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What are the main uses of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene, its main use, is related to the fields of organic synthesis, medicine and materials.
In the field of organic synthesis, this is an important intermediate. Due to the characteristics of chlorine atoms and trifluoromethyl in molecules, various chemical reactions, such as nucleophilic substitution and coupling reactions, can be used to construct various complex organic molecular structures. For example, in nucleophilic substitution reactions, chlorine atoms can be replaced by nucleophilic reagents such as hydroxyl and amino groups, and then corresponding substitution products can be formed, paving the way for the synthesis of special organic compounds.
In the field of medicine, 1-chloro-3- (trifluoromethyl) benzene also has key uses. Due to its unique chemical structure, it can endow drugs with specific physicochemical properties and biological activities. Using this as a starting material, through a series of synthesis steps, it may be able to prepare drug molecules with specific pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials, it also makes a difference. It can participate in the synthesis of polymer materials, and the trifluoromethyl introduced by it can improve the properties of materials, such as improving the weather resistance, chemical stability and surface properties of materials. This can play an important role in the development and production of materials such as coatings and plastics, making materials more suitable for specific environments and applications.
In short, the unique chemical structure of 1-chloro-3- (trifluoromethyl) benzene plays an important role in many fields such as organic synthesis, medicine and materials, providing a key raw material base for the development of many related industries.
What are the physical properties of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene is also an organic compound. Its physical properties have many specificities, as detailed below:
This substance is a colorless to pale yellow liquid at room temperature, and it is clear and transparent when viewed. It has a special odor. Its boiling point is about 184-186 ° C. At this temperature, the substance changes from liquid to gaseous. The melting point is about -35 ° C. When the temperature drops to this temperature, the substance begins to solidify from liquid to solid.
The density of 1-chloro-3- (trifluoromethyl) benzene is higher than that of water, about 1.37 g/cm ³, so if mixed with water, it will sink to the bottom of the water. Its solubility in water is very small, because it is a non-polar compound, and water is a polar solvent. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. in any ratio, because it has the characteristics of non-polar or weak polarity with such organic solvents.
Furthermore, the vapor pressure of this compound is relatively low at room temperature, which means that its volatilization rate is slow. However, it should be noted that although the volatilization is slow, its vapor is still toxic to a certain extent. If it accumulates in a confined space, it may cause harm to human health.
The refractive index of 1-chloro-3- (trifluoromethyl) benzene is about 1.45 (20 ° C), which makes it potentially useful in the field of optics. When light passes through the substance, the propagation direction changes at a specific angle, which can be helpful for related optical experiments and research.
In conclusion, the physical properties of 1-chloro-3- (trifluoromethyl) benzene are unique and are of great significance in organic synthesis, materials science and other fields, providing basic conditions for many chemical reactions and material preparation.
What are the chemical properties of 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene, which has different properties. This is one of the organohalogenated aromatic hydrocarbons, and the chlorine atom and trifluoromethyl are based on the benzene ring.
Its chemical properties are more active than benzene. Trifluoromethyl has strong electron-absorbing properties, causing the electron cloud density of the benzene ring to decrease, making the electrophilic substitution reaction difficult, but the nucleophilic substitution reaction is easy.
When electrophilic substitution, trifluoromethyl is the meta-locator. Although the chlorine atom also absorbs electrons, its lone pair electrons can be conjugated with the benzene ring to slightly increase the electron cloud density of the ortho and para-position. However, trifluorome
In the nucleophilic substitution, chlorine atoms are easily dissociated into carbon-positive intermediates due to the low electron cloud density of the benzene ring, and the instability of the ortho and para-carbon positive ions of the trifluoromethyl group, which is the site of attack by the nucleophilic reagents.
Its chemical properties also involve many reactions. Under basic conditions, chlorine can be replaced by nucleophilic reagents such as hydroxyl groups and amino groups to produce phenols and amines. With metal reagents, such as magnesium and lithium, it can form organometallic compounds for forming carbon-carbon bonds, which are especially important in organic synthesis.
Its stability is good, and it has weather resistance and chemical corrosion resistance due to the structure of the trifluoromethyl group. However, under high temperature or strong oxidants, its structure can be broken and decomposed.
1-chloro-3- (trifluoromethyl) benzene is chemically active and special, and is widely used in organic synthesis, materials science and other fields. It is also a key object of organic chemistry research.
What is the production method of 1-Chloro-3- (Trifluoromethyl) Benzene?
There are several common methods for preparing 1-chloro-3- (trifluoromethyl) benzene.
One is to use m-toluidine as the starting material, which is prepared by diazotization and halogenation. First, m-toluidine and sodium nitrite undergo diazotization under acidic conditions to form diazonium salts. This reaction requires careful temperature control to prevent the decomposition of diazonium salts. Then, the diazonium salt interacts with reagents such as cuprous chloride and hydrofluoric acid to achieve the replacement of diazonium groups with chlorine atoms, and the methyl group is replaced by trifluoromethyl to obtain the target product 1-chloro-3- (trifluoromethyl) benzene. This method is a little complicated, but the raw materials are relatively easy to obtain.
Second, it can be started from m-chlorobenzaldehyde. First, m-chlorobenzaldehyde is interacted with a halogenating reagent to convert the aldehyde group to trifluoromethyl. For example, using a variant of the Ullman reaction, in the presence of an appropriate catalyst and base, it reacts with the trifluoromethylating reagent. After that, a series of subsequent reactions, such as reduction and halogenation, remove unnecessary functional groups, and finally obtain 1-chloro-3- (trifluoromethyl) benzene. This approach requires precise control of the reaction conditions to ensure high yield and purity.
Third, isochlorobenzoic acid is used as the starting material. The isochlorobenzoic acid is first converted into the corresponding acyl chloride, and then reacted with the trifluoromethylation reagent under specific conditions to introduce trifluoromethyl. Subsequently, the carboxyl group is removed by reduction and decarboxylation, and the chlorine atom and trifluoromethyl are retained to achieve the synthesis of 1-chloro-3- (trifluoromethyl) benzene. This method involves relatively complex organic synthesis steps, and a deep understanding of the reaction mechanism of each step is required to optimize the reaction conditions and improve the quality and yield of the product.
What are the precautions for storing and transporting 1-Chloro-3- (Trifluoromethyl) Benzene?
1-Chloro-3- (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
The first thing to pay attention to is its chemical properties. This substance has certain chemical activity, and it may cause combustion and explosion in case of hot topics, open flames or oxidants. Therefore, the storage place must be kept away from fire, heat sources and strong oxidants. It should be placed in a cool and ventilated warehouse. The storage temperature should not exceed 30 ° C. The warehouse lighting, ventilation and other facilities should be explosion-proof, and the switch should be located outside the warehouse.
The second is the rigorous packaging. When transporting and storing, the packaging must be intact and sealed to prevent leakage. The packaging materials used must be able to resist its corrosion and penetration.
In addition, when handling, it should be handled lightly, and do not collide or invert to prevent material leakage due to package damage. Operators should wear appropriate protective equipment, such as gas masks, protective gloves, etc., to avoid skin contact and inhalation.
During transportation, pay extra attention. Should follow the prescribed route, do not stop in densely populated areas and residential areas. In summer transportation, it is advisable to choose morning and evening periods to avoid high temperature and hot sun.
In conclusion, during the storage and transportation of 1-chloro-3- (trifluoromethyl) benzene, strict safety procedures and careful operation are required to prevent accidents and ensure the safety of personnel and the environment from being polluted.