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1-Chloro-2-Fluoro-6-Nitrobenzene

1-Chloro-2-Fluoro-6-Nitrobenzene

Hongda Chemical

Specifications

HS Code

692765

Chemical Formula C6H3ClFNO2
Molar Mass 177.545 g/mol
Appearance Solid (usually)
Physical State At Room Temp Solid
Melting Point Data needed
Boiling Point Data needed
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Density Data needed
Odor Pungent (expected)
Color Colorless to pale yellow (expected)
Stability Stable under normal conditions but reactive to certain reagents
Hazard Class Irritant (can cause skin, eye and respiratory irritation)

As an accredited 1-Chloro-2-Fluoro-6-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 2 - fluoro - 6 - nitrobenzene: Packed in 500 - gram bottles for secure storage.
Storage 1 - chloro - 2 - fluoro - 6 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Follow local safety regulations for storage.
Shipping 1 - chloro - 2 - fluoro - 6 - nitrobenzene is a chemical. It should be shipped in tightly sealed, corrosion - resistant containers, following all hazardous materials regulations. Ensure proper labeling and handling to prevent leakage and risks during transit.
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1-Chloro-2-Fluoro-6-Nitrobenzene 1-Chloro-2-Fluoro-6-Nitrobenzene
General Information
Historical Development
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important product of chemistry. Looking back in the past, its development process has been tortuous and contains wisdom. At first, researchers were interested in benzene compounds containing chlorine, fluorine and nitro groups, so they focused on exploring their synthesis methods. After many attempts, a feasible path for synthesizing 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene was obtained. In the initial stage, the reaction conditions were harsh and the yield was low. However, researchers persevered and continuously improved the reaction process, adjusting factors such as temperature, pressure and catalyst. After years, the synthesis process has become more and more mature, and the yield has been greatly improved. This product has gradually shown its important value in the fields of medicine and materials, adding a strong color to the development of chemistry.
Product Overview
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical substance. Its yellowish color is a crystalline solid with a special odor. The melting point is about [X] ° C, and the boiling point is between [X] ° C.
This compound has a wide range of uses in organic synthesis. In pharmaceutical synthesis, it can be used as a key intermediate to help create a variety of drugs with specific therapeutic effects. Due to its unique chemical structure, the presence of chlorine, fluorine and nitro gives it specific reactivity and selectivity.
During the reaction, chlorine atoms can participate in nucleophilic substitution reactions, fluorine atoms can enhance the stability and electronic effects of molecules, and nitro groups can further regulate the reaction check point and activity. By precisely controlling the reaction conditions and the ratio of reactants, chemists can use 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene to construct complex organic molecular structures, laying the foundation for new drug development and materials science innovation. It is an indispensable and important substance for organic chemistry research.
Physical & Chemical Properties
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an organic compound. In terms of physical properties, it is mostly solid at room temperature, with a specific color and odor. This substance has a relatively high melting point. Due to the strong intermolecular force, it requires more energy to disintegrate its lattice structure and realize the transition from solid to liquid.
Chemically, the presence of chlorine, fluorine and nitro groups gives it unique activity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult. Chlorine and fluorine atoms can participate in nucleophilic substitution reactions. Among them, fluorine atoms have high stability due to high electronegativity and high stability of the carbon-fluorine bonds, and the substitution reaction conditions are more harsh. And when the compound encounters a specific reagent or undergoes a reduction reaction, the nitro group can be reduced to different functional groups such as amino groups.
Technical Specifications & Labeling
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical product. Its technical specifications and identification (product parameters) are extremely critical. When it comes to technical specifications, it is necessary to ensure that the content of chlorine, fluorine and nitro is accurate, which is related to the purity and quality of the product. Its color should be pure and free of variegation. And the physical parameters such as melting point and boiling point must fit a specific range, so as to be qualified.
As for the identification (product parameters), the product name, chemical formula, content, production batch and other information should be clearly marked on the packaging. In this way, the user can clearly know the product details and avoid misuse. Strictly adhere to this technical specification and identification (product parameters) to ensure the quality and application safety of 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene.
Preparation Method
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical product. The preparation method of its preparation is crucial to the selection of raw materials. Suitable aromatic hydrocarbons can be selected, such as benzene derivatives. After halogenation, chlorine and fluorine atoms are introduced. During this process, careful temperature control and reaction time are required. Then a nitrification reaction is performed, and a mixed acid of nitric acid and sulfuric acid is added. The reaction conditions are precisely grasped to ensure that the nitro group is correctly introduced into the designated position.
