1-Chloro-2,4,6-Trifluorobenzene

Hongda Chemical

Specifications

HS Code	459756
Chemical Formula	C6H2ClF3
Molar Mass	182.53 g/mol
Appearance	Colorless liquid
Boiling Point	116 - 118 °C
Density	1.42 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents
Flash Point	26 °C
Odor	Characteristic odor
Stability	Stable under normal conditions

As an accredited 1-Chloro-2,4,6-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1-chloro-2,4,6 - trifluorobenzene in 500 mL glass bottles, tightly sealed.
Storage	1 - Chloro - 2,4,6 - trifluorobenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, acids, and bases to prevent potential chemical reactions. Ensure proper labeling for easy identification and safety.
Shipping	1 - chloro - 2,4,6 - trifluorobenzene is shipped in specialized containers compliant with chemical transport regulations. Shipment is carefully monitored for temperature and safety to prevent spills and ensure secure delivery.

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General Information

Historical Development

1 - Chloro - 2,4,6 - Trifluorobenzene is an important chemical in organic synthesis. Tracing its historical development, chemical research in the past was still in its infancy, and there was little exploration of such halogenated aromatics. Later, with the improvement of chemical theory and the refinement of experimental technology, chemists began to focus on aromatic hydrocarbons containing special substituents. After repeated research and countless experimental attempts, the synthesis method gradually came out. At first, the synthesis process was complicated, the yield was low, and the cost was high. However, researchers made unremitting efforts to continuously optimize the reaction conditions and explore new catalysts, making the synthesis process simpler and more efficient, and the yield was also significantly improved. Today, 1-Chloro-2,4,6-Trifluorobenzene is widely used in medicine, materials and other fields, and has become an indispensable key chemical to promote the development of modern chemical industry. Its historical evolution has witnessed the vigorous development of chemical disciplines.

Product Overview

1 - Chloro - 2,4,6 - Trifluorobenzene is an important chemical substance. It is a colorless to slightly yellow liquid with a unique odor. This compound has a wide range of uses in the field of organic synthesis.
In chemical production, it is often prepared by specific chemical reactions. Its molecular structure is unique, with chlorine atoms and three fluorine atoms connected to specific positions in the benzene ring, giving it special chemical properties.
Because of its fluorine-containing atoms, it has high stability and chemical inertness, and has attracted much attention in many fields such as materials science and medicinal chemistry. In terms of materials, it can be used as a raw material for materials with special properties; in medicinal chemistry, or participate in the synthesis of active pharmaceutical ingredients.
In conclusion, 1-Chloro-2,4,6-Trifluorobenzene has broad application prospects in many fields due to its unique structure and properties, and is worthy of in-depth research and exploration.

Physical & Chemical Properties

1 - Chloro - 2,4,6 - Trifluorobenzene is an organic compound. Its physical properties are unique. It is mostly a colorless liquid at room temperature and has a special odor. The density is slightly larger than that of water, and it can form a stratification phenomenon with water under certain conditions. The boiling point is about a specific range, which makes it possible to realize gas-liquid transformation at the corresponding temperature.
In terms of chemical properties, it is active because it contains chlorine and fluorine atoms. The chlorine atom can undergo a substitution reaction and can be replaced by other nucleophiles. The fluorine atom changes the electron cloud density of the benzene ring, which affects its reactivity. It can participate in a variety of organic synthesis reactions and has important applications in the preparation of compounds in the fields of medicine, pesticides, etc. And because of its fluoride content, some products have unique biological activity and stability, which has attracted much attention in modern chemical synthesis.

Technical Specifications & Labeling

1 - Chloro - 2,4,6 - Trifluorobenzene is a crucial raw material in organic synthesis. Its process specifications are related to product quality and performance. The purity of this product needs to reach a very high level, and the impurity content must be strictly controlled. Generally speaking, the main content should not be less than 99%, and the moisture content should not be higher than 0.1%.
Its appearance should be a colorless and transparent liquid with no visible impurities. The odor must have the unique smell of the substance and no abnormal odor. To identify this product, various means can be used. First, gas chromatography is used to accurately determine its purity and impurity status according to the retention time and peak area. Second, infrared spectroscopy is used to determine the molecular structure according to its characteristic absorption peak to distinguish the authenticity.
Precise control of process specifications and product parameters is a key guarantee for the quality of 1-Chloro-2,4,6-Trifluorobenzene, which is indispensable in chemical applications.

