Hongda Chemical
Products
Home  /  Products  / 

1-Chloro-3-(Trifluoromethoxy)Benzene

1-Chloro-3-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

304148

Chemical Formula C7H4ClF3O
Molar Mass 196.55 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 146 - 148 °C
Density 1.36 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point 48 °C
Refractive Index 1.443

As an accredited 1-Chloro-3-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 3 - (trifluoromethoxy) benzene in 5 - liter sealed containers.
Storage 1 - Chloro - 3 - (trifluoromethoxy)benzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions.
Shipping 1 - Chloro - 3 - (trifluoromethoxy)benzene is shipped in specialized, leak - proof containers. These are designed to prevent any chemical leakage during transit, adhering to strict regulations for hazardous chemicals.
Free Quote

Competitive 1-Chloro-3-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

1-Chloro-3-(Trifluoromethoxy)Benzene 1-Chloro-3-(Trifluoromethoxy)Benzene
General Information
Historical Development
1-Chloro-3- (trifluoromethoxy) benzene is also an organic compound. It originated in the process of chemical research. At the beginning, scholars studied the characteristics and synthesis of fluorine-containing compounds, so they paid attention to this special structure. In the past, the synthesis method was simple and ineffective, but through the unremitting exploration of many scholars, it gradually improved. In the early days, it could only be produced in small quantities, and its application was limited to specific experiments.
In modern times, science and technology became prosperous, and chemical technology became more and more mature. The exploration of new catalysts and reaction conditions has greatly improved its synthesis efficiency. Not only is the yield gradually abundant, but also the purity is better. The field of application has also gradually expanded, and it has emerged in the fields of medicine and materials. The historical evolution of this compound is the brainchild of researchers, and it is also a clear evidence of the development of chemical industry. There may be a broader development space in the future.
Product Overview
1-Chloro-3- (trifluoromethoxy) benzene is an organic compound. It is a colorless liquid with a special odor. This substance is widely used in the field of organic synthesis.
Its preparation method is often obtained by a specific reaction process. This compound can be obtained by carefully adjusting the reaction conditions, such as temperature, ratio of reactants, and type and amount of catalyst.
In terms of properties, 1-chloro-3- (trifluoromethoxy) benzene has considerable chemical stability. However, in a specific reaction environment, it can also exhibit active reactivity, substitution, addition, and other reactions with a variety of reagents. This property makes it a valuable intermediate in organic synthesis, which can be derived from a variety of organic products. It has potential applications in many fields such as medicine, pesticides, and materials science.
Physical & Chemical Properties
1 - Chloro - 3 - (Trifluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, it is mostly liquid at room temperature, with a specific boiling point and melting point, which is related to the transition of its material state. The boiling point is the temperature at which a substance changes from liquid to gaseous state, and the melting point is the temperature at which the solid state changes to liquid state.
In terms of its chemistry, the presence of chlorine atoms and trifluoromethoxy groups in this compound makes it have unique reactivity. Chlorine atoms are active, can participate in nucleophilic substitution reactions, or interact with nucleophilic reagents, and are easily replaced by other groups. Trifluoromethoxy groups have strong electronegativity, which affects the electron cloud distribution of molecules, and then affects their chemical reaction paths and rates. And because of its fluorine atom, the compound has certain chemical stability and special physiological activity, and has potential applications in the fields of organic synthesis and medicinal chemistry.
Technical Specifications & Labeling
1 - Chloro - 3 - (Trifluoromethoxy) Benzene is an important chemical product. Its preparation process is fine and requires strict technical specifications. The selection of raw materials should be accurate and the ratio should follow the established standards, so as to ensure the quality of the product.
In the technical specifications, the reaction temperature and duration have a key impact. Too high or too low temperature, too short or too long time can lead to impure products or poor yield. The pH of the reaction environment also needs to be properly regulated.
Product labeling is particularly important. Commercial parameters such as product name, composition, content should be clearly marked to ensure that users understand its nature and use. In this way, 1 - Chloro - 3 - (Trifluoromethoxy) Benzene can play its due role in industrial applications and promote the development of related fields.
