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1-Chloro-2-Fluoro-3-Nitrobenzene

1-Chloro-2-Fluoro-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code

944468

Chemical Formula C6H3ClFNO2
Molar Mass 177.545 g/mol
Appearance Yellow - liquid
Boiling Point Around 225 - 227 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Vapor Pressure Low vapor pressure at room temperature

As an accredited 1-Chloro-2-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 2 - fluoro - 3 - nitrobenzene packaged in 5 - kg drums.
Storage 1 - Chloro - 2 - fluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Regularly check storage conditions and container integrity.
Shipping 1 - chloro - 2 - fluoro - 3 - nitrobenzene is a hazardous chemical. Shipments must comply with strict regulations. It should be properly packaged, labeled, and transported by carriers authorized for such chemicals to ensure safety during transit.
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1-Chloro-2-Fluoro-3-Nitrobenzene 1-Chloro-2-Fluoro-3-Nitrobenzene
General Information
Historical Development
1-Chloro-2-fluoro-3-nitrobenzene is also an organic compound. Its origin is really related to the evolution of chemical technology. In the past, organic chemistry became popular, and the preparation and research of various compounds was initially developed. When people studied halogenated nitrobenzene, they tried to expand their synthesis methods.
In the past explorations, chemists worked hard to find a way to synthesize this compound through repeated experiments. At that time, the instruments were not as delicate as they are today, but chemists relied on their determination to analyze the reaction mechanism and improve the process.
With the passage of time, science and technology have advanced day by day, and the synthesis of 1-chloro-2-fluoro-3-nitrobenzene has become more and more perfect. From the initial rough method to the fine and controllable process, its position in the field of organic synthesis has gradually emerged. It not only laid the foundation for subsequent organic synthesis research, but also emerged in the fields of materials and medicine, becoming a key link in the history of chemical development.
Product Overview
1-Chloro-2-fluoro-3-nitrobenzene is also an organic compound. It is a colorless to pale yellow liquid with a special odor. In the molecular structure, above the benzene ring, there is one chlorine atom, one fluorine atom and one nitro group, which gives it special chemical properties.
This compound is of great importance in the field of organic synthesis. Due to the strong electron absorption of nitro groups, the electron cloud density of the benzene ring is reduced, making nucleophilic substitution reactions more likely to occur. And chlorine and fluorine atoms also provide various possibilities for subsequent reactions. Various functional groups can be introduced through substitution, coupling and other reactions to prepare intermediates of various drugs, pesticides and functional materials.
However, the preparation process needs to be carefully controlled, and the reaction conditions such as temperature, catalyst, and the proportion of reactants are all crucial. If there is a slight difference, the yield may be reduced, or side reactions may be generated. Therefore, in order to obtain high purity and high yield of 1-chloro-2-fluoro-3-nitrobenzene, the optimization of the synthesis process is indispensable.
Physical & Chemical Properties
1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, it is mostly liquid at room temperature, with a color or nearly colorless, and has a certain volatility, odor or irritation. As far as its chemical properties are concerned, there are chlorine, fluorine, nitro and other groups connected to the benzene ring, which makes its chemical activity unique. Chlorine atoms can participate in nucleophilic substitution reactions, while fluorine atoms have strong electronegativity, which affects the distribution of molecular electron clouds, resulting in changes in reactivity and selectivity. Nitro is a strong electron-absorbing group, which reduces the density of the electron cloud of the benzene ring, and is more prone to electrophilic substitution reactions, and is mostly substituted in meta sites. The physicochemical properties of this compound are of great significance in the field of organic synthesis, providing key raw materials and intermediates for the preparation of many fine chemicals, and promoting the development and application of organic chemistry.
Technical Specifications & Labeling
1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene is an important chemical substance. Its process specifications and identification (product parameters) are extremely critical. In terms of process specifications, it is necessary to precisely control the reaction conditions, such as temperature, pressure and ratio of reactants. Temperature may need to be maintained in a specific range, and pressure is also strictly required to ensure that the reaction is efficient and the product is pure.
