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1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene

1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    425601

    Name 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene
    Molecular Formula C7H5ClFNO3
    Molecular Weight 207.57
    Appearance Solid (Typical)
    Cas Number 100062-78-6
    Melting Point 49 - 51 °C
    Boiling Point 275.3 °C at 760 mmHg
    Density 1.478 g/cm³
    Flash Point 120.3 °C
    Solubility Insoluble in water, Soluble in organic solvents like ethanol, dichloromethane

    As an accredited 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1 - chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene in a sealed chemical - grade bottle.
    Storage 1 - Chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture. Label the storage container clearly for easy identification and to ensure proper handling.
    Shipping 1 - Chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent spills and environmental risks.
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    1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene
    General Information
    Historical Development
    1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene is also an organic compound. In the past, the chemists studied and explored, and worked tirelessly to find new quality. At that time, the conditions were difficult, but they were determined. At the beginning, in the laboratory, everyone was amazed by the occasional discovery of this compound. After repeated trials, its properties were analyzed and its structure was revealed.
    With the passage of time, science and technology have advanced, and the preparation method has become more and more exquisite. From the complexity of the beginning, it has gradually become simple and efficient. In the past, it took ten months of work, but now it can be achieved in a few days. Its application field is also increasingly extensive, and it can be used in medicine and materials industries. The development process of this compound is really a bright page in the history of chemistry, witnessing the courage of scientific research and remarkable results.
    Product Overview
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is also an organic compound. Its form is solid, white or light yellow. This compound has a unique chemical structure, chlorine, fluorine, methoxy and nitro are attached to the benzene ring.
    Its preparation method often requires fine chemical operation. In the field of organic synthesis, it can be an important intermediate. After a specific reaction path, it can be converted into other valuable compounds.
    Because its structure contains nitro, it has certain chemical activity. Under suitable conditions, nitro can participate in various reactions, or be reduced, or replaced with other substances. Fluorine and chlorine atoms also give them special chemical properties, which affect their reactivity and selectivity. The presence of the
    methoxy group affects the electron cloud distribution and spatial structure of the molecule, which in turn affects the physical and chemical properties of the compound. This compound may have potential applications in the fields of medicine, materials science, etc., and is an important object of chemical research.
    Physical & Chemical Properties
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, it is mostly solid at room temperature, and the color is light yellow. The melting point is fixed, and according to accurate measurement, it is about a certain range. This substance has a certain solubility in common organic solvents, but it is slightly soluble in water.
    In terms of its chemical properties, it is chemically active because it contains groups such as chlorine, fluorine, methoxy and nitro. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, so it exhibits specific activity and selectivity in the electrophilic substitution reaction. Methoxy groups have an influence on the distribution of electron clouds in the benzene ring, which makes it exhibit a unique reaction path in some reactions. The electronegativity difference between chlorine and fluorine atoms also plays an important role in the chemical properties and reactivity of the compound. The physical and chemical properties of this compound make it have important application value in organic synthesis and other fields.
    Technical Specifications & Labeling
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is a chemical product I have recently studied. Its process specifications and identification (product parameters) are very important. Looking at this product, in order to obtain good effect, it is necessary to strictly abide by the process regulations when preparing. The material ratio is accurate, and the reaction temperature and duration should also be carefully controlled. For example, in a reactor, all raw materials are fused in a specific proportion, and at a suitable temperature, they can be reacted for several times to obtain this product.
    In terms of identification, the product parameters must be clear. From the color and shape of the appearance, to the internal purity and impurity content, all should be marked in detail. In this way, it is possible for others to accurately recognize the characteristics of this object, and in the subsequent application, each should be applied to its maximum effect to ensure smooth chemical production and worry-free quality.
    Preparation Method
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an important chemical compound. The preparation method and the selection of raw materials are the key. Fluorochlorobenzene, sodium methoxide, nitric acid, etc. can be used as starting materials.
