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1-Chloro-5-Fluoro-2-Nitrobenzene

1-Chloro-5-Fluoro-2-Nitrobenzene

Hongda Chemical

Specifications

HS Code

334160

Chemical Formula C6H3ClFNO2
Molecular Weight 175.545 g/mol
Appearance Yellow - brown liquid
Boiling Point 212 - 214 °C
Melting Point 19 - 21 °C
Density 1.476 g/cm³
Flash Point 92.2 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents
Odor Characteristic odor
Stability Stable under normal conditions
Hazard Class Irritant

As an accredited 1-Chloro-5-Fluoro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 5 - fluoro - 2 - nitrobenzene packaged in 1 - kg bottles.
Storage 1 - Chloro - 5 - fluoro - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions.
Shipping 1 - Chloro - 5 - fluoro - 2 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. Shipment follows strict hazardous material regulations, ensuring proper handling, labeling, and transport to prevent spills and risks.
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1-Chloro-5-Fluoro-2-Nitrobenzene 1-Chloro-5-Fluoro-2-Nitrobenzene
General Information
Historical Development
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is an important chemical compound in the field of chemical synthesis. Looking back in the past, its research and development process contains many arduous explorations. At the beginning, researchers became more interested in halogenated nitro-aromatic hydrocarbons and tried to develop a new and efficient synthesis path. After repeated attempts at various reaction conditions and raw material ratios, a feasible method for preparing 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene was explored. In the early days, the synthesis efficiency and purity were poor due to technical limitations and cognition. However, with the improvement of chemical theory and the advancement of experimental technology, the synthesis process was continuously improved, the purity of the product was improved, and the yield was also steadily increased. The application prospects of this compound in the fields of medicine and materials are increasingly broad, and its historical development has witnessed the unremitting progress and breakthroughs in chemical research.
Product Overview
1-Chloro-5-fluoro-2-nitrobenzene, also an organic compound. Its shape is colorless to light yellow liquid with a special odor. This compound is widely used in the field of organic synthesis.
Can be used as an intermediate for medicine and pesticides. Based on it, a variety of special drugs can be prepared to treat various diseases; in the preparation of pesticides, it can help to become efficient insecticides and fungicides, and protect the growth of crops.
The synthesis method often starts with benzene derivatives and is obtained by halogenation and nitrification reactions. The reaction conditions need to be precisely controlled, such as temperature, reagent ratio, etc., to ensure the purity and yield of the product.
1-chloro-5-fluoro-2-nitrobenzene has a certain chemical activity. When stored and used, it should be protected from mixing with oxidants and strong bases in accordance with safety procedures to avoid danger. In short, this compound has an important position in the chemical industry and has promising prospects.
Physical & Chemical Properties
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is mostly liquid, colored or light yellow, and has a special odor. Its boiling point is worth noting, about a certain temperature range, which is related to its separation and purification.
In terms of its chemical properties, chlorine, fluorine, and nitro are all active groups. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and easily initiates electrophilic substitution reactions. Although chlorine and fluorine are halogen atoms, their reactivity is also unique due to the benzene ring environment and electronic effects. This compound has a wide range of uses in the field of organic synthesis, and can be used as an intermediate to participate in many organic reactions. With its characteristics, it can build complex organic structures, and has potential value in the pharmaceutical, materials, and other industries.
Technical Specifications & Labeling
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is an important chemical product. Its technical specifications and labeling (product parameters) are extremely critical. The purity of this product needs to reach a very high standard, and the impurity content should be minimal to ensure that it can play a stable role in various chemical reactions and industrial applications. The appearance should be a specific color state, without obvious foreign objects. In terms of labeling, key information such as chemical name, molecular formula, molecular weight should be clearly marked to facilitate accurate identification and use by users. When storing and transporting, specific specifications should be followed according to its chemical properties to prevent it from deteriorating or causing safety hazards. Only in this way can the effective application of 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene in industrial production and scientific research be guaranteed.
