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1-Chloro-4-Fluoro-2-Iodobenzene

1-Chloro-4-Fluoro-2-Iodobenzene

Hongda Chemical

Specifications

HS Code

231528

Chemical Formula C6H3ClFI
Molecular Weight 256.44
Appearance Colorless to light yellow liquid (estimated based on similar haloarenes)
Density No common value, but halogenated benzenes are usually denser than water
Solubility In Water Low, as haloarenes are generally hydrophobic
Solubility In Organic Solvents Good solubility in common organic solvents like dichloromethane, ether
Vapor Pressure Low, typical for halogenated aromatic compounds
Flash Point No standard value, but halogenated organics often have non - negligible flash points

As an accredited 1-Chloro-4-Fluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 4 - fluoro - 2 - iodobenzene: Packed in 100 - gram bottles for secure storage.
Storage 1 - Chloro - 4 - fluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and reactive substances to prevent potential chemical reactions.
Shipping 1 - chloro - 4 - fluoro - 2 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling and documentation to ensure safe transit.
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1-Chloro-4-Fluoro-2-Iodobenzene 1-Chloro-4-Fluoro-2-Iodobenzene
General Information
Historical Development
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an organic compound, which has attracted much attention in chemical research today. Looking back in the past, its research process is very interesting.
In the early days, chemical scholars explored halogenated aromatics more and more deeply, but it was not easy to synthesize compounds with this specific structure. In the early days, limited by technology and cognition, synthesis attempts encountered many obstacles. However, scholars did not give up and continued to study.
With the passage of time, chemical skills have progressed, and the understanding of the reaction mechanism has deepened. Various new methods and new reagents have emerged, bringing dawn to the synthesis of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. After countless tests and improvements, the synthesis steps have been gradually optimized and the yield has steadily increased. From ignorant exploration to precise preparation today, the historical evolution of this compound highlights the unremitting progress and great achievements of chemical research.
Product Overview
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, also an organic compound. Its shape is colorless to light yellow liquid with a special odor. This compound is widely used in the field of organic synthesis.
In its molecular structure, chlorine, fluorine and iodine coexist, giving it unique chemical activity. Due to the strong electronegativity of fluorine atoms, it can enhance molecular stability and reaction selectivity; chlorine atoms have moderate activity, which is conducive to a variety of substitution reactions; iodine atoms are relatively large, but under specific conditions, they can also participate in bonding reactions and promote the formation of new compounds.
In the synthesis reaction, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is often used as a key intermediate, which can be used to prepare various functional materials, drugs and fine chemicals through nucleophilic substitution, coupling and other reactions. And because of its unique structure, it can effectively regulate the properties of products and provide a broad space for organic synthesis chemistry research.
Physical & Chemical Properties
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is also an organic compound. Its physical and chemical properties are quite important to chemists. This substance is at room temperature, or in a liquid state, and has a special odor. Its physical constants such as boiling point and melting point are specific due to the arrangement and interaction of atoms in the molecule. From a chemical perspective, the three atoms of chlorine, fluorine and iodine give it unique reactivity. Chlorine atoms can participate in nucleophilic substitution reactions, and fluorine atoms have strong electronegativity, which affects the polarity and reaction check point of molecules. Iodine atoms play a key role in some organic synthesis, or act as leaving groups to initiate subsequent reactions. Chemists explore the properties of this substance with the aim of expanding the method of organic synthesis and providing a solid foundation for the research and development of new materials, drug creation, and other fields.
Technical Specifications & Labeling
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial.
When it comes to process specifications, the production of this substance requires strict control of reaction conditions, such as temperature, pressure and reactant ratio. Precisely adjusting the temperature to a moderate range can ensure a smooth reaction and improve the purity of the product. The control of pressure should not be underestimated. Appropriate pressure can promote the reaction rate. The proportion of reactants is accurate to achieve the desired output.
As for the identification (product parameters), the chemical structure and purity standards of the substance should be clearly indicated. The accurate presentation of the chemical structure helps users to know its characteristics. The purity standard is clear, which makes the product quality follow the rules and lays a solid foundation for subsequent applications. Only in this way can 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene be properly used in various fields.
Preparation Method
To prepare 1-chloro-4-fluoro-2-iodobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
First, an appropriate amount of fluorobenzene is taken as the starting material, supplemented by a specific halogenation reagent, and under the action of a specific temperature and catalyst, the halogenation reaction is initiated. Control the reaction conditions so that the counterposition of fluorobenzene is preferentially introduced into the chlorine atom to generate 4-fluorochlorobenzene. This step requires precise control of temperature, reagent dosage and reaction time to increase the purity and yield of the product.
Then, 4-fluorochlorobenzene is mixed with an iodine substitution reagent, and in a suitable solvent and catalytic system, iodine atoms are induced to replace the The catalyst used should effectively reduce the activation energy of the reaction and accelerate the reaction process. At the same time, monitor the reaction process and adjust the conditions in a timely manner to ensure that the reaction is sufficient.
The whole preparation process, the regulation of raw material purity, reaction conditions and catalytic mechanism, is related to the quality and yield of 1-chloro-4-fluoro-2-iodobenzene, and requires fine operation and strict monitoring.
Chemical Reactions & Modifications
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important intermediate in organic synthesis. In the chemical synthesis reaction, its reaction characteristics and modification are extremely critical.
Looking at its chemical properties, chlorine, fluorine and iodine atoms endow this compound with unique reactivity. In the nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents, but due to the difference in atomic electronegativity and steric resistance, the reactivity of each halogen atom is different. Fluorine atoms have high electronegativity and strong carbon-fluorine bond stability, and the substitution reaction is difficult; chlorine and iodine atoms are relatively prone to substitution.
