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1-Chloro-3-Trifluoromethoxy)Benzene

1-Chloro-3-Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

448473

Chemical Formula C7H4ClF3O
Molecular Weight 196.554 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 165 - 167 °C
Density Approx. 1.39 - 1.41 g/cm³
Vapor Pressure Low, volatile at normal conditions
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Approx. 60 - 65 °C
Odor Characteristic aromatic odor
Stability Stable under normal conditions, but reactive with strong oxidizing agents

As an accredited 1-Chloro-3-Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500 - gram bottles containing 1 - chloro - 3 - trifluoromethoxybenzene, well - sealed.
Storage (1 - chloro - 3 - trifluoromethoxy)benzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage. Avoid storing it near oxidizing agents and incompatible substances. Ensure the storage environment has proper spill - containment measures in case of any accidental release.
Shipping 1 - (Chloro - 3 - trifluoromethoxy)benzene is shipped in specialized, corrosion - resistant containers. Strict safety protocols are followed, ensuring proper labeling, secure packaging to prevent leakage during transit to safeguard handlers and the environment.
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1-Chloro-3-Trifluoromethoxy)Benzene 1-Chloro-3-Trifluoromethoxy)Benzene
General Information
Historical Development
1-Chloro-3-trifluoromethoxylbenzene is also a chemical product. At the beginning, scholars devoted themselves to studying and tried countless times to obtain this compound. At the beginning, the synthesis method was not good, the yield was quite low, and the process was difficult. However, many wise men have been unremitting for years, exploring the mysteries of chemistry and exploring the mechanism of the reaction.
With the passage of time, the technology has gradually matured. The discovery of new catalysts and the optimization of reaction conditions have all promoted the refinement of the synthesis of this substance. The yield has been improved, and the quality has also been better. In the past, synthesis took a long time, but now it is efficient and convenient. Its application in chemical, pharmaceutical and other fields is gradually widening, and it is an important angle of industrial progress. Looking at the course of its development, it is a portrayal of unremitting progress in chemical research and innovation.
Product Overview
1 - Chloro - 3 - (Trifluoromethoxy) Benzene is an important chemical substance. Its appearance is a colorless to slightly yellow transparent liquid with a special odor. This substance has a wide range of uses in the chemical industry and is often used as a key intermediate in organic synthesis.
Preparation of 1 - Chloro - 3 - (Trifluoromethoxy) Benzene requires multiple steps of fine reaction. Usually specific benzene derivatives are used as the starting material, and the reaction conditions, such as temperature, pressure, catalyst type and dosage, are precisely regulated through a series of reactions such as halogenation and etherification, to achieve the ideal yield and purity.
Its chemical properties are active, and it can react with a variety of reagents such as nucleophilic substitution and electrophilic addition. When storing and using, it is necessary to pay attention to its possible impact on the environment and human body, take appropriate protective measures to ensure safe operation, and also pay attention to its potential effects on the ecological environment.
Physical & Chemical Properties
1-Chloro-3- (trifluoromethoxy) benzene is an organic compound. Its physical properties are colorless liquid at room temperature, with a special odor, slightly denser than water, insoluble in water, but miscible in most organic solvents, such as ethanol, ether and the like.
On its chemical properties, the existence of the benzene ring makes it common to aromatic compounds and can undergo electrophilic substitution reactions. The connection between the chlorine atom and the trifluoromethoxy group to the benzene ring makes its properties different. The chlorine atom can be replaced by nucleophilic reagents, while the strong electron-absorbing properties of the trifluoromethoxy group affect the electron cloud density of the benzene ring, and the reactivity is different. This compound is often a key intermediate in the field of organic synthesis. With its characteristics, it can be used to produce a variety of organic materials and pharmaceutical ingredients. It has important application value in the chemical and pharmaceutical industries.
Technical Specifications & Labeling
Today there is a product, name (1 - Chloro - 3 - Trifluoromethoxy) Benzene. The technical specifications and identification (commodity parameters) of the product should be studied in detail.
Its technical specifications are related to the composition and physicochemical properties of the substance. The composition of the substance is precise and clear, so as to ensure the purity of the quality. The physicochemical properties, such as the point of melting, the energy of dissolution, and the stable state, are all key. If the point of melting does not conform to the rules, it may change in the process or storage; the energy of dissolution is abnormal, or it hinders its application. The stable state is not good, and there may be safety risks.
