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What are the main uses of 1-Chloro-3- (Trifluoromethyl) -5- (3,3,3-Trifluoroprop-1-En-2-Yl) Benzene
1-Chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropylene-1-ene-2-yl) benzene, this is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of organic synthesis.
The process of organic synthesis, many delicate and complex molecular constructions, rely on this compound as a starting material. Due to its molecular structure, it has specific functional groups such as chlorine atom, trifluoromethyl and trifluoropropylene group, which endow it with unique reactivity and selectivity.
As far as chlorine atoms are concerned, they can interact with many nucleophiles through nucleophilic substitution reactions, thereby introducing other functional groups and expanding the structure of molecules. The existence of trifluoromethyl groups significantly changes the physical and chemical properties of molecules, such as improving the stability and fat solubility of compounds, which is of great significance in the field of medicinal chemistry and materials science. The trifluoropropyl-1-ene-2-based moiety can not only participate in addition reactions, but also participate in various pericyclic reactions as part of a conjugate system, providing rich possibilities for the synthesis of novel compounds.
In the field of drug development, this compound may be used to construct a drug molecular skeleton with specific biological activities. Due to its unique structure, or can interact with specific biological targets, it exhibits biological activities such as antibacterial, antiviral, and anti-tumor, bringing hope for the creation of new drugs.
In the field of materials science, it can be used as a functional monomer to participate in polymerization reactions and prepare polymer materials with special properties. For example, the resulting polymers may have excellent chemical resistance, thermal stability, and low surface energy, making them useful in coatings, plastics, and other fields.
In addition, in the field of pesticides, with its special structure and properties, new pesticides with high efficiency, low toxicity, and environmental friendliness may be developed, contributing to the pest control of agricultural production. In conclusion, 1-chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropylene-1-ene-2-yl) benzene has potential applications in many fields, providing an important material basis for chemical research and industrial production.
What are the physical properties of 1-Chloro-3- (Trifluoromethyl) -5- (3,3,3-Trifluoroprop-1-En-2-Yl) Benzene
1-Chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropylene-1-ene-2-yl) benzene-based organic compounds with unique physical properties.
Its color state may be colorless to pale yellow liquid at room temperature, and it is clear and transparent. Due to the interaction of aromatic rings and fluorine-containing groups in the molecular structure, the intermolecular force is moderate and does not crystallize.
Smell or have a special smell, but it is different due to individual olfactory differences. The chlorine-containing and fluorine-containing groups give it a special chemical smell.
The boiling point of this compound may be higher due to the presence of aromatic rings and multiple fluorine atoms in the molecular structure. The aromatic rings have a conjugated system, and there is a strong dispersion force between molecules; the electronegativity of fluorine atoms is large, so there is a certain dipole-dipole interaction between molecules. Together, the two cause molecules to break away from the liquid phase and require more energy, so the boiling point is high.
In terms of melting point, due to the asymmetric molecular structure and the steric resistance of fluorine-containing groups, the orderly arrangement of molecules is limited, and it is difficult to form a tight lattice structure, so the melting point is relatively low.
In terms of solubility, because it contains hydrophobic aromatic rings and lipophilic fluoroalkyl groups, it has good solubility in organic solvents such as dichloromethane, chloroform, and toluene. Due to the principle of similar phase dissolution, the intermolecular forces between these organic solvents and the compound can promote dissolution; while in water, the solubility is poor. Due to the overall hydrophobicity and weak forces between water molecules, it is difficult to form a homogeneous system with water.
The density may be greater than that of water. Due to the large relative atomic weight of chlorine and fluorine atoms in the molecule, the mass per unit volume increases, so the density is higher than that of water.
In addition, the compound may be volatile to a certain extent. Although its volatility is not as fast as that of small molecule organic solvents due to intermolecular forces, the molecules can still overcome intermolecular forces and enter the gas phase under suitable conditions.
What are the chemical properties of 1-Chloro-3- (Trifluoromethyl) -5- (3,3,3-Trifluoroprop-1-En-2-Yl) Benzene
1-Chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropane-1-ene-2-yl) benzene, an organic compound. Its chemical properties are interesting and I will explain in detail.
Start with its physical properties. This compound is usually in a liquid or solid state, depending on the ambient temperature and pressure. Its melting and boiling point is determined by intermolecular forces. Many fluorine atoms in the molecule can significantly affect intermolecular forces due to their high electronegativity. Fluorine atoms change the polarity of the molecule, causing its melting and boiling point to be different from that of similar compounds without fluorine.
