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1-Chloro-2,3-Difluorobenzene

1-Chloro-2,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

237550

Chemical Formula C6H3ClF2
Molar Mass 148.54 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 148 - 150 °C
Melting Point Unknown
Density 1.308 g/cm³ (at 20 °C)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 44 °C
Vapor Pressure Unknown
Odor Characteristic aromatic odor

As an accredited 1-Chloro-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - chloro - 2,3 - difluorobenzene in 500 - ml glass bottle, tightly sealed.
Storage 1 - Chloro - 2,3 - difluorobenzene should be stored in a cool, well - ventilated area away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. Store it separately from incompatible substances to prevent chemical reactions, and ensure the storage area is clearly labeled for easy identification.
Shipping 1 - chloro - 2,3 - difluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported via approved chemical - shipping methods, following strict safety regulations to prevent leakage and ensure safe transit.
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1-Chloro-2,3-Difluorobenzene 1-Chloro-2,3-Difluorobenzene
General Information
Historical Development
1 - Chloro - 2,3 - Difluorobenzene is an important compound in the field of organic synthesis. Its historical development, chemists in the past when exploring halogen-containing aromatic compounds, noticed this unique structure. Initially, the synthesis of this compound was difficult, the raw materials were rare and the reaction conditions were harsh. However, with the improvement of chemical technology, researchers worked tirelessly to improve the synthesis path. First find better raw materials, and then optimize the reaction process to gradually increase the yield. From the difficult attempt at the beginning to the relatively mature preparation method today, this compound has become increasingly important in chemical research and industrial production, laying the foundation for the development of many related fields.
Product Overview
1 - Chloro - 2,3 - Difluorobenzene is an important chemical substance. Its properties are colorless to light yellow liquid with a special odor. This substance has a wide range of uses in the chemical industry and is often used as a key intermediate in organic synthesis.
In organic synthesis reactions, 1 - Chloro - 2,3 - Difluorobenzene can participate in many reactions, such as nucleophilic substitution reactions, coupling reactions, etc., and then synthesize a variety of high-value organic compounds. Due to its chlorine and fluorine atoms, the product is endowed with unique physical and chemical properties, such as enhanced stability and altered solubility.
Preparation of 1 - Chloro - 2,3 - Difluorobenzene usually requires specific processes and conditions, with strict requirements for reaction temperature, catalyst and other factors. The production process must pay attention to safety and environmental protection to ensure the purity and quality of the product.
Overall, 1 - Chloro - 2,3 - Difluorobenzene plays an important role in the chemical industry and is of great significance for promoting the development of organic synthetic chemistry.
Physical & Chemical Properties
1 - Chloro - 2,3 - Difluorobenzene is an organic compound. It is a colorless liquid with a special odor. Its boiling point is between 140 and 142 degrees Celsius, which is one end of its physical properties. In terms of its chemical properties, its chlorine atoms and fluorine atoms are active and can participate in a variety of chemical reactions. If under suitable conditions, chlorine atoms can be replaced by nucleophiles to form new compounds. Fluorine atoms enhance the stability and electron cloud density of molecules, affecting their reactivity. This compound is widely used in the field of organic synthesis. It is often used as an intermediate for the preparation of special functional materials and drugs. Due to its unique physical and chemical properties, it has attracted much attention in chemical research and production.
Technical Specifications & Labeling
1 - Chloro - 2,3 - Difluorobenzene is an important chemical raw material. Its preparation process requires strict technical specifications and standards.
The selection of raw materials must be pure, and the reaction conditions should be precisely controlled. The temperature should be maintained in a specific range, and the pressure must also conform to the established parameters. The material of the reaction vessel should have good corrosion resistance and stability.
The product label should clearly indicate the various commodity parameters. Such as purity, the specific value should be clearly indicated; the appearance condition should be truthfully described. Packaging specifications should also be clear to ensure the quality of the product during storage and transportation.
Adhering to these technical specifications and labeling guidelines guarantees the quality of 1-Chloro-2,3-Difluorobenzene products and meets the needs of all parties.
