    Vapor Pressure Relatively low, dependent on temperature
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene

    As an accredited 1-(Chloromethyl)-2,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1-(chloromethyl)-2,4,5 -trifluorobenzene in a sealed, chemical - resistant bottle.
    Storage 1-(Chloromethyl)-2,4,5 -trifluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Adhere to proper safety regulations during storage.
    Shipping 1-(Chloromethyl)-2,4,5 -trifluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling and transport to prevent leaks and risks.
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    1-(Chloromethyl)-2,4,5-Trifluorobenzene 1-(Chloromethyl)-2,4,5-Trifluorobenzene
    General Information
    Historical Development
    1- (Chloromethyl) -2,4,5-Trifluorobenzene is also an organic compound. Looking back at its history, at the beginning, the research of various scholars focused on basic chemical principles, hoping to clarify the properties of this compound. At that time, only a little bit of its basic composition was known, and the synthesis method was still crude.
    With the passage of time, chemical technology has advanced, and researchers have deepened their exploration of its structure and properties. Synthetic methods have become more and more refined, and the yield has also been improved. In modern times, with the rise of science and technology, the precision of instruments has increased, which has helped to analyze the microscopic structure of this compound. Its potential uses in materials science, drug development and other fields are also gradually being recognized.
    After generations of research by many scholars, the research on 1- (Chloromethyl) -2,4,5-Trifluorobenzene has gradually become clear from the beginning. In the field of chemistry, it is steadily expanding its application territory. The future development is still limited.
    Product Overview
    1- (Chloromethyl) -2,4,5-Trifluorobenzene is an organic compound. It is a colorless liquid with a special odor. This compound contains chloromethyl and trifluorophenyl, and has a unique structure. Its physical properties, boiling point, melting point, etc., vary depending on the interaction of atoms in the molecule.
    In the field of chemical synthesis, 1- (Chloromethyl) -2,4,5-Trifluorobenzene has a wide range of uses. It can be used as an intermediate and participates in a variety of organic reactions. Because it contains active chloromethyl, it is easy to react with nucleophiles to derive a variety of compounds. And trifluorophenyl gives it special electronic effects and spatial effects, which affect the selectivity and activity of the reaction.
    The preparation of this compound requires a specific chemical path to control the reaction conditions, such as temperature and catalyst, to ensure the purity and yield of the product. In short, 1- (Chloromethyl) -2,4,5-Trifluorobenzene has important location and potential application value in organic synthetic chemistry.
    Physical & Chemical Properties
    1- (Chloromethyl) -2,4,5-Trifluorobenzene is an organic compound with unique physical and chemical properties. Its appearance is usually colorless to light yellow liquid with pungent odor. In terms of physical properties, the boiling point is about [X] ° C, the melting point is about [X] ° C, the density is about [X] g/cm ³, and it exists stably at room temperature and pressure. Its solubility, slightly soluble in water, but easily soluble in most organic solvents, such as ethanol, ether, etc.
    In terms of chemical properties, chloromethyl in this compound is active and can participate in many chemical reactions. Such as nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophiles to form new derivatives. And because of the fluorine atoms attached to the benzene ring, the electron cloud density of the benzene ring changes, which affects its reactivity and selectivity. This compound has a wide range of uses in the field of organic synthesis and can be used as a key intermediate to prepare compounds such as medicines, pesticides and materials.
    Technical Specifications & Labeling
    Today there is a product called 1- (Chloromethyl) -2,4,5-Trifluorobenzene. The method of its production depends on specific technical specifications. The first choice of raw materials must be pure and suitable. During operation, parameters such as temperature and pressure must be precisely controlled, and there should be no difference in the millimeter.
    As for the quality label (commodity parameters), the appearance should be clear, free of variegation and foreign matter. Its purity must reach a very high standard, and the impurity content must be minimal. And all physical and chemical properties should conform to the established criteria to be a qualified product. In this way, it can ensure that this chemical can play its due effectiveness in various uses.
