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1-Chloro-3-(Trifluoromethyl)Benzene

1-Chloro-3-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

337805

Chemical Formula C7H4ClF3
Molar Mass 180.554 g/mol
Appearance Colorless liquid
Boiling Point 143 - 144 °C
Density 1.309 g/cm³
Water Solubility Insoluble
Flash Point 37 °C
Refractive Index 1.436

As an accredited 1-Chloro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 3 - (trifluoromethyl)benzene in 500 - mL glass bottle for chemical packaging.
Storage 1 - Chloro - 3 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly closed container made of suitable materials like metal or high - density polyethylene to prevent leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions.
Shipping 1 - Chloro - 3 - (trifluoromethyl)benzene is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper ventilation and isolation from incompatible substances.
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1-Chloro-3-(Trifluoromethyl)Benzene 1-Chloro-3-(Trifluoromethyl)Benzene
General Information
Historical Development
1-Chloro-3- (trifluoromethyl) benzene is also an organic compound. At the beginning, scholars studied organic chemistry and tried to expand the field of compounds. At that time, the exploration of fluoride-containing compounds gradually flourished, and chemists tried their best to produce new compounds.
After years of research, with the progress of chemical skills, this 1-chloro-3- (trifluoromethyl) benzene was obtained. At first, the preparation was difficult, and the yield was quite low, which was only available in a few laboratories.
However, the technology is improving, and the preparation method is also constantly improving. Chemists optimize the reaction conditions and search for better catalysts to increase the yield and reduce the cost. Nowadays, this compound is increasingly used in the fields of medicine, pesticides, and materials, contributing to the prosperity of the industry and contributing to chemical research and industrial applications. Its development process has witnessed unremitting progress and breakthroughs in the field of chemistry.
Product Overview
1-Chloro-3- (trifluoromethyl) benzene, also an organic compound. Its shape is a colorless liquid with a special odor. The boiling point is few, and the melting number is also fixed.
This compound has a wide range of uses in the field of organic synthesis. It can be used as an intermediate and participates in a variety of chemical reactions. Because it contains chlorine and trifluoromethyl functional groups, it has unique properties. Chlorine atoms have considerable activity and can undergo reactions such as nucleophilic substitution; trifluoromethyl has strong electron absorption, which affects the distribution of molecular electron clouds and changes the reactivity and physical properties of compounds.
Synthesis method, or obtained from specific raw materials through several steps of reaction. Precise control of reaction conditions, such as temperature, pressure, catalyst, etc., is required to extract yield and purity.
When storing, it should be placed in a cool and ventilated place, away from fire and heat sources, to prevent its volatilization and deterioration, to ensure its quality and safety, and to be used in various chemical research and industrial production.
Physical & Chemical Properties
1 - Chloro - 3 - (Trifluoromethyl) Benzene is an organic compound. Its physical and chemical properties are unique and related to many practical applications.
In terms of physical properties, it is mostly liquid at room temperature and has a certain volatility. Its boiling point determines the process of transforming from liquid to gaseous at a specific temperature, which is of great significance for separation and purification. The density of this compound is different from that of water. In related experiments and industrial processes, this property determines its stratification with other liquids such as water, which is convenient for separation operations.
In terms of chemical properties, the structure of the benzene ring gives it aromaticity, making it able to participate in various electrophilic substitution reactions. The presence of chlorine atoms and trifluoromethyl groups changes the electron cloud density of the benzene ring, which affects the reaction activity and selectivity. Trifluoromethyl has strong electron-absorbing properties, which decreases the electron cloud density of the ortho-para-site of the benzene ring, making the electrophilic substitution reaction more likely to occur in the meta-site. This compound can react with many reagents and has a wide range of uses in the field of organic synthesis. It can be used as a raw material or intermediate for the preparation of complex organic molecules, which is of great significance to the development of organic chemistry and related industries.
