1-Chloro-2-Fluorobenzene

Hongda Chemical

Specifications

HS Code	849188
Chemical Formula	C6H4ClF
Molar Mass	128.546 g/mol
Appearance	Colorless liquid
Boiling Point	145 - 146 °C
Melting Point	-36 °C
Density	1.259 g/cm³
Solubility In Water	Insoluble
Flash Point	41 °C
Vapor Pressure	1.33 kPa at 28.4 °C
Refractive Index	1.515 - 1.517

As an accredited 1-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - chloro - 2 - fluorobenzene packaged in 5 - liter containers.
Storage	1 - Chloro - 2 - fluorobenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. It should be kept in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reactive chemicals, and foodstuffs to prevent potential reactions or contamination. Ensure proper labeling for easy identification and compliance with safety regulations.
Shipping	1 - Chloro - 2 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous material shipping regulations, with proper labeling indicating its toxic and flammable nature, ensuring safe transit.

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General Information

Historical Development

1 - Chloro - 2 - Fluorobenzene is an organic compound. In its historical evolution, chemists initially explored the wonders of the combination of various substances, and gradually paid attention to it in the complex research. In the past, chemical technology was not as sophisticated as it is today, but many scholars worked tirelessly.
At that time, the research conditions were simple, but everyone was eager to know. After years of trial and error, its molecular structure and characteristics were gradually clarified. In the early days or only knew its general outline, and then with the improvement of instruments and complete theory, the understanding of 1 - Chloro - 2 - Fluorobenzene deepened. Since the beginning of ignorance, to be able to study its reaction mechanism and preparation method in detail, the status of this compound in the field of chemistry has gradually emerged. Its historical evolution is the condensation of the efforts of countless chemists, and it is also a brilliant chapter in the long river of chemical development.

Product Overview

1-Chloro-2-fluorobenzene is also an organic compound. It is a colorless and transparent liquid with a special odor. This compound has a wide range of uses in the field of organic synthesis.
The introduction of chlorine and fluorine atoms gives it a unique chemical activity. In pharmaceutical chemistry, it is often a key intermediate, helping to create new drugs. Because it can participate in a variety of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., it can build complex molecular structures.
In the field of materials science, it has also emerged. Through specific reactions, it can be integrated into polymer materials to improve the properties of materials, such as improving heat resistance and chemical stability.
However, the preparation requires fine control of conditions. The purity of the raw materials, the temperature and time of the reaction are all factors that affect the quality and yield of the product. The synthesis method often relies on classical organic synthesis methods such as halogenation reaction to obtain high-purity 1-chloro-2-fluorobenzene through multi-step reaction, which lays the foundation for applications in various fields.

Physical & Chemical Properties

1 - Chloro - 2 - Fluorobenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, at room temperature and pressure, this substance is a colorless liquid with a special odor. Its boiling point is about 172 ° C, its melting point is about -38 ° C, and its density is larger than that of water, about 1.25g/cm ³. It is insoluble in water, but it can be miscible with organic solvents such as ethanol and ether.
When it comes to chemical properties, the presence of chlorine and fluorine atoms in this compound makes it uniquely reactive. The electron cloud density of the benzene ring changes due to the induction effect of halogen atoms, making it more prone to electrophilic substitution reactions. For example, under the action of appropriate catalysts, nitrification reactions can occur with mixed acids of nitric acid and sulfuric acid, and nitro groups can be introduced at specific positions in the benzene ring. Nucleophilic substitution reactions can also occur with nucleophilic reagents, and halogen atoms can be replaced by other groups, showing diverse chemical conversion capabilities, and are widely used in the field of organic synthesis.

Technical Specifications & Labeling

1 - Chloro - 2 - Fluorobenzene is an organic compound, and its preparation process and standards are very important. To prepare this compound, benzene is often used as the starting material and obtained by halogenation. During halogenation, the reaction temperature, time and proportion of reactants must be carefully controlled. If the temperature is too high, it is easy to cause the formation of polyhalogenates; if the temperature is too low, the reaction will be slow. If the time is too short, the raw materials will not be fully reacted; if the time is too long, it may cause side reactions. As for the proportion of reactants, it also needs to be precisely prepared to ensure the purity and yield of the product.
In terms of product standards, the purity needs to reach a certain level, and the impurity content should be extremely low. The appearance should be a colorless and transparent liquid with no visible impurities. The The detection method can be used by gas chromatography, mass spectrometry and other technologies to ensure that its quality meets standards, so that it can be properly applied in industrial production and scientific research.