The reaction steps should be gradual. When halogenating, pay attention to the amount of halogenating agent and the rate of addition. During nitrification, strictly monitor the temperature change to prevent the growth of side reactions. As for the catalytic mechanism, a specific catalyst can be selected to increase the reaction rate and yield. Some metal salts or Lewis acids, for example, can effectively promote the reaction process, making the preparation process more efficient and stable.
Chemical Reactions & Modifications
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important compound in organic synthesis. Its chemical reaction and modification are of great significance in the field of chemical research.
To obtain this compound, benzene is often used as the starting material. After halogenation, chlorine atoms and fluorine atoms are introduced, and then nitrogenation is used to add nitro groups. However, this traditional method has the drawbacks of harsh reaction conditions and many side reactions.
For improvement, today's scholars are committed to exploring new reaction paths. If a new catalyst with catalytic capacity is used, the reaction can be carried out under milder conditions, with better selectivity and effective reduction of by-product formation. This not only increases the yield of 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene, but also conforms to the concept of green chemistry, and has great application potential in industrial production. After this chemical modification, the properties of 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene can be optimized, which can better meet the needs of many fields.
Synonyms & Product Names
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical substance. The discussion of its synonyms and trade names is of great significance in the field of chemical research.
In many literature records, this substance may have another name. Its synonyms may vary depending on regions and research groups. Those who are otherwise known by their chemical structure characteristics may be referred to from their substituted positions and combinations of chlorine, fluorine, and nitro groups, or derived from other names.
As for trade names, each manufacturer may give a unique name to highlight the characteristics of the product. Or highlight its purity, or emphasize a specific use. For example, in the field of fine chemical synthesis, 1-Chloro-2-Fluoro-6-Nitrobenzene produced by a certain manufacturer may contain the meaning of efficient and precise synthesis.
When chemists are researching, they need to clarify many synonyms and trade names to ensure the accurate selection of experimental materials, avoid confusion due to different names, and promote the smooth progress of chemical research.
Safety & Operational Standards
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical product, which needs to be discussed in detail in terms of its safety and operating practices.
During production and preparation, many steps need to be carefully handled. The selection and treatment of raw materials must be based on precise proportions and purity requirements. In this case, the chemicals involved may be toxic and corrosive, such as raw materials containing chlorine, fluorine, and nitro, which can be harmful if they are not careful. The operation room must be well ventilated to prevent the accumulation of harmful gases. Workers should also wear complete protective equipment, such as gas masks, acid and alkali resistant protective clothing, to ensure safety.
When storing, there are also strict regulations. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical properties, it is easy to cause violent reactions or even explosions when exposed to heat, open flames or strong oxidants. Storage containers should also be strong and well sealed to prevent leakage. Check the condition of the container regularly. If there is any damage, replace it in time.
During use, the operator must be familiar with the operating procedures. In experiments or production processes, the established steps should be strictly followed. Reaction conditions such as temperature, pressure, and reaction time must be precisely controlled. Reaction equipment also needs regular maintenance and inspection to ensure normal operation. In the event of an unexpected situation such as a leak, an emergency plan should be activated immediately. Evacuate personnel, seal the scene, and deal with it in an appropriate way according to the nature of the leak. Do not act in a panic.
In conclusion, the safety and operation specifications of 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene run through the production, storage and use links. Only by strictly adhering to all guidelines can we ensure the safety of personnel and the smooth production.
Application Area
1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is an important chemical substance. Its application field is quite extensive. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help synthesize a variety of specific drugs, or have significant effects on specific diseases. In the field of materials science, it also has its place. It can participate in the preparation of new materials and endow materials with unique properties, such as enhancing the stability of materials or changing their optical properties. In the fine chemical industry, it can be used as a basic raw material to derive many high-value-added fine chemicals to meet the special needs of different industries. From this perspective, 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene is of great significance in various fields and is indispensable for promoting the development of related industries.
Research & Development
In recent years, Yu dedicated himself to the research of 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene. This compound has a unique structure and unique properties, and has potential uses in various fields.
At the beginning, the synthesis method was explored, and many tests were carried out, or the raw materials were rare, or the steps were cumbersome, and the yield was not satisfactory. However, Yu and colleagues were determined to repeatedly consider and improve the process.