Preparation Method
To make 1-chloro-5-fluoro-2-nitrobenzene, the raw materials and production process, reaction steps and catalytic mechanism are very critical.
First take an appropriate amount of fluorobenzene as the starting material and place it in a clean reactor. Using aluminum trichloride as the catalyst, at a moderate temperature and stirring rate, slowly add nitrate-sulfur mixed acid for nitrification. This step requires precise temperature control to prevent side reactions from breeding. When the reaction is smooth, 5-fluoro-2-nitrobenzene is obtained.
Then, 5-fluoro-2-nitrobenzene is transferred to another reaction device. Iron powder and hydrochloric acid are used as the reduction system, and the reaction conditions are carefully controlled to reduce the nitro group to an amino group to generate 5-fluoro-2-aminobenzene.
Finally, 5-fluoro-2-aminobenzene is placed in the chlorination reaction device, and chlorine gas is passed and catalyzed by copper chloride to realize the conversion of amino groups into chlorine atoms, and finally 1-chloro-5-fluoro-2-nitrobenzene is obtained. Each step of the reaction needs to be carefully regulated to ensure the purity and yield of the product.
Chemical Reactions & Modifications
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is an important compound in organic synthesis. Its chemical reaction and modification are very critical. In previous studies, the reaction path of this compound relied on traditional methods, but these methods may not have high survival efficiency and complicated side reactions.
At present, we strive to improve it. After repeated research, it is found that the reaction process can be optimized by the intervention of a specific catalyst. This catalyst can effectively promote the reaction, greatly reduce the occurrence of side reactions, and improve the purity and yield of the product. After this modification, 1-Chloro-5-Fluoro-2-Nitrobenzene has a broader application prospect in the chemical industry, which can provide more efficient and high-quality raw materials for subsequent related synthesis work, and help the advancement of chemical synthesis technology.
Synonyms & Product Names
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene, this thing is also worth studying in detail in my chemical research. The different names, or depending on the region, or due to the different uses, all refer to this thing.
Ancient scholars also have much research on the name of the thing. Although times change, the reason is the same. Today, 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene, or some people call it chlorofluoronitrobenzene, is also known in the industry.
As for the trade name, it may vary depending on the manufacturer. However, its essence is that they are all chemical products. In the chemical industry, knowing its different names and trade names is like a boat trip, which can help the industry to accurately identify, without the risk of misuse, and is beneficial to research and production. Only in this way can we understand its nature, make good use of it, and achieve the lofty pursuit of chemical research.
Safety & Operational Standards
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is an important chemical substance. During its production and use, safety and operating practices are of paramount importance.
The first word is safe, this substance is dangerous. Its chemical properties are active, and contact may cause burns to the skin and eyes. If inhaled or ingested inadvertently, it may endanger health and damage the respiratory and digestive systems. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and should also be stored separately from oxidants and reducing agents to prevent violent reactions.
As for the operating instructions, the operator must be professionally trained and familiar with the operating procedures. When operating, appropriate protective equipment, such as protective gloves, goggles and protective clothing, is required to prevent direct contact. Operating in a fume hood can effectively reduce the inhalation of harmful gases. When taking the substance, accurately measure it to avoid waste and pollution. After the operation, properly clean the experimental table and dispose of the remaining substances according to regulations.
In addition, the laboratory or production site should be equipped with corresponding emergency treatment equipment and drugs. In case of leakage, quickly evacuate unrelated personnel and isolate the contaminated area. Small leaks can be absorbed by inert materials such as sand and vermiculite; if there are large leaks, it is necessary to build a dike or dig a pit for containment, and transfer it to a special collector with a pump for recycling or transportation to a waste treatment site for disposal.
In conclusion, 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene must be treated in strict accordance with safety and operating practices in order to ensure the safety of personnel and the smooth progress of production activities.
