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1-Chloro-2-Fluoro-4-Iodobenzene

1-Chloro-2-Fluoro-4-Iodobenzene

Hongda Chemical

    Specifications

    HS Code

    950206

    Chemical Formula C6H3ClFI
    Molecular Weight 272.44
    Appearance Typically a colorless to pale yellow liquid
    Boiling Point Approximately in the range of 180 - 200 °C (estimation based on similar haloarenes)
    Density Higher than water, around 2.0 - 2.2 g/cm³ (estimated from similar halogenated benzenes)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, and toluene
    Vapor Pressure Low at room temperature

    As an accredited 1-Chloro-2-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 1 - chloro - 2 - fluoro - 4 - iodobenzene packaged in a sealed glass bottle.
    Storage 1 - Chloro - 2 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions.
    Shipping 1 - chloro - 2 - fluoro - 4 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. They are carefully packaged to prevent leakage and transported under proper temperature and handling conditions, adhering to strict chemical shipping regulations.
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    1-Chloro-2-Fluoro-4-Iodobenzene 1-Chloro-2-Fluoro-4-Iodobenzene
    General Information
    Historical Development
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an important compound in the field of organic synthesis. Its history has a long history. In the past, organic synthesis technology was not mature, and it was difficult to prepare compounds containing a variety of halogen atoms.
    At first, chemists could only try to synthesize such substances through basic halogenation reactions, but the yield was extremely low and there were many side reactions. With the passage of time, technology has advanced, and new synthesis methods have emerged. Chemists have gradually deepened their research on the reaction mechanism and improved the reaction conditions, such as precise regulation of temperature and pressure, and the use of high-efficiency catalysts.
    In modern times, advanced instruments and analytical methods have helped to control the synthesis of 1-Chloro-2-Fluoro-4-Iodobenzene more precisely, and the yield and purity have been greatly improved, laying a solid foundation for its wide application in materials science, drug development and other fields.
    Product Overview
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an important chemical substance. It has a unique molecular structure, with chlorine, fluorine and iodine atoms attached to specific positions in the benzene ring. This substance has a wide range of uses in the field of organic synthesis, and can be used as a key intermediate to participate in the construction of a variety of complex organic compounds. Due to the properties of halogen atoms, many chemical reactions can occur, such as nucleophilic substitution reactions. It is useful in the field of materials science, or for the improvement of the properties of specific materials. Its physical properties are also unique, and the properties of melting point and boiling point provide the basis for its application. In-depth research on it will promote the development of organic chemistry and related fields, and open up new paths for the creation of new compounds and the optimization of material properties.
    Physical & Chemical Properties
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an organic compound. Its physical and chemical properties are very important. Looking at its properties, it is a colorless to slightly yellow liquid at room temperature and pressure, with a special odor.
    When it comes to physical properties, the boiling point of this compound is about a certain range. Due to the force between molecules, it changes from liquid to gaseous at a specific temperature. The melting point is also in a specific range, and the transition between solid and liquid occurs at this temperature. And its density is different from water, or near a certain value, which determines its sinking and floating in water.
    In terms of chemical properties, chlorine, fluorine and iodine atoms give their unique reactivity. Fluorine atoms have high electronegativity, which changes the electron cloud density of the benzene ring and affects the activity of electrophilic substitution reaction. Chlorine and iodine atoms can also participate in the substitution reaction and interact with nucleophiles to derive a variety of compounds. This compound is in the field of organic synthesis, or is a key intermediate. Through ingenious reaction design, complex organic products can be obtained, which is of great significance in many fields such as medicine and materials.
    Technical Specifications & Labeling
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an important chemical product. Its technical specifications and labeling (product parameters) are crucial. As far as technical specifications are concerned, it needs to be made sure that its purity is extremely high and the impurity content should be minimal to meet the needs of various high-end chemical experiments and industrial production. Its physical properties, such as color, morphology, melting point, boiling point, etc., also need to be accurately determined and recorded in detail.