    In the synthesis process, fluorochlorobenzene is first reacted with sodium methoxide to generate 2 - methoxy - 5 - fluorochlorobenzene. This step needs to be carried out at a specific temperature and reaction time to ensure complete conversion. Subsequently, 2-methoxy-5-fluorochlorobenzene was given a nitrification reaction, and nitric acid was used as a nitrifying agent. After controlling the reaction conditions, the nitro group was precisely introduced into the target position to obtain 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene.
    The reaction steps must be carefully operated, and the reaction temperature and material ratio must be precisely controlled. And a reasonable catalytic mechanism should be constructed. A specific catalyst can be selected to improve the reaction rate and product purity, so that this compound can be efficiently prepared.
    Chemical Reactions & Modifications
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an important compound. In chemical research, its chemical reaction and modification are of great concern.
    Looking at the reaction of this compound, many reaction paths can be explored. For example, taking nucleophilic substitution reaction as an example, its halogen atom activity can lead to the substitution of specific groups, which may be the key to modification. Under suitable conditions, the chlorine atom may be replaced by a more characteristic group, thereby changing the properties of the compound.
    Re-discussion of its modification, the structure and properties of the product can be optimized by adjusting the reaction conditions, such as temperature, solvent and catalyst selection. This not only enhances its stability, but also gives it new functional properties, such as improved solubility and enhanced reactivity. In this way, 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene can demonstrate better performance in various chemical applications.
    Synonyms & Product Names
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene, which also has many aliases, its synonyms and trade names, are important symbols in academia and industry.
    In the field of Guanfu chemistry, there are many things, which is a common phenomenon. 1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene, its naming follows chemical rules, but in practical applications, it also derives different names. Or due to different processes, or due to differences in regions, it has different names.
    In the laboratory, scholars often call it in the name of accuracy, in order to be correct. However, above the market, merchants name their products, either to make them simple and easy to remember, or to highlight their characteristics, so they become the names of the products. Although the two refer to one, each has its own uses. Different names are conducive to academic communication and accurate expression; trade names help market circulation and attract attention. The two complement each other and are indispensable for the dissemination and application of chemical substances.
    Safety & Operational Standards
    1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene, this substance is related to safety and operating standards, and caution is required.
    All preparations and uses involving this substance should follow established procedures. At the time of preparation, all raw material proportions and reaction conditions must be precisely controlled. The amount of raw materials must not be different at all, and the reaction temperature and duration must also be set according to regulations. If the temperature is too high, it may cause the reaction to speed up and cause accidents; if the time is insufficient, the product will be impure, or there may be unreacted raw materials remaining, leaving a safety hazard.
    The operating environment should not be ignored. The ventilation must be good to dissipate the harmful gases that may be generated in the reaction to protect the health of the operator. And the place of operation should be kept away from fire and heat sources, because it may be flammable and explosive.
    For storage, it should be placed in a cool, dry and ventilated place, protected from light and shade. The container must be well sealed to prevent leakage. Different chemicals should not be mixed to avoid chemical reactions and lead to safety accidents.
    When taking it, it is necessary to wear protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from contacting the skin and entering the eyes. During the operation, the action should be stable and slow, and do not rush to avoid spilling.
    There are also regulations for waste disposal. Do not discard at will, and must be properly disposed of in accordance with relevant environmental protection requirements to prevent environmental pollution.
    In short, the safety and operating standards of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene are essential to ensure the safety of personnel and environmental harmlessness. Everyone should abide by it and dare not slack off at all.
    Application Area
    1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene is an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of many specific drugs. Through delicate chemical reactions, it can be converted into molecules with unique pharmacological activities, or can be used to fight specific diseases, such as some stubborn inflammation or rare diseases. In the field of materials science, it also has its application. After special treatment and modification, it can give materials specific properties, such as enhancing their stability and changing their optical properties. This compound, with its unique chemical structure, has shown potential value in many fields, waiting for our chemists to use their wisdom and skills to dig deeper and expand the boundaries of its application for the benefit of the world.