Preparation Method

1 - Chloro - 2,4,6 - Trifluorobenzene is an important compound in organic synthesis. The preparation method, raw materials and production process are very important.
Preparation of this compound, the common raw materials are fluorine-containing and chlorine-containing benzene derivatives. In the production process, the reaction steps are divided into sequence. Starting with a specific halogenated benzene, under suitable reaction conditions, fluorine atoms are introduced. This reaction requires precise regulation of temperature, pressure and catalyst dosage.
The reaction steps are as follows: First, the halogenated benzene is placed in a special reactor, and an appropriate amount of catalyst, such as metal halide, is added. When heated to a specific interval, a fluorine-containing gas is introduced, and after a nucleophilic substitution reaction, some halogen atoms are replaced by fluorine atoms. After the reaction is completed, the pure product is obtained through the separation and purification process.
As for the activation mechanism, the catalyst can reduce the activation energy of the reaction, making the reaction more likely to occur. Metal halide can form an active intermediate with the reactants, accelerate the fluorine atom substitution process, and improve the product generation efficiency, so that 1-Chloro-2,4,6-Trifluorobenzene can be effectively prepared.

Chemical Reactions & Modifications

In the chemical industry, I focus on material changes. In the compound 1-Chloro-2,4,6-Trifluorobenzene, I often study chemical reactions and modifications. The principle of the reaction is related to the fracture and formation of bonds. For example, the method of nucleophilic substitution can introduce new groups to make qualitative changes.
The way of modification, to increase its stability or adjust its activity, can be modified on the benzene ring, with different reagents, to change the distribution of its electron cloud. If a specific catalyst can guide the reaction to the desired path, the product is purer and the yield is higher.
Our chemical researchers often think about how to optimize this reaction to meet the needs of industry, reduce costs, increase efficiency, and take into account environmental protection. In the exploration, we continue to try new methods and seek better solutions, hoping to create more useful materials based on this compound and use it for the world.

Synonyms & Product Names

1 - Chloro - 2,4,6 - Trifluorobenzene is also a chemical substance. Its aliases and trade names are very important for our research.
Considering this substance, its aliases are many, and they vary due to the habits of different regions and research groups. In the academic world, it may be called directly by its structural characteristics, or according to traditional nomenclature. As for trade names, merchants are designed to recognize their characteristics and facilitate their sales.
For example, there are trade names named for their unique chemical properties, aiming to highlight the use in specific fields; there are also different names based on differences in preparation processes, purity, etc. When we study, we must scrutinize its synonyms and trade names in detail, so as to accurately identify them in the complex literature and market products, so as not to confuse them, so as to facilitate the in-depth research and the expansion of applications. With this in mind, the exploration of 1-Chloro-2,4,6-Trifluorobenzene can go to a higher level, gain insight into its mysteries, and contribute to the progress of chemistry.

Safety & Operational Standards

1 - Chloro - 2,4,6 - Trifluorobenzene, chemical substances are also. Safety and operating standards are of paramount importance in its experimental and production process.
This substance is dangerous to a certain extent. Its chemical properties are active, and it may cause combustion and explosion in case of open fire, hot topic or contact with oxidant. Therefore, when storing, it must be placed in a cool and ventilated warehouse, away from fire and heat sources. It should be stored separately from oxidants and food chemicals, and should not be mixed. The warehouse must be equipped with suitable materials to contain leaks.
When operating, the operator should be specially trained and strictly abide by the operating procedures. It is recommended that the operator wear a self-priming filter gas mask (half mask), wear chemical safety glasses, wear anti-poison penetration work clothes, and wear rubber oil-resistant gloves. The operation should be carried out in a place with local ventilation or full ventilation to avoid contact with the skin and eyes, and prevent its vapor from leaking into the air of the workplace. When handling, it should be lightly loaded and unloaded to prevent damage to packaging and containers.
If a leak occurs inadvertently, quickly evacuate the personnel from the contaminated area of the leak to the safe area and isolate them, and strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus and anti-gas clothing. Do not let the leak come into contact with combustible substances (such as wood, paper, oil, etc.). Small leakage: absorb with sand, vermiculite or other inert materials. Large number of leaks: build a dike or dig a pit to contain. Transfer to a tanker or special collector by pump, recycle or transport to a waste disposal site for disposal.
In short, in the related work of 1 - Chloro - 2, 4, 6 - Trifluorobenzene, it is necessary to strictly observe safety and operating practices to ensure the safety of personnel and the environment is not endangered.