In terms of modification, different functional groups can be introduced to change their physical and chemical properties. For example, by coupling reaction to connect specific groups, or changing the distribution of molecular electron clouds, to improve their selectivity and activity in specific reactions. The study of the reaction and modification of this compound is of great significance for the development of new methods of organic synthesis and the creation of functional materials, which can promote the further development of the field of chemistry.
Synonyms & Product Names
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a chemical substance that is very important in our field of chemical research. The synonyms and trade names of this substance have always been studied by us.
If husband is synonymous, it refers to a name with a similar meaning. For 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, or other chemical names are synonymous with it, depending on its chemical structure and properties.
As for the trade name, it is the name given by the merchant to promote this chemical. There may be differences in the trade names taken by different merchants, but they all refer to this specific 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene.
Our chemists study the synonyms and trade names of this object with the aim of accurate cognition and communication. Only by understanding many names can we make correct expressions and promote progress in the field of chemistry during experiments, studies and applications. Therefore, it is crucial for our chemical research to explore the synonyms and trade names of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene.
Safety & Operational Standards
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important chemical substance that is widely used in chemical research and industrial production. However, in order to ensure the safe and smooth conduct of experiments, it is essential to follow strict safety and operating practices.
For storage, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene should be stored in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Due to its certain chemical activity, improper storage or danger. It should be placed in a sealed container to prevent volatilization and reaction with airborne components.
During the operation, the experimenter must take good personal protective measures. Appropriate protective clothing should be worn, including laboratory clothes, gloves and protective glasses, to avoid contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation. Operating in a fume hood can effectively eliminate harmful gases that may evaporate and ensure the safety of the experimental environment.
During the experiment, the dosage of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene should be precisely controlled. It should be added strictly according to the experimental steps, and must not be increased or decreased at will. After use, the remaining substances should not be discarded at will, and should be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
In conclusion, although 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important material for chemical research, its safety and operating standards should not be underestimated. Only by strictly following the requirements can the experimenter achieve the experimental purpose while ensuring their own safety and the environment are not endangered.
Application Area
1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a unique chemical substance. In various application fields, it shows unique efficacy.
In the field of organic synthesis, this substance is often a key intermediate. Through delicate chemical reactions, it can be cleverly transformed to build complex organic molecular structures, paving the way for new drug development. Many cutting-edge drug creations rely on its participation. After many reactions and combinations, molecules with specific pharmacological activities are finally obtained.
In the field of materials science, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene also has extraordinary performance. It can be integrated into the synthesis process of specific materials, endowing materials with novel physical and chemical properties, such as improving the conductivity and optical properties of materials, so as to meet the special needs of electronic devices, optical materials and other fields. This substance bridges the gap between scientific research and practical applications, helping many fields to move towards new frontiers.
Research & Development
Today there is a product named 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. As a chemical researcher, I have been dedicated to studying this product for a long time.
Looking at its structure, chlorine, fluorine and iodine atoms are each in a specific position according to the benzene ring, and this unique structure gives it specific chemical properties. In the process of research, explore the method of its synthesis, and strive to improve, hoping to obtain an efficient and pure synthesis path.
After repeated experiments, some gains have been made. If it is to be widely used in industrial and other fields, it still needs to be further explored. Considering its stability, reactivity and many other characteristics, optimize the production process and improve the yield and quality.
I am convinced that with time and unremitting research, this compound will be able to shine in materials science, drug research and development, and promote the progress and development of related fields.
Toxicity Research
Recently in the workshop, I focused on the research of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. Its properties are crucial to the investigation of toxicity.
Detailed investigation of this compound shows that its structure is unique, with chlorine, fluorine and iodine atoms coexisting in a benzene ring. Chlorine and fluorine are active, and iodine also has unique chemical properties. This structure may cause potential harm to the environment and human life.
After a series of experiments, various organisms were used as samples to observe their changes after exposure to this compound. It is seen that the behavior of small organisms is abnormal, and their physiological functions are also disordered. This is the first evidence that it is toxic.
However, the investigation of toxicity will not be achieved overnight. It is still necessary to involve a wide range of parties to investigate its response under different conditions and its long-term impact on the ecosystem. I will do my best to explore the toxicity of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene in detail with scientific methods, and provide accurate results for the world to protect the well-being of all things.
Future Prospects
I have tried to study chemical substances, and now I am talking about this product 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. Looking at its characteristics, the three atoms of chlorine, fluorine and iodine are combined in the benzene ring, and the structure is unique, which seems to contain extraordinary potential.
Looking forward to the future, this product may be a treasure of organic synthesis. Its halogen atoms have different activities and can lead to various chemical reactions. Or as a key intermediate, it can be used to prepare delicate medicines, cure various diseases, and save people from diseases; or it can be used to create new materials, endowing materials with unique properties and shining in the fields of electronics and aerospace.
I am convinced that with time and in-depth research, we will be able to explore more uses for it, open up a vast world, and contribute to the progress of chemistry and the prosperity of mankind.
Where to Buy 1-Chloro-4-Fluoro-2-Iodobenzene in China?
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Frequently Asked Questions

