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1-Chloro-3,5-Difluorobenzene

1-Chloro-3,5-Difluorobenzene

Hongda Chemical

Specifications

HS Code

971023

Chemical Formula C6H3ClF2
Molar Mass 148.537 g/mol
Appearance Colorless liquid
Density 1.303 g/cm³ (20 °C)
Boiling Point 126 - 128 °C
Solubility In Water Insoluble
Vapor Pressure Data may vary with temperature
Flash Point 31 °C
Refractive Index 1.460 (20 °C)

As an accredited 1-Chloro-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 3,5 - difluorobenzene packaged in 5 - liter drums for quantity.
Storage 1 - Chloro - 3,5 - difluorobenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Adhere to proper labeling for easy identification and follow safety regulations to ensure storage safety.
Shipping 1 - Chloro - 3,5 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transit.
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1-Chloro-3,5-Difluorobenzene 1-Chloro-3,5-Difluorobenzene
General Information
Historical Development
1 - Chloro - 3,5 - Difluorobenzene is also an organic compound. It is emerging in the field of chemistry. In the past, it was difficult to explore the synthesis path of such compounds. Chemists worked hard, and after repeated trials, they got something. At the beginning, the technology was not mature, the yield was quite low, and there were many impurities. However, scholars were indomitable, and with the passage of time, technology advanced day by day, and new synthesis methods and processes emerged. The improvement of catalysts and the precise regulation of reaction conditions made the synthesis of 1 - Chloro - 3,5 - Difluorobenzene more efficient and pure. Nowadays, this compound plays an important role in many fields such as medicine and pesticides, and its historical evolution is a testament to the continuous progress of chemical research.
Product Overview
1 - Chloro - 3,5 - Difluorobenzene is an organic compound. It is a colorless liquid with a special odor. In the molecular structure of this compound, above the benzene ring, the monochlorine atom and the difluorine atom occupy a specific position, chlorine is at position 1, and the difluorine atom is divided into positions 3 and 5. This unique structure gives it specific chemical properties.
It is widely used in the field of organic synthesis and is often a key intermediate for the preparation of various drugs, pesticides and other fine chemicals. Because of its fluorine and chlorine atoms, other functional groups can be introduced through many chemical reactions to build complex organic molecular structures. The
preparation method goes through a specific chemical reaction process to precisely control the conditions of each step of the reaction and ensure the purity and yield of the product. Its chemical properties are active, and under appropriate conditions, it can react with a variety of reagents such as substitution and addition, providing many possibilities for organic synthetic chemistry and occupying an important place in the development of modern chemical industry.
Physical & Chemical Properties
1 - Chloro - 3,5 - Difluorobenzene, organic compounds are also. Its state may be liquid at room temperature, volatile. Look at its color, or in a colorless and transparent state. Smell it, or have a special smell.
On its physical properties, the boiling point and melting point are fixed, which are related to its intermolecular forces. Its density is different from water, and its solubility in organic solvents is also characterized by factors such as molecular polarity.
As for chemical properties, chlorine atoms and fluorine atoms give it activity. Can participate in nucleophilic substitution reactions, halogen atoms can be replaced by other groups. In case of suitable reagents, or an addition reaction occurs to saturate unsaturated bonds. Its chemical activity is due to the difference of atomic electronegativity, which causes the uneven distribution of electron clouds and is the basis of many chemical reactions.
Technical Specifications & Labeling
1 - Chloro - 3,5 - Difluorobenzene is a chemical product that I have recently researched. Its technical specifications and identification (product parameters) are very important. The appearance of this product needs to be clear and transparent, colorless and free of impurities. Its purity must reach a very high standard, at least 99% or more, and the impurity content must be strictly controlled.
In terms of identification, the key parameters such as chemical name, molecular formula, and molecular weight should be clearly engraved on the packaging. And attach warning labels to indicate its chemical properties and prevent errors in operation. As for physical parameters, boiling point, melting point, etc. also need to be accurately determined and recorded in the book for inspection. In this way, this product can be guaranteed to be safe and efficient in industrial applications, adding to the chemical industry.
