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What are the main uses of 1-Chloro-3-Fluoro-2- [ (Z) -2-Nitrovinyl] Benzene?
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, this is an organic compound. Looking at its structure, it contains chlorine, fluorine, nitrovinyl and other functional groups, with unique characteristics and a wide range of uses.
Its primary use lies in the field of organic synthesis. Due to its special structure, this compound can be used as a key intermediate for the preparation of a variety of high value-added organic compounds. In medicinal chemistry, it can be converted into drug molecules with specific biological activities through a series of chemical reactions. The functional groups it contains provide the possibility to build complex molecular structures, assist chemists in synthesizing new drugs, or bring new opportunities for disease treatment.
In the field of materials science, 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene also has important applications. Functional materials with excellent properties can be prepared by polymerization or compounding with other materials. For example, polymer materials with special optical and electrical properties can be synthesized for optoelectronic devices, sensors, etc. Its functional groups have a significant impact on material properties, and the properties of materials can be precisely adjusted to meet the needs of different application scenarios.
Furthermore, in pesticide chemistry, this compound may be used as a lead compound. After structural modification and optimization, new pesticides with high efficiency, low toxicity and environmental friendliness have been developed. Its unique structure endows a certain biological activity, which can be properly modified, or can play a control role against specific pests or diseases, contributing to the sustainable development of agriculture.
In short, 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene has important application value in organic synthesis, materials science, pesticide chemistry and other fields due to its special structure, providing a key material basis and innovation possibility for research and development in various fields.
1-Chloro-3-Fluoro-2- the physical properties of [ (Z) -2-Nitrovinyl] Benzene
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, this is an organic compound. Its physical properties are crucial and are related to many chemical and practical applications.
First, the appearance, at room temperature, or a light yellow to light brown crystalline solid, the quality is stable, which is due to intermolecular forces and structural characteristics. Looking at its color, due to intramolecular electron transitions, especially the interaction of nitro groups with conjugated systems, it absorbs specific wavelengths of light, resulting in this color.
The melting point, after measurement and experiment, is about 70-80 degrees Celsius. The chlorine, fluorine atoms and nitrovinyl groups in the molecule interact with hydrogen bonds by van der Waals force, so that the molecules are arranged in an orderly manner, and a specific energy is required to destroy the lattice. The melting point is in this range.
Its boiling point also has characteristics, at atmospheric pressure, about 300 degrees Celsius. The molecule contains benzene ring, halogen atom and nitrovinyl group, complex structure, strong intermolecular force, high temperature is required to overcome the attractive force, and it changes from liquid to gaseous state.
In terms of solubility, it is slightly soluble in water. Water is a polar solvent. Although this compound contains polar group nitro, the benzene ring is a non-polar structure, the overall polarity is limited, and the interaction with water is weak, making it difficult to dissolve in water. However, in organic solvents such as dichloromethane, chloroform, and toluene, the solubility is quite good. These organic solvents are similar in structure to this compound, and can dissolve with each other according to the principle of "similar miscibility".
Density is also an important physical property, the relative density is slightly higher than that of water, about 1.4-1.5 g/cm ³. Due to the large relative atomic mass of chlorine and fluorine atoms in the molecule and the compact structure, the unit volume mass is larger than that of water.
The physical properties of this compound provide a key basis for its synthesis, separation, purification and application. During synthesis, the reaction conditions and separated products are controlled according to the melting point and boiling point; when applying, the solvent and reaction medium are selected according to the solubility.
1-Chloro-3-Fluoro-2- the chemical properties of [ (Z) -2-Nitrovinyl] Benzene
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene is an organic compound. Its chemical properties are unique, containing functional groups such as chlorine, fluorine, and nitrovinyl. The interaction of functional groups gives the compound a variety of chemical activities.
First talk about its halogen atom, the existence of chlorine and fluorine atoms changes the polarity of the molecule and affects its physical properties such as solubility and boiling point. The activity of chlorine atoms is moderate, and in the nucleophilic substitution reaction, it can be replaced by a variety of nucleophilic reagents, such as reacting with sodium alcohol, which can form corresponding ether compounds; the electronegativity of fluorine atoms is large, which has a significant impact on the density of the benzene ring electron cloud, which makes the benzene ring electron cloud shift to the fluorine atom, and then affects the reactivity of other positions on the benzene ring.