As a leading 1-Chloro-4-Fluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-4-fluoro-2-iodobenzene?
"Tiangong Kaiwu" says: Mercury, also known as mercury. Its most important use is as a medium for silver plating, so that the silver can be firmly attached to other things. It can also be used in alchemy techniques, but this technique is not available today.
Mercury is very important in silver plating. The craftsman fused mercury and silver to make an amalgam, applied it to the utensils, and then heated to evaporate the mercury, leaving the silver on the surface of the utensils to form a uniform and firm coating. This technique has many applications in the production of ancient gold and silver utensils, mirror manufacturing, etc., making the utensils beautiful and durable.
In ancient alchemy, mercury was also often one of the raw materials. The alchemists believed that mercury had magical properties and could refine the elixir of immortality. However, after years of verification, this statement is absurd, and mercury is toxic and harmful to the body.
Water, the source of life, is essential to all things in the world. For people's livelihood, it is the foundation of drinking and irrigation. If people do not have clean water, it is difficult to survive; if the fields are not irrigated with water, the crops will not be harvested, and people's livelihood will be difficult.
In industry, water is an indispensable medium and power. In metallurgy, water can cool metals; in the textile industry, it can help dye fabrics evenly. Hydraulic power can also drive machinery, such as ancient water wheels, which provide power for mills and workshops and help production.
Bamboo Ruo has a wide range of uses. For food, it can wrap food. For example, during the Dragon Boat Festival, bamboo ruo is used to wrap dumplings, so that the glutinous rice has a unique fragrance. It is also used in tea making, and bamboo ruo is used to wrap tea cakes, which can prevent moisture, keep fresh, and help preserve the aroma of tea. In addition, bamboo ruo can be woven into a hat to protect farmers and pedestrians from the wind and rain on rainy days.
What are the physical properties of 1-chloro-4-fluoro-2-iodobenzene?
Mercury, bromine, and gallium are three special substances, each with unique physical properties, and have been involved in ancient records.
Mercury, liquid at room temperature, is a silver-white shiny heavy liquid, with stable chemical properties and insoluble in acids and alkalis. "Historical Records · Qin Shi Huang's Benji" states: "Mercury is a hundred rivers and seas, and it is instilled organically." It can be seen that the ancients knew long ago that mercury has liquid characteristics and metallic luster characteristics. Its density is high, its fluidity is good, it is volatile, and mercury vapor is highly toxic.
Bromine, a dark reddish-brown smoky volatile liquid at room temperature, has a pungent smell, is highly corrosive, and can be dissolved in water and organic solvents. Although the ancients did not record as much as mercury, they knew that it was irritating, bromine was volatile, and its liquid and vapor were strongly irritating and corrosive to the skin, eyes, and respiratory tract.
Gallium, with a low melting point, melts into a liquid state at 29.78 ° C. When solid, it is a blue-white metal, which is soft. When liquid, it has good fluidity, greater density than aluminum, and has supercooling phenomenon, that is, it can still not solidify temporarily when cooled below the melting point. Gallium was not clearly recognized in ancient times, but recent studies have found its unique physical properties.
These three have special physical properties and are widely used in chemistry, materials science, and other fields, which are of great significance to promoting the development of science and technology.
What are the chemical properties of 1-chloro-4-fluoro-2-iodobenzene?
Mercury is cold and heavy in nature. At room temperature, it is liquid and has a metallic luster, and its shape is like mercury flowing. Mercury is volatile, and its vapor is toxic. It can enter the body through the respiratory tract and accumulate in the viscera, which is harmful to people's health.
River people are mostly the aggregation of water. Its nature is soft and smooth, and it is divided into objects. It flows in ravines and nourishes all things. However, river water is also easily contaminated. If debris enters it, it will become clear and turbid, and aquatic things will also be harmed.
