1-Chloro-3-fluoro-2-methoxybenzene, an organic compound, is widely used in the chemical and pharmaceutical fields.
In the chemical field, it is often an intermediate in organic synthesis. Due to the unique chemical properties of chlorine, fluorine, and methoxy groups in molecules, multiple organic compounds can be derived through many chemical reactions. For example, chlorine atoms are highly active and easily replaced by other nucleophiles in nucleophilic substitution reactions, such as reacting with sodium alcohol to form ether compounds; the introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, improve their stability, fat solubility, etc., and help to prepare materials with specific properties. Taking the preparation of fluoropolymers as an example, 1-chloro-3-fluoro-2-methoxylbenzene can be connected to the polymer backbone through a series of reactions, endowing the material with unique weather resistance and chemical corrosion resistance.
In the field of medicine, as an important intermediate, it can participate in a variety of drug synthesis. Due to its structural characteristics, it can add specific activity and selectivity to drug molecules. For example, when developing small molecule drugs targeting specific targets, this compound can be used as a starting material to construct a target-compatible pharmacophore through multi-step reactions. Studies have shown that the structural unit containing fluorine and methoxy groups helps to enhance the interaction between drugs and receptors and improve the bioavailability of drugs. In the synthesis of many anticancer and antimicrobial drugs, 1-chloro-3-fluoro-2-methoxybenzene is found, providing a key structural foundation for pharmaceutical research and development, and helping to create new drugs with better efficacy and fewer side effects.

1-Chloro-3-fluoro-2-methoxybenzene is a kind of organic compound. It has unique physical properties, which are described in detail by you today.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This form is convenient for it to be evenly dispersed in many chemical reaction systems and fully contacted with other reactants, thereby promoting the progress of the reaction.
Smell, it has a special smell. Although this smell is difficult to describe accurately, it is quite distinct and can be used as a basis for preliminary identification.
When it comes to the melting point, the melting point is relatively low. This property makes it not a solid state at room temperature, but a liquid state. The boiling point is in a specific range due to intermolecular forces. This boiling point value is of great significance for the setting of its separation, purification and storage conditions. To purify by distillation, it is necessary to precisely control the temperature to make it just reach the boiling point, so as to achieve effective separation from impurities.
Its density is slightly different from that of water. This difference makes it float on water or sink underwater when mixed with water, depending on the specific density value. This property is crucial in operations involving liquid-liquid separation.
In terms of solubility, 1-chloro-3-fluoro-2-methoxybenzene is soluble in many organic solvents, such as ethanol, ether, etc. This solubility makes it widely used in the field of organic synthesis because it can react smoothly with many organic reagents in a solution environment. However, its solubility in water is very small, due to the difference in molecular polarity and water molecular polarity.
In addition, the vapor pressure of 1-chloro-3-fluoro-2-methoxybenzene is also an important physical property. The size of the vapor pressure is related to its rate of volatilization in the air, which is instructive for the sealing requirements of the storage environment and the ventilation conditions during operation. If the vapor pressure is too high, a tighter seal is required during storage, and good ventilation is also required during operation to prevent it from evaporating into the air, causing loss or safety hazards.
In summary, the physical properties of 1-chloro-3-fluoro-2-methoxybenzene are diverse, and each property is interrelated, which together determine its application mode and operation requirements in the fields of chemical industry and scientific research.

The chemical properties of 1-chloro-3-fluoro-2-methoxybenzene are quite stable under normal conditions. In this compound, chlorine, fluorine and methoxy are each connected to the benzene ring. The benzene ring is relatively stable, and its π electron cloud forms a conjugated system, which stabilizes the benzene ring structure.
Although the chlorine atom has a certain electron-withdrawing property, the electronic effect caused by it on the benzene ring is not enough to easily break the stable structure of the benzene ring. The fluorine atom is also an electron-withdrawing group, but its radius is very small, and its influence on the benzene ring electron cloud is also limited. The methoxy group is the power supply group, and its conjugation with the benzene ring can partially cancel the electron-withdrawing effect of chlorine and fluorine, and further maintain the stability of the molecule.
Under normal temperature and pressure, if there are no specific chemical reaction conditions, such as suitable catalysts, specific reaction temperatures and pressures, and suitable reactants, etc., 1-chloro-3-fluoro-2-methoxybenzene is not prone to spontaneous chemical reactions. For example, if there are no strong acids, strong bases, or specific nucleophiles, electrophiles, etc., the substituents on its benzene ring will not be easily replaced.
However, although it is stable under normal conditions, it is not absolutely unreactive. In case of strong oxidants, the substituents on the benzene ring may be oxidized; if there are suitable nucleophilic reagents and the reaction conditions are appropriate, chlorine atoms or fluorine atoms may also be nucleophilic substitutions. However, in general, the chemical properties of 1-chloro-3-fluoro-2-methoxybenzene are relatively stable under common environments and general experimental conditions.