Preparation Method

1 - Chloro - 2 - Fluorobenzene is an organic compound. The preparation method is related to the raw material, production process, reaction steps and catalytic mechanism.
To prepare this substance, o-fluoroaniline can be used as the raw material. It can be obtained by diazotization and Sandmeier reaction. First, the o-fluoroaniline reacts with sodium nitrite at low temperature in hydrochloric acid medium to form a diazonium salt. This is the diazotization step. The diazonium salt is unstable and needs to be converted in time. Then add the cuprous chloride hydrochloric acid solution, the diazonium group is replaced by a chlorine atom to complete the Sandmeier reaction and obtain 1 - Chloro - 2 - Fluorobenzene. In this process, cuprous chloride is used as a catalyst to promote the reaction and improve the yield. During operation, attention should be paid to the low temperature environment to prevent the decomposition of diazonium salts, which will affect the purity and yield of the product.

Chemical Reactions & Modifications

1 - Chloro - 2 - Fluorobenzene is an organic compound that has attracted much attention in the field of chemical synthesis. Its chemical reaction and modification are of great significance for optimizing performance and expanding its use.
In the past, the synthesis of 1 - Chloro - 2 - Fluorobenzene had many drawbacks, such as harsh reaction conditions and poor yield. Today's chemists have worked hard to improve it.
Chemists use new catalysts to make the reaction conditions milder and increase the yield. And the reaction path is modified to optimize the reaction selectivity.
At the modification level, researchers have tried to introduce specific functional groups to change their physical and chemical properties. This move may increase its solubility and stability, and expand its application in the fields of materials science and drug development.
Looking to the future, the chemical reaction and modification research of 1-Chloro-2-Fluorobenzene is expected to pave a new path for the creation of new materials, efficient drug development and other fields, injecting vigorous vitality into the development of chemistry.

Synonyms & Product Names

1 - Chloro - 2 - Fluorobenzene, also known as o-chlorofluorobenzene. In the field of chemistry, the same thing is common.
The industry of Guanfu Chemical Industry, for the sake of clarity, has strict naming standards. However, the common name is another name, which is also circulated among the people. The name of o-chlorofluorobenzene is named after the position of its chlorine and fluorine atoms adjacent to the benzene ring. Its official name is 1 - Chloro - 2 - Fluorobenzene, and the position and type of the substituent are marked with benzene as the group according to the system naming method.
Although the names refer to the same substance, the occasions of use vary. In academic writings and professional discussions, it is often named systematically to show accuracy. And industrial practice, daily communication, common names are aliases or more convenient. But no matter what it is called, it refers to this specific compound, so as to facilitate the smooth operation of all things in the chemical industry.

Safety & Operational Standards

1 - Chloro - 2 - Fluorobenzene is an organic compound, which is crucial for its safety and operating practices.
When storing, place in a cool and well-ventilated place. Keep away from fire and heat sources to prevent accidents. It should be placed separately from oxidants and food chemicals, and should not be mixed to avoid chemical reactions. The storage area should be equipped with suitable materials to contain leaks in order to respond to emergencies in a timely manner.
When it comes to operating standards, operators must undergo special training and strictly abide by operating procedures. The operation should be carried out in a well-ventilated place. It is recommended that the operator wear a self-priming filter gas mask (half mask), wear chemical safety protective glasses, wear anti-poison infiltration work clothes, and wear rubber oil-resistant gloves to protect their own safety in an all-round way. Keep away from fire and heat sources during the operation. Smoking is strictly prohibited in the workplace. Use an explosion-proof ventilation system and equipment to prevent steam leakage into the air of the workplace. Avoid contact with oxidants. When handling, pack and unload lightly to prevent damage to packaging and containers.
If a leak unfortunately occurs, quickly evacuate the personnel in the leaked contaminated area to a safe area, and isolate and strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and wear anti-gas clothing. Cut off the source of leakage as much as possible. Prevent flow into restricted spaces such as sewers and flood ditches. Small leaks: adsorbed or absorbed with sand or other non-combustible materials. It can also be scrubbed with emulsions made of non-combustible dispersants, diluted and placed into the wastewater system. Large leaks: build embankments or dig pits for containment. Cover with foam to reduce vapor hazards. Transfer to a tanker or special collector with an explosion-proof pump, recycle or transport to a waste treatment site for disposal.
In this way, the safety of 1 - Chloro - 2 - Fluorobenzene during storage and operation can be ensured, accidents can be avoided, and the safety of people and the environment can be guaranteed.