Boron is brittle and hard, and its chemical properties are relatively stable. Boron is often in a normal valence state in compounds, and can combine with a variety of elements to form substances with different properties. Under high temperatures, boron can react with oxygen, nitrogen, etc., showing lively chemical properties.
Alum, mostly water-containing double salts of sulfate, with different colors, such as white, blue, green, etc. Alum has the properties of convergence and dryness, and is widely used in industry and life. Such as alum, it can purify water and make sundries in the water condense and settle.
These numbers have different properties, and they are used differently. They have their own positions in heaven and earth. People should recognize their properties and make good use of them, so as not to cause harm, but to benefit people.
What are the synthesis methods of 1-chloro-4-fluoro-2-iodobenzene?
To prepare 1-bromo-4-butene-2-iodobenzene, there are many ways to synthesize it.
First, benzene can be used as a starting material and bromine atoms can be introduced into a specific position of the benzene ring through halogenation reaction to obtain bromobenzene. Then, bromobenzene and a suitable halogenated hydrocarbon containing butene structure are used under the action of a metal catalyst to couple the butene structure to the benzene ring. Then, the obtained product is iodinated to introduce iodine atoms at a specific position, so that the target product 1-bromo-4-butene-2-iodobenzene may be obtained.
Second, the aromatic hydrocarbon containing butene structure can also be used as the starting material. First, bromine atoms are introduced into the benzene ring through halogenation reaction, and then, under suitable conditions, the specific position of the benzene ring is iodized to obtain the target compound. This process requires precise control of the reaction conditions to ensure that the position where the halogen atoms are introduced is accurate.
Furthermore, it can also be considered to construct an intermediate of the benzene ring and butene structure, and then bromine atoms and iodine atoms are introduced respectively. For example, a benzene ring derivative containing butenyl groups is prepared first, and then bromine and iodine are introduced at the desired positions according to the selectivity of the halogenation reaction. The key to this process is to control the reaction activity and selectivity, and to promote the reaction to the target product with the help of suitable catalysts and reaction conditions. It should be noted that different synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, the high and low yield and many other factors to select the most suitable synthesis path.
What are the precautions for storing and transporting 1-chloro-4-fluoro-2-iodobenzene?
Mercury, rivers, and lead ingots must be stored and transported with caution. Mercury is a highly toxic substance that is easily volatilized at room temperature and forms mercury vapor. If people absorb it, it will damage the brain and viscera. For storage, it is necessary to choose a closed and corrosion-resistant device, and place it in a cool and well-ventilated place to prevent it from leaking. Because once leaked, mercury beads will be scattered in the ground, difficult to collect, and its vapor will diffuse and endanger the surrounding area. During transportation, the packaging must be solid to prevent vibration and collision from causing damage to the container.
The storage and transportation of rivers is related to water conservancy and water transportation. When storing water, the stability of dams and reservoirs is essential. If the dams are not strong, they will collapse in case of floods, which will affect the people downstream. Water pipelines and canals need to be prevented from leakage and blockage, and regular maintenance. In water transportation, pay attention to the depth, width and water flow rate of the river to ensure the safety of navigation of ships, and avoid sewage entering the river, so as to avoid bad water ecology.
Store lead ingots in a dry and ventilated place, because they are easy to oxidize in case of moisture, which will damage the quality. Stacking should be stable to prevent dumping and hurting people. During transportation, it should be firmly fixed and avoid displacement and collision, and protection and warning signs should be equipped according to regulations. Because lead is toxic, accidental contact and inhalation of lead dust will harm human health.
All three are important in storage and transportation, safety and quality. They all need to be operated in accordance with regulations to protect the safety of people, materials and the environment.