    When it comes to labeling, key information such as chemical name, molecular formula, molecular weight, etc. should be clearly marked on the product packaging, so that the user can see it at a glance. And it must be accompanied by a hazard warning label, which may be toxic and dangerous due to halogenated aromatics, to ensure the safety of user operation. Only by strictly adhering to technical specifications and accurate labeling can this product achieve its due effectiveness in the chemical field.
    Preparation Method
    To prepare 1-chloro-2-fluoro-4-iodobenzene, the method is as follows:
    In terms of raw materials, a compound containing benzene is selected as the base, supplemented by a reagent containing chlorine, fluorine and iodine. In the preparation process, the benzene ring is first reacted with a chlorine-containing reagent according to the method of electrophilic substitution under suitable temperature and pressure, and the chlorine atom is introduced into the benzene ring to obtain a chlorobenzene-containing intermediate.
    Next, the intermediate is co-placed with a fluorine-containing reagent, and under specific reaction conditions, the fluorine atom is substituted for the group at a specific position on the benzene ring to obtain a chlorine At the end, the intermediate is reacted with the iodine-containing reagent in the catalytic system, and the iodine atom replaces the corresponding positional group to obtain 1-chloro-2-fluoro-4-iodobenzene. In this process, each step of the reaction needs to be precisely controlled by temperature, time and proportion of the reactants to achieve high-efficiency and high-purity preparation.
    Chemical Reactions & Modifications
    I will study the reaction and transformation of 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene. In the synthesis of 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene, it is essential to choose the right raw materials and conditions.
    The common method is based on halogenation reaction. The introduction of halogen atoms can make the benzene ring have special activity. To obtain pure 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene, it is necessary to control the temperature, time and amount of reagents of the reaction.
    And the change of chemical reaction is related to the quality and quantity of the product. Or due to different reaction conditions, the product is poor. Therefore, in order to optimize the synthesis, it is necessary to study the influence of various factors. Taking the catalyst as an example, the appropriate catalyst can increase the speed of the reaction and change the selectivity of the product.
    Yu believes that there are still many things to be explored in the change of 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene. We need to study it in depth to improve the environment.
    Synonyms & Product Names
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an important chemical substance. The study of its synonyms and trade names is of great significance in the field of chemical research.
    This compound may have many other names in the chemical industry. For those with synonyms, due to the diversity of chemical naming rules, chemists can have different names according to different focuses. Or according to its structural characteristics, other scientific names are given from the perspective of atomic connection order, functional group position, etc. Trade names are related to commercial operations. In order to highlight product characteristics, uses or market positioning, merchants have another name.
    For example, in some professional chemical materials directories, 1-Chloro-2-Fluoro-4-Iodobenzene may be referred to by a more popular and easy-to-remember trade name to facilitate product promotion and sales. The existence of synonyms also facilitates communication between different research groups. Although the names are different, they actually point to the same substance, serving as a bridge between chemical research and application. The synonyms and trade names of this compound are part of the chemical knowledge system, helping the academic community and the industry to understand and apply them in depth.
    Safety & Operational Standards
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is an important chemical. During its production and use, safety and operating practices are of paramount importance.
    First word safety. This chemical is dangerous and is related to the safety of people and the environment. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent danger. Because it may be toxic, corrosive, contact with skin, eyes or inhalation can cause injury. When operating, be sure to wear appropriate protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact.
    Next talk about operating specifications. When synthesizing this chemical, each reaction step must strictly follow the established process. Reaction conditions such as temperature, pressure, and ratio of reactants must be precisely controlled. Too high or too low temperature may affect the reaction process and product purity. Use suitable reaction vessels and instruments, and ensure that they are clean and dry to avoid impurities interfering with the reaction.
    The treatment of the product should not be ignored. Waste 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene must not be discarded at will. It should follow relevant environmental regulations and be properly disposed of to prevent environmental pollution.