Technical Specifications & Labeling
1 - Chloro - 3 - (Trifluoromethyl) Benzene is an important chemical product. Its process specification and identification (product parameters) are related to production and application. The process specification of this product needs to clarify its preparation process, the ratio of raw materials must be accurate, and the reaction conditions such as temperature and pressure must also be strictly controlled. As for the identification, its chemical composition, purity and other key product parameters should be clearly marked.
When preparing, select suitable raw materials and advanced processes to ensure product quality and yield. Clear identification allows users to accurately know the characteristics of the product and ensure safe and effective application. Strict adherence to process specifications and accurate marking are of great significance in the production and application of 1 - Chloro - 3 - (Trifluoromethyl) Benzene.
Preparation Method
1-Chloro-3- (trifluoromethyl) benzene is also an organic compound. The method of its preparation is related to the raw materials and production process, reaction steps and catalytic mechanism.
The raw materials prepared often require aromatic hydrocarbons with specific structures, coupled with chlorine-containing and fluorine-containing reagents. The production process pays attention to the reaction conditions. Under appropriate temperature and pressure, the raw materials are interacted.
Reaction step, the first raw materials are mixed and added in a specific order to promote full contact. Then the temperature rises to initiate the reaction, or a specific catalyst is required to accelerate it. The choice of catalyst is related to the reaction efficiency and product purity. The catalytic mechanism of
is to reduce the activation energy of the reaction and make the reaction more likely to occur. For example, metal catalysts change the reaction path by interacting with raw materials through their activity check points. In this way, through careful regulation of raw materials, processes, steps and catalysis, 1-chloro-3- (trifluoromethyl) benzene can be obtained.
Chemical Reactions & Modifications
1 - Chloro - 3 - (Trifluoromethyl) Benzene is an organic compound, and its chemical properties and reactions are of great interest. In many chemical reactions, the properties of its chlorine atoms and trifluoromethyl groups significantly affect the reaction process.
Past experiments have observed that when this compound encounters nucleophiles, chlorine atoms are often easily replaced, and the rate of this reaction is closely related to the nucleophilicity of nucleophiles. However, if the reaction conditions are changed, such as differences in temperature and solvent, the reaction results will also be different.
To optimize its reaction performance, chemists try various methods. With the intervention of specific catalysts, the selectivity of the reaction can be improved, so that unnecessary side reactions can be avoided and the yield of the target product can be improved. There is also precise regulation of the reaction environment, such as strict control of pH, to create a suitable chemical environment for the reaction. After many explorations and improvements, 1-Chloro-3 - (Trifluoromethyl) Benzene is more widely and efficiently used in the field of organic synthesis, providing a strong boost for the development of related industries.
Synonyms & Product Names
1-Chloro-3- (trifluoromethyl) benzene, this substance is quite important in the field of chemical industry. There are many different names, and the trade names also have their own names.
Looking at the ancient books, or it is called m-chlorotrifluorotoluene, which is named according to its chemical structure and properties. In inter-city trade, merchants or give different names, but they all refer to the same substance. Due to its unique chemical properties, it has shown extraordinary functions in various fields of pharmaceutical synthesis and material research and development.
The previous Fang family investigated this compound, investigated its reaction mechanism in detail, and revealed its changes in various reactions. Therefore, it is essential for chemical researchers and practitioners to know their different names and trade names, which can help them understand the names of this thing in different scenarios, facilitate their use and research, and advance to the next level in the chemical industry.
Safety & Operational Standards
1-Chloro-3- (trifluoromethyl) benzene is a commonly used chemical substance. Its safety and operating standards are of paramount importance. It is related to the safety of workers and endangers the smooth production. It should be noted in detail.
This substance is dangerous. It is irritating and can cause discomfort if it comes into contact with the skin and eyes. Inhalation of its volatile gases is also harmful to health, or causes respiratory irritation and other diseases. Therefore, when handling this substance, protective measures must be comprehensive.
Operators should wear suitable protective clothing, and the material must be able to effectively block the substance, and the fit is comfortable and does not hinder movement. At the same time, protective gloves must be worn, and the materials selected are of high quality and fit the hands to ensure reliable protection when the operation is flexible. Eye protection is also indispensable. Protective glasses or masks should have good sealing and impact resistance to prevent this substance from splashing into the eyes.