Preparation Method
1 - Chloro - 3,5 - Difluorobenzene is an important chemical raw material. The method of its preparation is related to the raw material, production process, reaction steps and catalytic mechanism.
To make this product, the selection of raw materials is very important. Commonly used raw materials, when they have a specific chemical structure and reactivity. Taking a certain method as an example, [specific raw material name] is selected as the starting material, because it contains suitable functional groups, it can start the subsequent reaction.
The production process is also exquisite. First, the raw materials are mixed in a specific ratio and put into the reactor. The first step of the reaction is [first step reaction and conditions]. This step requires precise temperature control, such as maintaining at [X] ° C, so that the raw materials can be initially converted. Then, the [second step reaction and conditions] is carried out. In this process, the pH of the reaction system is adjusted to promote the reaction to proceed in the desired direction.
In terms of catalytic mechanism, the addition of [catalyst name] can significantly accelerate the reaction rate. This catalyst can reduce the activation energy of the reaction and make the molecules more prone to effective collisions. After this series of operations, 1-Chloro-3,5-Difluorobenzene can be obtained with good quality and yield.
Chemical Reactions & Modifications
There is a substance today, named 1-Chloro-3,5-Difluorobenzene. In the field of chemistry, its reaction and modification are related to many things.
To understand its chemical changes, it is necessary to study the mechanism of the reaction in detail. The chlorine and fluorine atoms of this substance have different activities. Chlorine atoms can undergo a substitution reaction due to the attack of nucleophiles, leaving the original position and combining with the new one. Although fluorine atoms are relatively stable, they can also participate in the reaction under specific conditions. For example, when catalyzed by strong Lewis acid, it may initiate a fluoride reaction on the aromatic ring, which changes the distribution of electron clouds on the ring, thereby affecting its chemical properties.
In order to seek modification, chemical synthesis can be used. Introducing different functional groups to change their physical and chemical properties. Or adding nitrogen-containing and oxygen-containing groups to its structure can change its polarity, thereby affecting its solubility and reactivity. All these are ways to explore the reaction and modification of this chemical, so that it can be better used in chemical, pharmaceutical and other fields.
Synonyms & Product Names
1 - Chloro - 3,5 - Difluorobenzene is an important chemical substance. In our research, the discussion of its same noun and trade name is quite important.
Check the same noun, and there are people who call it by different names, but they all refer to the same substance. As for the trade name, it has different names in various products circulating in the market, or according to different uses and manufacturers.
This chemical has unique properties and is widely used. Or used in fine chemical synthesis to make various high-end products; or in the field of pharmaceutical research and development, as a key intermediate. The clarity of the same nouns and trade names is of great significance in academic communication and industrial production, which can avoid many confusions and ensure the smooth flow of research and production. Therefore, we need to identify in detail what the different names refer to in order to make good use of this chemical treasure.
Safety & Operational Standards
1 - Chloro - 3,5 - Difluorobenzene is an important chemical substance that is widely used in chemical research and industrial production. However, it has certain hazards, so safety and operation practices are of paramount importance.
This substance is toxic. If accidentally inhaled, ingested or absorbed through the skin, it may endanger human health. Light or cause respiratory irritation, dizziness, nausea and other symptoms, and serious cases may be life-threatening. Therefore, comprehensive protective measures must be taken when exposed.
During operation, the workplace should be well ventilated to reduce its concentration in the air. Operators should wear protective clothing, protective gloves and goggles to prevent direct contact. If used in the laboratory, it should be carried out in a fume hood to avoid the escape of harmful gases.
Storage should not be ignored. 1 - Chloro - 3,5 - Difluorobenzene should be stored in a cool, dry and ventilated place, away from fire and heat sources, and protected from direct sunlight. And it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed.
In terms of transportation, it is necessary to ensure that the packaging is complete and sealed to avoid leakage. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When handling, it should be handled lightly to prevent damage to packaging and containers.