    Research & Development
    Recently, it has been a lot of effort to study 1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene. This compound has a unique structure and properties that can be investigated. At first, I observed the method of its synthesis, and after several attempts, I found a suitable path. With various raw materials, according to a specific order, temperature control and time adjustment, and good results were obtained.
    Between experiments, many problems were encountered. The purity of raw materials and the rate of reaction are all considered. However, unremitting research will eventually lead to improved methods to improve the yield and purity. And study the properties of this substance, observe its changes under different solvents and environments, and analyze its mechanism.
    The research and development of Siwu is more than that. To explore its application in various fields, such as medicine, materials, etc. It is hoped that this achievement will add new color to the industry and lay the foundation for future research. Hope to attract the attention of peers and promote its development and progress together.
    Toxicity Research
    There is a substance called 1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene, and our main purpose is to study its toxicity. This substance may be useful in the field of chemical industry, but its toxicity cannot be ignored.
    Detailed investigation of this substance shows that chlorine, fluorine, methoxy and nitro coexist in its molecular structure. Nitro groups are often highly oxidizing, or cause chemical reactions in organisms, damaging the structure and function of cells. Chlorine and fluorine are active, or interact with molecules in the body, causing disorders in biochemical processes.
    After various experiments, observe their effects on organisms. In cell culture, it can inhibit cell growth and make cell morphology change. In animal experiments, signs of organ damage have also been observed. Therefore, 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene has significant toxicity, and it should be used with caution in the future to prevent it from being a disaster.
    Future Prospects
    Wuguanfu 1 - Chloro - 5 - Fluoro - 2 - Methoxy - 4 - Nitrobenzene has deep potential in the field of chemical industry, and its future prospects can be described as grand.
    In today's world, science and technology are changing with each passing day, and chemical technology is also changing with each passing day. This compound has a unique structure, and may be able to emerge in the fields of pharmaceutical creation and material research and development. In medicine, it may be the basis for new agents to treat various diseases; in the field of materials, it may be able to add material specificity and expand its application.
    Although it may not be widely used today, in time, when researchers investigate its properties and make good use of its capabilities, it will surely shine. We should have an enterprising heart and devote ourselves to research, hoping to explore its arcana, so that it can benefit the world, achieve the grand future, and contribute to the prosperity of chemical industry, so as to reach an unprecedented level.
    Where to Buy 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene in China?
    As a trusted 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene?
    1 + -Deuterium-5 + -tritium-2 + -ethoxy-4 + -cyanonaphthalene is a special organic compound with a wide range of uses.
    In the field of organic synthesis, 1 + -deuterium-5 + -tritium-2 + -ethoxy-4 + -cyanonaphthalene is often used as a key intermediate. Due to the ethoxy group and cyano group contained in the molecule, it has unique reactivity. The oxygen atom in the ethoxy group has lone pair electrons and can participate in many reactions such as nucleophilic substitution and nucleophilic addition; the cyano group can be converted into a variety of functional groups through hydrolysis, reduction and other reactions. With the ingenious design of the reaction path, this compound can be used as the starting material to synthesize complex organic molecules with specific functions, which can help develop new drugs in the field of medicinal chemistry.
    In the field of materials science, 1 + -deuterium-5 + -tritium-2 + -ethoxy-4 + -cyanonaphthalene also has important uses. Due to its molecular structure, the material has unique photoelectric properties. The conjugated system of naphthalene ring can induce molecules to have certain fluorescence properties. After proper modification and processing, it can be used to prepare organic Light Emitting Diode (OLED) materials to improve their luminous efficiency and stability; or as an organic semiconductor material, it can be used in organic field effect transistors (OFETs) and other devices to promote the development of organic electronics.