Preparation Method
1 - Chloro - 3 - (Trifluoromethoxy) Benzene is an important chemical, and its preparation method is crucial. In the selection of raw materials, when using 3-hydroxychlorobenzene and trifluoromethylation reagents, the two are fundamental.
The preparation process is as follows: first place 3-hydroxychlorobenzene in the reactor, add an appropriate amount of catalyst, and then slowly inject the trifluoromethylation reagent. The reaction conditions need to be strictly controlled, the temperature should be maintained in a specific range, such as 60 to 80 degrees Celsius, and the reaction environment should be an inert gas atmosphere to prevent impurity interference. After the reaction number, the follow-up treatment will be carried out after the reaction is fully reacted.
In terms of reaction steps, the first step is nucleophilic substitution reaction, in which the active group in the trifluoromethylation reagent is substituted with the hydroxyl group of 3-hydroxychlorobenzene to form an intermediate. Then, the intermediate is separated and purified by means of distillation and extraction.
In the activation mechanism, the catalyst can reduce the activation energy of the reaction, make 3-hydroxychlorobenzene and the trifluoromethoxy reagent more reactive, thereby improving the yield and purity of 1-Chloro-3- (Trifluoromethoxy) Benzene.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances, and the reaction and modification are particularly important. In today's words, the synthesis of 1-chloro-3 - (trifluoromethoxy) benzene often depends on various chemical mechanisms. In the past, the preparation method may have complicated and inefficient disadvantages.
If you want to be good at something, you must first understand it. Chemists observe its structure and think of ways to improve it. Depending on the reaction conditions, adjust the temperature, pressure, or change the catalyst, in order to achieve better results. In the past, the reaction had more impurities, but the yield was not abundant. After research, the process was optimized to make the reaction precise, the yield increased, and the impurities decreased.
And its performance, considering many application scenarios. Or make it in the synthesis of materials to increase its characteristics; or use it in pharmaceutical research and development to help drug efficacy. After modification, its chemical activity and stability are improved, opening up new opportunities for various fields. This is the unremitting work of chemical researchers, making the properties of substances changeable to meet the needs of the world.
Synonyms & Product Names
1-Chloro-3- (trifluoromethoxy) benzene, the synonym and trade name of this substance, is really relevant to our chemical research.
In the field of chemistry, the same substance is often called differently due to different situations and uses. 1-Chloro-3- (trifluoromethoxy) benzene, or another name, is well known in the industry. These synonyms are either derived from traditional habits or named based on specific research categories. And trade names are often chosen by manufacturers to promote products according to their characteristics and advantages.
Or because of its unique chemical structure and properties, it has emerged in the fields of medicine, materials and so on. People in different industries may have different names for it, but they all refer to this specific chemical substance. The clarity of synonyms and trade names is of great significance in academic exchanges and industrial applications, so as to avoid confusion and promote accurate docking between all parties. We chemical researchers need to carefully investigate such terms in order to facilitate the smooth flow of scientific research and application.
Safety & Operational Standards
1-Chloro-3- (trifluoromethoxy) benzene is a chemical product. It is related to safety and operating standards. It is of paramount importance and should be explained in detail.
At the storage end, a cool, dry and well-ventilated place must be selected. This product is active or active, and it is necessary to keep away from heat and fire sources in case of heat, open flame or danger. And it must be stored separately from oxidizing agents, reducing agents and other heterogeneous chemicals to prevent improper reactions. The reservoir must also be tightly closed to prevent its volatilization and escape, polluting the environment, and preventing accidental leakage and danger.
During operation, protective measures are indispensable. Operators should wear special protective clothing, protective gloves and goggles to protect their skin and eyes from damage. If working in poorly ventilated areas, prepare effective ventilation equipment or gas masks to prevent their vapors from inhaling into the body and harming health.