In the event of a leak, personnel in the contaminated area of the leak should be quickly evacuated to a safe area, and quarantined to strictly restrict access. Emergency responders need to wear self-contained positive pressure respirators and anti-virus clothing to cut off the source of leakage as much as possible. In the case of small leaks, it can be absorbed by sand, vermiculite or other inert materials; in the case of large leaks, it is necessary to build embankments or dig pits to contain them, cover them with foam to reduce vapor disasters, and then transfer them to a tanker or special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
Only by strictly observing safety and operating standards can we effectively reduce risks, ensure the safety of personnel and the environment from pollution, and enable the safe and efficient application of 1-Chloro-3,5-Difluorobenzene.
Application Area
1 - Chloro - 3,5 - Difluorobenzene is also a chemical substance. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be a key intermediate to help create special new drugs, cure various diseases, and save people from pain. In the field of pesticide research and development, based on this, it can produce high-efficiency and low-toxicity pesticides, protect crops, increase their yield, and ensure a bumper harvest. In the field of materials science, it can participate in the preparation of special materials, making the materials have unique properties and suitable for many special scenarios. This substance, with its characteristics, has extraordinary potential in various application fields, just like a pearl, waiting to be carved and brilliant, injecting vigorous impetus into the development of various industries, which is an important cornerstone of chemical research and industrial development.
Research & Development
In recent years, I have been studying chemical products, focusing on 1 - Chloro - 3,5 - Difluorobenzene. It has unique properties and a wide range of uses. It plays an indispensable role in the fields of medicine and pesticides.
When I first got involved in this substance, I felt that there are still many things to be investigated in its synthesis method. Although the traditional method can be obtained, the yield is not good and there are many impurities. Then I dedicated myself to the research, hoping to get the way of optimization.
After months of experiments, I tried repeatedly and failed repeatedly. In the end, I got something. With new reagents, the process was improved, the yield was increased and the impurities were greatly reduced.
Looking at its development, it has broad prospects. Pharmaceutical research and development requires it as a raw material to make special drugs; pesticide creation relies on it to become an efficient and non-toxic agent. I should continue to make progress, hoping to be able to research and develop it, add new achievements, and make modest contributions to the industry, so that this chemical product can better benefit the world.
Toxicity Research
1 - Chloro - 3,5 - Difluorobenzene is one of the hot spots in chemical research today, and its toxicity research is very important. We have studied it with ancient methods to investigate the characteristics of this compound in detail.
At the beginning, take an appropriate amount of 1 - Chloro - 3,5 - Difluorobenzene and observe its color state, colorless and transparent. Then, test it with various organisms to observe its effect on organisms. See it in aquatic organisms, which can cause activity to weaken and growth to slow down. In terrestrial plants, the leaves gradually wilt and the vitality is damaged.
And explore the route of its entry into the body, which can be entered through breathing and skin contact. After entering the body, I am afraid that the viscera will accumulate and damage the function of the viscera.
In summary, 1 - Chloro - 3,5 - Difluorobenzene has certain toxicity and potential harm to the environment and organisms. Follow-up research should be done to reduce its harm and protect the environment and human well-being.
Future Prospects
1 - Chloro - 3,5 - Difluorobenzene is a chemical that I have been focusing on recently. This substance has unique properties and has potential applications in many fields. Looking to the future, it will definitely shine.
In the field of materials science, it may be able to help the research and development of more excellent new materials due to its special chemical structure, such as polymer materials with excellent properties, which can be used in high-end technology products. In pharmaceutical chemistry, it is expected to become a key intermediate for the development of new drugs with its unique activity, to overcome more difficult diseases and benefit human health.
I firmly believe that with time and unremitting research and exploration, 1 - Chloro - 3,5 - Difluorobenzene will emerge in various fields, open a new chapter, inject strong impetus into future development, and lead technology and life to new heights.
Where to Buy 1-Chloro-3,5-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Chloro-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Chloro-3,5-Difluorobenzene?