Application Area
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is a unique compound. It has outstanding applications in many fields. In the field of pharmaceutical research and development, this compound can be used as a key intermediate to help create new drugs for the treatment of various diseases. If it can precisely act on specific disease targets, it will bring benefits to patients. In the field of materials science, it also has a place, which may improve the properties of materials and give them unique physical and chemical properties, such as enhancing the stability and conductivity of materials. In the fine chemical industry, 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene can be used to synthesize a variety of fine chemicals, improve the quality and function of products, and is widely used in coatings, dyes and other fields, contributing to the development of related industries. Such various applications demonstrate its important value in many industries today, and it is a chemical raw material that cannot be ignored.
Research & Development
1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is an important chemical product. When we studied this substance, we dedicated ourselves to exploring its properties and reaction mechanism. After repeated experiments, we observed its changes under different conditions.
Initially, we focused on analyzing its chemical structure and understood the interaction between atoms. This is the basis for the study. Then, observe its reaction with various reagents. Under the action of specific temperatures and catalysts, the substance exhibits unique reactivity.
On the synthesis path, many attempts were made to find an optimization method to improve its yield and purity. This research not only enriches the understanding of the compound, but also lays the foundation for its further application and development. It is expected to find broad application prospects in materials science, medicinal chemistry and other fields, and promote the progress and development of related fields.
Toxicity Research
Taste chemical substances, their properties or differences, related to people's health, must be observed. Today there is 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene, the toxicity of this substance should be investigated in detail.
Look at its molecular structure, the genus of chlorine, fluorine, and nitro, or potentially harmful. In living organisms, it may interfere with biochemical reactions and damage the normal function of cells. And its chemical activity, or cause metabolic disorders, involve the viscera.
To clarify its toxicity, rigorous experiments are required. Take animals as models to observe their characteristics after ingestion or exposure, observe the changes in viscera, and analyze the differences in biochemical indicators. It is also necessary to consider the way it spreads in the environment and its impact on the ecology. From soil to water, from the bottom of the biological chain to the top, all need to be examined.
Only by deeply studying its toxicity can we know its risk, lay the foundation for protection and governance policies, and ensure the well-being of the people and protect the ecological peace.
Future Prospects
The future prospect, 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene, is the need for research and development. We can see the way forward, and we can encounter it like a million times.
In the process of synthesis, the daily precision. Or we can get better methods, increase its efficiency, reduce its consumption, and make the process easier. In this way, it can be used in the field.

The field of is expected to be newly developed and cleared. With its unique properties, or the raw materials of the system, it will save the world and save people, and the amount of merit.
Material science, also exist. Or it can be made of high-tech materials, so that the materials have special properties, and promote the development of phase technology.
However, before Lufeitan, there are also many options. To ensure the safety, be careful and careful, and make the synthesis method harmful to the environment. Safety is essential, not to be ignored, and the operation must be adhered to.
Of course, 1 - Chloro - 5 - Fluoro - 2 - Nitrobenzene is not yet available, full of hope and challenge, we are the researchers, diligent and refined, so as to make it possible.
Where to Buy 1-Chloro-5-Fluoro-2-Nitrobenzene in China?
As a trusted 1-Chloro-5-Fluoro-2-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-5-Fluoro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-5-fluoro-2-nitrobenzene?
1-Alkane-5-ene-2-carbonyl aniline, which is used in the scope of "Tiangongkai" or in many chemical synthesis processes.
In the field of organic synthesis, it can be used as a key intermediate. For example, through a specific reaction process, its alkenyl, carbonyl and amino activities can build complex organic structures. Take the construction of multiple cyclic compounds as an example, alkenyl groups can participate in cyclic addition reactions, carbonyl groups play an important role in nucleophilic addition reactions, and amino groups can be introduced into nitrogen heterostructures, so they can cooperate to create various organic molecules with special properties, laying the foundation for the research and development of new drugs and functional materials.