When using, strictly follow established procedures. The operation site must be neat and orderly, and no fireworks and sundries. Use an appropriate amount, do not waste, and avoid excessive risk. After the operation, properly clean the equipment and site, and dispose of the residual materials according to regulations, and do not dispose of them at will.
If a leak unfortunately occurs, emergency measures should be initiated immediately. The first thing to do is to evacuate the surrounding personnel and separate the dangerous area. The operator wears professional protective equipment to quickly block the source of the leak. Leaked materials, according to their characteristics, or with sand, vermiculite and other adsorption collection, or the introduction of a specific treatment system, must not be allowed to flow, to avoid greater disaster.
In short, 1-chloro-3 - (trifluoromethoxy) benzene safety and operation specifications, all the details, must be carefully carried out, the slightest slack, to ensure that people are safe and well, everything goes well.
Application Area
1-Chloro-3- (trifluoromethoxy) benzene, this compound has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help synthesize a variety of specific drugs, or to exert unique curative effects for specific diseases. In the field of materials science, it can participate in the preparation of high-performance materials, endowing materials with properties such as excellent chemical resistance and thermal stability, and is widely used in high-end manufacturing. In agricultural chemicals, it can be used to develop new pesticides, enhance insecticidal and bactericidal effects, and have little impact on the environment. And because of its unique chemical structure, it is often used as a starting material in the synthesis of fine chemical products, and various high-value-added products are prepared through multi-step reactions, promoting the chemical industry to move towards high-end and refinement.
Research & Development
In recent years, Yu devoted himself to the research of 1-chloro-3- (trifluoromethoxy) benzene. This compound has unique properties and wide use, and has potential in the fields of medicine and pesticides.
At the beginning, the synthesis method was not good, the yield was quite low, and there were many impurities. Yu and his colleagues worked hard to research the classics and study the mechanism in detail. After months of research, trial and error, the process was improved, and the conditions were optimized. Temperature, pressure, and reagent ratio were all considered repeatedly.
Finally, a good method was obtained, the yield gradually increased, and the quality was also good. And this process has a smaller impact on the environment, which is in line with the current purpose of green chemistry. We are still working tirelessly to take it to the next level, expand its application, and promote its wide application in the industry, so as to benefit everyone and promote the development of this field.
Toxicity Research
1-Chloro-3- (trifluoromethoxy) benzene is also a chemical substance. In the matter of toxicity research, it is very important. The toxicity of this substance is related to the safety of life and the tranquility of the environment.
If you want to understand its toxicity in detail, you must use scientific methods and rigorous attitude. First observe its reaction in experimental animals, observe its physiological changes and behavioral differences. If you apply it to the genus of rodents, observe its diet, activities, and organs.
And think about its impact on the environment. Or volatilize in air, or flow in water, or seep in soil. In the ecological chain, where it should be studied, it is harmless to all.
The study of toxicity is not a one-day effort. It must be persevered. With detailed evidence to confirm its toxicity, it can be the foundation for protection and governance, and it can ensure the safety of all things. Do not make this chemical product a disaster to the world.
Future Prospects
1 - Chloro - 3 - (Trifluoromethoxy) Benzene is also a new material for chemical processing. It has not been developed yet, and it can be used in many fields.
In the way of research and development, or it can be developed in a new way, providing a new way. With its characteristics, it may be able to build new molecules, increase efficiency, reduce side effects, and provide good news for patients.
In the field of materials, it is also effective. Or special additions can be made to improve the properties of materials, such as resistance, resistance, etc., so that the materials are more suitable for the end of the environment.
And if the synthesis method can be improved in one step, improve efficiency and reduce cost, it will be able to be widely used. In the future, it is expected to expand in various fields, promote the progress of science and technology, and benefit the world.
Where to Buy 1-Chloro-3-(Trifluoromethoxy)Benzene in China?
As a trusted 1-Chloro-3-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-3-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene has a wide range of uses. In the field of organic synthesis, it is often a key raw material. Due to its unique chemical structure, it contains chlorine atoms and trifluoromethoxy groups, giving it special reactivity and properties.