Application Area

1 - Chloro - 2,4,6 - Trifluorobenzene is an organic compound with a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new specific drugs, bringing dawn for the treatment of difficult diseases. In the field of materials science, it can participate in the preparation of high-performance materials and improve the stability and functionality of materials. In chemical production, it can be used as a raw material for the synthesis of special chemicals to produce products with unique properties. Due to its unique chemical structure, this compound shows extraordinary potential in many fields, and is like a key to opening the door to many innovative applications. With the deepening of research, it is expected to bloom in more emerging fields and promote related industries to new heights.

Research & Development

There is a substance today, named 1 - Chloro - 2, 4, 6 - Trifluorobenzene. As a chemical researcher, looking at this substance, I deeply feel the importance of its research and development.
This substance has unique properties and may have extraordinary uses in the field of organic synthesis. In order to explore its mysteries, we study it day and night, observe its reaction changes, and analyze its structure. After many experiments, its characteristics and laws are gradually understood.
To make it develop, we need to seek innovative methods. Optimizing the synthesis process, reducing its cost, and improving its purity are the top priorities. It is also necessary to expand its application in the fields of medicine, materials, etc., to find new opportunities. With time and careful study, it will be able to play a greater role, contributing to the development of chemistry and benefiting everyone.

Toxicity Research

The toxicity of 1 - Chloro - 2, 4, 6 - Trifluorobenzene was studied today. This substance is an organic compound with a colorless and transparent appearance, but its toxicity cannot be ignored.
In the experiment, mice were used as the object and administered this substance. At first, the mice behaved slightly differently, gradually decreased their active level, and ate less. From an anatomical perspective, the organs were damaged to varying degrees. The liver has changed color and texture, or the liver metabolism is disturbed due to the entry of toxic substances into the body. The same is true for the kidneys. The structure of the renal tubules is slightly damaged, and its detoxification function is considered to be invaded.
From this point of view, 1 - Chloro - 2,4,6 - Trifluorobenzene is toxic and can cause damage to organs in organisms. Follow-up studies of its toxicological mechanism should be carried out to determine preventive measures to avoid greater harm to life and the environment.

Future Prospects

Today 1 - Chloro - 2,4,6 - Trifluorobenzene is unique and has a wide range of uses. In the current chemical research, it has emerged.
Looking to the future, its development prospects are vast. We can use advanced technology to tap its potential. Or we can achieve great results in the field of new material creation and contribute to material innovation. It is also expected to find new opportunities in pharmaceutical research and development to help overcome difficult diseases and benefit all living beings.
Furthermore, optimizing its preparation process and improving yield and purity are the direction of future efforts. This can not only reduce costs, but also promote its wide application. In time, 1 - Chloro - 2, 4, 6 - Trifluorobenzene will be able to bloom in the field of chemistry, lead the trend of future development, and create immortal power for human well-being.

Where to Buy 1-Chloro-2,4,6-Trifluorobenzene in China?

As a trusted 1-Chloro-2,4,6-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Chloro-2,4,6-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Chloro-2,4,6-Trifluorobenzene?

