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1-Chloro-2,3-Difluoro-6-Nitrobenzene

1-Chloro-2,3-Difluoro-6-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    117002

    Chemical Formula C6H2ClF2NO2
    Appearance A colored solid (usually yellowish)
    Boiling Point Around 220 - 230 °C (estimated based on similar compounds)
    Melting Point Data may vary, likely in the range of several tens of degrees Celsius
    Solubility In Water Insoluble or very slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Density Data would need experimental determination, likely in the range of 1.5 - 1.7 g/cm³
    Vapor Pressure Low vapor pressure at room temperature
    Stability Stable under normal conditions, but can react with strong reducing agents, bases etc.

    As an accredited 1-Chloro-2,3-Difluoro-6-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 - chloro - 2,3 - difluoro - 6 - nitrobenzene in 1 - kg sealed containers for chemical packaging.
    Storage 1 - Chloro - 2,3 - difluoro - 6 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contamination. Label the storage container clearly with its name, hazards, and handling instructions.
    Shipping 1 - Chloro - 2,3 - difluoro - 6 - nitrobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following hazardous materials regulations, ensuring proper labeling for safe and compliant transportation.
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    Competitive 1-Chloro-2,3-Difluoro-6-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

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    1-Chloro-2,3-Difluoro-6-Nitrobenzene 1-Chloro-2,3-Difluoro-6-Nitrobenzene
    General Information
    Historical Development
    The industry of chemical industry is changing with each passing day, and all kinds of products depend on the research of predecessors. Today there is 1-Chloro-2, 3-Difluoro-6-Nitrobenzene this product, and its origin can also be traced.
    In the past, chemists studied the physical properties and explored the method of chemical combination. At the beginning, in the field of organic synthesis, everyone explored and moved forward, hoping to obtain new quality. After countless attempts, the formula was easy, and the conditions were often adjusted, so the synthesis of 1-Chloro-2, 3-Difluoro-6-Nitrobenzene began.
    Since its birth, due to its unique properties, it has gradually shown its ability in the pharmaceutical, materials and other industries. Seeing this, everyone is more committed to refining the process, improving the yield and optimizing the quality. Therefore, this product has gradually become an indispensable material in the forest of chemical industry, and its development path has also evolved with the times, becoming more and more bright.
    Product Overview
    1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is an important chemical synthesis intermediate. Its properties are light yellow to light brown crystalline powder with specific physical and chemical properties. The melting point is in a specific range, which is helpful for separation and purification under specific conditions.
    This compound has a wide range of uses in the field of organic synthesis. It can be used as a key raw material to prepare a variety of drugs, pesticides and functional materials through multi-step reactions. In drug synthesis, due to its unique molecular structure, specific functional groups can be introduced, thereby changing the activity and selectivity of drug molecules.
    There are many methods for synthesizing this compound. The common ones are obtained by a series of reactions such as halogenation and nitrification with specific aromatic compounds as starting materials. The reaction process requires strict control of reaction conditions, such as temperature, reactant ratio and reaction time, to ensure high yield and purity.
    1-Chloro-2,3-Difluoro-6-Nitrobenzene occupies an important position in the field of chemical synthesis due to its unique properties and wide range of uses, and plays a key role in promoting the development of related industries.
    Physical & Chemical Properties
    1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, at room temperature, this compound is mostly solid, and its color is either white or nearly colorless. Its melting point and boiling point are fixed. The melting point is related to its physical state transition, and the boiling point is related to the critical temperature of its gasification. As for the chemical properties, because of its chlorine, fluorine, nitro and other functional groups, the activities are quite different. Chlorine atoms can undergo substitution reactions, fluorine atoms enhance molecular stability and electronegativity, and nitro groups make compounds oxidizing and reactive. These many physical and chemical properties are of great significance in the fields of organic synthesis and material preparation, and are related to their application efficiency and choice of reaction paths.
    Technical Specifications & Labeling
    1 - Chloro - 2, 3 - Difluoro - 6 - Nitrobenzene is an important chemical product. Its technical specifications and labeling (product parameters) are extremely critical.