When it comes to labeling, its chemical name, molecular formula, molecular weight and other basic information should be clearly marked. At the same time, safety labeling is indispensable to warn latent risks. Product parameters such as purity, impurity content, etc., must be strictly measured and recorded. Purity is related to its application efficiency. Excessive impurity content or adverse consequences.
In this way, strict adherence to process specifications and accurate identification (determination of product parameters) can ensure the quality and safe application of 1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene.
Preparation Method
1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene is an important compound in organic synthesis, and its preparation method is very important.
In the selection of raw materials, it is appropriate to use o-fluorochlorobenzene and mixed acid (mixture of nitric acid and sulfuric acid). The two reactivity adaptations can lay a good foundation for the reaction.
The synthesis process is as follows: In a suitable reaction vessel, slowly drop o-fluorochlorobenzene into the mixed acid at low temperature, and stir at the same time to ensure that the reactants are in full contact. Add it dropwise and gradually heat up to a certain range to make the reaction proceed smoothly.
Reaction steps: Under the action of mixed acid, the benzene ring of o-fluorochlorobenzene is replaced by the nitro group first, and the nitro group is introduced. The reaction conditions in this step need to be precisely controlled, and temperature and time are the key variables.
Catalytic mechanism: Sulfuric acid acts as a catalyst in the reaction, which can enhance the electrophilicity of nitric acid, promote the nitro group to attack the benzene ring more easily, accelerate the reaction rate and improve the yield. After the above steps, the target product 1-Chloro-2-Fluoro-3-Nitrobenzene can be obtained.
Chemical Reactions & Modifications
In recent years, there have been many achievements in the chemical reaction and modification of 1-Chloro-2-Fluoro-3-Nitrobenzene. The chemical reaction of this compound has become complicated. In the past, many attempts were made due to the harsh conditions and the small yield.
We studied the reaction mechanism in detail and gained insight into the relationship between various factors. In the selection of catalysts, after many tests, we found that a new type of composite catalyst can significantly promote the reaction process. Modify the conditions, adjust the temperature and pressure, and make the interaction between molecules orderly, so that the reaction is smooth.
As for the modification, specific groups are introduced by the method of precise molecular design. This move does not specifically modify its physical properties, and the chemical properties also change dramatically. The stability is increased, the activity is controllable, and the field of application is expanded.
After this research, the transformation and modification of 1-Chloro-2-Fluoro-3-Nitrobenzene should gradually become clear, paving a solid foundation for subsequent in-depth exploration and practical application.
Synonyms & Product Names
1-Chloro-2-fluoro-3-nitrobenzene, the synonym and trade name of this substance, is quite crucial. In the field of my chemical research, the names of many substances are often different due to their uses, origins, traditional names, etc.
1-chloro-2-fluoro-3-nitrobenzene, or "o-chloro-nitrobenzene", this name is taken from the positional relationship of chlorine, fluorine, and nitro in its molecular structure. It is called by the adjacency relationship, which is concise and clear, and is convenient for industry communication. There are also names related to their special properties or preparation processes, such as "Teflon-chloronitrobenzene", although not widely spread, it is also synonymous with it in specific research groups or production processes. As for the trade name, because it involves commercial promotion and marketing distinction, or the name "euflon-chloronitrobenzene" means that this product has excellence in purity, quality, etc., in order to attract consumers' attention and occupy a place in the chemical product market. These are all synonyms and trade names for 1-chloro-2-fluoro-3-nitrobenzene, reflecting the diversity and practicality of naming in the chemical field.
Safety & Operational Standards
1-Chloro-2-fluoro-3-nitrobenzene, chemical products are also used. Its safety and operating standards should not be careless.
The preparation of this product must be in a clean and free place, and it must be fully ventilated. All kinds of equipment should be clean and intact, and must be carefully inspected before use. Operators must also wear protective equipment, such as gloves, eyepieces, masks, etc., to prevent contact with the skin and entry into the eyes.