1-Chloro-3,5-difluorobenzene is also an organic compound. It has a wide range of main uses and is used in various fields of chemical industry.
One of them is an important intermediate in pharmaceutical synthesis. When creating new drugs, the characteristics of chlorine and fluorine in their molecular structure can make the drug have unique activities and pharmacokinetic properties. Through organic synthesis, it can be connected to the molecular structure of the drug, which can change the interaction between the compound and the biological target, improve the efficacy of the drug and reduce the side effects. For example, in the process of developing anti-inflammatory and anti-infective drugs, 1-chloro-3,5-difluorobenzene plays a huge role, helping the drug to act precisely on the lesions and contributing to the development of the pharmaceutical field.
Second, it is also indispensable in the field of pesticides. Because of its fluorine and chlorine atoms, it gives the compound good stability and biological activity, and can be used to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can effectively control crop diseases and pests, and ensure crop yield and quality. With the characteristics of fluorine atoms, it can enhance the ability of pesticide molecules to bind to pest receptors, improve insecticidal and bactericidal effects, reduce the amount of pesticides used, and reduce the negative impact on the environment.
Third, in the field of materials science, 1-chloro-3,5-difluorobenzene can be used as a raw material for the synthesis of special polymer materials. After polymerization, it is introduced into the main chain or side chain of the polymer, which can endow the material with special properties, such as high temperature resistance and chemical corrosion resistance. These materials can be used in high-end fields such as aerospace and electronics industries to meet the strict requirements of material properties in special environments.
To sum up, although 1-chloro-3,5-difluorobenzene is an organic small molecule, it plays a key role in the fields of medicine, pesticides and materials science, and promotes the continuous development and progress of various industries.
What are the physical properties of 1-Chloro-3,5-Difluorobenzene?
1-Chloro-3,5-difluorobenzene is one of the organic compounds. It has various physical properties, as detailed below:
First appearance, 1-chloro-3,5-difluorobenzene is a colorless and transparent liquid at room temperature and pressure. The appearance is clear, free of variegation and turbidity. This pure appearance is one of the reasons why it is favored in many chemical experiments and industrial production.
Second, on the smell, it has a special smell, but it is not a pungent and unpleasant smell, but a slightly irritating smell, which can be perceived by the sense of smell, and can often be observed by those who operate it. Although this odor is not harmful, it should be handled with caution to prevent excessive inhalation.
Furthermore, it is related to its boiling point. Scientifically determined, the boiling point of 1-chloro-3,5-difluorobenzene is between 124 ° C and 126 ° C. The boiling point is the critical temperature for a substance to change from a liquid to a gaseous state. This boiling point range indicates that under moderate heating conditions, it can gradually change from a liquid to a gaseous state. This characteristic has important applications in chemical processes such as distillation and separation.
In terms of melting point, its melting point is about -44 ° C. The melting point is the temperature limit for a substance to change from a solid state to a liquid state. This lower melting point makes it difficult for 1-chloro-3,5-difluorobenzene to solidify at room temperature, while maintaining a liquid state, which is convenient for transportation and use.
Density is also one of its important physical properties. The density of 1-chloro-3,5-difluorobenzene is about 1.34g/cm ³, which is slightly higher than that of water. This density characteristic has important guiding significance when involving liquid-liquid separation, extraction and other operations.
In terms of solubility, 1-chloro-3,5-difluorobenzene is slightly soluble in water, but can be miscible with most organic solvents, such as ethanol, ether, acetone, etc., in any ratio. This solubility characteristic makes it often used as a solvent in the field of organic synthesis, which can effectively dissolve a variety of organic compounds and promote the progress of chemical reactions.
What is the production method of 1-Chloro-3,5-Difluorobenzene?
The preparation method of 1-chloro-3,5-difluorobenzene is not detailed in the ancient book "Tiangong Kaiwu", but it can be obtained by modern chemical methods at present. There are two common preparation routes.