Preparation Method
1 - Chloro - 2,3 - Difluorobenzene is an important chemical. The method of preparation and the selection of raw materials is very important. 2,3 - difluoroaniline can be used as the starting material. After the diazotization reaction, sodium nitrite and hydrochloric acid are treated at low temperature to form a diazonium salt.
Then, the diazonium salt is reacted with the hydrochloric acid solution of cuprous chloride, which is a Sandmeier reaction. After this step, the diazonium group is replaced by a chlorine atom to obtain 1 - Chloro - 2,3 - Difluorobenzene.
During the reaction process, the temperature, the ratio of reactants and the reaction time need to be precisely controlled. The low temperature environment is conducive to the stable progress of the diazotization reaction and the avoidance of side reactions. And the reaction equipment needs to have good temperature control and stirring device to ensure the uniform reaction and improve the purity and yield of the product. In this way, a relatively pure 1-Chloro-2,3-Difluorobenzene can be obtained.
Chemical Reactions & Modifications
1 - Chloro - 2,3 - Difluorobenzene is an important raw material for organic synthesis. Its chemical reactions are related to many chemical processes. The reactivity and modification of this compound are often the key to research.
Looking at its chemical reactions, the properties of halogenated aromatics make it possible to participate in reactions such as nucleophilic substitution. Under suitable conditions, chlorine atoms or fluorine atoms can be replaced by other functional groups to construct novel molecular structures.
When talking about modification, its physical and chemical properties can be adjusted by chemical modification. For example, the introduction of specific groups can change its solubility and stability. The research on the reactivity and modification of this compound has opened up broad prospects for the field of organic synthesis, helping to create more efficient functional materials and drug molecules, and occupies an important position in modern chemical research.
Synonyms & Product Names
1 - Chloro - 2,3 - Difluorobenzene is an important chemical substance. Its synonyms and trade names are of great significance to our research.
This compound has many other names. It may be named according to its structural properties, or it may be called differently according to industry habits. Those named after its atomic arrangement and chemical bond characteristics are all synonyms. As for trade names, manufacturers will give unique names in recognition of their product characteristics, uses or market positioning.
If you want to delve deeper into 1 - Chloro - 2,3 - Difluorobenzene, it is essential to clarify its synonyms and trade names. This can help researchers fully grasp relevant information in literature search, product application, etc., and avoid research bias due to name confusion. In the chemical industry exchanges and trade exchanges, accurate recognition of these names can also ensure correct communication and promote the smooth development of the industry.
Safety & Operational Standards
1 - Chloro - 2,3 - Difluorobenzene is an important chemical product. It needs to be detailed in terms of its safety and operating practices.
This chemical has specific physical and chemical properties. When operating, it is essential to ensure that the environment is well ventilated. Because it may be volatile, if the ventilation is poor, the gas will accumulate, which is prone to potential hazards.
Furthermore, the operator must wear appropriate protective equipment. Such as protective gloves, which can avoid direct contact with the skin to prevent irritation or corrosion to the skin. Protective glasses are also indispensable to effectively protect the eyes from accidental spills.
For storage, it should be placed in a cool, dry place away from fire and heat sources. Because of its flammability, it may cause fire or even explosion in case of open flames and hot topics. And it needs to be stored separately from oxidizers, acids and other substances to prevent chemical reactions.
During access and operation, strictly follow the established operating procedures. Avoid excessive dumping or violent shaking to prevent liquid splashing. If leakage occurs accidentally, emergency measures should be taken immediately. In the case of small leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of large leakage, it is necessary to build a dike or dig a pit for containment, and transfer it to a special collection container with an explosion-proof pump for proper disposal.
After the operation, thoroughly clean the equipment and site used to prevent subsequent hazards caused by residual chemicals. In this way, the safety of 1-Chloro-2,3-Difluorobenzene during the entire use cycle can be ensured, and various risks can be effectively prevented.