After months of research, a method was finally obtained, which can be more efficient. The raw materials are easy to obtain, the process is gradually simplified, and the yield has also increased significantly.
Looking at its application today, it can be used as a key intermediate in medicinal chemistry to help the research and development of new drugs; in materials science, it may be able to add new quality to materials.
We will continue to make progress, deeply explore its characteristics, expand the field of application, and hope to contribute to its development, so that its function can be widely used in the world.
Toxicity Research
Study on the toxicity of 1-chloro-2-fluoro-6-nitrobenzene
I have heard that all kinds of substances have their own properties, either beneficial or harmful. At present, the toxicity of 1-chloro-2-fluoro-6-nitrobenzene is very important for our chemical researchers.
1-chloro-2-fluoro-6-nitrobenzene has a unique molecular structure. Chlorine, fluorine, and nitro are combined with the benzene ring. The genus chlorofluorine is active and invasive, and the nitro group is also highly oxidizing and reactive. After various experiments, observe its effects on the organism. When it touches the skin, it often causes discomfort, redness or swelling, or even ulceration. If it inhales its qi, it hurts the lungs, the breath is difficult to smooth, and the cough is not stopped. As for entering the mouth and abdomen, it damages the organs, transports and transports.
Investigate the cause, this chemical enters the body, or interferes with the metabolism of cells, disrupting the order of their biochemistry; or breaks the cell structure and impairs the ability of its barrier. Because of its significant toxicity, researchers should be cautious to prevent its harm, and for the well-being of the public, study the toxicity in detail, explore protection methods, and ensure safety.
Future Prospects
Husband 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene, it is also a thing of transformation. We study it, and hope that it will have a great impact in the future.
In today's world, technology is changing with each passing day, and the field of transformation is also advancing. This compound is unique, or it can be used in many aspects. The way of material research, or it can be used to make new ways, to make new diseases. Materials, or because of their characteristics, make new materials, increase their energy, and use them in tools.
Our researchers must be diligent and unremitting to study the properties and inverse reasons of this compound. With the hope of the results of intensive research, it will be used in the world. In the future, I hope 1 - Chloro - 2 - Fluoro - 6 - Nitrobenzene can be used by the world to benefit people, and add a new chapter to the history of chemistry.
Where to Buy 1-Chloro-2-Fluoro-6-Nitrobenzene in China?
As a trusted 1-Chloro-2-Fluoro-6-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-2-Fluoro-6-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Chloro-2-Fluoro-6-Nitrobenzene?
1-Chloro-2-fluoro-6-nitrobenzene has a wide range of uses. In the field of organic synthesis, it is a key intermediate. Due to the active chemical properties of chlorine, fluorine and nitro functional groups in the molecule, various organic compounds can be derived through many reactions.
For example, in nucleophilic substitution reactions, chlorine and fluorine atoms can be replaced by various nucleophilic reagents. With this reaction, functional groups such as hydroxyl, amino and alkoxy groups can be introduced, paving the way for the creation of new compounds. In the field of medicinal chemistry, it is often used as a starting material to synthesize drug molecules with specific biological activities through multi-step reactions.
Furthermore, nitro can also participate in various transformations. Nitro groups can be reduced to amino groups, which can be further derived, and play an extraordinary role in the construction of complex organic structures. And in materials science, derivatives prepared from 1-chloro-2-fluoro-6-nitrobenzene, or due to their unique electronic properties and structural characteristics, exhibit specific physical and chemical properties such as photoelectric properties and thermal stability, and have great potential in the development of new materials.
It also plays a role in the field of dye synthesis. Through a series of reactions, it can be converted into compounds containing specific chromophores, giving dyes unique color and properties. It is widely used in textiles, printing and dyeing and other industries to add color and enrich the color of the world.
What are the physical properties of 1-Chloro-2-Fluoro-6-Nitrobenzene?
1-Chloro-2-fluoro-6-nitrobenzene is one of the organic compounds. Its physical properties are impressive, let me tell them one by one.
Looking at its properties, under normal temperature and pressure, it is mostly colorless to light yellow liquid, and its appearance is clearly recognizable, which is its primary physical characteristic.
Talking about the boiling point, it is about a specific temperature range. Due to various factors such as intermolecular forces, it needs to reach a certain temperature before it can be converted from liquid to gaseous state. The value of this boiling point is of great significance for its separation and purification operations.
Melting point is also one of the important physical properties. At this temperature, the substance transitions from solid to liquid, reflecting the change of molecular arrangement and structure. The melting point of 1-chloro-2-fluoro-6-nitrobenzene falls within a specific range due to molecular composition and interaction, which is crucial for studying the transition process between solid and liquid states.
Density cannot be ignored. Its density is different from that of water. This property is related to its distribution in solution and has a significant impact on many chemical processes, such as extraction and phase separation.
In terms of solubility, it has a certain solubility in organic solvents, such as ethanol, ether, etc. This is because of the principle of "similarity and miscibility", and its molecular structure is compatible with organic solvents. However, in water, the solubility is very small, because its molecular polarity is quite different from that of water, making it difficult for the two to blend.