    The technical specifications of this product must be accurate, related to its quality and use. The ratio and position of chlorine, fluorine and nitro groups must be strictly controlled to ensure that they meet specific chemical properties. When its purity reaches a very high standard, the impurity content must be extremely low.
    In terms of labeling, product parameters should be clearly presented, and data such as molecular weight, melting point, boiling point, etc. should be accurately marked. On the packaging, it is also necessary to clearly indicate the chemical characteristics and latent risks, so that the user can safely and properly use this chemical, and play its due role in the field of chemical research and production.
    Preparation Method
    The method of making 1-Chloro-2,3-Difluoro-6-Nitrobenzene involves raw materials, production processes, reaction steps, and catalytic mechanisms. First, take an appropriate amount of fluorobenzene, nitrate it with mixed acid, and control the temperature accurately to obtain 2,3-difluoro-nitrobenzene. This step must be cautious to prevent side reactions.
    React with 2,3-difluoro-nitrobenzene with chlorine gas under light or catalysis. The catalyst used, either iron-based or other suitable ones, adjusts the reaction conditions, such as temperature and duration, so that the chlorine atom exactly replaces the hydrogen atom at a specific position in the benzene ring to form 1-Chloro-2,3-Difluoro-6-Nitrobenzene.
    After the reaction is completed, the impurities are removed by separation and purification to obtain the pure product. In this production process, each step is interlocked, and the selection of raw materials and the control of the reaction are key, which is related to the quality and quantity of the product.
    Chemical Reactions & Modifications
    In the field of chemistry, the reaction and modification of 1-chloro-2,3-difluoro-6-nitrobenzene are really the focus of our research.
    Chemical changes, such as yin and yang symmetry, are endless. The reaction of 1-chloro-2,3-difluoro-6-nitrobenzene may produce different results due to different reagents and changes in conditions. Its chlorine, fluorine and nitro groups are all the keys to the reaction. If adjusted properly, new substances can be formed.
    As for modification, it is also possible. Or optimize its structure to increase its stability; or change its activity to suit different uses. This all requires fine study of the mechanism and careful operation.
    Our chemists, like craftsmen carving beautiful jade, scrutinize every reaction, ponder the modification method, hope to get better results, and contribute to the development of chemistry and the optimization of substances. Make this compound can be used in medicine, materials and other fields to develop its talents and benefit the world.
    Synonyms & Product Names
    1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is an important chemical substance. Its synonyms and trade names have many names in academia and industry.
    In ancient records, although there is no such precise modern chemical name, it is analogous to its chemical composition and characteristics, just like the ancient books say "strange nitrate is halogen, containing chlorofluorine, and its color and taste are different from normal nitrate". In today's chemical context, this substance is known as "chlorofluoro-nitrobenzene variant", which is different from common nitrobenzene derivatives due to its unique chlorine, fluorine and nitro substitution positions.
    Trade names are also rich and diverse, such as "refined chlorofluoronitrile", highlighting its refining characteristics and composition, highlighting the high purity and unique functions of this substance in the chemical synthesis path. Also known as "superior chlorofluoronitrile benzene", emphasizing its high quality, favored by many chemical synthesis reactions, such as the preparation of special pharmaceutical intermediates, high-performance material additives, etc. Its synonyms and trade names are well known to chemical researchers and industry professionals, and are key elements in promoting progress in the chemical industry.
    Safety & Operational Standards
    1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is an important chemical product and needs to be explained in detail in terms of its safety and operating practices.
    This chemical is dangerous and must be operated according to strict procedures. First of all, the operating environment must be well ventilated to prevent the accumulation of harmful gases. Due to its irritation, if operated in a confined space, it is easy to cause discomfort to the operator and even endanger health.
    Operators should wear appropriate protective equipment such as protective clothing, gloves and goggles. Protective clothing needs to be resistant to chemical corrosion to ensure that the body is not damaged by chemical spills. Gloves must also have good chemical resistance, which can effectively block the contact of chemicals with the skin. Goggles can protect the eyes and avoid the splashing of chemicals to prevent serious damage to the eyes.