Application Area
1 - Chloro - 2,3 - Difluorobenzene is an important raw material for organic synthesis, and its application field is quite wide. In the field of medicinal chemistry, it can be used to create a variety of specific drugs. With its unique chemical structure, it can accurately act on specific physiological targets and improve drug efficacy. In the field of pesticides, the pesticides developed with this starting material have the characteristics of high efficiency and low toxicity, which can effectively resist pests and diseases and ensure the harvest of crops. In the field of materials science, it also plays a key role in the synthesis of high-performance functional materials, such as materials with special optical and electrical properties, to meet the needs of the electronics and optical industries. With its structural advantages, this compound has shown important value in many application fields and has made significant contributions to the development of related industries.
Research & Development
In recent years, I have focused on the research of 1-Chloro-2,3-Difluorobenzene. This material has unique properties and has great potential in the chemical industry. At the beginning, we explored the method of its synthesis, and after various attempts, we found an effective path. The selection of raw materials and the control of reaction conditions are all key, and the yield is not good if there is a slight difference.
Then its application is researched. In the field of pharmaceutical intermediates, it can help the research and development of new drugs and contribute to the conquest of difficult diseases. In the field of materials science, it is expected to give rise to novel functional materials and improve material properties.
However, there are many obstacles in the way of research. The treatment of reaction by-products is difficult, and the environmental protection pressure is quite high; the purification process also needs to be refined to achieve higher purity standards.
We should work tirelessly to optimize the synthesis and application methods, so that 1-Chloro-2,3-Difluorobenzene can be widely used, promote the development of the chemical industry, and contribute to social progress.
Toxicity Research
1 - Chloro - 2,3 - Difluorobenzene is an important chemical substance, and its toxicity research is crucial. We carefully investigate the characteristics of this substance with caution.
In the experimental investigation, we took an appropriate amount of 1 - Chloro - 2,3 - Difluorobenzene and measured its toxicity in various ways. It was applied to specific biological samples to observe their physiological reactions. It was seen that it had a significant effect on the activity of biological cells, and some cells had abnormal morphology and reduced vitality.
Animals were used as samples to inject this substance in trace amounts. It has been observed over time that the animal behavior is abnormal, or drowsy, or slow to move, all of which indicate that 1-Chloro-2,3-Difluorobenzene has certain toxicity. We should study its mechanism of action in depth, so that in the future chemical production and application, we can properly protect, avoid its poison, and protect life and environment.
Future Prospects
I try to study the compound of 1 - Chloro - 2,3 - Difluorobenzene. This substance also has unique properties and has great potential in various fields of chemical industry.
Looking at the future, its application may become more and more widespread. In the system of medicine, it can be a key raw material to help the research of new drugs and solve the pain of the world. In the field of materials, it may be able to introduce new substances and increase the properties of materials to meet diverse needs.
However, to achieve the grand vision of its future, more efforts are needed. Researchers should study its properties deeply, explore its subtlety, and find better ways to improve its yield and quality. And we need to combine the power of various disciplines to pioneer and innovate, so that this compound will shine in the future, contribute to the progress of the world, and live up to our vision for the future.
Where to Buy 1-Chloro-2,3-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Chloro-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-2,3-difluorobenzene?
1-alkane-2,3-dienyne is one of the organic compounds. It has a wide range of main uses and has important applications in many fields.
In the field of organic synthesis, 1-alkane-2,3-dienyne is a key synthesizer. Due to its unique molecular structure and high reactivity and selectivity, chemists can use ingenious design and regulation of reaction conditions to participate in various chemical reactions to build complex and novel organic molecules. For example, in the reaction of building carbon-carbon bonds, 1-alkane-2,3-dienyne can react with a variety of nucleophiles or electrophiles to form various carbon chains or carbon ring structures, laying the foundation for the synthesis of complex organic compounds such as natural products and drug molecules.
In the field of materials science, 1-alkane-2,3-dienyne also shows potential application value. Due to its special conjugate structure, it may endow materials with unique optical and electrical properties. Researchers can introduce it into the structure of polymer materials to prepare materials with special optoelectronic properties, such as for organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, which are expected to improve the performance and efficiency of the devices.