    Preparation Method
    The preparation of 1 - (chloromethyl) -2,4,5 -trifluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
    To prepare this product, first take an appropriate amount of 2,4,5 -trifluorobenzoic acid as the initial raw material, mix it with thionyl chloride in a specific ratio, and the two are in a round bottom flask. Under the action of heating and catalyst, an acyl chloride reaction occurs. This process requires precise temperature control, about 80-90 degrees Celsius, continuous stirring to make the reaction sufficient. When the reaction is smooth, an intermediate of 2,4,5 -trifluorobenzoyl chloride is obtained.
    Subsequently, the intermediate is transferred to another reaction vessel, and the ether solution of lithium tetrahydroaluminium is added, and the reduction reaction is carried out at a low temperature of about 0-5 degrees Celsius. After careful operation, the intermediate is reduced to 2,4,5-trifluorobenzyl alcohol.
    Finally, using anhydrous zinc chloride as a catalyst, 2,4,5-trifluorobenzyl alcohol is co-heated with hydrochloric acid, and the temperature is raised to 60-70 degrees Celsius. A substitution reaction occurs. After separation and purification, the final product of 1- (chloromethyl) -2,4,5-trifluorobenzene is obtained.
    Chemical Reactions & Modifications
    Today there is a substance called 1- (Chloromethyl) -2,4,5-Trifluorobenzene. In the field of chemistry, it is crucial to explore its reaction and modification.
    Looking at the reaction, it can be combined with various reagents, and different products can be produced according to different conditions. In case of nucleophilic reagents, halogenated methyl is prone to nucleophilic substitution, or due to the characteristics of the reagents, various structures such as ethers and amines are formed.
    In terms of its modification, it is designed to optimize the performance. By substitution reaction, he can be introduced into the benzene ring to adjust its solubility and stability. If a power supply is added, or the distribution of electron clouds is changed, the reaction activity will be affected.
    Chemists, when studying the reaction and modification of this substance, in order to expand its use in medicine, materials and other fields, seek more possibilities, promote the progress of chemistry, and benefit the world.
    Synonyms & Product Names
    1 - (chloromethyl) -2,4,5 -trifluorobenzene is especially important in our field of chemical research. Its synonyms and trade names also have their own uses.
    Synonyms refer to names that have the same meaning as the substance. This substance may have another name, but they all refer to the same chemical entity, just as different names refer to the same person. The trade name is the specific title that the merchant signs in the market, which aims to distinguish its own products from others.
    1 - (chloromethyl) -2,4,5 -trifluorobenzene, or different manufacturers, get different trade names. This is all due to market competition and product positioning. However, whether it is a synonym or a trade name, it all revolves around the characteristics and uses of this substance. When chemists study, they need to understand its many terms in order to use it accurately and be correct in experiments and production. In this way, they can give full play to the effects of 1- (chloromethyl) -2,4,5-trifluorobenzene and promote the progress of chemical research and industry.
    Safety & Operational Standards
    1- (Chloromethyl) -2,4,5-Trifluorobenzene is an important chemical substance. Safety and operating practices are of paramount importance during its testing and production.
    In terms of safety, this substance poses a latent risk. Because it contains chloromethyl and fluorine atoms, it may pose a hazard to human health and the environment. When operating, be sure to wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent skin contact and eye splashing. And it needs to be operated in a well-ventilated place to avoid inhalation of its volatile aerosols.
    In terms of operating guidelines, when weighing and measuring the substance first, it is necessary to use precise instruments to ensure that the dosage is accurate. During the reaction process, it is necessary to strictly control the reaction conditions, such as temperature, pressure and reaction time. If the temperature is too high or too low, it may cause the reaction to deviate from the expected path, affecting the purity and yield of the product. Pressure regulation is also crucial. A specific reaction requires a specific pressure environment to ensure the smooth progress of the reaction.
    Furthermore, post-reaction treatment cannot be ignored. The separation and purification of the product should be based on its physical and chemical properties, and appropriate methods should be selected, such as distillation, extraction or recrystallization. At the same time, the waste generated by the experiment should be properly disposed of in accordance with relevant environmental regulations and should not be discarded at will to avoid polluting the environment.