Application Area

1 - Chloro - 2 - Fluorobenzene is also an organic compound. Its application field is quite wide, and it can be a key intermediary in the field of medicinal chemistry. With its unique chemical structure, it can participate in a variety of organic synthesis reactions, help create new drugs, or optimize the efficacy of existing drugs.
It also has potential in materials science. It can be integrated into polymer materials through specific chemical reactions to give materials novel properties, such as improved stability and corrosion resistance.
In the synthesis of pesticides, 1-Chloro-2-Fluorobenzene may be used as raw materials to participate in the preparation of efficient and low-toxicity pesticides, which help to prevent and control agricultural pests and ensure the yield of crops. All of these demonstrate its important application value in many fields, and are actually substances that cannot be ignored in chemical research and industrial production.

Research & Development

In the field of chemical industry, new products are emerging one after another. 1-Chloro-2-Fluorobenzene has attracted our attention recently. Its unique properties and extraordinary potential in the process of organic synthesis.
We have dedicated ourselves to studying its physicochemical properties in detail. Looking at the structure of its molecules, chlorine and fluorine atoms are coexisting with benzene rings, and the diversity of electron clouds makes its reactivity unique.
During the experiment, all kinds of reagents dance with it to observe the changes in its reaction. Either nucleophilic substitution or addition polymerization, all of which are wonderful. After repeated investigation, it is gradually clear that the optimal reaction environment, temperature geometry, pressure, and catalyst are all clear.
As for the direction of application, it can enter the system of medicine, which is the foundation of synthetic special effects; it can also enter the field of materials and give materials novelty.
Although it has achieved little success on the road of research, the road ahead is long, and it still needs to be deeply cultivated.

Toxicity Research

In recent years, I have been studying the toxicity of chemicals, especially 1-Chloro-2-Fluorobenzene. This compound, with its unique structure, contains chlorine and fluorine atoms, and the characteristics of the two are combined, which is worthy of in-depth study on the influence of the environment and biological systems.
After various experiments and animal models, 1-Chloro-2-Fluorobenzene was introduced into the body, but the effect was not obvious at first, but it accumulated for a long time, damaging organs such as liver and kidney. At the cellular level, it disrupts its metabolic pathways and causes cell dysfunction. And in the environment, it degrades slowly or causes long-term pollution.
The source of toxicity is the reactivity of chlorine and fluorine atoms, which easily react with biomolecules and destroy their structure and function. Although the current understanding is still shallow, I must investigate it carefully, hope to understand its harm, and make plans for protection and treatment to ensure ecological and human safety.

Future Prospects

1 - Chloro - 2 - Fluorobenzene is also an organic compound. Its development in the future is quite promising. Looking at the current trend of chemical research, the technology of fine synthesis is advancing. 1 - Chloro - 2 - Fluorobenzene can be an important raw material in the fields of pharmaceutical creation and material research and development.
In the field of medicine, it may help the development of new drugs. With its unique molecular structure, it is expected to give rise to special agents to treat intractable diseases. As for materials, it can be used as a precursor to prepare new materials with outstanding properties. For example, those with special optoelectronic properties may be of great use in the fields of electronic devices.
Our generation of chemical researchers, when diligently studying and exploring its potential, hope to open up new frontiers, make 1-Chloro-2-Fluorobenzene shine in the future, and contribute to the well-being of mankind.

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Frequently Asked Questions

As a leading 1-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Chloro-2-Fluorobenzene?