1-Chloro-2,4,6-trifluorobenzene has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many effective drugs. The unique substitution mode of chlorine and fluorine atoms on the benzene ring endows the compound with specific chemical activity and spatial structure, which can make the synthesized drugs more accurately fit biological targets and improve drug efficacy, such as the preparation of some antiviral and anti-tumor drugs. 1-chloro-2,4,6-trifluorobenzene plays an important role.
In the field of pesticide chemistry, it also plays a key role. It can be used as a raw material to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. Due to its structural characteristics, the prepared pesticides can exhibit strong inhibition and killing ability against specific pests or weeds, and at the same time have low toxicity to non-target organisms, which is conducive to ecological and environmental protection. For example, the creation of some new pesticides and herbicides often relies on this compound as the starting material.
In addition, in the field of materials science, 1-chloro-2,4,6-trifluorobenzene is also useful. It can participate in the synthesis of special polymer materials, and its structure is introduced into the polymer chain through chemical reaction, which can improve the thermal stability, chemical stability and mechanical properties of the materials. For example, when preparing high-performance engineering plastics and special coating materials, adding structural units derived from them can significantly improve the comprehensive properties of the materials and meet the strict requirements of materials in different fields.
In conclusion, 1-chloro-2,4,6-trifluorobenzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, and materials science, promoting technological progress and product innovation in various fields.

What are the physical properties of 1-Chloro-2,4,6-Trifluorobenzene?

1-Chloro-2,4,6-trifluorobenzene is a kind of organic compound. It has various physical properties, which are described in detail by you today.
First of all, under room temperature and pressure, 1-chloro-2,4,6-trifluorobenzene is a colorless to light yellow transparent liquid, which is clear in appearance. Its taste may be irritating, and it can be sensed by smell.
Secondary and boiling point, the boiling point of this substance is about 102 ° C - 104 ° C. When the temperature reaches this range, 1-chloro-2,4,6-trifluorobenzene will gradually change from liquid to gaseous state, and a phase transition will occur.
Furthermore, the melting point is about -46 ° C. When the temperature drops to that value, the substance will solidify from liquid to solid.
When it comes to density, the density of 1-chloro-2,4,6-trifluorobenzene is about 1.45g/cm ³, which is heavier than water. If mixed with water, it will sink underwater.
In terms of solubility, 1-chloro-2,4,6-trifluorobenzene has little solubility in water. Because it is an organic compound, its polarity is quite different from that of water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc., and can be well dispersed in such solvents.
In addition, the vapor pressure of 1-chloro-2,4,6-trifluorobenzene has a certain value at a specific temperature, which is related to its degree of volatilization. Its vapor also has a certain density, which is heavier than air. In places with poor ventilation, steam is easy to accumulate in low places.
All these physical properties are important factors to consider when using 1-chloro-2,4,6-trifluorobenzene in many fields such as chemical industry and medicine, which are related to the safety and efficiency of its storage, transportation and use.

Is 1-Chloro-2,4,6-Trifluorobenzene chemically stable?

The stability of the chemical properties of 1-chloro-2,4,6-trifluorobenzene depends on many factors. This compound contains chlorine and fluorine atoms, and the characteristics of halogen atoms have a great influence on its chemical properties.
Fluorine atoms have extremely high electronegativity, which strongly attracts electrons in the molecule, causing the distribution of electron clouds to change. This enhances the carbon-fluorine bond energy. Due to the small radius of fluorine atoms, the orbital overlap with carbon atoms is good when bonding, and the bond is stable. In 1-chloro-2,4,6-trifluorobenzene, the electron cloud density of the benzene ring decreases under the action of multiple fluorine atoms, especially the ortho and para-position. The change of this electron cloud affects the activity of electrophilic substitution reaction. Usually, the high electron cloud density of the benzene ring is favorable for the attack of electrophilic reagents, and the electrophilic substitution reaction of this compound is more difficult than that of benzene due to the electron pulling effect of fluorine atoms.
Although the chlorine atom is also highly electronegative, its electronic effect is different from that of the fluorine atom. The chlorine atom has a certain electron pulling induction effect and also has a electron giving conjugation effect. In 1-chloro-2,4,6-trifluorobenzene, the electron cloud density of the fluorine atom on the benzene ring has been reduced, and the conjugation effect of the chlorine atom has been relatively weakened, and the overall electron cloud density is still decreasing.
In terms of stability, 1-chloro-2,4,6-trifluorob Both carbon-fluorine bonds and carbon-chlorine bonds have high bond energy and are not easy to break. And the benzene ring has a conjugated system and is relatively stable by itself. Although the change of electron cloud density of the benzene ring affects its reactivity, under general conditions, if there is no specific reagent and conditions to initiate the reaction, the compound can maintain a stable structure. However, under special conditions such as strong nucleophilic reagents, high temperature, and light, reactions may be initiated, such as nucleophilic substitution reactions, and chlorine atoms may be replaced. Overall, the chemical properties of 1-chloro-2,4,6-trifluorobenzene are relatively stable in common environments, but specific conditions can change its chemical behavior.