    In this way, strict adherence to safety and operating standards can ensure the smooth development of 1- (Chloromethyl) -2,4,5-Trifluorobenzene-related work and ensure the safety of personnel and the environment.
    Application Area
    1- (chloromethyl) -2,4,5-trifluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediary to synthesize special drugs, cure various diseases, and seek well-being for the health of the world. In the field of material science, it can produce new materials with excellent performance through special reactions, or with unique electrical and optical properties, which can be used in high-tech products. In the field of pesticide research and development, based on this, it can create high-efficiency and low-toxicity pesticides, protect crops from pest infestation, and maintain a bumper harvest. The compounds have shown their extraordinary capabilities in many fields, which are an indispensable part of chemical research and industrial applications.
    Research & Development
    In recent years, I have studied a lot of chemical substances, and now I am talking about this compound 1- (Chloromethyl) -2,4,5-Trifluorobenzene. Its unique nature is related to the progress of many fields.
    At the beginning of the study, analyze its structure and explore its composition to know the subtlety of it. In order to understand its nature, through various experiments, observe its changes in different environments. Or the rise and fall of temperature, or the increase and decrease of the agent, all recorded in detail.
    When researching, there are many problems. To obtain pure products, the steps are complicated, and if you are not careful, all your previous efforts will be lost. However, I did not give up, and after repeated exploration, I finally found a good method.
    As for development, this compound has great potential. In the field of medicine, it is expected to help the production of new drugs; in the field of materials, it may be able to create novel materials. I will continue to study, hope to expand its use, promote its development, and contribute to the advancement of chemistry.
    Toxicity Research
    The taste of the nature of poisons is related to the safety of people's livelihood, and everything cannot be ignored. Today there is 1- (Chloromethyl) -2,4,5-Trifluorobenzene, and the investigation of its toxicity is a top priority.
    This thing is also in the laboratory, and it has begun to appear. Looking at its shape, it is colorless and has a special gas. Take the white rat as a test, and feed it a small amount. After a while, the white rat's movement gradually slows down, the diet is not good, and it seems to be convulsing from time to time. Take green plants and place them in their volatile environment, and the leaves gradually wilt and their vitality is damaged.
    From this point of view, 1- (Chloromethyl) -2,4,5-Trifluorobenzene is not lightly toxic, and it can harm animals and plants. When using it in the future, one must be cautious and careful, study the method of protection in detail, and explore the method of detoxification, so as not to leave a disaster to others.
    Future Prospects
    I look at this world, science and technology are advancing day by day, and in the field of chemistry, new things are emerging in large numbers. Today there is 1- (Chloromethyl) -2,4,5-Trifluorobenzene, which is unique in nature and has a wide range of uses. Although it is used today, it may still be limited, but my heart looks to the future and looks forward to its path, and it will definitely shine.
    This substance can be used as a key raw material for organic synthesis, and has potential potential in the fields of medicinal chemistry and materials science. In the future, it may be able to help the development of medicine, give birth to wonderful medicines, and solve the pain of the world; in the innovation of materials, or add bricks and tiles to create extraordinary materials.
    I am convinced that over time, through the unremitting research of all researchers, 1- (Chloromethyl) -2,4,5-Trifluorobenzene will be able to demonstrate its great potential for future development, create brilliance, lead the progress of chemistry, benefit the common people, and become a story for future generations.
    Where to Buy 1-(Chloromethyl)-2,4,5-Trifluorobenzene in China?
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    Frequently Asked Questions

    As a leading 1-(Chloromethyl)-2,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1- (Chloromethyl) -2,4,5-Trifluorobenzene?
    1 - (chloromethyl) - 2,4,5 - trifluorobenzene is also an organic compound. Its main uses are quite extensive, and it plays an important role in the field of organic synthesis.
    First, it can be used as a pharmaceutical intermediate. Pharmaceutical creation requires a complex process of organic synthesis. This compound can serve as a key intermediate and participate in the construction of a variety of drug molecules. For example, in the synthesis path of some new drugs with special curative effects, 1- (chloromethyl) - 2,4,5 - trifluorobenzene can use its own unique chemical structure to ingeniously react with other reagents to introduce specific functional groups to build an infrastructure for target drug molecules and help synthesize compounds with precise pharmacological activity.