In pharmaceutical chemistry, this is used as a starting material. Through various chemical reactions, a variety of bioactive compounds can be prepared, or as potential pharmaceutical ingredients, to deal with various diseases. The particularity of its structure helps to form a suitable interaction between drugs and biological targets, so as to achieve the desired pharmacological effect.
In the field of materials science, it is also important. Materials with special properties can be prepared through the polymerization reaction or other chemical modification methods in which they participate. For example, fluorine-containing groups can improve the chemical resistance, thermal stability and surface properties of materials, and are used in high-end fields such as aerospace and electronics to meet special environmental and performance requirements.
Furthermore, in the field of pesticide chemistry, 1-chloro-3 - (trifluoromethoxy) benzene can also be an important intermediate for the synthesis of new pesticides. The synthesized pesticides, by virtue of their chemical properties, may have high insecticidal, bactericidal or herbicidal activities, and due to the introduction of fluorine atoms, may reduce the impact on the environment, meeting the needs of modern pesticide green and efficient development. Overall, it plays an indispensable role in many chemical-related fields, promoting technological progress and development in various fields.
What are the physical properties of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene is also an organic compound. Its unique physical properties are described as follows:
Under normal temperature and pressure, this substance is mostly a colorless to light yellow transparent liquid, which is clear and translucent. Its boiling point is about 145-147 ° C. At this temperature, the liquid will gradually transform into a gaseous state, from liquid to gaseous. The melting point is about -28 ° C. When the temperature drops to this temperature, the substance will solidify from liquid to solid. The density of
1-chloro-3- (trifluoromethoxy) benzene is about 1.38g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. Its vapor pressure also has a specific value within a certain temperature range, which is related to its volatility. The higher the vapor pressure, the stronger the volatility. In a closed space, the greater the tendency of its gas molecules to escape from the liquid surface.
Furthermore, the solubility of the compound is also an important property. It is insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. Due to the similar miscibility principle, the molecular structure and polarity of organic solvents and 1-chloro-3- (trifluoromethoxy) benzene are similar, so they can be miscible with each other.
Its smell is quite special, with a certain irritation, and the smell can make people feel the characteristics of its chemical substances. And because it contains fluorine, chlorine and other halogen elements, its chemical properties are also unique. In many chemical reactions, it shows different reactivity and selectivity from ordinary hydrocarbon compounds, and is widely used in organic synthesis and other fields.
What are the chemical properties of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are unique and it is widely used in the field of organic synthesis.
In this compound, both the chlorine atom and the trifluoromethoxy group are key functional groups. Chlorine atoms have certain activities and can participate in many substitution reactions. For example, in nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophiles. Due to the polarity of the carbon-chlorine bond, the chlorine atom is partially positively charged and vulnerable to attack by nucleophiles. For example, when reacting with nucleophiles such as sodium alcohol and sodium phenol, chlorine atoms can be replaced by alkoxy and phenoxy groups, thereby forming new carbon-oxygen bonds and generating corresponding ether compounds.
The presence of trifluoromethoxy gives this compound unique characteristics. Trifluoromethoxy has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring. This electronic effect affects the reactivity and selectivity on the benzene ring. In the aromatic electrophilic substitution reaction, due to the electron-absorbing effect and conjugation effect of trifluoromethoxy, the reaction check point tends to be far away from the position of this group on the benzene ring, that is, the meta-localization effect is weak, and the ortho and para-substitution are relatively difficult. In addition, the strong electronegative fluorine atom of trifluoromethoxy enhances the stability of the compound and affects its physical properties, such as boiling point and solubility.
In terms of redox reaction, 1-chloro-3- (trifluoromethoxy) benzene is relatively stable, and it is not easy to be oxidized or reduced under normal conditions. However, under specific strong oxidation or strong reduction conditions, the corresponding transformation can also occur. For example, under the action of strong reducing agents, chlorine atoms may be reduced and removed to form chlorine-free benzene derivatives.