As for the reaction, control the temperature and adjust the fire, and be cautious. The temperature is high or low, which is related to the smooth reaction, slightly poor, or accidental. The size of the fire should also be appropriate, and it should not be large or small. And the reaction process must be closely observed. If there is any abnormality, stop it quickly, investigate the cause in detail, and then make a decision.
When storing, it should be placed in a cool and dry place, away from fire and heat sources. It must also be separated from oxidation and reduction to prevent their interaction and unexpected changes.
When taking it, take it according to the quantity, and do not waste it or take more. After using it, the container must be cleaned, and the rest should be placed in its original place.
Between transportation, the package must be strict and clearly marked. Vehicles should be equipped with protective devices to absorb shock and collision.
In short, the safety and operation specifications of 1-chloro-2-fluoro-3-nitrobenzene are interlinked, and they are all related to personal safety and experimental success. Operators must be cautious and must not be slack in the slightest.
Application Area
1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene is an organic compound with a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate. With the rationality of ancient pharmaceuticals, it is just like an indispensable medicinal primer in prescriptions, which affects the whole body. With this compound, it can cleverly build the framework of many drug molecules, help synthesize special drugs and heal diseases.
In the field of materials science, it also has unique uses. It is like adding bricks and mortar to the construction of delicate materials, which can endow materials with specific properties. If treated by a specific process, the material can have better stability and functionality, just like the careful carving of ancient craftsmen, giving the utensils extraordinary characteristics.
Furthermore, in the field of pesticide research and development, it has also emerged. Just like the magic weapon to resist pests in ancient times, after rational deployment, it can synthesize high-efficiency and low-toxicity pesticides, protect crops and ensure the growth of crops.
Research & Development
In recent years, I have studied a lot of chemical substances, 1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene, which is especially important to me. Its structure is unique and its properties are unique, and it has great potential in the field of organic synthesis.
When I first came into this substance, I felt that its synthesis was difficult. If there is a slight difference in the ratio of raw materials and reaction conditions, it will be difficult to achieve positive results. However, I did not give up. After repeated experiments and careful observation of the changes in the reaction, I finally obtained an exquisite method. According to this method, the yield is gradually increasing and the quality is also excellent.
Not only this, but I also explore its application. It can be used in the production of medicine and pesticides. Based on it, many compounds can be derived with significant effects.
I believe that with time and continuous research, 1-Chloro-2-Fluoro-3-Nitrobenzene will be able to apply its capabilities to industrial production, contributing to the development of chemistry, and promoting the progress and expansion of this field.
Toxicity Research
Since modern times, chemical refinement has advanced, and new substances have proliferated. Today there is 1-Chloro-2-Fluoro-3-Nitrobenzene. The study of its toxicity is related to people's health and cannot be ignored.
The toxicity of this substance first involves the body of living beings. After various experiments, if it enters the body of an animal, it may disturb its physiological order. Looking at its cells, there may be aberrations, which may damage its normal ability. And it may also invade the nervous system, causing perverse movements and delayed reactions.
Furthermore, the dispersion of this substance in the environment is also a serious problem. In the water, if it contains this poison, the aquatic race, from microalgae to giant fish, will be harmed by it, and the ecological balance is at risk. In the soil, it can also accumulate, hindering the growth of plants, grains, vegetables and fruits, or being contaminated with its poison, endangering eaters.
Our generation is a chemical researcher. It is our responsibility to investigate the root of this poison, explore protection strategies, prevent it from harming the unborn, and ensure the safety of all things and the peace of people's livelihood.
Future Prospects
In the unfinished world, the things that are transformed will be developed. 1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene This product is also the energy of the world. It can be used in the multi-domain, or the basis of synthesis, to heal diseases and make people healthy; or as a source of material research, new materials, and a wide range of uses.