When it comes to chemical properties, the chlorine atom is one of the active check points of this molecule. Chlorine atoms have good activity and can participate in a variety of chemical reactions. For example, nucleophilic substitution reactions, under suitable conditions, chlorine atoms can be replaced by various nucleophilic reagents. Nucleophilic reagents such as hydroxyl (-OH) and amino (-NH2O) may be substituted with chlorine atoms to derive new compounds.
In addition, trifluoromethyl (-CF) in the molecule also has unique properties. Trifluoromethyl is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, thereby affecting the reactivity of other groups connected to the benzene ring. Due to the electron-withdrawing effect of trifluoromethyl, the activity of the electrophilic substitution reaction on the benzene ring may decrease, and the reaction check point will also change.
And the 3,3,3-trifluoropropylene-1-ene-2-based moiety contains a carbon-carbon double bond, which imparts unsaturation to the molecule. The carbon-carbon double bond can participate in the addition reaction, such as addition with hydrogen, halogen elements, hydrogen halide and other substances. Under the action of a suitable catalyst, it can be added with hydrogen to form a saturated alkyl group; with halogen elements, it can be directly added to form halogenated products.
In addition, the compound contains many fluorine atoms, which makes it have certain chemical stability and corrosion resistance. In some chemical reaction systems, it can exhibit unique reaction properties, providing a different choice for the field of organic synthesis, and has potential application value in many fields such as materials science and medicinal chemistry.
What is the synthesis method of 1-Chloro-3- (Trifluoromethyl) -5- (3,3,3-Trifluoroprop-1-En-2-Yl) Benzene
The synthesis of 1-chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropylene-1-ene-2-yl) benzene is an interesting topic in organic synthetic chemistry. To synthesize this compound, you can follow the following steps.
The first step is to prepare suitable starting materials. Usually, benzene derivatives containing chlorine and trifluoromethyl can be used as starting materials, and then a reagent that can introduce trifluoropropylene-1-ene-2-group can be found. In this case, suitable halogenated olefins, such as halogenated propylene derivatives containing trifluoromethyl groups, can be considered as raw materials for introducing the specific alkenyl group.
Next step, choose the appropriate reaction conditions. Metal-catalyzed reaction pathways are often required. For example, palladium-catalyzed cross-coupling reactions can be used. In such reactions, palladium catalysts can activate halogenated aromatics and halogenated olefins, promoting the formation of carbon-carbon bonds between the two. In order to make the reaction proceed smoothly, appropriate ligands need to be added to enhance the activity and selectivity of the palladium catalyst. Common ligands include phosphine ligands, such as triphenylphosphine.
Furthermore, the choice of base is also crucial. A suitable base can assist the palladium catalyst to complete the catalytic cycle, and at the same time adjust the pH of the reaction system to promote the progress of the reaction. Inorganic bases such as potassium carbonate and sodium carbonate, or organic bases such as potassium tert-butanol, can all play a role in such reactions.
During the reaction, the starting material, palladium catalyst, ligand and base are added to a suitable organic solvent in an appropriate proportion. Common organic solvents include toluene, dichloromethane, etc. Stir the reaction at an appropriate temperature. This temperature may vary depending on the specific reaction conditions, generally between room temperature and 100 ° C.
After the reaction is completed, the reaction mixture needs to be post-treated. The organic product is first separated from the reaction system by conventional extraction methods. The organic phase is often extracted with an organic solvent, and then dried with a desiccant such as anhydrous sodium sulfate. Then, by column chromatography and other purification methods, the by-products generated in the reaction are removed to obtain a pure 1-chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropane-1-ene-2-yl) benzene product. Although this synthesis method has certain challenges, it can be obtained by following the above steps with caution.
What is the price range of 1-Chloro-3- (Trifluoromethyl) -5- (3,3,3-Trifluoroprop-1-En-2-Yl) Benzene in the market?
1-Chloro-3- (trifluoromethyl) -5- (3,3,3-trifluoropropane-1-ene-2-yl) benzene, which is on the market, its price range is not easy to determine. The price of the compound often varies due to many reasons, such as the difficulty of preparation, the price of the required raw materials, and the supply and demand situation in the market.
If the preparation method of this compound is simple, and the raw materials are easy to purchase and inexpensive, its price may be relatively low. However, if the preparation process is complicated and rare or expensive raw materials are required, its price will increase.
The supply and demand side of the market is also the main reason. If there are many people who want it, and the supply is small, the price will necessarily increase; conversely, if the supply exceeds the demand, the price may drop.
Check the records of past transactions, or you can get a rough idea of the price. Unfortunately, I do not have the exact past transaction data of this compound, so it is difficult to specify the price range. Or you can consult the merchants specializing in chemical reagents, who have been involved in this industry for a long time, or you can tell the price of this product in the market. Or you can consult professional reports on the price of chemical products, which may describe the range and trend of the price of this compound.