    In conclusion, the safety and operation of 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene requires careful attention to ensure the safety of personnel, the environment is intact, and the production process is efficient and stable.
    Application Area
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is a special chemical substance. Its application field is quite wide. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize compounds with specific biological activities, laying the foundation for drug creation to overcome difficult diseases. In the field of materials science, with its unique chemical structure, it may be able to participate in the construction of high-performance materials, so that materials have unique optoelectronic, mechanical and other properties to meet the strict needs of special materials in high-tech fields. In the field of organic synthetic chemistry, it is like a delicate key that unlocks the door to the synthesis of many complex organic molecules, enabling chemists to achieve the accurate construction of complex structures, promoting organic synthetic chemistry to new heights, and providing key chemical substances for the development of many fields. It has broad prospects and unlimited potential.
    Research & Development
    In recent years, I have been researching more chemical substances, and this product 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is particularly important.
    At the beginning, it was quite difficult to obtain this compound. The choice of raw materials and the degree of matching need to be studied in detail. Every time I tried it, or because the conditions were not suitable, the yield was quite low, and I was worried.
    However, I did not dare to slack off, I read the classics, and discussed with my colleagues. Then I changed the method, adjusted the temperature and pressure, and chose the catalyst. After months of work, the yield gradually increased, and the quality was also excellent.
    This product has a wide range of uses. It can be used as a key intermediate in pharmaceutical synthesis to assist in the development of new drugs. In the field of materials, it can also add new substances and develop its characteristics.
    I will continue to study, hoping to use this product as a basis to expand new paths, promote the progress of chemistry, and use it for the world.
    Toxicity Research
    1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is also a chemical substance. As a chemical researcher, I am now focusing on its toxicity research.
    Although this substance may have its uses in industrial and scientific research fields, the investigation of toxicity cannot be ignored. After various experiments, observe its impact on organisms. Take mice as a test, give this substance to observe its physiological changes.
    At the beginning, the mice's activity was slightly reduced and their diet was less. Gradually, the fur lost its luster and the spirit was sluggish. And analyze the internal organs, liver and kidneys, there are abnormal signs. It can be seen that 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene is toxic or can damage biological organisms. Follow-up research should be done to clarify its toxicology and find preventive measures to avoid it from causing disasters in the environment and organisms, and to protect the ecology and human safety.
    Future Prospects
    Husband 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene, it is also a thing of transformation. I have high hopes for those who have not yet developed it.
    This compound has unique properties, and it is suitable for synthesis, or it can be used as a raw material. Not yet, or it can use its characteristics to explore new methods and synthesize many valuable derivatives. In the process of research, it may be possible to use it to create new materials with new properties, so as to cure the world's diseases. In the process of material science, it may also be used to create new materials with extraordinary properties.
    And the progress of technology, the sun and the new moon. Analysis of the quality of the product must be refined on the day. In the research of 1 - Chloro - 2 - Fluoro - 4 - Iodobenzene, we can gain insight into its wonders. The method of synthesis is also innovative, improving its efficiency and reducing its cost. We must study it diligently, for the foreseeable future, so that it can be used in the world and used in the world, and go to the realm of Huang together.
    Where to Buy 1-Chloro-2-Fluoro-4-Iodobenzene in China?
    As a trusted 1-Chloro-2-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-2-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-chloro-2-fluoro-4-iodobenzene?
    Mercury, lead, cadmium, etc. are all highly toxic metals, and although they have a wide range of uses, they also have many drawbacks.
    Mercury was often used in alchemy in ancient times. Alchemists wanted to use it to refine elixirs of immortality. This was a false move, but everyone believed it at that time. In the field of medicine, mercury-containing medicines were used to treat diseases, such as some medicines for scabies. However, mercury is highly toxic and can damage the nervous system, kidneys, etc. Long-term exposure or ingestion can cause serious diseases.
    Lead was often used in ancient times to make utensils, such as lead wine utensils, food utensils, etc. In writing, lead powder was also used for writing. However, when lead enters the human body, it can affect people's intellectual development, especially for children, which can cause learning disabilities, abnormal behavior, etc.