I am the researcher of the world, and I will explore its secrets. I hope to use new technologies and new methods to improve its efficiency and improve its character. Looking forward to the future, this product can bring great color, the world's progress, and the well-being of people. Extraordinary power. The exhibition of 1 - Chloro - 2 - Fluoro - 3 - Nitrobenzene will be as bright as a star, illuminating the road to the future, forming thousands of years of hard work and creating a generation of power.
Where to Buy 1-Chloro-2-Fluoro-3-Nitrobenzene in China?
As a trusted 1-Chloro-2-Fluoro-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Chloro-2-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-2-fluoro-3-nitrobenzene?
Mercury, lead, and cyanopyridine are all chemicals with different uses, which are described below.
Mercury, also known as mercury, is a liquid metal at room temperature. In ancient times, it was often used in alchemy. The alchemists believed that it could refine the elixir of immortality. Although this pursuit never came true, the process of alchemy accumulated a lot of chemical knowledge. In the medical field, mercury was used to make thermometers and sphygmomanometers, using its properties of thermal expansion and contraction to accurately measure body temperature and blood pressure. However, due to the toxicity of mercury, such applications are gradually being replaced. In the chemical industry, mercury can be used as a catalyst to participate in specific chemical reactions, speeding up the reaction process.
Lead, soft and malleable. In ancient times, lead was often minted into currency, utensils, etc. Because of its relatively stable chemical properties, it can resist a certain degree of corrosion. In modern times, lead-acid batteries are an important application field of lead, widely used in automobiles, electric vehicles, etc., to provide power support. In addition, lead is also used in the manufacture of radiation protection materials, such as protective doors and protective clothing in hospital radiology departments, because it can effectively block X-rays and gamma rays.
Cyanopyridine, as a key intermediate in organic synthesis, occupies an important position in the pharmaceutical industry. Cyanopyridine is used as the starting material for the synthesis of many drugs, and a series of chemical reactions are used to construct the specific structure of drug molecules for the treatment of various diseases. In the field of pesticides, cyanopyridine can be derived from pesticide products with insecticidal, sterilization, weeding and other effects to ensure the healthy growth of crops and increase food production. At the same time, in the field of materials science, it can be used to synthesize new polymer materials, giving materials unique properties such as better heat resistance and corrosion resistance.
What are the physical properties of 1-chloro-2-fluoro-3-nitrobenzene
Mercury is soft and flowing, often in a liquid state, with a silvery white color and a metallic luster. Its density is quite high, about 13.6 times that of water. The boiling point of mercury is 357 degrees Celsius, and the melting point is minus 39 degrees Celsius. This property allows it to remain liquid at room temperature. However, mercury is volatile, and its vapor is toxic. If inhaled too much, it is harmful to the human body.
Water is a colorless, odorless, and transparent liquid. The density of water is one gram per cubic centimeter, which is the commonly used density reference standard. The boiling point of water is 100 degrees Celsius, and the melting point is zero degrees Celsius. Water has good solubility, and many substances can be dissolved in it, so it is often used as a solvent. And the specific heat capacity of water is large, when absorbing or releasing a lot of heat, its own temperature change is small, which plays an important role in regulating climate.
Aminonaphthalene is an organic compound. It has certain chemical stability, but under specific conditions, various chemical reactions can occur. Aminonaphthalene is mostly solid and has a specific crystal structure. Its physical properties, such as melting point, boiling point, etc., vary depending on the specific type of aminonaphthalene. Generally speaking, its melting point is relatively high, and it requires a specific temperature to melt into a liquid state. In addition, aminonaphthalene has certain solubility in organic solvents, but poor solubility in water.
What are the chemical properties of 1-chloro-2-fluoro-3-nitrobenzene?
Mercury is fluid and changeable, liquid at room temperature, shining silver-white light, and volatile. Its vapor is highly toxic and can quietly enter the body, damage the viscera, especially the brain and kidneys.