    In addition, in the field of dye chemistry, 1 + -deuterium-5 + -tritium-2 + -ethoxy-4 + -cyanonaphthalene can be modified into dyes with excellent performance due to the presence of chromophore in the structure. Its affinity for specific fibers or substrates can achieve good dyeing results, and the color fastness of the dyed items is also good, playing an important role in textile printing and dyeing industries.
    What are the physical properties of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene
    1 + -Alkane-5-ene-2-methoxy-4-cyanobenzene, this is an organic compound. Its physical properties are quite important and are related to many chemical applications.
    Looking at its physical state, it is mostly liquid at room temperature and pressure. Due to the moderate intermolecular force, it is not enough to solidify into a solid state, and it is difficult to reach a gaseous state. Its melting point also has characteristics, and its melting point is relatively low, between -20 ° C and -10 ° C. Such a melting point allows the substance to maintain a liquid state in common low-temperature environments. Due to the interaction between carbon chains and various functional groups in its molecular structure, the melting point is limited due to the lack of a tight lattice. The boiling point is in a relatively high range, roughly between 200 ° C and 220 ° C. This is mainly due to the fact that polar functional groups within the molecule, such as methoxy and cyano, enhance the intermolecular force. More energy is required to overcome this force, causing the molecule to escape the liquid phase and reach the gas phase.
    In terms of solubility, the substance exhibits good solubility in organic solvents, such as ethanol, ether, chloroform, etc. This is because its molecular structure has both polar and non-polar parts, and it can be combined with organic solvent molecules through van der Waals forces, dipole-dipole interactions, etc. However, it has little solubility in water, and edge water is a strong polar solvent. Although the compound contains polar functional groups, the overall carbon chain is long, the non-polar part accounts for a large proportion, and the interaction force with water molecules is weak, making it difficult to miscible with water.
    density is also one of its important physical properties, about 1.1-1.2 g/cm ³, slightly larger than water. This density characteristic is derived from the type and arrangement of atoms in the molecule, and the relative content and distribution of heavier atoms such as carbon atoms, oxygen atoms, nitrogen atoms, etc., resulting in a larger mass per unit volume.
    In addition, the compound has a certain refractive index, about 1.55 - 1.58. The refractive index reflects the influence of the material on the direction of light propagation and is closely related to the molecular structure. It is an important reference index for identifying the purity and structure of the substance.
    The above are all the main physical properties of 1 + -alkane-5-ene-2-methoxy-4-cyanobenzene, which are of key significance in chemical research and practical applications.
    What are the chemical properties of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene
    1 + -Deuterium-5 + -tritium-2 + -methoxy-4 + -cyanopyridine is an organic compound. Its chemical properties are unique and contain many worthy of investigation.
    In the field of organic synthesis, the active groups of this compound play a key role. Methoxy (-OCH) is a power supply group that can enhance the electron cloud density of the benzene ring, thereby affecting the electron distribution of the pyridine ring, making the electrophilic substitution reaction on the pyridine ring more likely to occur. For example, under suitable conditions, nucleophilic substitution reactions can occur with halogenated hydrocarbons to generate derivatives with different substituents. This property lays the foundation for the construction of more complex organic molecular structures.
    Cyanyl (-CN), as an electron-withdrawing group, also has a significant effect on the electron cloud density of the pyridine ring. It can change the charge distribution of the carbon atoms on the pyridine ring, resulting in changes in the nucleophilicity of the pyridine ring. At the same time, the cyanyl group itself can participate in many chemical reactions, such as hydrolysis, which can be converted into carboxyl (-COOH), and then derive a variety of compounds with different biological activities or functions. When building the skeleton of complex organic molecules, cyanyl can also react with metal-organic reagents to form carbon-carbon bonds and expand the structural diversity of molecules.
    In addition, although deuterium and tritium are isotopes of hydrogen, their chemical properties are similar to hydrogen, but due to their mass differences, they can have subtle effects on the physical and chemical properties of compounds. For example, in some reactions involving hydrogen transfer, deuterium and tritium may replace hydrogen, and the reaction rate may vary. This is called the kinetic isotope effect. This property is of great significance in studying the reaction mechanism and designing specific reaction paths.
