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1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene

1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

479414

Chemical Formula C7H3ClF4
Molecular Weight 198.545
Appearance Liquid (assumed, common for similar aromatic halides)
Solubility In Water Low (aromatic halides are generally hydrophobic)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether, dichloromethane
Packing & Storage
Packing 1 - chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene packaged in 500 - mL bottles.
Storage 1 - chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions.
Shipping 1 - chloro - 2 - fluoro - 4 - (trifluoromethyl)benzene is shipped in accordance with chemical regulations. It's typically in sealed, corrosion - resistant containers, carefully labeled, and transported by carriers experienced in handling hazardous chemicals.
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1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene 1-Chloro-2-Fluoro-4-(Trifluoromethyl)Benzene
General Information
Historical Development
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is a kind of chemical substance. Its origin can be traced back to the past. At that time, the science of chemistry was gradually emerging, and various sages dedicated themselves to the exploration of substances. At the beginning, only a few or two of its characteristics were known, and the method of synthesis was not complete.
Years have passed, science and technology have advanced, and scholars have studied more and more deeply. After repeated tests and corrections, the method of synthesis has become more and more exquisite, and the yield has gradually increased. From ignorance to clarity, from crude method to exquisite skill, the research process of this substance is like a long river rushing, and it has never stopped. In the past, synthesis was often difficult, and the quality and quantity of the product were unsatisfactory. However, today is different from the past, with advanced instruments and excellent theories, its production and application have been expanded, emerging in many fields, and future development is also full of endless possibilities.
Product Overview
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is a unique compound. It has unique properties, is a colorless to slightly yellow liquid, and has a special odor. This compound is widely used in the field of organic synthesis.
Looking at its chemical structure, chlorine atoms, fluorine atoms and trifluoromethyl atoms are cleverly connected to the benzene ring, and the structure is exquisite, giving it special chemical activity. Because of its fluorine-containing atoms, it is more active and can participate in many organic reactions. It is a key raw material for the synthesis of new organic materials, pharmaceutical intermediates, etc.
In the preparation process, it often requires delicate craftsmanship, several steps of reaction, and careful regulation of reaction conditions, such as temperature, pressure, catalyst, etc., to obtain this product. When storing, it should be placed in a cool, dry, well-ventilated place, away from fires and heat sources, to prevent deterioration or danger. In short, 1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is of great value in chemical research and industrial production.
Physical & Chemical Properties
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an organic compound. Its physical properties are colorless liquid at room temperature, with a special odor, higher density than water, insoluble in water, soluble in organic solvents such as ethanol, ether, etc.
From the perspective of chemical properties, due to the existence of benzene ring and halogen atom, it has a certain chemical activity. Benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Halogen atoms change the density of adjacent and para-potential electron clouds, which affects the reaction check point and activity. At the same time, halogen atoms can participate in nucleophilic substitution reactions and are replaced by other nucleophilic reagents under suitable conditions. It contains fluorine and chlorine atoms, which affect the stability and reactivity of compounds, and has important applications in the field of organic synthesis.
Technical Specifications & Labeling
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important chemical substance. Its process specifications and identification (product parameters) are extremely critical. The preparation of this substance requires a specific process. The selection of raw materials needs to be precise, and the proportion should be strictly controlled. The reaction conditions cannot be ignored, such as temperature and pressure must be precisely regulated.
In terms of identification, key information such as its chemical name and molecular formula should be clearly indicated. In terms of product parameters, the purity should reach a high standard, and the impurity content must be strictly limited. In this way, the product can be guaranteed to play a stable and reliable role in various application scenarios, providing a solid guarantee for the development of related fields.
Preparation Method
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important organic compound. The preparation method is as follows:
In terms of raw material selection, select suitable aromatic compounds containing chlorine, fluorine and methyl as starting materials. The preparation process involves first mixing the raw materials in a reactor in a specific ratio, controlling the temperature and pressure, and catalyzing the reaction with a suitable catalyst. The reaction step is that under mild heating conditions, the raw materials are first substituted and chlorine atoms are introduced; then the reaction conditions are adjusted, and the fluorination reaction is carried out, and the fluorine atoms and trifluoromethyl atoms are added.
As for the activation mechanism, the selected catalyst can effectively reduce the activation energy of the reaction, promote the breaking and formation of chemical bonds, and improve the reaction rate and yield. In this way, 1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene can be efficiently prepared.
Chemical Reactions & Modifications
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important chemical substance. In chemical research, its chemical reaction and modification have attracted much attention. Past studies focused on conventional reaction paths, but today, scholars are striving for new breakthroughs.