In the field of medicinal chemistry, its structural properties endow it with potential biological activity. Or it can be modified and modified to fit specific targets and become a lead compound for the treatment of diseases. For example, by optimizing its structure, it can enhance its ability to bind to receptors to achieve precise treatment of certain diseases, such as targeting key proteins in the proliferation signaling pathway of specific cancer cells, or it can design targeted drugs based on this.
In the field of materials science, with its reactivity, polymer materials with unique properties can be prepared. For example, by using alkenyl double bonds to copolymerize with other monomers through polymerization reactions, new properties can be imparted to materials, such as improving their mechanical properties, thermal stability, or optical properties, providing a new path for the development of new polymer materials, which can be applied to high-end fields such as aerospace and electronic devices to improve the comprehensive properties of materials.
What are the physical properties of 1-chloro-5-fluoro-2-nitrobenzene?
1-% -5-% oxygen-2-% aminosilicon, its physical properties are as follows:
First, under normal conditions, 1-% -5-% oxygen-2-% aminosilicon is mostly a transparent liquid, which is like clear water, uniform to the ground, observable by eyesight, reflected by light, refracted and shining, and has the beauty of flow.
In addition, this compound emits a small and special smell, which is not pungent or pleasant. Only under the subtle smell can you detect its special taste, and after a long time, this taste is familiar.
And the boiling temperature, 1-% -5-% oxygen-2-% aminosilicon melting temperature is low, the normal temperature is already liquid, and it needs high temperature, so it can hold the current temperature; and its boiling temperature is high, if you want to make it boil and melt, you need to apply the amount of phase to achieve this.
Its density is also special. Compared with water, the density of 1-% -5-% oxygen-2-% aminosilicon is slightly higher. If it enters the water, it can be sunk in the bottom of the water, and the moisture level is clear and the boundaries are clear.
In terms of solubility, 1-% -5-% oxygen-2-% aminosilane exhibits good solubility on the surface in multi-soluble materials, such as ethanol and acetone, which can be rapidly miscible, and then one. However, the solubility in water is limited, and it is partially soluble. When it is completely miscible, it can form a certain degree of dispersion.
The surface force of 1-% -5-% oxygen-2-% aminosilane cannot be ignored. The surface molecular force forms a specific surface force, causing it to form a specific shape on the solid surface. On some smooth surfaces, droplets similar to balls may be formed, exhibiting the effect of surface force.
What are the chemical properties of 1-chloro-5-fluoro-2-nitrobenzene?
The chemical properties of 1-alkane-5-ene-2-aminonaphthalene are particularly important and are often manifested in various chemical reactions.
This compound has alkenyl groups, alkenyl groups, and functional groups containing carbon-carbon double bonds. The carbon-carbon double bond is electron-rich, so it is easy to attract electrophilic reagents to approach and electrophilic addition reactions occur. For example, in the case of hydrogen halide, a halogen atom is added to one end of the double bond, and a hydrogen atom is added to the other end, following the Markov rule, that is, hydrogen atoms tend to be added to double-bonded carbon atoms containing more hydrogen. If peroxides are present, the anti-Markov rule is added. It can react rapidly with halogen elements, such as bromine water or bromine carbon tetrachloride solution, to fade bromine water. This is a common method for testing carbon-carbon double bonds. The double bond is broken, and two bromine atoms are added to the carbon atoms at both ends of the original double bond.
It also contains an amino group, and the amino group is a basic group. It can react with acids to form salts. If it reacts with hydrochloric acid, the lone pair of electrons on the amino nitrogen atom binds hydrogen ions to form a corresponding ammonium salt. This property makes the compound soluble in acidic solutions. And the nitrogen atom of the amino group has lone pair electrons, which are nucleophilic and can undergo nucleophilic substitution reactions with electrophilic reagents such as halogenated hydrocarbons. The nitrogen atom attacks the carbon atom connected to the halogen in the halogenated hydrocarbons, and the halogen leaves to form a new carbon-nitrogen bond.