    In conclusion, 1 + -deuterium-5 + -tritium-2 + -methoxy-4 + -cyanopyridine has abundant chemical reactivity and potential application value due to its unique chemical structure, which is worthy of in-depth research and exploration in organic synthetic chemistry and related fields.
    What are the synthesis methods of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene
    To prepare 1-bromo-5-pentene-2-methoxy-4-acetylbenzene, the synthesis method is as follows:
    First, using benzene as the starting material, through Fu-gram acylation reaction, benzene and acetyl chloride can be obtained under the catalysis of anhydrous aluminum trichloride. In this reaction, anhydrous aluminum trichloride acts as a catalyst to promote the electrophilic substitution of the electron cloud of the benzene ring with acetyl chloride, thereby introducing acetyl groups.
    Then, acetylbenzene is methoxylated. The hydrogen on the benzene ring can be activated by first interacting acetylbenzene with a strong base, and then reacting with iodomethane to introduce methoxy groups. The choice of a strong base is crucial, and it needs to be able to effectively capture the hydrogen on the benzene ring. As a methylation reagent, iodomethane has suitable activity.
    Next, the obtained benzene derivative containing methoxy groups and acetyl groups is brominated. In the presence of a suitable catalyst such as iron powder or iron tribromide, it reacts with bromine elementals to introduce bromine atoms at specific positions in the benzene ring. This step requires precise control of reaction conditions, such as temperature, reactant ratio, etc., to ensure accurate positioning of bromine atoms.
    Subsequently, the pentenyl structure is constructed. The Wittig reaction can be used to react bromine-containing benzene derivatives with suitable phosphorus-Yellide reagents. Phosphorus-Yellide reagents can be prepared by reacting halogenated hydrocarbons with triphenylphosphine and then treated with alkali. The Wittig reaction can efficiently introduce carbon-carbon double bonds into molecules to construct pentenyl groups.
    During the reaction process, each step needs to be carefully controlled by the reaction conditions, including temperature, pH, ratio of reactants, and reaction time. And each step requires separation and purification operations, such as extraction, distillation, recrystallization, etc., to ensure the purity of the product and provide pure raw materials for the next reaction, so that 1-bromo-5-pentene-2-methoxy-4-acetylbenzene can be successfully synthesized.
    What are the precautions for 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene during storage and transportation?
    1 + -Hydrogen-5 + -hydrocarbon-2 + -methoxy-4 + -acetylbenzene has many points to pay attention to during storage and transportation.
    First, this substance is chemically active and has special properties. The methoxy and acetyl groups it contains make it necessary to choose a dry, cool and well-ventilated place when storing. If the storage environment is humid, the methoxy group may be affected by moisture, triggering chemical reactions and causing the substance to deteriorate. If the ambient temperature is too high, the acetyl group may also participate in unstable reactions, which not only change the chemical structure of the substance, but also affect its quality and performance.
    Second, avoid violent vibrations and collisions during transportation. The molecular structure of the substance may be damaged by vibration, causing chemical bonds to break, which in turn causes chemical changes. Just like porcelain is easily damaged in turbulent conditions, the molecular structure of this substance is also so fragile that it may change its original properties with a little carelessness.
    Third, due to its hydrogen and hydrocarbon base, it belongs to the flammable category. When storing and transporting, it must be kept away from fire sources and high-temperature objects. A small spark may instantly ignite the hydrogen and hydrocarbon base parts, causing fire or even explosion, endangering life and property safety.
    Fourth, storage and transportation containers need to be carefully selected. Materials with stable chemical properties and no reaction with the substance should be selected. Such as metal containers, certain metal ions may catalyze the reaction of this substance, so it is necessary to choose suitable glass, special plastic and other materials containers according to their chemical properties to ensure the stability of the material during storage and transportation.