As far as chemical reactions are concerned, although traditional methods can produce this substance, the yield and purity are not ideal. Therefore, it is urgent to explore ways to optimize the reaction conditions and improve the reaction efficiency. Such as adjusting the reaction temperature, pressure, and selecting suitable catalysts are all directions that can be explored.
When talking about modification, it is hoped that by introducing new groups, it will give it different properties. Or enhance its stability, or change its solubility, so that the substance has a wider range of applications in materials science, drug development and other fields. In this way, it can promote chemical research and make this substance play a greater value.
Synonyms & Product Names
Today there is a thing called 1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene. Although its name is different from the common name, in the academic world, there are also many synonymous names and commodity names.
This compound, in the field of chemistry, has quite obvious functions. The synonymous name is another name established by chemists to distinguish its nature and quality. Either according to its structure or according to its reaction, the names are different, all of which illustrate its essence. The name of a commodity is related to the circulation of commerce. Merchants sell their products under names that are easy to identify and remember to attract customers' attention.
Although the names of synonyms and commodities refer to each other, they all revolve around this thing. Chemists use the name of synonyms to express their precise meaning in academic exchanges and research discussions. Merchants use the name of commodities to promote and trade in the market. Although the two are different, they are both 1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene's existence and use in the world to exert its effect.
Safety & Operational Standards
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is a special chemical. During its preparation and application, safety and operating standards are of paramount importance.
Preparation of this chemical requires operation in a well-ventilated place. Because of its certain volatility and irritation, if there is no good ventilation, harmful gases will accumulate, which can easily cause physical discomfort to the operator, or even lead to the risk of poisoning. The equipment used must be clean and dry to prevent impurities from mixing and affecting the purity of the product and the reaction process.
When operating, the experimenter should wear complete protective equipment. Wearing protective clothing can avoid direct contact with chemicals on the skin to prevent corrosion and burns; wearing protective gloves, chemical-resistant materials should be selected to ensure hand safety; goggles are also indispensable, which can effectively block chemicals from splashing into the eyes and avoid damage.
The reaction process requires precise temperature control. Different stages have different temperature requirements. Too high or too low temperature may cause the reaction to deviate from expectations, or cause side reactions to occur, reducing product quality and yield. And the stirring rate also needs to be appropriate to ensure that the reactants are fully contacted and the reaction is carried out evenly.
When storing, it should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources, as it may be flammable or dangerous to decompose by heat. Keep it separate from other chemicals to avoid mutual reaction. Storage containers must be well sealed to prevent leakage.
Waste disposal should not be ignored. It should not be dumped at will. It should follow relevant environmental regulations and use appropriate methods to avoid polluting the environment.
In short, the operation of 1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene must strictly abide by safety and operating practices to ensure personnel safety, product quality and the environment are not damaged.
Application Area
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is a unique chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize drugs with special curative effects and contribute to the treatment of diseases. In the field of materials science, it can participate in the creation of new functional materials through specific reactions, endow materials with unique physical and chemical properties, or enhance their stability, or improve their optical properties. Furthermore, in the fine chemical industry, it is also indispensable. It can be used as a raw material for the synthesis of high-end fine chemicals to produce products such as special fragrances, high-performance coatings, etc., to meet the fine needs of different industries, and to contribute to the development of many fields. It also promotes technological innovation and industrial progress.
Research & Development
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important raw material for organic synthesis and has a wide range of uses in medicine, pesticides and other fields. I have been studying this substance for a long time.
Initially, explore its synthesis path. After repeated tests of different reaction conditions and reagent combinations, the final optimization method can improve the yield and purity. During synthesis, precise control of temperature, reaction time and proportion of reactants are all key.
Then, consider its application and expansion. In pharmaceutical research and development, try to construct new compounds on this basis, hoping to obtain molecules with unique biological activities, and find new ideas for disease treatment. In the field of pesticides, explore the insecticidal and bactericidal properties of its derived compounds, hoping to add to the development of agriculture.
Looking to the future, continue to deepen the research and development of this compound, optimize the synthesis process to reduce costs, expand the scope of application, and contribute to the development of the chemical industry.
Toxicity Research
The industry of chemical industry is related to people's livelihood, and the study of poisons is also a priority. Today there is 1-Chloro-2-Fluoro-4 - (Trifluoromethyl) Benzene, and we should investigate its toxicity in detail.
Looking at its structure, it contains several halogen atoms, and chlorine, fluorine and trifluoromethyl coexist. Halogen elements are many active, or cause their extraordinary toxicity. After various experiments, its effect on organisms cannot be underestimated.