1-Chloro-2-fluorobenzene is also an organic compound. It has a wide range of main uses and is often used as a raw material for organic synthesis in the chemical industry.
First, it plays a pivotal role in the synthesis of medicine. The preparation of many drugs depends on it as the starting material. For example, when synthesizing specific antibacterial drugs, 1-chloro-2-fluorobenzene can be introduced through a series of chemical reactions to introduce key structural fragments. After halogenation, substitution, condensation and other steps, the molecular structure required for drug activity can be shaped to obtain compounds with specific pharmacological activities and help human health.
Second, it is also indispensable in the creation of pesticides. It can be used as an important intermediate for the synthesis of new pesticides. After chemical modification, the pesticide is endowed with unique insecticidal, bactericidal or herbicidal properties. Based on it, a molecule with special spatial structure and electron cloud distribution is constructed, so that the pesticide can accurately act on the target organism, improve the efficacy, reduce the impact on non-target organisms, and help the sustainable development of agriculture.
Third, it has made a name for itself in the field of materials science. It can be used to synthesize polymer materials with special properties. After polymerization, its structural units are introduced into the polymer chain, giving the material excellent properties such as chemical corrosion resistance and high temperature resistance. It is used in high-end fields such as aerospace and electronics to meet the strict requirements of material properties in special environments.
In summary, although 1-chloro-2-fluorobenzene is a small molecule compound, it plays a key role in many fields such as medicine, pesticides, and materials, and promotes the progress and development of technologies in various fields.

What are the physical properties of 1-Chloro-2-Fluorobenzene?

1-Chloro-2-fluorobenzene is one of the organic compounds. Its physical properties are quite important, let me explain in detail.
First of all, its appearance, under room temperature and pressure, 1-chloro-2-fluorobenzene is a colorless to light yellow transparent liquid, clear in appearance, like a clear spring. Its smell is slightly aromatic, but this fragrance is not pleasant, but it has a pungent feeling, and the smell is uncomfortable.
As for the boiling point, it is about 132-134 ° C. When the temperature reaches this point, the substance changes from liquid to gaseous state, like the rise of clouds. The melting point is about -47 ° C. If the temperature drops to this temperature, this substance solidifies from a flowing liquid to a solid state, just like water turns into ice when it encounters cold.
Its density is heavier than water, about 1.256 g/cm ³, so if it is mixed with water, it will sink to the bottom of the water, like a stone falling into the abyss. And it is difficult to dissolve in water, and the two meet, just like oil and water, distinct and distinct, and each does not melt.
1-chloro-2-fluorobenzene is soluble in many organic solvents, such as ethanol, ether and the like. In organic solvents, it can be evenly dispersed, just like a fish getting water, free.
In addition, the vapor density of 1-chloro-2-fluorobenzene is greater than that of air. If it evaporates in the air, the vapor will spread close to the ground, like a mist covering the earth. Its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of open fire and high heat, just like dry wood in case of fire, it will explode at the touch of a hair, so be careful when using and storing it to avoid disasters.

Is 1-Chloro-2-Fluorobenzene chemically stable?

1-Chloro-2-fluorobenzene is also an organic compound. The stability of its chemical properties needs to be carefully observed.
In this compound, the chlorine atom and the fluorine atom are connected to the benzene ring. The benzene ring has a conjugated π electron system and is very stable. However, the introduction of chlorine and fluorine atoms changes the electron cloud density distribution of the benzene ring.
Both chlorine atoms and fluorine atoms have an electron-absorbing induction effect. The fluorine atom has a particularly strong electron-withdrawing induction effect because of its extremely high electronegativity. However, the two also have a conjugation effect for electrons, but this conjugation effect is relatively weaker than its electron-withdrawing induction effect.
The electron cloud density of 1-chloro-2-fluorobenzene decreases due to the electron-withdrawing induction effect, resulting in lower electrophilic substitution activity than benzene. For example, when halogenation, nitrification, sulfonation and other electrophilic substitution reactions are carried out, the reaction conditions may be more harsh than benzene.
However, in the nucleophilic substitution reaction, 1-chloro-2-fluorobenzene exhibits different properties. Because of chlorine and fluorine atoms, the electron cloud density of the benzene ring decreases, which is conducive to the attack of nucleophilic reagents. And when there is an electron-withdrawing group connected to the benzene ring, it can enhance the tendency of halogen atoms to leave.
As for its stability, 1-chloro-2-fluorobenzene is relatively stable at room temperature and pressure. In case of high temperature, open flame or strong oxidant, it may be dangerous. It can burn, and when burned, it may release harmful gases containing chlorine and fluorine.
In some specific chemical reaction environments, the chlorine and fluorine atoms of 1-chloro-2-fluorobenzene can participate in the reaction, and many changes such as substitution and elimination occur, depending on the reaction conditions and the added reagents.
In summary, the stability of 1-chloro-2-fluorobenzene is not absolute, and its chemical properties and stability exhibit complex states under different environments and reaction conditions, which need to be carefully considered according to local conditions.