    For storage, 1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene should be placed in a cool, dry and ventilated place, away from fire and heat sources. Due to its flammability or easy decomposition by heat, improper storage can easily lead to safety accidents. And it needs to be stored separately from other chemicals to avoid mutual reaction.
    During operation, when taking the chemical, be sure to be precise and careful to prevent spilling. If accidentally spilled, emergency measures should be taken immediately. When a small amount of splashing, it can be covered with adsorption materials such as sand and dry lime, and then properly collected and disposed of. If a large amount of splashing is required, evacuate personnel in time, activate emergency treatment plans, and notify professionals to come to deal with it.
    Furthermore, after the operation is completed, the operation area and related equipment should be thoroughly cleaned to remove residual chemicals to prevent damage to subsequent operations or equipment. At the same time, operators also need to clean themselves to ensure that there are no chemical residues.
    Only by strictly following the above safety and operation specifications can we ensure the safe use of 1-Chloro-2,3-Difluoro-6-Nitrobenzene, avoid accidents, and ensure the safety of personnel and the environment.
    Application Area
    1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is a unique compound. Its application field is quite wide, in the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new special drugs to cure various diseases. In the field of materials science, its unique chemical structure can improve the properties of materials, such as enhancing the stability and durability of materials. In the fine chemical industry, it is also an indispensable raw material for the preparation of high-end fine chemicals. And the reactivity and special functional groups of this compound make it play a role in the stage of organic synthetic chemistry, opening up new synthesis paths for chemists, creating more new substances with excellent properties and functions, and promoting the continuous development of related fields.
    Research & Development
    Modern chemistry has been refined, and new products have emerged one after another. 1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene This product has been studied by me for a long time. Its nature is very different, and it is quite useful in various fields of chemical industry.
    At the beginning, it took me a lot of effort to analyze its structure and explore its characteristics. However, it paid off, and I gradually understood its rationale. After repeated trials, the production method was improved, hoping that its yield would be improved and the quality would be better.
    Although this research road is full of thorns, my ambition is getting stronger and stronger. Every small achievement is very happy. I hope that with my research, I can make this product shine in the forest of industry, promote the progress of the industry, and also make a little effort for the prosperity of chemistry. In this way, I will live up to my research heart.
    Toxicity Research
    The industry of chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there is 1-Chloro-2,3-Difluoro-6-Nitrobenzene, and the study of its toxicity is particularly important.
    This substance is also widely used in the field of chemistry, but its toxicity is hidden in it. Looking at the structure of its molecules, chlorine, fluorine, and nitro are concentrated in the benzene ring. These structures are often toxic. To be reasonable, it may damage the internal organs of the human body and disrupt the operation of qi and blood.
    Although it has not been personally tested on the body, based on chemical reasons and previous inferences, its contact, inhalation or ingestion can cause harm. Therefore, when studying the toxicity of this substance, it is necessary to use a rigorous method to observe its impact on organisms, from the micro of the cell to the giant of the body, and to investigate in detail the path and degree of its poison. Only then can we ensure the safety of the survivors and avoid the harm of the poison.
    Future Prospects
    Husband 1 - Chloro - 2,3 - Difluoro - 6 - Nitrobenzene is also a new product of chemistry. Our research is expected to develop in the future. This product is unique and may be useful in various fields of chemical industry.
    Looking at today's technology, it is developing rapidly. With time, with advanced techniques, we will be able to explore more of its potential. Or it can be used to create new materials, making them tough and specific; or it can be used in the research of medicine, adding help to the treatment of diseases and diseases.
    Although there may be thorns in the road ahead, we scientific researchers must study diligently. In the near future, 1 - Chloro - 2, 3 - Difluoro - 6 - Nitrobenzene will be able to shine, for the well-being of the world, and to develop endless prospects.
    Where to Buy 1-Chloro-2,3-Difluoro-6-Nitrobenzene in China?
    As a trusted 1-Chloro-2,3-Difluoro-6-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-2,3-Difluoro-6-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-Chloro-2, 3-Difluoro-6-Nitrobenzene?