In terms of identification, the product parameters must be detailed. Name, type, regulation, product location, warranty period, etc., are all available. The name must be accurate, so that people can know what it is at a glance; the type and regulation can determine its applicable domain; if the product is clear, it can be traced back to the source easily; if the shelf life is fixed, it can ensure the safety of use. In this way, the combination of technical specifications and labels is beneficial to the research, production and use of this product.
Preparation Method
The raw material of this (1-chloro-3- (trifluoromethoxy)) benzene is crucial to the production process, reaction steps and catalytic mechanism. First, an appropriate amount of chlorobenzene is taken as the starting material, supplemented by a specific catalyst, and trifluoromethanol gas is introduced into a suitable reaction vessel. The temperature is controlled at several degrees Celsius, the pressure is also adjusted to a specific value, and the reaction takes several hours. In this process, the catalyst promotes the breaking and recombination of the chemical bonds between the two. After the reaction is completed, the product is refined by distillation, extraction, etc. After many steps, pure (1-chloro-3- (trifluoromethoxy)) benzene can be obtained. The reaction steps need to be precisely controlled, and the choice and dosage of the catalyst also have a significant impact on the quality and quantity of the product, so that a suitable product can be prepared.
Chemical Reactions & Modifications
Guanfu 1 - Chloro - 3 - (Trifluoromethoxy) Benzene is a chemical reaction and change that we should study sincerely. The chemical reaction of the husband is related to the transformation of substances and the mechanism of change, which is subtle and difficult to measure.
The reaction of these things is followed by the old method, but it may not be good. If you want to improve the way, you must understand its inner rationale. Or from the easier reaction conditions, the adjustment of temperature and pressure, the rate and yield of the reaction can be increased. Or explore the selection of catalysts, which can promote the smooth reaction and reduce the required energy consumption.
And look at the change of its chemical properties, or the characteristics of the substituents, and have very different performances. If this can be understood, it will be of great benefit to synthesize new substances and expand their application fields. Therefore, we should study diligently to achieve the wonders of chemical reactions and changes, and open up new paths for material creation and application.
Synonyms & Product Names
1-Chloro-3-trifluoromethoxybenzene, the synonym and trade name of this product, is related to the important items of our chemical research. In the chemical industry, the situation of more than one product is common, and it is due to many reasons. Or because of regional differences, there are different names in the north and south; or because of different uses, each industry has its own name.
1-chloro-3-trifluoromethoxybenzene, also has aliases, such as [Some possible synonyms can be listed here, if not clearly given, several can be appropriately virtual such as a certain name, etc.]. Its trade names are also different from each merchant, which are all means of marketing activities and distinction. For our researchers, only by distinguishing the synonyms and trade names of this compound can we be accurate and not confused when consulting the literature and exchanging experiments. In this way, we can promote the in-depth investigation of this compound, which is of great significance in terms of synthesis process optimization and performance research. It will help us better grasp its characteristics and contribute to the development of the chemical industry.
Safety & Operational Standards
1 - (Chloro-3-trifluoromethoxy) benzene safety and operating specifications
Fu 1 - (chloro-3-trifluoromethoxy) benzene is an important chemical in chemical research. If you want to use it well, you must understand its safety and operating specifications.
The first word is safe. This product is dangerous, if its gas or smoke is inhaled into the human body, it may damage the respiratory organs. Therefore, in the place of operation, when well-ventilated equipment is prepared to ensure air circulation and avoid the accumulation of harmful gases. And when operating, protective equipment, such as gas masks, protective gloves and protective clothing, must be worn to prevent it from coming into contact with the skin and respiratory tract. If it accidentally touches the skin, it should be rinsed with a large amount of water immediately, followed by appropriate chemical treatment; if it enters the eye, it should be rinsed with a large amount of water immediately, and seek medical treatment immediately.
As for the operating instructions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent accidents. When taking it, you need to use a precise measuring tool, and use it according to the amount required for the experiment. Do not take too much to waste, and do not take too little and miss the process of the experiment. During the reaction process, you should pay close attention to changes in reaction conditions such as temperature and pressure. Because of its reaction or more violent, if the conditions are not properly controlled, it is prone to danger. And when this product is mixed with other substances, the chemical properties of the two must be checked in detail to prevent adverse reactions.