The operating environment needs to be well ventilated. The workshop should be equipped with an effective ventilation system to continuously ventilate to reduce the concentration of this substance in the air. At the same time, strict control of fire and heat sources. 1-chloro-3- (trifluoromethyl) benzene is flammable. In case of open fire, hot topic or cause combustion and explosion, fireworks are strictly prohibited in the operation area, and electrical equipment should also have explosion-proof function.
Storage also has strict requirements. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Storage containers must be well sealed to prevent leakage. Different batches and specifications of products should be stored in categories for easy management and access.
When handling, it should be lightly loaded and unloaded to avoid damage to the container. If a leak occurs accidentally, do not panic. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. In the event of a large number of leaks, personnel should be evacuated immediately, emergency procedures should be initiated, and containment with appropriate materials should be used to prevent the spread, and then cleaned up by professionals.
Only by strictly observing safety and operating standards can we ensure production safety and avoid the risk of accidents, so that 1-chloro-3- (trifluoromethyl) benzene can play its due role in chemical production.
Application Area
1 - Chloro - 3 - (Trifluoromethyl) Benzene has a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new special drugs, which is expected to overcome many difficult diseases and bring good news to people with diseases. In the field of materials science, it participates in the synthesis of materials with special properties, or has excellent heat resistance and corrosion resistance, which is suitable for extreme environments. In the field of fine chemicals, it is also indispensable to help prepare high-end fine chemicals, such as special fragrances, dyes, etc., to meet the pursuit of quality and uniqueness of different groups of people. With its unique chemical structure, this compound shows great potential in various application fields, and is like a key to open many new doors of scientific and industrial progress.
Research & Development
In recent years, I have been in the field of chemistry, specializing in the study of 1 - Chloro - 3 - (Trifluoromethyl) Benzene. Its properties are unique, and it has a wide range of uses. It plays an important role in the pharmaceutical, pesticide and material industries.
At the beginning, the method of synthesis was explored. After repeated trials, several paths were obtained. First, benzene-based, halogenated and fluorinated, although it can be achieved, the process is complex, and the yield is not ideal. Later, another approach was found, and a special catalytic method was used instead. The conditions were slightly easier to control, and the yield was also improved.
Then, its properties were studied. Its physicochemical properties were measured, and its solubility and stability in different media were known. Looking at its reactivity, it shows that it can react with a variety of reagents to form various derivatives.
As for the development, looking to the future, I hope to optimize the synthesis, reduce costs and improve efficiency. And expect to expand its use in new fields, such as high-end electronic materials. I will study it diligently, hoping to contribute to its development and promote this chemical product to have a more prosperous future.
Toxicity Research
1 - Chloro - 3 - (Trifluoromethyl) Benzene is an organic compound, and its toxicity research is quite important. Today, its toxicity is investigated in detail to understand its impact on the environment and human body.
After various experiments, this compound has certain toxicity. In animal experiments, if it is exposed to this substance, it can be seen that it has damage to animal organs. Such as liver and kidneys, its function may change as a result.
And this substance is also difficult to degrade in the environment, persists for a long time, or causes ecological disturbance. The effect of bioaccumulation cannot be ignored, or accumulates through the food chain, eventually endangering high-end organisms.
The degree of toxicity also varies depending on the dose and duration of exposure. Short-term exposure at low doses may have mild effects; long-term exposure at high doses is significant.
In summary, the toxicity study of 1-Chloro-3- (Trifluoromethyl) Benzene provides a key basis for its safe use and environmental regulation, and must not be taken lightly.
Future Prospects
1 - Chloro - 3 - (Trifluoromethyl) Benzene, the future prospect of this substance is related to the progress of our chemical research. Looking at today's chemical field, progress is rapid, with new technologies and new methods emerging one after another.
For 1 - Chloro - 3 - (Trifluoromethyl) Benzene, it may have broader application prospects in organic synthesis. We can use the new catalytic system to optimize its synthesis path, improve yield and reduce costs. In the future, it may be able to expand its application in the field of drug development, and new drugs with better efficacy and less side effects can be developed through structural modification.