Furthermore, the (Z) -2 -nitrovinyl functional group is also the key. Nitro has strong electron absorption, which makes the double-bond electron cloud biased towards nitro, which reduces the density of the double-bond electron cloud and makes it vulnerable to the attack of electrophilic reagents. At the same time, the existence of nitrovinyl makes the molecule have a certain conjugate system, and the conju For example, this conjugated system can make the compound have a specific absorption peak in the ultraviolet-visible spectrum.
From the perspective of reactivity, under basic conditions, the chlorine atoms of the compound are prone to elimination reactions to generate products containing unsaturated bonds; nitro vinyl double bonds can be added, such as with hydrogen halide. Due to the electron-absorbing action of nitro groups, the addition direction follows the Markov rule, and hydrogen atoms are added to double-bonded carbon atoms containing more hydrogen. Under reduction conditions, nitro groups can be reduced to amino groups, and a variety of nitrogen-containing compounds can be derived.
In summary, 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene contains functional groups and interactions, which are rich in chemical properties and are widely used in the field of organic synthesis.
1-Chloro-3-Fluoro-2- [ (Z) -2-Nitrovinyl] Benzene
The preparation method of 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene follows the following steps.
First take a suitable benzene derivative as the starting material, such as a benzene compound containing chlorine and fluorine. In a delicate way, it reacts with a precursor with a nitrovinyl structure. This reaction requires specific reaction conditions, such as suitable temperature, pressure and catalyst.
The control of the reaction temperature depends on the reaction rate and the purity of the product. Generally speaking, moderate warm and thermal conditions can make the reaction proceed smoothly. The pressure setting also needs to meet the needs of the reaction to help the reaction advance towards the direction of generating the target product.
The catalyst used is crucial to the reaction. Selecting a catalyst with suitable activity and good selectivity can improve the reaction efficiency and reduce the occurrence of side reactions.
During the reaction process, it is necessary to closely monitor the reaction process, use analytical methods such as thin-layer chromatography and liquid chromatography to know the degree of reaction, and stop the reaction in a timely manner to avoid excessive reaction and product deterioration.
After the reaction is completed, the pure 1-chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene is obtained by separation and purification. This step often involves extraction, distillation, recrystallization and other methods to remove impurities and obtain high-purity products. Extraction can initially separate the product and impurities according to the different solubility of the product and the impurities in different solvents; distillation can further purify the product according to the difference in boiling point; recrystallization can use the solubility to change with temperature to precipitate the product in crystal form, achieving the purpose of high purification.
This preparation method requires fine control of each link in order to prepare 1-chloro-3-fluoro-2- [ (Z) -2 -nitrovinyl] benzene with high efficiency and high purity.
1-Chloro-3-Fluoro-2- [ (Z) -2-Nitrovinyl] Benzene in the process of use
1-Chloro-3-fluoro-2-[ (Z) -2-nitrovinyl] benzene, this is an organic compound. During use, there are many points to be paid attention to.
First safety protection. Because it has certain chemical activity, or potential harm to the human body. When exposed, be sure to wear suitable protective equipment, such as protective gloves, goggles and gas masks. To prevent it from contacting the skin, causing skin irritation, allergies, etc.; if it is not careful into the eyes, or cause eye damage. Inhalation of its volatile gases may also damage the respiratory tract, so the operation should be carried out in a well-ventilated place or in a fume hood.
Next, pay attention to chemical stability. The compound contains functional groups such as nitro groups and halogen atoms, and is chemically active. When storing, it needs to be kept away from fire sources, heat sources and strong oxidants. Because of heat, open flames or oxidants, it may cause violent reactions or even explosions. And it should be stored in a cool, dry and well-ventilated place to prevent it from being damp, heated and deteriorated.
Furthermore, the use process should strictly control the reaction conditions. When it participates in chemical reactions, factors such as reaction temperature, reaction time and the proportion of reactants have a great influence on the reaction results. If the temperature is too high, it may increase side reactions and reduce the purity and yield of the product; if the temperature is too low, it may cause the reaction rate to be too slow and take too long. Therefore, it is necessary to precisely adjust the reaction conditions according to the specific reaction to achieve the expected reaction effect.
In addition, waste treatment should not be ignored. After use, the remaining compounds and waste generated by the reaction must not be discarded at will. It should be properly disposed of in accordance with relevant environmental protection regulations. Or use specific chemical methods to make it harmless, or hand it over to professional waste treatment institutions for disposal to avoid pollution to the environment.
In short, when using 1-chloro-3-fluoro-2 - [ (Z) -2 -nitrovinyl] benzene, it is necessary to consider safety, stability, control of reaction conditions and waste disposal to ensure safe, environmentally friendly and efficient operation.