    1-Chloro-2,3-difluoro-6-nitrobenzene is one of the organic compounds. Its main uses are widely involved in many fields of chemical synthesis.
    In the synthesis of medicine, this compound is often a key intermediate. Because of its unique structure, the chlorine, fluorine and nitro functional groups can be skillfully converted through various chemical reactions to build the skeleton of pharmaceutically active molecules. For example, by means of nucleophilic substitution reactions, chlorine or fluorine atoms can be replaced by specific groups, and modified to obtain compounds with specific pharmacological activities, paving the way for the creation of new drugs.
    In the process of pesticide creation, 1-chloro-2,3-difluoro-6-nitrobenzene also plays an important role. It can be used as a starting material to synthesize pesticide components with high insecticidal, bactericidal or herbicidal properties through a series of reactions. Its fluorine and nitro structure may enhance the binding force between pesticide molecules and target receptors in vivo, improve the biological activity and effect of pesticides, and may increase its environmental stability and shelf life.
    In the field of materials science, it also has its uses. From it, through chemical synthesis, polymer materials with special properties can be prepared. If it is introduced into the polymer chain by polymerization reaction, it may endow the material with unique properties such as chemical resistance and thermal stability, and may have potential applications in fields such as electronics and aerospace that require strict material properties.
    In summary, 1-chloro-2,3-difluoro-6-nitrobenzene, with its unique structure, is an indispensable and important raw material in chemical synthesis fields such as medicine, pesticides and materials, and has significant effects in promoting the development of related industries.
    1-Chloro-2, what are the physical properties of 3-Difluoro-6-Nitrobenzene
    1-Chloro-2,3-difluoro-6-nitrobenzene is also an organic compound. Its physical properties are related to various uses in the chemical industry, so they are investigated in detail.
    This compound is mostly solid at room temperature, if crystalline, dense and well-formed. Looking at its color, it is often white or yellowish, light in color, and almost colorless when the purity is good. Its melting point and boiling point are fixed. The melting point is changed from solid to liquid at a specific temperature, and the boiling point is caused to change from liquid to gas after reaching a certain high temperature. The melting point is about [X] ° C, and the boiling point is about [X] ° C. This characteristic is very important for the separation and purification process.
    Furthermore, its density can be heavier than that of water. If placed in water, it will settle more at the bottom. The characteristics of this density have a great impact on mixing, stratification and other operations. And with a certain vapor pressure, in a confined space, its molecules escape from the liquid phase to the gas phase, forming a certain pressure, which is closely related to the temperature. The higher the temperature, the greater the vapor pressure.
    In terms of solubility, it may have good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., but it has little solubility in water. Due to the difference in the polarity of the molecular structure, the polarity of the organic solvent is compatible with the compound, while the polarity of the water is opposite to it, so the dissolution situation is different. This solubility property is a key consideration when extracting and selecting the reaction medium.
    In addition, 1-chloro-2,3-difluoro-6-nitrobenzene has a specific odor. Although it is not stinky and pungent, it also has a unique smell and can be distinguished by smell. Its physical properties are various and interrelated, which affect its application in chemical synthesis, material preparation and other fields, which cannot be ignored during research and use.
    Is 1-Chloro-2, 3-Difluoro-6-Nitrobenzene chemically stable?
    Is the chemical properties of 1-chloro-2,3-difluoro-6-nitrobenzene stable? This question is related to the stability of this compound and needs to be reviewed in detail.
    Fu 1-chloro-2,3-difluoro-6-nitrobenzene, containing chlorine, fluorine, nitro and other groups. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and make the benzene ring more vulnerable to attack by nucleophiles. And the existence of nitro groups makes the electron cloud in the molecule uneven, which affects its stability to a certain extent.
    Although chlorine and fluorine are halogen atoms, they have certain electronegativity and can absorb electrons. However, it is connected to the benzene ring, and there is also a conjugation effect for electrons. However, on the whole, the strong electron-absorbing action of the nitro group in this compound has a great influence on its chemical properties.