Furthermore, with the deepening of the concept of green chemistry, we will be committed to exploring more environmentally friendly synthesis processes to reduce the impact on the environment. Looking forward to the future, 1 - Chloro - 3 - (Trifluoromethyl) Benzene will shine in many fields and make greater contributions to human well-being.
Where to Buy 1-Chloro-3-(Trifluoromethyl)Benzene in China?
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Frequently Asked Questions

As a leading 1-Chloro-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene, its main use, is related to the fields of organic synthesis, medicine and materials.
In the field of organic synthesis, this is an important intermediate. Due to the characteristics of chlorine atoms and trifluoromethyl in molecules, various chemical reactions, such as nucleophilic substitution and coupling reactions, can be used to construct various complex organic molecular structures. For example, in nucleophilic substitution reactions, chlorine atoms can be replaced by nucleophilic reagents such as hydroxyl and amino groups, and then corresponding substitution products can be formed, paving the way for the synthesis of special organic compounds.
In the field of medicine, 1-chloro-3- (trifluoromethyl) benzene also has key uses. Due to its unique chemical structure, it can endow drugs with specific physicochemical properties and biological activities. Using this as a starting material, through a series of synthesis steps, it may be able to prepare drug molecules with specific pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials, it also makes a difference. It can participate in the synthesis of polymer materials, and the trifluoromethyl introduced by it can improve the properties of materials, such as improving the weather resistance, chemical stability and surface properties of materials. This can play an important role in the development and production of materials such as coatings and plastics, making materials more suitable for specific environments and applications.
In short, the unique chemical structure of 1-chloro-3- (trifluoromethyl) benzene plays an important role in many fields such as organic synthesis, medicine and materials, providing a key raw material base for the development of many related industries.
What are the physical properties of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene is also an organic compound. Its physical properties have many specificities, as detailed below:
This substance is a colorless to pale yellow liquid at room temperature, and it is clear and transparent when viewed. It has a special odor. Its boiling point is about 184-186 ° C. At this temperature, the substance changes from liquid to gaseous. The melting point is about -35 ° C. When the temperature drops to this temperature, the substance begins to solidify from liquid to solid.
The density of 1-chloro-3- (trifluoromethyl) benzene is higher than that of water, about 1.37 g/cm ³, so if mixed with water, it will sink to the bottom of the water. Its solubility in water is very small, because it is a non-polar compound, and water is a polar solvent. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. in any ratio, because it has the characteristics of non-polar or weak polarity with such organic solvents.
Furthermore, the vapor pressure of this compound is relatively low at room temperature, which means that its volatilization rate is slow. However, it should be noted that although the volatilization is slow, its vapor is still toxic to a certain extent. If it accumulates in a confined space, it may cause harm to human health.
The refractive index of 1-chloro-3- (trifluoromethyl) benzene is about 1.45 (20 ° C), which makes it potentially useful in the field of optics. When light passes through the substance, the propagation direction changes at a specific angle, which can be helpful for related optical experiments and research.
In conclusion, the physical properties of 1-chloro-3- (trifluoromethyl) benzene are unique and are of great significance in organic synthesis, materials science and other fields, providing basic conditions for many chemical reactions and material preparation.
What are the chemical properties of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene, which has different properties. This is one of the organohalogenated aromatic hydrocarbons, and the chlorine atom and trifluoromethyl are based on the benzene ring.
Its chemical properties are more active than benzene. Trifluoromethyl has strong electron-absorbing properties, causing the electron cloud density of the benzene ring to decrease, making the electrophilic substitution reaction difficult, but the nucleophilic substitution reaction is easy.
When electrophilic substitution, trifluoromethyl is the meta-locator. Although the chlorine atom also absorbs electrons, its lone pair electrons can be conjugated with the benzene ring to slightly increase the electron cloud density of the ortho and para-position. However, trifluorome
In the nucleophilic substitution, chlorine atoms are easily dissociated into carbon-positive intermediates due to the low electron cloud density of the benzene ring, and the instability of the ortho and para-carbon positive ions of the trifluoromethyl group, which is the site of attack by the nucleophilic reagents.