In the process of organic synthesis, 1-chloro-3- (trifluoromethoxy) benzene is often used as an important intermediate. Through the reaction modification of chlorine atom and benzene ring, organic compounds with various structures can be prepared, which are widely used in medicine, pesticides, materials and many other fields.
What are the synthesis methods of 1-Chloro-3- (Trifluoromethoxy) Benzene?
There are several ways to synthesize 1-chloro-3- (trifluoromethoxy) benzene.
First, m-chlorophenol is used as the starting material. First, m-chlorophenol is mixed with a base, such as sodium hydroxide or potassium hydroxide, in a suitable solvent to form a phenate salt. Then, a trifluoromethyl halide, such as trifluoromethyl iodine or trifluoromethyl bromide, is added. This reaction needs to be carried out at an appropriate temperature and reaction time to cause the oxygen anion of the phenate to attack the carbon atom of the trifluoromethyl halide and form a carbon-oxygen bond, thereby preparing 1-chloro-3- (trifluoromethoxy) benzene. This reaction mechanism is a nucleophilic substitution reaction. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO) can be used as solvents to improve the nucleophilicity of phenols and increase the reaction rate.
Second, start from m-chloroaniline. First, m-chloroaniline is converted into diazonium salt through diazotization reaction. Generally, m-chloroaniline is treated with sodium nitrite and hydrochloric acid at low temperature. The resulting diazonium salt is then reacted with a trifluoromethoxy reagent, such as trifluoromethoxy copper salt. The diazo group is replaced by trifluoromethoxy to obtain the target product. This process requires precise control of the reaction temperature and the amount of reagents. The diazotization reaction usually needs to be carried out at 0-5 ° C to prevent the decomposition of diazonium salts and affect the yield of the product.
Third, m-chlorobenzoic acid is used as the starting material. First, the isochlorobenzoic acid is reduced and converted into isochlorobenzyl alcohol. Commonly used reducing agents include lithium aluminum hydride (LiAlH). M-chlorobenzyl chloride can be prepared by halogenation of isochlorobenzyl alcohol with sulfoxide chloride (SOCl ³) or phosphorus trichloride (PCl ³) as halogenating reagents. After that, m-chlorobenzyl chloride reacts with trifluoromethoxy negative ions to synthesize 1-chloro-3- (trifluoromethoxy) benzene. There are many steps in this synthesis route, and the reaction conditions of each step need to be carefully controlled. For example, the reduction reaction needs to be carried out under anhydrous and anaerobic conditions to prevent the failure of the reducing agent.
What to pay attention to when storing and transporting 1-Chloro-3- (Trifluoromethoxy) Benzene
1-Chloro-3- (trifluoromethoxy) benzene is an organic compound. During storage and transportation, many matters need to be taken care of.
First word storage. This substance should be placed in a cool, dry and well-ventilated place. Cover a cool environment to avoid chemical changes or dangerous reactions caused by excessive temperature. Dry conditions are also critical. If the environment is humid, water vapor or interaction with the compound can cause it to deteriorate. Well-ventilated, harmful gases that may escape can be dissipated in time to ensure the safety of the storage space. And it must be kept away from fire and heat sources. Open flames and high temperatures can cause the compound to burn or even explode, so fireworks should be strictly prohibited. Furthermore, it should be stored separately from oxidants, edible chemicals, etc. Different chemical substances come into contact with each other, or react violently, endangering safety.
Times and transportation. During transportation, it is necessary to ensure that the container is well sealed to prevent leakage. The selected means of transportation should be clean and dry, and there should be no residual substances that may react with it. During transportation, the driving should be stable and avoid violent actions such as sudden braking and sharp turning to avoid damage to the container due to vibration. Transportation personnel should also be familiar with the characteristics of the chemical and emergency treatment methods. In case of leakage and other emergencies, they can respond in a timely and appropriate manner. In addition, transportation vehicles should follow the designated route to avoid densely populated areas and important facilities, so as to reduce the hazards in the event of accidents. In conclusion, when storing and transporting 1-chloro-3- (trifluoromethoxy) benzene, careful attention should be paid to the environment, container, operation and personnel to ensure safety.