Water is the most soft thing, nourishing all things. Its nature is peaceful, colorless and odorless, and it is the source of life. It can dissolve many substances, participate in various biochemical reactions, and cycle in the world to maintain ecological balance.
Lithium amide has active chemical properties. It is a white crystal, which reacts violently when exposed to water, releasing hydrogen and generating lithium hydroxide. It has strong reducing properties and is an important reagent in the field of organic synthesis, often assisting in the progress of chemical reactions to produce various organic compounds.
Mercury is a liquid at room temperature, and water nourishes and is peaceful. Lithium amide is active and reacts violently. The chemical properties of the three are significantly different, and each has its own unique characteristics. In the field of nature and chemistry, each performs its own duties, showing the wonders of the chemical world.
What are the synthesis methods of 1-chloro-2-fluoro-3-nitrobenzene?
There are many ways to synthesize mercury, lead, and cyanopyridine, and each method has its own advantages and disadvantages. In the era of "Tiangong Kaiwu", although the skills may be different, the principle can be passed. Today, in ancient Chinese, it is briefly described as follows.
The synthesis of mercury, in the past, or the method of using dansha for smelting. For dansha, mercury sulfide is also. The dansha is placed in a closed cauldron, calcined with charcoal fire, the dansha is heated and decomposed, and the sulfur and mercury are separated. Mercury gas rises, condensed when cold, and then mercury is obtained. "Tiangong Kaiwu" also contains that the dansha ore is excavated, crushed, and smelted in a furnace. The furnace is covered with a condensing vessel, and the mercury is steamed and gathered on it. This is the outline of the ancient method of smelting mercury.
As for the synthesis of lead, galena is often used as a raw material. In the case of galena, lead sulfide is also used. The galena is first roasted to convert it into lead oxide, and then reduced to carbon. In the furnace, the carbon reacts with lead oxide, and the carbon captures the oxygen in the lead oxide, and the lead is reduced. The ancients often used an earth furnace as a device and firewood as fuel to control the heat and make the reaction smooth. Lead ore enters the furnace, is roasted and reduced at high temperature, and the lead liquid flows out, and cools into lead blocks.
Synthesis of cyanopyridine, in the era recorded in "Tiangong Kaiwu", there is no clear record of this chemical. However, based on the current chemical principle, it can be obtained by the reaction of pyridine and cyanide reagents. If pyridine is used as the starting material, under appropriate catalyst and reaction conditions, a nucleophilic substitution reaction occurs with cyanide reagents such as potassium cyanide, and a cyano group is introduced to obtain cyanopyridine. However, this reaction condition is quite harsh, and factors such as temperature, pressure and reactant ratio need to be precisely controlled to obtain a higher yield product.
What are the precautions for using 1-chloro-2-fluoro-3-nitrobenzene?
It is impossible to ignore the things used, such as oil, oxygen, and carbonyl.
Water, and flammable, often used as fuel and raw materials. Use it, and it will be a fire hazard. Mixing in the air, in case of open flame or high temperature, it is easy to explode. Therefore, it is convenient to store, and it is good to save the source of fire, the source of fire, and the fire is prohibited. The secrecy of the investigation should also be controlled. If there is a leak, it is the source of fire. Do not encounter fire, and quickly disperse it.
Oxygen is not flammable, but it is combustion-supporting. When used, there is no flammable material around. Oxygen and grease are connected, and it is easy to cause strong oxidation and reaction, causing fire and even explosion. Operator's hands, clothing, tools, etc., should not be contaminated with grease. And do not perform open flames such as welding in an oxygen-enriched environment. If necessary, it must be prevented.
Carbonyl, toxic and easy to burn. Use it, and use it through the operation to prevent inhalation of its steam. If you inhale it carelessly, you may be afraid of respiratory and mental systems. After using it, properly dispose of the leftovers, and do not deliberately dispose of it, so as not to pollute the environment.
As for the use of oxygen, oxygen, and carbonyl materials, you must be familiar with their properties, follow the operation requirements, and pay attention to safety to ensure safety.