Furthermore, in the field of biomedicine, 1-alkane-2,3-dienyne and its derivatives may have certain biological activities. Scientists can modify its structure to develop new drug molecules. Some derivatives may specifically act on specific targets in organisms, demonstrating biological activities such as antibacterial and anti-tumor, opening up new avenues for drug development.
In conclusion, 1-alkane-2,3-dienyne has broad application prospects in the fields of organic synthesis, materials science and biomedicine due to its unique structure and reaction characteristics, providing rich research materials and innovation opportunities for the development of related fields.
What are the physical properties of 1-chloro-2,3-difluorobenzene?
1-Bromo-2,3-divinylbenzene organic compound, its physical properties are as follows:
- ** Properties **: Usually a colorless to light yellow liquid, stable at room temperature and pressure. This color and state are conducive to observation and preliminary identification. In many organic synthesis scenarios, this appearance property helps to judge the reaction process and product purity.
- ** Boiling point **: about 100 ° C - 110 ° C/0.5mmHg. The boiling point is an important physical constant of a substance. This value indicates that the compound will undergo a transition from liquid to gaseous state under a specific pressure, which is of great significance for its separation and purification. For example, during distillation operations, the temperature can be precisely controlled according to the boiling point to achieve effective separation from other substances with large boiling points.
- ** Density **: about 1.35 - 1.38 g/cm ³. The density reflects the mass of the substance per unit volume. In practical applications, it is crucial to determine the amount of the substance, calculate the concentration, and design the mixing system. For example, when preparing a solution of a specific concentration, it is necessary to measure the density accurately.
- ** Solubility **: Soluble in common organic solvents, such as ether, dichloromethane, chloroform, etc., but insoluble in water. This solubility characteristic determines its behavior in different solvent environments. In organic synthesis and extraction operations, it can use its solubility in organic solvents for product extraction, and can also carry out separation work according to the partition coefficient between water and organic solvents.
- ** Refractive index **: about 1.600 - 1.610. Refractive index is an index to measure the degree of refraction of light when passing through the substance. It is crucial to identify the purity and concentration of the substance. By accurately measuring the refractive index and comparing it with the standard value, it can be judged whether the purity of the substance is up to standard.
Is 1-chloro-2,3-difluorobenzene chemically stable?
The chemical properties of 1-alkane-2,3-dienyl naphthalene are not very stable. This compound contains multiple unsaturated bonds, which are often reactive in the field of organic chemistry.
Both carbon-carbon double bonds and triple bonds have high electron cloud densities and are vulnerable to attack by electrophilic reagents. In 1-alkane-2,3-dienyl naphthalene, the diene structure is conjugated. Although the conjugate system imparts certain stability to the molecule, it also makes the electron cloud distribution more delocalized and enhances its tendency to react with electrophilic reagents.
In case of electrophilic reagents such as hydrogen halide, an electrophilic addition reaction can occur. Halogen atoms are added to double or triple bond carbons with high electron cloud density, and hydrogen atoms are added to other carbons, which is determined by the stability of the reaction intermediates. And the conjugate system can increase the check point of the reaction, and the reaction products may also be diverse.
Furthermore, in an oxidizing environment, unsaturated bonds are easily oxidized. Strong oxidants such as potassium permanganate can cause carbon-carbon double or triple bonds to break, resulting in corresponding oxidation products, such as carboxylic acids, ketones, etc. Even under mild oxidation conditions, partial oxidation may occur, affecting its chemical structure and properties.
In addition, the stability of 1-alkane-2,3-dienaphthalene naphthalene is also affected by the surrounding substituents. If the alkyl group is substituted, the alkyl group has a electron donor effect, or affects the electron cloud distribution of the conjugated system, which in turn affects its reactivity and stability.
In summary, 1-alkane-2,3-dienaphthalene is prone to various reactions in many chemical environments due to its unsaturated conjugate structure, active chemical properties and poor stability, resulting in changes in its structure and properties.