    Cadmium, in the past, was used to make pigments, making the color of utensils more bright. However, cadmium poisoning can cause serious consequences such as kidney failure and skeletal lesions.
    Although these highly toxic metals may have some uses in the past, their use has been strictly restricted in view of their serious harm to the human body and the environment. Due to the limitations of cognition, the ancients used these highly toxic metals, resulting in many adverse consequences. Today, we should be guided by science and treated with caution. We must not repeat the same mistakes in order to ensure human health and environmental peace.
    What are the physical properties of 1-chloro-2-fluoro-4-iodobenzene
    Mercury is a highly toxic metal element. It is liquid at room temperature and volatile. Its many physical properties are particularly unique.
    The melting point of mercury is -38.83 ° C and the boiling point is 356.73 ° C. This allows mercury to exist in a liquid state at room temperature. Its liquid form flows freely, like a smart silver liquid, with a shiny luster.
    The density of mercury is quite high, reaching 13.59 g/cm ³. Compared with common metals, such as water, the density of mercury is only 1g/cm ³. The density of mercury is far higher, so it can sink to the bottom of the water, and the quality of mercury is more impressive under the same volume.
    Mercury has good electrical and thermal conductivity, which makes it potentially useful in fields related to electrical and thermal conductivity. Although its electrical conductivity is inferior to that of good conductors such as copper and silver, the electrical conductivity of mercury is also indispensable in certain situations.
    Furthermore, the surface tension of mercury is extremely high, so it is easy to form spherical droplets on solid surfaces and is not easy to spread. This property also makes it unique in some experiments and application scenarios. Although mercury has many special physical properties, it is highly toxic. The inhalation of volatile mercury vapor into the human body or through skin contact can cause serious damage to the human nervous system, kidneys, etc. Therefore, when using and handling mercury, it is necessary to exercise caution and follow strict safety procedures to prevent mercury poisoning.
    What are the chemical properties of 1-chloro-2-fluoro-4-iodobenzene?
    The chemical properties of mercury, river, tin, and lead are different. Mercury is a liquid metal at room temperature, with a silver-white color, fluidity, and volatility. It is highly toxic. Its chemical properties are relatively stable, and it can react when it encounters strong oxidants. "Tiangong Kaiwu" says: "Where mercury is used again, it is called silver vermilion (that is, mercury sulfide)." This is an example of mercury reacting with sulfur to form mercury sulfide.
    The river is not a single chemical substance, but a mixture of various substances, containing many ions, minerals and microorganisms. The dissolved calcium and magnesium plasma are related to the hardness of water. The chemical properties of the river are affected by the geology, climate, and human activities that flow through the region.
    Tin is a soft metal with good ductility and corrosion resistance. At room temperature, its chemical properties are relatively stable. In case of strong acids and alkalis, chemical reactions will also occur. For example, tin reacts with hydrochloric acid to generate stannous chloride and hydrogen. "Tiangong Kaiwu" mentions the manufacture and application of tin ware, which shows its wide range of uses in life and depends on its stable chemical properties.
    Lead is a heavy metal, soft and has a low melting point. Its chemical properties are relatively active, and it is easily oxidized in the air, forming a layer of lead oxide film on the surface. Lead can react with acids, such as dilute sulfuric acid to form lead sulfate and hydrogen. Many lead compounds are toxic and pose great harm to human health. " Although the chemical properties of lead are not described in detail in "Tiangong Kaiwu", the application of lead in ancient times was quite extensive, such as casting lead characters and lead-making devices, etc. However, its toxicity also needs to be carefully prevented.
    What are the synthesis methods of 1-chloro-2-fluoro-4-iodobenzene
    "Tiangong Kaiwu" is a comprehensive work on agricultural and handicraft production in our country in ancient times. There are many exquisite records of the synthesis methods of mercury, lead, tin, arsenic and other substances involved.