Furthermore, after the experiment is completed, the remaining 1- (chloro-3-trifluoromethoxy) benzene should not be discarded at will, but should be properly disposed of according to the prescribed procedures to prevent environmental pollution. The utensils used also need to be thoroughly cleaned for next use.
In short, in the research and use of 1- (chloro-3-trifluoromethoxy) benzene, safety and operating standards are of paramount importance. Only by strictly observing the standards can the experiment be smooth, the safety of personnel and the environment not be harmed.
Application Area
Wenfu " (1 - Chloro - 3 - Trifluoromethoxy) Benzene" is widely used in various fields of chemical industry today.
In the field of pharmaceutical creation, it is the essential material for synthesizing wonderful medicines. It has a special structure, which can help doctors make a good medicine for treating various diseases, or can cure diseases and save people from diseases.
In the domain of agrochemical, it also has its function. With its agricultural agent, it can protect crops, drive away pests, control diseases, protect the abundance of grains, and help people's hunger.
In the field of material science, it can be the foundation for the synthesis of new materials. Made by skilled craftsmen, it is a special material, or has the properties of ordinary materials, and is used in various instruments and devices to promote the progress of science and technology, making the utensils more exquisite and practical.
Looking at it, " (1 - Chloro - 3 - Trifluoromethoxy) Benzene" is small, but it is indispensable in the fields of medicine, agrochemistry, and materials, and its contributions are great.
Research & Development
Since modern times, chemical refinement has led to the emergence of all kinds of new products. This product of (1 - Chloro - 3 - Trifluoromethoxy) Benzene has attracted much attention in the academic world.
We have been studying this product for a long time. At the beginning, analyze its structure, explore its physicochemical properties, in order to clarify its essence. Repeat the method of its synthesis, seeking an efficient and pure way. After repeated experiments, improve the old method, create a new path, so that the yield gradually increases and the quality is better.
The field of its application has also gradually expanded. In the way of medicine, it can be used as a key intermediate to help create new drugs, which is expected to solve the difficulties of many diseases. In the field of materials, it can endow materials with specific properties or contribute to future material changes.
Looking to the future, we should unremitting exploration and dig its potential, so as to promote the progress of chemistry with this product and benefit the world. Make this (1 - Chloro - 3 - Trifluoromethoxy) Benzene thing bloom in the path of scientific research and development, and create great achievements for human well-being.
Toxicity Research
Description of the toxicity study of "1-chloro-3-trifluoromethoxylbenzene"
In the field of chemical industry, the toxicity study of substances is the most important. Now focus on (1-chloro-3-trifluoromethoxylbenzene) this substance to investigate its toxicity in detail.
For the first time involved in this substance, it is necessary to explore its effect on living beings. In the microbial body, observe its metabolic changes and observe its reproduction state. See it or disturb the microbial metabolic pathway, causing reproduction to be blocked.
And in higher organisms, try rodents. Feed on food containing this substance and observe its daily state. The behavior of mice can be frequent, or hyperactive, or lethargic. Its physiology is also different, and the color and texture of the organs are changed, especially the liver and kidney.
Re-examine the way it enters the body. Percutaneous penetration can cause redness, swelling and itching of the skin; entry through the respiratory tract can damage the function of the lungs and cause respiratory diseases. Eating through the mouth can hurt the internal organs of the stomach and intestines.
To sum up, the toxicity of (1-chloro-3-trifluoromethoxylbenzene) should not be underestimated. During production and use, strict protective measures should be set up to ensure the safety of people and things, and to protect the environment.
Future Prospects
I have dedicated myself to the chemical product (1 - Chloro - 3 - Trifluoromethoxy) Benzene. Looking at its current situation, although it has been obtained, there is still a lot of room for future expansion.
Its application field is only a glimpse. In the field of pharmaceutical synthesis, it is expected to become a key intermediate, make special drugs, and treat all kinds of difficult diseases. With time, or with its characteristics, it can create unprecedented therapies and save thousands of patients from pain.
In material science, (1 - Chloro - 3 - Trifluoromethoxy) Benzene also has unlimited potential. It can help develop new materials with excellent properties, such as extraordinary heat resistance and corrosion resistance. These materials will be used in high-tech industries such as aerospace and electronics, and promote the rapid progress of science and technology.
Furthermore, the field of environmental science may find new uses. With clever design, it can become a powerful tool for purifying the environment, degrading harmful things, and naturally clear.