What are the production methods of 1-chloro-2,3-difluorobenzene?
There are several common methods for preparing 1-bromo-2,3-divinylbenzene:
One is the nucleophilic substitution method. Select an appropriate halogenated aromatic hydrocarbon, such as a bromine-containing aromatic hydrocarbon compound, and make it react with a vinyl nucleophilic reagent under suitable reaction conditions. Among these, the activity of the nucleophilic reagent, the reaction temperature, and the choice of solvent are all crucial. If the activity of the nucleophilic reagent is too strong, or the side reactions may increase; if the temperature is too high, it may also trigger an overreaction. Generally speaking, the selection of polar aprotic solvents, such as dimethylformamide (DMF), can promote the reaction. By precisely regulating the reaction parameters, the nucleophilic test agent is promoted to replace the bromine atom of the halogenated aromatics, thereby introducing vinyl, and gradually constructing the structure of 1-bromo-2,3-divinylbenzene.
The second is the olefin metathesis method. Using benzene derivatives containing double bonds as the starting material, with the help of transition metal catalysts, such as Grubbs catalysts, under specific conditions, the olefin metathesis reaction with vinyl olefins is carried out. This reaction requires strict control of the amount of catalyst and the purity of the reaction environment. If the amount of catalyst is too small, the reaction rate is slow; if there are impurities in the environment, it may affect the activity of the catalyst and then interfere with the reaction process. By ingeniously designing the structure and ratio of the reactants, taking advantage of the characteristics of olefin metathesis reaction, the carbon-carbon double bond is recombined to precisely synthesize the target product 1-bromo-2,3-divinylbenzene.
The third is the step-by-step method of halogenation and vinylation. First, the benzene ring is halogenated, and a specific halogenating agent, such as a brominating agent, is used to introduce bromine atoms into the benzene ring at a specific position in a suitable reaction system. Subsequently, vinyl is introduced by reacting with halogenated benzene derivatives using organometallic reagents, etc. In this process, the localization selectivity of the halogenation reaction and the optimization of the vinylation reaction conditions are the key points. Ensure that the halogenation reaction occurs precisely at the target location, and at the same time, the vinylation reaction is carried out efficiently to avoid unnecessary side reactions, and finally achieve the effective preparation of 1-bromo-2,3-divinylbenzene.
What are the precautions for storing and transporting 1-chloro-2,3-difluorobenzene?
In the storage and transportation of 1-alkane-2,3-diolefins, many key matters need to be paid attention to.
First, because of its active chemical properties, it is easy to oxidize with oxygen in the air, so when storing, make sure that the container is tightly sealed to prevent air intrusion. During transportation, it is also necessary to maintain the tightness of transportation equipment to prevent leakage from causing it to contact with air in a large area and deteriorate.
Second, this substance is quite sensitive to temperature changes. Excessive temperature can easily lead to decomposition or polymerization reactions, resulting in changes in the properties of the substance. Therefore, when storing, choose a cool and well-ventilated place to avoid direct sunlight and high temperature environments. During transportation, if there is a high temperature period, it is necessary to take necessary cooling measures, such as using refrigerated equipment or choosing to transport at night.
Third, 1-alkane-2,3-diolefin has certain flammability and is a flammable and explosive substance. The storage area must be strictly prohibited from fireworks, away from fire and heat sources, and equipped with complete fire protection facilities and equipment. When transporting, the transportation vehicle must comply with relevant fire safety standards, equipped with fire extinguishing devices and static elimination equipment to prevent static electricity from causing fire or explosion.
Fourth, because of its certain toxicity, protective measures should be taken whether it is stored or transported. Operators should wear appropriate protective equipment, such as gas masks, protective gloves, etc., to avoid direct contact and inhalation. Storage places and transportation vehicles need to be well ventilated to reduce their concentration in the air.
Fifth, the storage and transportation process should be strictly supervised and recorded. Record information such as storage quantity, storage time, transportation route, etc., so that if there is a problem, it can be quickly traced and effective countermeasures can be taken.