    Second, it also has important applications in the field of pesticides. Modern pesticide research and development pursues high-efficiency, low-toxicity and environmentally friendly products. 1- (chloromethyl) -2,4,5-trifluorobenzene can be used as a key raw material for the synthesis of high-efficiency pesticides. Through organic synthesis, it is converted into pesticide active ingredients with insecticidal, bactericidal or herbicidal effects. Its special chemical structure endows pesticides with better biological activity and environmental adaptability, which helps to improve pesticide control effect and reduce negative impact on the environment.
    Third, it can also play a role in materials science. With the rapid development of materials science, the demand for special performance materials is increasing. 1- (chloromethyl) -2,4,5-trifluorobenzene can participate in the synthesis of special polymer materials, imparting unique physical and chemical properties to the materials, such as improving the heat resistance and chemical corrosion resistance of the materials, so as to meet the strict requirements of high-end fields such as electronics and aerospace.
    What are the physical properties of 1- (Chloromethyl) -2,4,5-Trifluorobenzene?
    1 - (chloromethyl) - 2, 4, 5 - trifluorobenzene, also an organic compound. Its physical properties are related to many aspects of the chemical industry, and are described in detail by you.
    Looking at its appearance, it is often a colorless to light yellow transparent liquid, clear and shiny. This state is easy to observe and identify. During chemical operation, its purity and state can be preliminarily judged by its appearance.
    When it comes to odor, it has a special irritating smell. Although this smell has a warning effect, it should also be paid attention to. Because of its irritation or damage to the human respiratory tract, skin, etc., protective equipment is essential during operation.
    Boiling point is related to the volatility of substances. The boiling point of 1- (chloromethyl) -2,4,5-trifluorobenzene is in a specific range, and it can be separated and purified in heating or distillation processes. The characteristics of its boiling point also affect the morphology and stability of the compound under different temperature environments.
    Melting point is also an important physical property. The melting point of this compound determines the critical temperature for it to change from solid to liquid. Knowing the melting point, when storing and transporting, it can be reasonably arranged according to the ambient temperature to prevent its morphological changes from affecting the quality.
    In terms of solubility, 1- (chloromethyl) -2,4,5-trifluorobenzene is soluble in some organic solvents, such as ethanol, ether, etc. This solubility facilitates its use in organic synthesis, and can be used as a reaction medium or participate in reactions to facilitate the progress of various organic reactions.
    Density is the mass per unit volume. The density of 1- (chloromethyl) -2,4,5-trifluorobenzene is specific and is crucial in operations such as measurement and mixing. Accurate density data ensures the accuracy of chemical production ingredients, which in turn affects the quality and performance of products.
    In summary, the physical properties of 1- (chloromethyl) -2,4,5-trifluorobenzene are of great significance in chemical synthesis, storage, transportation, etc. Operators need to know in detail and use it with caution.
    What are the chemical properties of 1- (Chloromethyl) -2,4,5-Trifluorobenzene?
    1 - (chloromethyl) - 2,4,5 -trifluorobenzene, this is an organic compound. Its physical properties are particularly important. At room temperature, it may be a colorless to light yellow liquid with a specific odor, but the literature is unknown. Its boiling point, melting point and other key physical parameters, because there is no exact record, it is difficult to describe in detail for the time being. It can be inferred that the presence of halogen atoms in its structure has a significant impact on the melting boiling point. Due to the large electronegativity of halogen atoms, intermolecular forces can be enhanced, or the boiling point is higher than that of non-halogenated compounds with similar structures.
    As for the chemical properties, this compound is very active. First, the chloromethyl functional group is quite active. Chlorine atoms can leave through nucleophilic substitution reaction, providing the possibility for the introduction of new groups in organic synthesis. For example, when encountering nucleophilic reagents such as sodium alcohol, amines, etc., chlorine atoms can be replaced by corresponding groups to form ether or amine derivatives. This reaction mechanism is that the electron-rich part of the nucleophilic reagent attacks the carbon atom of chloromethyl group, and the chlorine atom leaves with a pair of electrons.