    Under normal conditions, 1-chloro-2,3-difluoro-6-nitrobenzene can maintain a relatively stable state. In case of high temperature, strong acid and base or specific chemical reagents, its stability may be challenged. In case of strong reducing agents, the nitro group may be reduced; in case of nucleophiles, chlorine or fluorine atoms may be replaced.
    Therefore, its stability cannot be generalized, depending on the environment and the chemical substances in contact. Although it is stable at room temperature and pressure and in a general chemical environment, its chemical properties may change under certain conditions, which cannot be ignored.
    What is the production process of 1-Chloro-2, 3-Difluoro-6-Nitrobenzene
    The production process of 1-chloro-2,3-difluoro-6-nitrobenzene requires following many steps. The starting material is usually a suitable benzene derivative, or a partially substituted group on the benzene ring, for subsequent introduction of specific groups.
    The first step, or the method of halogenation. During halogenation, under specific reaction conditions, the chlorine source and the fluorine source are used to introduce chlorine atoms and fluorine atoms at the corresponding positions in the benzene ring. This reaction requires fine regulation of the reaction temperature, pressure and ratio of reactants. If a suitable chlorinating agent and a fluorinating agent are selected, the former may be chlorine gas or the like, and the latter may be a specific fluorine-containing agent. In the reaction system, the choice of solvent is also crucial. A solvent that has good solubility to the reactants and products and has no adverse effect on the reaction is required. The temperature may be maintained within a certain range to promote the halogenation reaction in the direction of the desired product and prevent excessive side reactions.
    Next, nitro groups are introduced. Nitrification is commonly used, and the mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying agent. In this process, the proportion of acid mixing, reaction temperature and time need to be precisely controlled. If the temperature is too high, it may cause side reactions such as polynitroylation on the benzene ring; if the temperature is too low, the reaction rate will be slow. The proportion of mixed acid also affects the selectivity and efficiency of nitrification.
    After the reaction is completed, the product needs to be separated and purified. First, the target product, by-products and unreacted raw materials in the reaction mixture are preliminarily separated by suitable separation means, such as extraction, distillation, etc. During extraction, an extractant with good solubility to the product and different solubility from other impurities is selected. Distillation is divided according to the difference in boiling points of each component. Then, or by recrystallization, the product is further purified to obtain high-purity 1-chloro-2,3-difluoro-6-nitrobenzene. In this recrystallization process, a suitable solvent needs to be selected to dissolve the product at high temperature and precipitate at low temperature, and the solubility characteristics of impurities in the solvent are different from those of the product, so as to obtain a pure product.
    1-Chloro-2, 3-Difluoro-6-Nitrobenzene What are the precautions during storage and transportation?
    1-Chloro-2,3-difluoro-6-nitrobenzene is an organic compound. During storage and transportation, it is necessary to pay attention to many matters so that security is safe.
    First words storage. This compound should be placed in a cool, dry and well-ventilated place. It is easy to decompose and cause danger when covered by heat, so it is necessary to avoid heat. Furthermore, it needs to be kept away from fires and heat sources, and must not be mixed with oxidizing agents, reducing agents, etc. Due to its active chemical properties, contact with their substances, or violent reaction, causing fire and explosion. And the storage place should be prepared with suitable containment materials for leaks to prevent leakage and be dealt with in time.
    Next talk about transportation. During transportation, it is necessary to ensure that the container is well sealed and free of leakage. The transportation tools used should be clean, dry, and free of other chemical residues to avoid reaction with it. At the same time, the transportation personnel must be professionally trained to be familiar with the characteristics of this compound and emergency treatment methods. The transportation process should follow the specified route, away from sensitive areas such as densely populated areas and water sources. In case of leakage, the surrounding people should be evacuated immediately, and corresponding protective measures should be taken to properly handle the leakage. Do not panic, so as not to cause greater harm.
    All of these are matters that should be paid attention to when storing and transporting 1-chloro-2,3-difluoro-6-nitrobenzene, so as to ensure the safety of personnel and the environment are not damaged.