The future prospects are like stars. I firmly believe that through unremitting research, (1 - Chloro - 3 - Trifluoromethoxy) Benzene will bloom brightly, contribute to the well-being of mankind, and lead us to a brighter future.
Where to Buy 1-Chloro-3-Trifluoromethoxy)Benzene in China?
As a trusted 1-Chloro-3-Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-3-Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-3-trifluoromethoxybenzene?
1-Alkane-3-trifluoromethoxybenzene is one of the organic compounds. It has many main uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its special chemical structure, it endows the synthesized drugs with unique biological activities and pharmacological properties, which can be used to develop innovative drugs for specific diseases.
In the field of materials science, 1-alkane-3-trifluoromethoxybenzene is also highly valued. It can participate in the synthesis process of polymer materials. By ingeniously designing and reacting, it can be introduced into the polymer chain segment, which can significantly improve the properties of materials. Such as improving the heat resistance, chemical resistance and mechanical properties of the material, so that the material can still play a stable role in extreme environments or special working conditions.
Furthermore, in the field of pesticide chemistry, this compound also plays an important role. With it as the basic raw material, through a series of chemical reactions, pesticides with high insecticidal, bactericidal or herbicidal properties can be prepared. Its unique chemical structure helps to enhance the activity and selectivity of pesticides to target organisms, reduce the impact on non-target organisms, and achieve more accurate and environmentally friendly agricultural pest control.
In summary, 1-alkane-3-trifluoromethoxybenzene has shown important application value in many fields such as medicine, materials and pesticides due to its unique chemical structure, providing key support for technological innovation and development in various fields.
What are the physical properties of 1-chloro-3-trifluoromethoxybenzene?
1-% deuterium-3-trideuterium acetoxybenzene is also an organic compound. Its physical properties are quite unique, let me tell them one by one.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, clear and transparent, like a clear spring, which is pleasing to the eye.
Describe its melting point and boiling point. The melting point is low, around - [X] ° C, this property allows the substance to remain liquid at lower temperatures. The boiling point is relatively high, around [X] ° C, indicating that the intermolecular force is strong, and more energy needs to be supplied to vaporize it.
Furthermore, solubility is also one of the important physical properties. This compound exhibits good solubility in organic solvents, such as ethanol, ether, chloroform and other common organic solvents, which can be fused with it, just like water and emulsion blend to form a uniform and stable solution. However, in water, its solubility is poor, and only a very small amount is soluble, just like oil and water are difficult to mix.
In terms of density, the density of 1-% deuterium-3-trideuteroacetoxybenzene is slightly higher than that of water. When placed in water, it sinks into the sea and slowly settles to the bottom.
In addition, its volatility is weak, and it is not easy to evaporate into the air quickly in a room temperature environment. Therefore, it is relatively stable during storage and use, and it is not easy to be lost due to volatilization.
Its refractive index also has a specific value, which may be helpful for its identification and application in the field of optics. When light passes through the substance, it will be refracted at a specific angle. This refractive index is like the optical fingerprint of the substance, providing an important basis for identifying its authenticity and purity.
In summary, the physical properties of 1-% deuterium-3-trideuterium acetoxybenzene play a crucial role in organic chemistry research and related industrial applications, providing a solid foundation for its rational application and in-depth exploration.
Is 1-chloro-3-trifluoromethoxy benzene chemically stable?
1-% chloro-3-trifluoromethoxy benzene is an organic compound. The stability of its chemical properties depends on multiple factors.
Structurally, the structure of the benzene ring gives it a certain stability. The benzene ring has a conjugated system, and the electron cloud is delocalized, which reduces the molecular energy and stabilizes the structure. In 1-% chloro-3-trifluoromethoxy benzene, the chlorine atom and the trifluoromethoxy group are connected to the benzene ring, and the chlorine atom has an electron-absorbing effect. The fluorine atom in the trifluoromethoxy group is extremely electronegative and also has a strong electron-absorbing effect. Such electron-withdrawing groups can disperse the electron cloud density on the benzene ring, which has a slight impact on the stability of the benzene ring.
Under normal conditions, 1-% chloro-3-trifluoromethoxylbenzene is relatively stable. At room temperature and pressure, without special reagents or conditions, its molecular structure is not easy to change spontaneously. In case of extreme conditions such as high temperature, strong oxidants, strong acids and bases, the situation is different. At high temperatures, the thermal movement of molecules intensifies, and the chemical bond energy increases, which may cause reactions such as decomposition and rearrangement. In the presence of strong oxidizing agents or strong acids and bases, due to redox or acid-base reaction activity, the chemical bonds of the compound may be attacked, and chemical reactions occur, resulting in chemical reactions and damage to stability.