In animal experiments, when this substance is administered, the physiological function of the subject is gradually disrupted. The system of respiration and circulation is disturbed by it. What's more, the organs are damaged, or there are signs of disease. At the cellular level, it can also be seen that it destroys the structure and function of cells and affects the expression of genes.
In summary, 1-Chloro-2-Fluoro-4 - (Trifluoromethyl) Benzene is significantly toxic. Those who study this substance should be careful to prevent it from escaping, so as not to cause harm to the world, and it should not be ignored in terms of people's livelihood and health and ecology.
Future Prospects
1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is also a new product of chemical engineering. As of now, its use or not has been developed, but there is no prospect of it.







and in the field of materials, it is also expected to develop its capabilities. The new materials require special raw materials, which may be able to become the best materials and help materials with high performance. It is used in aerospace, electronics and other applications.
It is also in the process of synthesis, or an important cornerstone. With its beginning, it can be a kind of molecule, and the frontier of synthesis can be expanded.
Of course, 1 - Chloro - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene has not yet been developed. It is like a new rise in the future. It is full of hope, and it is waiting for us to explore it in depth. To make it possible.
Frequently Asked Questions
What are the main uses of 1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene?
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is widely used in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. Specific groups can be introduced through many chemical reactions to build a drug activity skeleton. For example, some antibacterial and antiviral drugs are synthesized, and their unique structures are combined with specific targets of pathogens to block the pathogenic process and achieve therapeutic effect.
Second, it is also an important raw material in the creation of pesticides. Based on this, chemically modified pesticides can be prepared with high efficiency, low toxicity and environmental friendliness. Due to its fluorine-containing structure, pesticides have better fat solubility and stability, so that they can better adhere to the surface of crops, resist pest attacks, and protect crop growth.
Third, in the context of material science, it is also useful. Can participate in the synthesis of special polymer materials, such as fluoropolymers. Such materials have excellent weather resistance, chemical resistance, and low surface energy, and are often used in high-end fields such as aerospace and electronics. In aerospace, it can be used as a protective material for the outer layer of aircraft to resist harsh environmental erosion; in electronic appliances, it can be used to make high-performance insulating materials to ensure the stable operation of electronic equipment.
Furthermore, in the field of organic synthetic chemistry, it is a powerful tool for organic synthetic chemists. Due to the differences in the activity of chlorine and fluorine atoms, they can selectively undergo substitution, addition and other reactions, providing the possibility for the construction of complex organic molecular structures and assisting the exploration and creation of new organic compounds.
What are the physical properties of 1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is an organic compound. It has the following physical properties:
The appearance is mostly colorless to light yellow liquid, which exists stably at room temperature and pressure. Looking at its color and state, it is intuitively observable.
The boiling point is related to the gasification temperature of this compound. Generally speaking, the boiling point of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene is within a certain range, but the exact value varies according to the experimental conditions. The boiling point is affected by the intermolecular force, and the characteristics of the intermolecular force determine the difficulty of gasification of this compound.
Melting point is the temperature at which a substance changes from solid to liquid. The melting point of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene is also a specific value, reflecting the conditions for its solid-liquid conversion. The melting point is related to the molecular arrangement and interaction, and the regularity of the molecular structure and the strength of the interaction force determine the melting point.
Density reflects the mass of the substance per unit volume. The density of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene is relatively stable. Due to its inherent physical properties, it is an important reference value for the mixing, separation and related process design of substances.
Solubility is related to the solubility of this compound in different solvents. 1-Chloro-2-fluoro-4- (trifluoromethyl) benzene has good solubility in organic solvents such as ethers and aromatics, but poor solubility in water. This property is based on the principle of "similar phase solubility", that is, molecules with similar polarities are easily soluble in each other, and their molecular polarity determines their solubility in different solvents.
Volatility refers to the ability of a substance to change from liquid to gaseous and dissipate. 1-chloro-2-fluoro-4- (trifluoromethyl) benzene has a certain volatility, and intermolecular forces and temperature affect its volatilization rate. Volatility affects the diffusion and existence of this substance in the environment, and needs attention in chemical production and use.
Refractive index is a measure of the degree of refraction of light when passing through the substance. The refractive index of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene is a specific constant, which is related to the molecular structure and electron cloud distribution, and can be used for the detection and identification of material purity.
What are the chemical properties of 1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene?
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene, this is an organic compound. Its chemical properties are unique, let me explain in detail for you.