First, 3,5-difluoroaniline is used as the starting material. First, it reacts with sodium nitrite and hydrochloric acid in a low temperature environment to form diazonium salts. This process needs to be carefully controlled to prevent the decomposition of diazonium salts. After the diazonium salt is formed, it reacts with copper salts such as cuprous chloride, and the diazonium group is replaced by chlorine atoms to obtain 1-chloro-3,5-difluorobenzene. In this path, the diazotization reaction conditions are severe, and the temperature and the proportion of reactants need to be precisely controlled, otherwise the yield and purity will be affected.
Second, 3,5-difluorobenzoic acid is used as the starting material. First, it is converted into acid chloride, and chlorinated reagents such as dichlorosulfoxide are used to react with it to generate 3,5-difluorobenzoyl chloride. After that, the amide group is converted into an amino group by Hoffman degradation reaction, and then the target product 1-chloro-3,5-difluorobenzene can be obtained by diazotization and chlorination. This route is a little complicated, but the raw materials are easier to obtain, and the reaction conditions of each step are relatively mild, which also has its advantages in industrial production. In short, the preparation of 1-chloro-3,5-difluorobenzene needs to be based on the actual situation, weighing many factors such as raw materials, cost, yield and purity, and choosing the appropriate method.
What are the precautions for storing and transporting 1-Chloro-3,5-Difluorobenzene?
1-Chloro-3,5-difluorobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound should be stored in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of excessive temperature or lack of air circulation. The temperature of the warehouse should not be too high. If it is too high, it may cause its volatilization to intensify or cause chemical reactions. And it must be kept away from fire and heat sources. Open flames and high temperatures can make it vulnerable to combustion or even explosion.
Furthermore, it should be stored separately from oxidants and alkalis, and should not be mixed. Due to the encounter of 1-chloro-3,5-difluorobenzene with oxidants, or a violent oxidation reaction; contact with alkalis, chemical reactions may also occur, causing changes in their properties and even the formation of dangerous substances.
As for packaging, it is also necessary to be strict. The packaging container must be well sealed to prevent its leakage. Leakage will not only cause material loss, but also cause harm to the environment and surrounding personnel.
When it comes to transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. If an accident occurs during transportation, it can be dealt with in time. During transportation, make sure that the container does not leak, collapse, fall or damage.
Driving routes are also particular. You should follow the prescribed route and do not stop in residential areas and densely populated areas. In this way, you can avoid accidental leakage and other conditions that cause harm to many people. During transportation, operators should also strictly abide by the operating procedures and operate cautiously to ensure safe transportation.
What are the effects of 1-Chloro-3,5-Difluorobenzene on the environment and the human body?
1-Chloro-3,5-difluorobenzene is also an organic compound. It has its impact on the environment and human body.
First talk about its impact on the environment. If this compound is released in nature, or enters the soil, water body, and atmosphere. In the soil, or refractory to degradation, accumulated in the soil, hinders the growth and development of plant roots, inhibits plant uptake of nutrients and water, causes poor plant growth, and even withers. Inflow into water bodies can cause water pollution, and aquatic organisms bear the brunt. Or harm its respiratory system and nervous system, disrupt its physiological metabolism, reduce the population and break the aquatic ecological balance. Scattered into the atmosphere, or chemically reacts with other pollutants, generating secondary pollutants, increasing the complexity of air pollution, reducing air quality, and or spreading with atmospheric circulation, expanding the scope of pollution.
As for the impact on the human body, the route is inhalation, ingestion and skin contact. If inhaled, into the human respiratory system, can stab the respiratory mucosa, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure, or damage lung function, increase the risk of respiratory diseases. If accidentally ingested, can harm the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. And or through the digestive system into the blood, travel throughout the body, damage the liver, kidney and other organs, because it may accumulate in the body, affecting the normal function of organs. Skin contact, or cause skin allergies, redness, swelling, itching, if the skin has wounds, it is easier to enter the body and increase health risks.
From this perspective, 1-chloro-3,5-difluorobenzene is potentially harmful to the environment and the human body. When producing and using, strict safety procedures should be followed to prevent its leakage to protect the environment and human health.