Its chemical properties also involve many reactions. Under basic conditions, chlorine can be replaced by nucleophilic reagents such as hydroxyl groups and amino groups to produce phenols and amines. With metal reagents, such as magnesium and lithium, it can form organometallic compounds for forming carbon-carbon bonds, which are especially important in organic synthesis.
Its stability is good, and it has weather resistance and chemical corrosion resistance due to the structure of the trifluoromethyl group. However, under high temperature or strong oxidants, its structure can be broken and decomposed.
1-chloro-3- (trifluoromethyl) benzene is chemically active and special, and is widely used in organic synthesis, materials science and other fields. It is also a key object of organic chemistry research.
What is the production method of 1-Chloro-3- (Trifluoromethyl) Benzene?
There are several common methods for preparing 1-chloro-3- (trifluoromethyl) benzene.
One is to use m-toluidine as the starting material, which is prepared by diazotization and halogenation. First, m-toluidine and sodium nitrite undergo diazotization under acidic conditions to form diazonium salts. This reaction requires careful temperature control to prevent the decomposition of diazonium salts. Then, the diazonium salt interacts with reagents such as cuprous chloride and hydrofluoric acid to achieve the replacement of diazonium groups with chlorine atoms, and the methyl group is replaced by trifluoromethyl to obtain the target product 1-chloro-3- (trifluoromethyl) benzene. This method is a little complicated, but the raw materials are relatively easy to obtain.
Second, it can be started from m-chlorobenzaldehyde. First, m-chlorobenzaldehyde is interacted with a halogenating reagent to convert the aldehyde group to trifluoromethyl. For example, using a variant of the Ullman reaction, in the presence of an appropriate catalyst and base, it reacts with the trifluoromethylating reagent. After that, a series of subsequent reactions, such as reduction and halogenation, remove unnecessary functional groups, and finally obtain 1-chloro-3- (trifluoromethyl) benzene. This approach requires precise control of the reaction conditions to ensure high yield and purity.
Third, isochlorobenzoic acid is used as the starting material. The isochlorobenzoic acid is first converted into the corresponding acyl chloride, and then reacted with the trifluoromethylation reagent under specific conditions to introduce trifluoromethyl. Subsequently, the carboxyl group is removed by reduction and decarboxylation, and the chlorine atom and trifluoromethyl are retained to achieve the synthesis of 1-chloro-3- (trifluoromethyl) benzene. This method involves relatively complex organic synthesis steps, and a deep understanding of the reaction mechanism of each step is required to optimize the reaction conditions and improve the quality and yield of the product.
What are the precautions for storing and transporting 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
The first thing to pay attention to is its chemical properties. This substance has certain chemical activity, and it may cause combustion and explosion in case of hot topics, open flames or oxidants. Therefore, the storage place must be kept away from fire, heat sources and strong oxidants. It should be placed in a cool and ventilated warehouse. The storage temperature should not exceed 30 ° C. The warehouse lighting, ventilation and other facilities should be explosion-proof, and the switch should be located outside the warehouse.
The second is the rigorous packaging. When transporting and storing, the packaging must be intact and sealed to prevent leakage. The packaging materials used must be able to resist its corrosion and penetration.
In addition, when handling, it should be handled lightly, and do not collide or invert to prevent material leakage due to package damage. Operators should wear appropriate protective equipment, such as gas masks, protective gloves, etc., to avoid skin contact and inhalation.
During transportation, pay extra attention. Should follow the prescribed route, do not stop in densely populated areas and residential areas. In summer transportation, it is advisable to choose morning and evening periods to avoid high temperature and hot sun.
In conclusion, during the storage and transportation of 1-chloro-3- (trifluoromethyl) benzene, strict safety procedures and careful operation are required to prevent accidents and ensure the safety of personnel and the environment from being polluted.