In this compound, the presence of chlorine, fluorine and trifluoromethyl significantly affects its properties. The chlorine atom has a certain electronegativity, which can change the electron cloud density distribution of the benzene ring, and the electrophilic substitution reactivity of the benzene ring is different. Due to its electron-sucking induction effect, the electron cloud density of the benzene ring is relatively reduced, and the meta-potential is relatively high, so the electrophilic reagents are more likely to attack the meta-potential.
The fluorine atom is extremely electronegative, and its effect on the molecular properties On the one hand, the molecular polarity is strengthened, and on the other hand, the C-F bond energy is quite high, which enhances the stability of the compound. The introduction of fluorine atoms can change the molecular physical properties, such as boiling point, melting point, etc.
Trifluoromethyl is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and further weakens the electrophilic substitution activity of the benzene ring. However, under certain conditions, this group can participate in the reaction, such as the substitution reaction with nucleophiles.
1-chloro-2-fluoro-4 - (trifluoromethyl) benzene The chemical properties of benzene are active or not, depending on the reaction conditions and the reactants. Under suitable reagents and conditions, electrophilic substitution reactions such as halogenation reaction, nitrification reaction, and sulfonation reaction can occur. It can also be used as a raw material to participate in organic synthesis and prepare compounds with special functions.
What are the synthesis methods of 1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene
The synthesis of 1-chloro-2-fluoro-4- (trifluoromethyl) benzene is an important topic in organic synthetic chemistry. There are several common synthesis paths.
One of them can be initiated by halogenation reaction. First, the benzene derivative containing trifluoromethyl is used as the raw material, and chlorine atoms and fluorine atoms are introduced under specific reaction conditions. If a suitable halogenation reagent is selected, such as chlorine gas, ferric chloride, etc. are combined in a suitable temperature and solvent environment to realize the chlorination reaction at a specific position on the benzene ring. Then, fluorine-containing reagents, such as potassium fluoride, are used to introduce fluorine atoms into the predetermined position by means of nucleophilic substitution reaction. In this process, the choice of solvent is crucial. Polar aprotic solvents such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF) often help the reaction to proceed, because it can enhance the activity and solubility of the reagent.
Second, the target molecule can also be constructed by aromatic electrophilic substitution reaction. Using benzene with a specific substituent as a substrate, trifluoromethylation reagents such as trifluoromethylsulfonic anhydride are used to achieve the introduction of trifluoromethyl in the presence of Lewis acid catalysts such as aluminum trichloride. Subsequently, the chlorination and fluorination reactions are carried out in sequence. This path requires precise control of the reaction conditions to ensure that the substituents are connected to the benzene ring in the desired order and position. After each step of the reaction, high-purity intermediate products and final target products need to be obtained by separation and purification methods such as column chromatography and recrystallization to ensure the smooth progress of the reaction and the quality of the products. All these synthetic methods need to be carefully selected based on factors such as actual experimental conditions, availability of raw materials, and cost.
1-Chloro-2-Fluoro-4- (Trifluoromethyl) Benzene What to watch out for when storing and transporting
1-Chloro-2-fluoro-4- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage. This compound should be placed in a cool and ventilated warehouse. Because of its certain volatility and chemical activity, high temperature and no ventilation can easily cause its volatilization to intensify, or react with surrounding substances, endangering safety. The temperature of the warehouse should be controlled within a reasonable range, usually not exceeding 30 ° C. And it must be kept away from fire and heat sources. Open flames and hot topics can cause it to burn or even explode, so do not be careless.
In addition, it should be stored separately from oxidants and alkalis, and must not be stored in combination. The chemical properties of 1-chloro-2-fluoro-4 - (trifluoromethyl) benzene can meet with oxidants or cause severe oxidation reactions; contact with alkalis may also trigger chemical reactions, resulting in deterioration of substances, and even dangerous accidents.
Storage containers are also crucial. A well-sealed container must be used to prevent leakage. If using metal containers, consider their compatibility with compounds to avoid leakage due to corrosion and perforation.
As for transportation, transportation vehicles should be equipped with corresponding types and quantities of fire equipment and leakage emergency treatment equipment. During driving, make sure that the container does not leak, collapse, fall or damage. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to baffle to reduce shock and generate static electricity, because static electricity may cause the compound to burn and explode.
During transportation, do not stop in densely populated areas or residential areas. In the event of an emergency such as leakage, it should be dealt with immediately according to the emergency plan to evacuate the surrounding people and prevent secondary disasters such as poisoning and fire. Transport personnel should also be familiar with its characteristics and emergency treatment methods, so as to ensure the safety of storage and transportation.