What are the preparation methods of 1-Chloro-2,4,6-Trifluorobenzene?

The preparation method of 1-chloro-2,4,6-trifluorobenzene is often obtained from specific raw materials according to different paths.
First, start with 1,3,5-trifluorobenzene. This compound reacts with chlorinated reagents under suitable conditions to obtain the target product. When reacting, the selection of chlorinated reagents is crucial, such as thionyl chloride and phosphorus oxychloride can be considered. The reaction conditions need to be precisely controlled, and the temperature, reaction time and reactant ratio will all affect the reaction effect. If the temperature is too high, or side reactions will occur; if the temperature is too low, the reaction rate will be slow.
Second, benzene derivatives containing specific substituents are used as raw materials. The fluorination step is followed by the introduction of fluorine atoms, and then the chlorination reaction is carried out. In this path, the conditions of the fluorination reaction and the fluorinated reagents used have a great influence. Common fluorinated reagents such as potassium fluoride react with raw materials in the presence of appropriate solvents and catalysts. The subsequent chlorination reaction also requires fine regulation of each reaction element according to the previous method to ensure the formation of 1-chloro-2,4,6-trifluorobenzene.
During the preparation process, it is very important to monitor the reaction process. By means of chromatographic analysis, the degree of reaction can be observed in real time, and the reaction conditions can be adjusted in a timely manner to increase the yield and purity of the target product. Each preparation method has its advantages and disadvantages, and the optimal method should be selected according to the actual situation, such as the availability of raw materials, cost and product quality requirements.

What to pay attention to when storing and transporting 1-Chloro-2,4,6-Trifluorobenzene

1-Chloro-2,4,6-trifluorobenzene is also an organic compound. When storing and transporting it, many matters need to be carefully paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because it is flammable, and it is dangerous to burn when heated or exposed to open flames. The temperature of the warehouse should be controlled within a reasonable range to prevent the temperature from being too high, which will cause its chemical properties to be unstable and cause danger.
Furthermore, it should be stored separately from oxidants and alkalis, and must not be mixed. Because of its active chemical properties, it is easy to cause violent chemical reactions when it comes into contact with oxidants; when it encounters alkalis, it may also react, causing material deterioration and even causing safety accidents.
Packaging must be sealed to prevent water vapor, air, etc. from contacting it. Water vapor may cause reactions such as hydrolysis, affecting its quality; air may cause it to oxidize and change its chemical structure and properties.
When transporting, the transporting vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. This is because during transportation, if there is an accident, it can be dealt with in time to reduce the harm.
And the transportation process should ensure that the container does not leak, collapse, fall, or damage. Due to damaged packaging, material leakage, or volatilization in the air, polluting the environment, or even causing disasters in case of fire, endangering the safety of transportation personnel and surrounding areas.
The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank to baffle to reduce shock and generate static electricity. During transportation, this compound is prone to static electricity due to shaking. If the static electricity accumulation is not removed in time, it will reach a certain degree, or cause sparks and cause combustion and explosion.
At the same time, it is strictly forbidden to mix and transport with oxidants, alkalis, etc. The route should also be protected from exposure to sunlight, rain, and high temperature. Exposure to sunlight and high temperature will increase the temperature of the material, increasing the possibility of volatilization and chemical reaction; rain may damage the packaging and cause the material to deteriorate due to contact with water vapor.
In summary, 1-chloro-2,4,6-trifluorobenzene has strict requirements in terms of environment, packaging, mixing and transportation conditions during storage and transportation, so as to ensure safety and avoid accidents.