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What is the main use of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene has a wide range of uses. In the field of organic synthesis, it is often a key raw material. Due to its unique chemical structure, it contains chlorine atoms and trifluoromethoxy groups, giving it special reactivity and properties.
In pharmaceutical chemistry, this is used as a starting material. Through various chemical reactions, a variety of bioactive compounds can be prepared, or as potential pharmaceutical ingredients, to deal with various diseases. The particularity of its structure helps to form a suitable interaction between drugs and biological targets, so as to achieve the desired pharmacological effect.
In the field of materials science, it is also important. Materials with special properties can be prepared through the polymerization reaction or other chemical modification methods in which they participate. For example, fluorine-containing groups can improve the chemical resistance, thermal stability and surface properties of materials, and are used in high-end fields such as aerospace and electronics to meet special environmental and performance requirements.
Furthermore, in the field of pesticide chemistry, 1-chloro-3 - (trifluoromethoxy) benzene can also be an important intermediate for the synthesis of new pesticides. The synthesized pesticides, by virtue of their chemical properties, may have high insecticidal, bactericidal or herbicidal activities, and due to the introduction of fluorine atoms, may reduce the impact on the environment, meeting the needs of modern pesticide green and efficient development. Overall, it plays an indispensable role in many chemical-related fields, promoting technological progress and development in various fields.
What are the physical properties of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene is also an organic compound. Its unique physical properties are described as follows:
Under normal temperature and pressure, this substance is mostly a colorless to light yellow transparent liquid, which is clear and translucent. Its boiling point is about 145-147 ° C. At this temperature, the liquid will gradually transform into a gaseous state, from liquid to gaseous. The melting point is about -28 ° C. When the temperature drops to this temperature, the substance will solidify from liquid to solid. The density of
1-chloro-3- (trifluoromethoxy) benzene is about 1.38g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. Its vapor pressure also has a specific value within a certain temperature range, which is related to its volatility. The higher the vapor pressure, the stronger the volatility. In a closed space, the greater the tendency of its gas molecules to escape from the liquid surface.
Furthermore, the solubility of the compound is also an important property. It is insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. Due to the similar miscibility principle, the molecular structure and polarity of organic solvents and 1-chloro-3- (trifluoromethoxy) benzene are similar, so they can be miscible with each other.
Its smell is quite special, with a certain irritation, and the smell can make people feel the characteristics of its chemical substances. And because it contains fluorine, chlorine and other halogen elements, its chemical properties are also unique. In many chemical reactions, it shows different reactivity and selectivity from ordinary hydrocarbon compounds, and is widely used in organic synthesis and other fields.
What are the chemical properties of 1-Chloro-3- (Trifluoromethoxy) Benzene?
1-Chloro-3- (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are unique and it is widely used in the field of organic synthesis.
In this compound, both the chlorine atom and the trifluoromethoxy group are key functional groups. Chlorine atoms have certain activities and can participate in many substitution reactions. For example, in nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophiles. Due to the polarity of the carbon-chlorine bond, the chlorine atom is partially positively charged and vulnerable to attack by nucleophiles. For example, when reacting with nucleophiles such as sodium alcohol and sodium phenol, chlorine atoms can be replaced by alkoxy and phenoxy groups, thereby forming new carbon-oxygen bonds and generating corresponding ether compounds.
The presence of trifluoromethoxy gives this compound unique characteristics. Trifluoromethoxy has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring. This electronic effect affects the reactivity and selectivity on the benzene ring. In the aromatic electrophilic substitution reaction, due to the electron-absorbing effect and conjugation effect of trifluoromethoxy, the reaction check point tends to be far away from the position of this group on the benzene ring, that is, the meta-localization effect is weak, and the ortho and para-substitution are relatively difficult. In addition, the strong electronegative fluorine atom of trifluoromethoxy enhances the stability of the compound and affects its physical properties, such as boiling point and solubility.
In terms of redox reaction, 1-chloro-3- (trifluoromethoxy) benzene is relatively stable, and it is not easy to be oxidized or reduced under normal conditions. However, under specific strong oxidation or strong reduction conditions, the corresponding transformation can also occur. For example, under the action of strong reducing agents, chlorine atoms may be reduced and removed to form chlorine-free benzene derivatives.