The preparation method of 1-chloro-3-fluoro-2-methoxybenzene can be as follows.
First take an appropriate starting material, such as 2-hydroxy-3-fluoroanisole as the starting material. In an appropriate reaction vessel, add this starting material and react with it with an appropriate amount of halogenating reagent. Commonly used halogenating reagents, such as thionyl chloride. Under suitable reaction conditions, such as heating and in the presence of a catalyst, thionyl chloride undergoes a substitution reaction with 2-hydroxy-3-fluoroanisole. When reacting, pay close attention to the reaction temperature and reaction time. The temperature is generally controlled within a certain range. If the temperature is too low, the reaction rate will be slow and it will be difficult to achieve the expected degree of reaction. If the temperature is too high, it may trigger side reactions and affect the purity of the product. The time also needs to be precisely controlled. The reaction time is too short, the starting material is not fully reacted, and the yield is low. If the reaction time is too long, or the product is further reacted, it is also not conducive to the acquisition of the product. In this reaction, the chlorine atom of the thionyl chloride replaces the hydroxyl group of 2-hydroxy-3-fluoroanisole, thereby generating 1-chloro-3-fluoro-2-methoxybenzene.
Another approach can be started from 2-methoxy-3-fluoroaniline. First, it undergoes a diazotization reaction. Sodium nitrite reacts with an appropriate amount of inorganic acid, such as hydrochloric acid, under low temperature conditions to form a diazonium salt. Then, under appropriate reducing agents and specific conditions, the diazonium group is replaced by chlorine atoms, and 1-chloro-3-fluoro-2-methoxybenzene can also be obtained. In this process, low temperature conditions are extremely critical to prevent the decomposition of diazonium salts and ensure that the reaction proceeds according to the expected path. The choice and dosage of the reducing agent also have an important impact on the reaction result. The appropriate reducing agent and dosage can effectively promote the conversion of diazo groups into chlorine atoms, and ensure high yield and purity.
In the preparation process, after the reaction is completed, it often needs to go through separation and purification steps. Methods such as distillation, extraction, column chromatography, etc. can be used to obtain high-purity 1-chloro-3-fluoro-2-methoxybenzene products. During distillation, according to the boiling point characteristics of the product, the temperature is controlled to separate the product from the impurities; extraction uses the difference in solubility between the product and the impurities in different solvents to achieve preliminary separation; column chromatography can further purify the product according to the difference in adsorption and distribution between the product and the impurities on the stationary phase and the mobile phase.

The price of 1-chloro-3-fluoro-2-methoxybenzene in the market is difficult to determine. The change in its price is related to many reasons.
First, the production method is simple and simple, and the price of the raw materials used often fluctuates. If the production requires rare and expensive materials, or the process is difficult and labor-intensive, the price will be high. On the contrary, if the raw materials are easy to obtain, the process is convenient, and the price may be slightly cheaper.
Second, the supply and demand of the market is also the key. If there are too many people using this, the demand will exceed the supply, and the price will rise; if there is too much industry and too little demand, the supply will exceed the demand, and the price will fall.
Furthermore, the reputation of the industry and the quality of the goods also have an impact. Reputation and high quality, the price may be higher than others.
Looking at past market conditions, the price of similar compounds may hover between a few yuan and a few tens of yuan per gram. However, the price of 1-chloro-3-fluoro-2-methoxybenzene may exceed this range due to its own characteristics. To know its exact price, when consulting the supplier of chemical materials, he can give the latest price according to the current market conditions. Or check the platform of chemical trading in detail to get a more accurate price.