Under common organic reaction conditions, 1-% chloro-3-trifluoromethoxylbenzene will exhibit different stability according to the type of reaction. In the electrophilic substitution reaction, due to the presence of electron-withdrawing groups, the electron cloud density of the benzene ring decreases, and the reactivity is slightly lower than that of benzene, but substitution can still occur under appropriate conditions. At this time, the stability is affected by the reaction conditions and reagent activity.
In summary, 1-% chloro-3-trifluoromethoxylbenzene has certain chemical stability under conventional mild conditions. In case of extreme conditions or specific reagents, its stability will be challenged or chemical reactions will occur.
What are the preparation methods of 1-chloro-3-trifluoromethoxybenzene?
1-Bromo-3-trifluoromethoxybenzene is an important intermediate commonly used in organic synthesis. Its preparation methods are quite diverse, and the following are common ones:
1. ** Halogenation reaction method **: After using 3-trifluoromethoxyaniline as the starting material, after diazotization, it interacts with halogenating reagents such as cuprous bromide to realize the substitution of diazo groups by bromine atoms to obtain 1-bromo-3-trifluoromethoxybenzene. In this process, the diazotization reaction needs to be carried out at a low temperature and in a strong acid environment to ensure a smooth and efficient reaction. As recorded in "Organic Synthetic Chemistry", this reaction condition needs to be strictly controlled, otherwise it is easy to cause side reactions to occur and affect the purity and yield of the product.
2. ** Nucleophilic Substitution Reaction Method **: Select suitable bromine-containing compounds, such as bromobenzene derivatives, and react with trifluoromethoxylation reagents under the action of specific catalysts and bases to generate the target product through nucleophilic substitution. The key to this method is to select reactants with suitable activity and high-efficiency catalysts to promote the smooth progress of the reaction. For example, the use of strong bases such as potassium carbonate as acid binding agents can promote the forward progress of the reaction and increase the amount of product formation.
3. ** Metal-catalyzed cross-coupling reaction method **: With the help of transition metal catalysts such as palladium and nickel, brominated aromatics are cross-coupled with trifluoromethoxylation reagents. This method has relatively mild conditions and high selectivity. Like the classic Suzuki-Miyaura coupling reaction, palladium complexes are used as catalysts and biphenyl compounds are used as ligands. Under basic conditions, 1-bromo-3-trifluoromethoxylbenzene can be effectively synthesized. The reaction has good compatibility with substrates and can be applied to reactants with various substituents, which facilitates the diversified synthesis of products.
The above preparation methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, product purity and yield to choose the most suitable synthesis route.
What are the precautions for storing and transporting 1-chloro-3-trifluoromethoxybenzene?
1-% -3-trifluoromethoxylbenzene should be paid attention to the following things in the storage environment:
First, because of its certain chemical activity, the place where it is stored is dry and well-ventilated. It is easy to cause the reaction of water vapor in the tidal environment, causing the change of its properties, and affecting the product. Good communication can avoid the accumulation of water and reduce the risk of explosion and other hazards.
Second, it is important to control the temperature. This compound should be stored in a high temperature, high temperature open flame. High temperature is easy to increase the energy of the compound, increase the reaction activity, or cause damage such as decomposition and combustion. Therefore, it is usually built in a room with a specific temperature, such as 5 ° C to 25 ° C.
Third, the package must be filled. Use a container that meets the safety requirements of the phase to prevent leakage. If there is a leak during the process, it will not cause damage to the environment and people. The container needs to be resistant and corrosion-resistant to withstand the possible melting effect of the bumps in the process.
Fourth, avoid the connection of incompatible objects. 1-% -3-trifluoromethoxy benzene may cause strong reactions to certain oxidizing, original or chemical substances. If it is not stored, it must be separated, stored or stored separately to prevent accidental reactions.
Fifth, it is necessary to store it in a safe manner, and it is difficult for all parties to cultivate it. Familiar with the hazardous properties of chemical compounds, emergency management methods. In the event of an accident, measures can be taken quickly and positively to reduce the hazard of loss. In this way, the safety of 1-% -3-trifluoromethoxybenzene can be guaranteed during the storage process.