What is 1-Chloro-2-Fluorobenzene production method?

The preparation method of 1-chloro-2-fluorobenzene has been around for a long time, and this is a detailed description for you.
First, the halogenation method. This is a common method. Take benzene as the initial substance, and make it substitution reaction with chlorine first. At a suitable temperature and in the presence of a catalyst, such as ferric chloride, benzene reacts with chlorine gas to obtain chlorobenzene. Afterwards, chlorobenzene reacts with fluoride. Fluorination reagents with high activity, such as potassium fluoride, are often heated in a specific solvent and assisted by a phase transfer catalyst to promote fluorine to replace the chlorine atoms on chlorobenzene. However, this process requires attention to the precise control of the reaction conditions. Too high or too low temperature, improper dosage of reagents, etc., may affect the yield and purity of the product.
Second, the diazotization method. First, the o-amino chlorobenzene is converted into a diazo salt through a diazotization reaction. The o-amino chlorobenzene is treated with sodium nitrite and hydrochloric acid in a low temperature environment to form a diazo salt. Subsequently, fluoroboric acid is added to form a diazo salt precipitation of fluoroboronic acid. After separation and drying, the diazonium salt of fluoroboronic acid can be decomposed by heating to obtain 1-chloro-2-fluorobenzene. In this process, the diazotization reaction needs to be carried out at low temperature and strictly controlled conditions to prevent side reactions such as diazonium salt decomposition from occurring and affecting the formation of products.
Third, Grignard reagent method. Using o-chlorobenzene as raw material, Grignard reagent is first prepared. The o-chlorobenzene is reacted with magnesium chips in anhydrous ether and other solvents to make Grignard reagent. After that, it reacts with fluorinated reagents, such as fluorine trifluoromethanesulfonate, to generate 1-chloro-2-fluorobenzene. This method has high requirements for the anhydrous and anaerobic reaction system, otherwise the Grignard reagent is easy to fail and it is difficult to achieve the expected reaction effect.
All methods have advantages and disadvantages. In actual production, the preparation method should be carefully selected according to specific needs, raw material availability, cost considerations and many other factors.

What are the precautions in storage and transportation of 1-Chloro-2-Fluorobenzene?

1-Chloro-2-fluorobenzene is an organic compound, and many matters must be paid attention to when storing and transporting.
First, it is related to storage. This compound has certain toxicity and volatility, so it should be stored in a cool and ventilated warehouse. The temperature of the warehouse should not be too high to prevent its volatilization from intensifying, and it should be kept away from fire and heat sources, because it may cause danger when exposed to open flames, hot topics or. At the same time, it should be stored separately from oxidants and edible chemicals, and must not be mixed to avoid chemical reactions and safety risks. In addition, the warehouse should be equipped with suitable materials to contain leaks, in case of leaks, and can be properly handled in a timely manner.
Second, about transportation. During transportation, the packaging must be tight to ensure that there is no leakage. Transportation vehicles should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. When driving, it is necessary to prevent exposure to the sun, rain and high temperature. When road transportation, it is necessary to follow the prescribed route and do not stop in residential areas and densely populated areas. If it is rail transportation, it is also necessary to strictly follow the relevant regulations to ensure transportation safety. Escort personnel must be familiar with the characteristics and emergency treatment methods of 1-chloro-2-fluorobenzene, and always pay attention to the condition of the goods during transportation. If there is any abnormality, it should be properly disposed of immediately. In this way, when storing and transporting 1-chloro-2-fluorobenzene, the safety of personnel and the environment can be guaranteed to the greatest extent.