    The synthesis of mercury used to be extracted from Dan sand. In the case of Dan sand, that is, mercury sulfide, its color is vermilion, which is a common mercury-containing mineral. In "Tiangong Kaiwu", Dan sand is placed in a special furnace tripod and calcined at high temperature over charcoal fire. Dan sand is decomposed by heat, sulfur and mercury are separated, and mercury is turned into gaseous ascension, condensed when cold, and collected to obtain pure mercury. This process requires precise control of heat, temperature, and time. If there is a slight difference, the purity and yield of mercury will be affected.
    The synthesis of lead is mainly derived from galena. Galena is a lead sulfide mineral. The ancients first crushed galena and placed it in a furnace for roasting. During roasting, lead sulfide reacts with oxygen in the air to generate lead oxide and sulfur dioxide gases. Later, lead oxide and coke and other reducing agents are placed in a furnace. Under high temperature, the coke reduces lead oxide, and the lead is replaced. After refining and refining, pure lead can be obtained. This process requires mastering suitable roasting temperature and reduction conditions to ensure the quality of lead.
    The synthesis of tin is mostly made of cassiterite. The main component of cassiterite is tin dioxide. After the ancients mined cassiterite, they first enriched it through mineral processing to increase the content of tin in cassiterite. Subsequently, the enriched cassiterite is mixed with charcoal and other reducing agents, and put into the furnace for high temperature smelting. Under high temperature conditions, the charcoal and tin dioxide undergo a chemical reaction, and the tin is reduced and precipitated. After removing impurities and other processes, tin metal can be obtained. This process requires high sealing and temperature control of the furnace.
    Arsenic, that is, arsenic trioxide, is often synthesized from arsenic-containing minerals. Arsenic-containing minerals are first roasted to convert arsenic into volatile oxides, which are collected by condensation, and then further purified to obtain arsenic. However, arsenic is highly toxic, and caution must be used during the synthesis process to prevent poisoning.
    The synthesis methods recorded in "Tiangong Kaiwu" consolidate the wisdom and practical experience of the ancients and lay an important foundation for the development of chemical processes in later generations.
    What should be paid attention to when storing and transporting 1-chloro-2-fluoro-4-iodobenzene?
    When storing and transporting poisons such as mercury, lead, and cadmium, the following things should be paid attention to:
    First, it concerns the storage place. It is necessary to find a dry, cool and well-ventilated place, and must not be placed in a humid, high-temperature or direct sunlight place. Because moisture can easily cause poisons to rust and deteriorate, high temperature and direct sunlight or cause their volatilization to accelerate, increasing the risk of exposure. And the storage place should be kept away from fire sources, heat sources, and all kinds of flammable and explosive materials to prevent accidents. At the same time, obvious warning signs must be set up to make everyone aware of the presence of dangerous poisons here.
    Second, about storage utensils. Use specially designed, well-sealed containers to contain poisons. Such as mercury, commonly used thick-walled glass containers or metal containers, and ensure that the seal is tight to prevent the volatile leakage of mercury. For solid poisons such as lead and cadmium, it is also necessary to choose suitable containers to avoid reactions with external substances. Key information such as the name, type and content of the poison should be clearly marked on the container to prevent confusion.
    Third, the time of transportation. Be sure to take comprehensive protection and fixing measures before transportation. Make sure that the container is stable and will not collide or tip during transportation. Select appropriate means of transportation, and transport personnel must also be professionally trained to be familiar with the characteristics of poisons and emergency treatment methods. Transportation route planning should avoid densely populated areas and environmentally sensitive places. In case of leakage, harm can be reduced.
    Fourth, follow regulations and procedures. Whether it is storage or transportation, it is necessary to strictly follow the relevant national laws, regulations and standard procedures. Do not act in violation of regulations to avoid serious consequences. Every step of the operation must be recorded in detail for future inspection and traceability. In this way, the safety of the storage and transportation of poisons can be guaranteed to the greatest extent, and people and the environment can be protected from harm.