In the process of organic synthesis, 1-chloro-3- (trifluoromethoxy) benzene is often used as an important intermediate. Through the reaction modification of chlorine atom and benzene ring, organic compounds with various structures can be prepared, which are widely used in medicine, pesticides, materials and many other fields.
What are the synthesis methods of 1-Chloro-3- (Trifluoromethoxy) Benzene?
There are several ways to synthesize 1-chloro-3- (trifluoromethoxy) benzene.
First, m-chlorophenol is used as the starting material. First, m-chlorophenol is mixed with a base, such as sodium hydroxide or potassium hydroxide, in a suitable solvent to form a phenate salt. Then, a trifluoromethyl halide, such as trifluoromethyl iodine or trifluoromethyl bromide, is added. This reaction needs to be carried out at an appropriate temperature and reaction time to cause the oxygen anion of the phenate to attack the carbon atom of the trifluoromethyl halide and form a carbon-oxygen bond, thereby preparing 1-chloro-3- (trifluoromethoxy) benzene. This reaction mechanism is a nucleophilic substitution reaction. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO) can be used as solvents to improve the nucleophilicity of phenols and increase the reaction rate.
Second, start from m-chloroaniline. First, m-chloroaniline is converted into diazonium salt through diazotization reaction. Generally, m-chloroaniline is treated with sodium nitrite and hydrochloric acid at low temperature. The resulting diazonium salt is then reacted with a trifluoromethoxy reagent, such as trifluoromethoxy copper salt. The diazo group is replaced by trifluoromethoxy to obtain the target product. This process requires precise control of the reaction temperature and the amount of reagents. The diazotization reaction usually needs to be carried out at 0-5 ° C to prevent the decomposition of diazonium salts and affect the yield of the product.
Third, m-chlorobenzoic acid is used as the starting material. First, the isochlorobenzoic acid is reduced and converted into isochlorobenzyl alcohol. Commonly used reducing agents include lithium aluminum hydride (LiAlH). M-chlorobenzyl chloride can be prepared by halogenation of isochlorobenzyl alcohol with sulfoxide chloride (SOCl ³) or phosphorus trichloride (PCl ³) as halogenating reagents. After that, m-chlorobenzyl chloride reacts with trifluoromethoxy negative ions to synthesize 1-chloro-3- (trifluoromethoxy) benzene. There are many steps in this synthesis route, and the reaction conditions of each step need to be carefully controlled. For example, the reduction reaction needs to be carried out under anhydrous and anaerobic conditions to prevent the failure of the reducing agent.
What to pay attention to when storing and transporting 1-Chloro-3- (Trifluoromethoxy) Benzene
1-Chloro-3- (trifluoromethoxy) benzene is an organic compound. During storage and transportation, many matters need to be taken care of.
First word storage. This substance should be placed in a cool, dry and well-ventilated place. Cover a cool environment to avoid chemical changes or dangerous reactions caused by excessive temperature. Dry conditions are also critical. If the environment is humid, water vapor or interaction with the compound can cause it to deteriorate. Well-ventilated, harmful gases that may escape can be dissipated in time to ensure the safety of the storage space. And it must be kept away from fire and heat sources. Open flames and high temperatures can cause the compound to burn or even explode, so fireworks should be strictly prohibited. Furthermore, it should be stored separately from oxidants, edible chemicals, etc. Different chemical substances come into contact with each other, or react violently, endangering safety.
Times and transportation. During transportation, it is necessary to ensure that the container is well sealed to prevent leakage. The selected means of transportation should be clean and dry, and there should be no residual substances that may react with it. During transportation, the driving should be stable and avoid violent actions such as sudden braking and sharp turning to avoid damage to the container due to vibration. Transportation personnel should also be familiar with the characteristics of the chemical and emergency treatment methods. In case of leakage and other emergencies, they can respond in a timely and appropriate manner. In addition, transportation vehicles should follow the designated route to avoid densely populated areas and important facilities, so as to reduce the hazards in the event of accidents. In conclusion, when storing and transporting 1-chloro-3- (trifluoromethoxy) benzene, careful attention should be paid to the environment, container, operation and personnel to ensure safety.