And the naphthalene ring part, naphthalene is a fused ring aromatic hydrocarbon, which is aromatic. Although more active than benzene, aromatic electrophilic substitution reactions can occur. Because the amino group is an ortho-and para-site group, the electrophilic reagent is easy to attack the neighbor and para-site of the naphthalene ring and the amino-connected benzene ring. If nitrification occurs, the nitro
1-alkane-5-ene-2-aminonaphthalene is rich in chemical properties due to its alkenyl, amino and naphthalene rings. It can be used as a key intermediate in organic synthesis and other fields, and participates in the construction of many complex organic compounds.
What are the preparation methods of 1-chloro-5-fluoro-2-nitrobenzene?
In order to make 1-alkane-5-ene-2-carbonylbenzene, the ancient method relies on various materials and exquisite skills.
First, the alkenes and the benzene-containing aldehyde are used as the starting materials. Choose the appropriate alkenes, such as those with five carbons and containing alkenyl bonds, and mix them with the carbonyl-containing benzaldehyde in a certain proportion. In a special kettle, place an appropriate amount of catalyst, which can promote the phase combination of the two, or a complex of metal salts and ligands. Control the temperature in the kettle to a suitable environment, or between tens and hundreds of degrees Celsius, depending on the activity of the catalyst used. And adjust the pressure, or slightly higher than normal pressure, so that the reaction between the materials is smooth. Over time, the two are added and other reactions, and gradually form the embryonic form of 1-alkane-5-ene-2-carbonylbenzene. After separation and purification, the pure product is obtained.
Second, start with benzene derivatives and alkenyl-containing carbonyl compounds. Take benzene derivatives with reactive groups and place them in the reaction vessel together with alkenyl carbonyl groups. Add alkali catalysts, such as sodium hydroxide or potassium carbonate, which can help to initiate the reaction. The temperature is controlled in a water bath or an oil bath, and the temperature is slowly raised to the degree that the reactants can react, about tens of degrees Celsius. Under gentle stirring, the material is subjected to nucleophilic substitution, rearrangement and other reaction steps, and finally polymerized into the target. After distillation and extraction, the impurities are removed to obtain the refined product.
Third, it is accumulated in a multi-step reaction. First, benzene is used as a group, and an appropriate substituent is introduced. After halogenation, nitrification and other reactions, the specific substituted benzide is prepared. Then, through reduction, addition and other reactions, the structural units of alkenyl and carbonyl are gradually added. Each step of the reaction requires fine regulation of the reaction conditions, from the proportion of the material to the temperature and pressure, all of which are related to success or failure. After several setbacks, the structure of the target molecule was constructed one after another, and finally 1-alkane-5-ene-2-carbonylbenzene was formed. Although this way is complex, it has good controllability and can obtain high-purity products.
What are the precautions for storing and transporting 1-chloro-5-fluoro-2-nitrobenzene?
If 1-alkane-5-ene-2-aminonaphthalene is hidden and transported, there are several things to pay attention to.
When hiding, the first place is where you are. Must choose a dry and cool place, and avoid open fires and hot topics. Cover this thing flammable, fire is dangerous, a little careless, or cause a fire, disaster around. In addition, it must be separated from oxidizing agents, acids and other substances. Encounters with this number may cause a violent chemical reaction, endangering safety.
When shipping, there are also many details. The transporter must receive professional training, be familiar with the properties of this object, and follow safety regulations. When loading and unloading, be careful to prevent damage to the packaging. If the packaging leaks and the object escapes, it will not only pollute the environment, but also increase the danger. Vehicles for transportation should also meet the safety standards and be equipped with emergency treatment tools for fire suppression and leakage. When driving on the way, drive slowly and steadily, avoid sudden brakes and bumps, and avoid packaging breaking due to vibration.
All things in storage and transportation must be done in accordance with the regulations, and there must be no slack. Everyone is united and strictly abides by the rules of safety, so that 1-alkane-5-ene-2-aminonaphthalene can be safely transported between Tibet and avoid disasters.