The odor of 1-chloro-2-fluoro-6-nitrobenzene is particularly irritating and can be felt by smelling. This odor characteristic, during operation and use, requires personnel protection, and is also an important clue to identify the substance.
The above are all important physical properties of 1-chloro-2-fluoro-6-nitrobenzene, which are of great value in chemical research, industrial production and other fields.
What is the chemical synthesis method of 1-Chloro-2-Fluoro-6-Nitrobenzene?
The chemical synthesis of 1-chloro-2-fluoro-6-nitrobenzene is a key issue in the field of organic synthesis. To synthesize this substance, there are several common methods.
First, it can be started from benzene derivatives. First, the benzene is nitrified, and the mixed acid of sulfuric acid and nitric acid is used as the nitrifying agent. Under these conditions, the nitro group is introduced into the benzene ring. This reaction needs to be controlled by temperature. Generally, low temperature is appropriate to avoid the formation of polynitro substitution products.
Then, the halogenation reaction is carried out. The chlorine atom is introduced first, and suitable chlorination reagents, such as phosphorus trichloride, phosphorus pentachloride, etc., can be used. In the presence of an appropriate catalyst, chlorine atoms are introduced As for the introduction of fluorine atoms, a nucleophilic substitution reaction is often used. Fluorine-containing reagents, such as potassium fluoride, are used to replace suitable leaving groups on the benzene ring with fluorine atoms under specific solvents and conditions, so as to achieve the purpose of introducing fluorine atoms at a predetermined position.
There is also another method, which can first carry out halogenation reaction, successively introduce chlorine atoms and fluorine atoms, and then carry out nitrification reaction. However, this order needs to consider the effect of each reaction condition on the activity of the benzene ring, as well as the localization effect of the substituent. Because different substituents have a guiding effect on the position of subsequent reaction groups, such as nitro as meta-locator, while halogen atoms are ortho-para-locator. In the
synthesis process, each step of the reaction requires fine control of the reaction conditions, such as temperature, reaction time, and proportion of reactants. At the same time, the separation and purification of the product is also crucial. Distillation, recrystallization, column chromatography and other means are often used to obtain high-purity 1-chloro-2-fluoro-6-nitrobenzene.
1-Chloro-2-Fluoro-6-Nitrobenzene What are the precautions during storage and transportation?
1-Chloro-2-fluoro-6-nitrobenzene is an organic compound. When storing and transporting, it is necessary to pay careful attention to many matters.
First words storage, this compound is active in nature and requires strict storage environment. It should be placed in a cool, dry and well-ventilated place, and must not be near fire or heat sources to prevent it from being decomposed by heat or triggering the risk of combustion and explosion. Because of its nitro group, it is easy to react violently when heated. And it should be stored separately from oxidizing agents, reducing agents, alkalis, etc. If these meet with it, or have a chemical reaction, it will cause safety. The storage area should be equipped with suitable materials to contain possible leakage.
As for transportation, it should not be ignored. Before transportation, it is necessary to ensure that the packaging is intact, and the packaging materials used must be able to effectively prevent leakage and damage. During transportation, severe vibration, impact and friction should be avoided to prevent material leakage caused by package rupture. Transportation vehicles should also meet safety standards and be equipped with corresponding fire fighting equipment and emergency treatment equipment. Escort personnel must be professionally trained and familiar with the characteristics of this compound and emergency disposal methods. If a leak occurs during transportation, effective measures should be taken immediately to evacuate the surrounding personnel, strictly prohibit fire from approaching, and contain the leakage with appropriate materials, and handle it properly according to regulations.
In conclusion, the storage and transportation of 1-chloro-2-fluoro-6-nitrobenzene is related to the overall safety situation, and all links must strictly follow relevant regulations and operating procedures to ensure safety.
1-Chloro-2-Fluoro-6-Nitrobenzene impact on the environment and human health
1-Chloro-2-fluoro-6-nitrobenzene is a genus of organic compounds. Its impact on the environment and human health cannot be ignored.
At the end of the environment, if this compound is released in nature, it is difficult to degrade because of its chemical stability. It flows into water bodies, or causes water pollution, and aquatic organisms suffer from it. It may be fat-soluble, easily accumulates in organisms, conducts through the food chain, and endangers upper organisms. If dispersed in the atmosphere or reacts with other pollutants, new harmful substances are formed, which affects air quality.
As for human health, 1-chloro-2-fluoro-6-nitrobenzene may be toxic. Through breathing, skin contact or ingestion, it can damage many organs of the human body. It may irritate the respiratory tract, causing cough and asthma; contact with the skin, causing allergies and inflammation. After entering the body, it may affect the metabolic organs such as the liver and kidneys, interfering with normal physiological functions. Long-term exposure may increase the risk of cancer, because of the nitro and other groups in the structure or mutagenicity, which damages human genetic material.
Therefore, such compounds should be handled with caution and their production, use and emission should be strictly controlled to ensure the safety of the environment and personal health.