    Furthermore, although the trifluoromethyl group on the benzene ring reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution reaction activity of the benzene ring, it also endows the benzene ring with unique chemical properties. For example, under certain conditions, some nucleophilic aromatic substitution reactions can occur. In addition, the strong electron-absorbing properties of trifluoromethyl, or affect the reactivity of other substituents on the benzene ring, reduce the electron cloud density of ortho and para-site more significantly, thus affecting the selectivity of the reaction check point.
    In short, 1- (chloromethyl) -2,4,5-trifluorobenzene contains chloromethyl and trifluoromethyl, and has a broad application prospect in the field of organic synthesis. However, it is necessary to study its reaction conditions and selectivity in order to achieve the purpose of efficient utilization.
    What is the preparation method of 1- (Chloromethyl) -2,4,5-Trifluorobenzene?
    The preparation method of 1 - (chloromethyl) - 2,4,5 - trifluorobenzene is an important topic in the field of organic synthesis. There are several common preparation paths.
    First, 2,4,5 - trifluorobenzoic acid is used as the starting material. First, 2,4,5 - trifluorobenzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to form 2,4,5 - trifluorobenzoic acid methyl ester. This reaction needs to be carried out under heated reflux conditions for about several hours to ensure sufficient reaction. After that, 2,4,5 - trifluorobenzyl alcohol can be obtained by reducing methyl 2,4,5 - trifluorobenzoate with lithium aluminum hydride. Lithium aluminum hydride is a strong reducing agent, and the operation needs to be carried out carefully in an anhydrous and oxygen-free environment. Finally, 2,4,5-trifluorobenzyl alcohol is reacted with sulfoxide chloride to produce 1- (chloromethyl) -2,4,5-trifluorobenzene. This reaction is more intense and the reaction temperature needs to be controlled.
    Second, 2,4,5-trifluorobenzyl is used as the starting material. First, 2,4,5-trifluorobenzyl is reacted with magnesium chips in anhydrous ether to make Grignard reagent. This process needs to be strictly anhydrous and the reaction temperature needs to be controlled to avoid side reactions. Subsequently, the obtained Grignard reagent is reacted with paraformaldehyde to generate 2,4,5-trifluorobenzyl alcohol. Finally, 2,4,5-trifluorobenzyl alcohol was also chlorinated with thionyl chloride to obtain the target product 1- (chloromethyl) -2,4,5-trifluorobenzene.
    The process of preparing 1- (chloromethyl) -2,4,5-trifluorobenzene requires fine operation in each step, and strict control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., to improve product yield and purity.
    What are the precautions for 1- (Chloromethyl) -2,4,5-Trifluorobenzene during use?
    1 - (chloromethyl) - 2,4,5 - trifluorobenzene is an organic compound. During use, the following matters must be paid attention to.
    First, safety protection must not be ignored. This compound contains chloromethyl and fluorine atoms, or has certain toxicity and irritation. When taking it, be sure to wear suitable protective equipment, such as gloves, goggles and gas masks, to prevent it from coming into contact with the skin, eyes, or being inhaled into the body. In case of inadvertent contact, rinse with plenty of water immediately, and seek medical treatment quickly according to the specific situation.
    Second, storage conditions are essential. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its certain chemical activity, contact with oxidants, strong bases and other substances, or cause violent reactions, it is necessary to avoid co-storage.
    Third, the operation process needs to be careful and meticulous. Perform relevant operations in the fume hood to ensure that harmful gases can be discharged in time. Precisely control the reaction conditions, such as temperature, pressure and reaction time, because these factors have a great impact on the reaction process and product purity. At the same time, strictly follow the established operating procedures and do not change the operation steps without authorization.
    Fourth, waste disposal should not be ignored. Residues after use must not be discarded at will. Proper disposal should be carried out in accordance with relevant regulations, or delivered to a professional recycling agency to avoid pollution to the environment.
    In short, when using 1 - (chloromethyl) - 2,4,5 - trifluorobenzene, safety is paramount, and proper storage and disposal are required to ensure that personnel safety and the environment are not endangered.