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1-Chloro-2,3-Difluoro-5-Nitrobenzene

1-Chloro-2,3-Difluoro-5-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    912476

    Chemical Formula C6H2ClF2NO2
    Molecular Weight 195.535
    Appearance Solid (Typical)
    Melting Point 46 - 49 °C
    Solubility Soluble in organic solvents (Typical for aromatic compounds)
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

    As an accredited 1-Chloro-2,3-Difluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1 - chloro - 2,3 - difluoro - 5 - nitrobenzene in sealed, corrosion - resistant container.
    Storage 1 - Chloro - 2,3 - difluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential chemical reactions.
    Shipping 1 - Chloro - 2,3 - difluoro - 5 - nitrobenzene is a chemical. Shipping should be in well - sealed, corrosion - resistant containers, following hazardous chemical regulations, ensuring safe transport to prevent spills and environmental/health risks.
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    1-Chloro-2,3-Difluoro-5-Nitrobenzene 1-Chloro-2,3-Difluoro-5-Nitrobenzene
    General Information
    Historical Development
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is an important compound in organic synthesis. Its origin can be traced back to the early days of chemical research. At that time, chemists studied the synthesis of various compounds and tried to expand the boundaries of chemistry.
    At first, the road to synthesize this compound was full of thorns, and chemists encountered many setbacks. However, he maintained his perseverance and unremitting exploration. With the passage of time, chemical technology has changed with each passing day, and the understanding of the reaction mechanism has become more and more profound.
    After countless experiments and improvements, the synthesis method has gradually matured. From the initial rough trial, the reaction conditions can be precisely regulated to improve the yield and purity. This compound has risen to prominence in the fields of medicine, materials, etc., contributing to the birth of many innovative achievements, leaving a strong mark in the history of chemical development.
    Product Overview
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is an important chemical substance. It is a derivative of benzene. In its molecular structure, chlorine atoms, fluorine atoms and nitro groups on the benzene ring are at specific positions. This compound has a wide range of uses in the field of organic synthesis and is often used as a key intermediate. Because of its unique substituents, it endows molecules with special chemical activities and reactive properties. In many organic reactions, the characteristics of its substituents can guide the reaction in a specific direction to synthesize a series of organic compounds with specific functions. In the field of medicinal chemistry, it can be used as a starting material for the synthesis of specific drugs, and modified by subsequent reactions to obtain biologically active molecules. In the field of materials science, it may also be used to prepare materials with special optoelectronic properties, providing assistance for the development of related fields.
    Physical & Chemical Properties
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is also an organic compound. Its color is yellowish, it is a solid at room temperature, and its properties are stable. Its melting point is about [X] ° C, and its boiling point is between [X] ° C, which is related to its physical properties.
    When it comes to chemical properties, chlorine, fluorine, and nitro functional groups in this compound are all active. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making it prone to nucleophilic substitution reactions. Although chlorine and fluorine atoms are halogen atoms, their reactivity is also unique due to the influence of the benzene ring conjugation system. When encountering nucleophilic reagents, chlorine atoms or fluorine atoms can be replaced to form new derivatives. In the field of organic synthesis, this compound is often an important intermediate. It can build a variety of complex organic molecular structures through specific reaction paths, and is a very attractive object in organic chemistry research.
    Technical Specifications & Labeling
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is an important chemical product. Its process specifications and identification (product parameters) are extremely critical. The preparation of this product requires a precise chemical process, the ratio of raw materials must be accurate, and the reaction conditions such as temperature, pressure, and duration should be strictly controlled.
    As far as the label is concerned, its chemical name, molecular formula, and molecular weight must be clearly indicated to illustrate its chemical properties. Physical properties such as appearance, melting point, boiling point, etc. should also be described in detail to help users distinguish. Among the product parameters, purity is crucial, and high purity can ensure its effectiveness in various fields of application. The impurity content must also be strictly limited to avoid affecting subsequent reactions or product quality. Only in this way can the quality and application value of 1 - Chloro - 2, 3 - Difluoro - 5 - Nitrobenzene be ensured.
    Preparation Method
    The method of making 1-Chloro-2,3-Difluoro-5-Nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
    The first raw materials are taken from fluorobenzene and the like, supplemented by nitric acid and sulfuric acid, which are the important agents for nitrification. At the right temperature, the fluorobenzene is reacted with the mixed acid, and through the nitrification step, m-difluoro-nitrobenzene is obtained.
    Then, by the method of chlorination, a suitable chlorination agent, such as phosphorus trichloride, is selected. Under specific conditions, m-difluoro-nitrobenzene is substituted to form 1-Chloro-2,3-Difluoro-5-Nitrobenzene. In the
    reaction, temperature control is very important to prevent side reactions. And the catalytic mechanism cannot be ignored. Looking for a high-efficiency catalyst can promote the reaction rate and yield increase. After various steps and fine processes, this product is prepared to meet the needs of chemical industry and so on.
    Chemical Reactions & Modifications
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene This product, the way of modification of chemical reversal, is what our researchers are interested in.
    Its transformation and reversal need to be controlled by precise components. If the degree of reversal is high or low, it can cause the deviation of the reversal. The degree of reversal is appropriate, the molecular activity is high, and the combination of each atom is orderly, so the product can be obtained in the future. If the degree of reversal is inappropriate, or the reaction is slow, or the reaction is strong and out of control, it can be produced.
    As for modification, it can be started with its molecules. Adding some bases, or changing the way atoms are connected, is expected to give this product new properties. Such as the introduction of water-based compounds, it can increase its solubility in water; change the position of nitro groups, or adjust their chemical activity. Where this is needed, it is necessary to speculate and reverse the modification, so as to realize the delicacy of anti-modification, so that 1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene can achieve its maximum effectiveness.
    Synonyms & Product Names
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is a chemical substance, and its synonyms and trade names are quite important in our chemical research.
    This compound has many aliases. Due to the characteristics of its chemical structure, some are named after its structural characteristics. From the combination of halogen and nitro, it may be called halogenated nitrobenzene. Its trade names are also different in market circulation and industrial applications.
    In my research experience, I have seen different manufacturers name it differently. This is due to differences in industry habits and application fields. However, no matter what kind of synonyms or trade names, they refer to this specific chemical substance. Only by clarifying its synonyms and trade names can it be accurate and accurate in research, production, and trading, avoiding confusion, and ensuring the smooth flow of chemical research and industrial activities.
    Safety & Operational Standards
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is a chemical substance, which is crucial for its safety and operation standards.
    This compound is dangerous. From the perspective of chemical properties, it contains chlorine, fluorine, nitro and other groups. Nitro is a strong electron-absorbing group, which makes the compound chemically active. Under specific conditions, it may react chemically or cause danger. In case of reducing agent, the nitro group may be reduced, and the reaction may be violent, causing the release of heat and gas. If it is in a closed space or causes the pressure to rise, there is a risk of explosion.
    When operating, follow strict specifications. The experimenter must wear appropriate protective equipment, such as protective clothing, protective gloves and goggles, to prevent it from coming into contact with the skin and eyes. Because the substance is absorbed through the skin or irritates the eyes, it can cause discomfort or even damage.
    It is also key to operate in a well-ventilated place. Its volatile gas may be toxic, and good ventilation can be discharged in time to reduce the concentration in the air and reduce the risk of inhalation. If inhaled, it may cause respiratory irritation, dizziness and other symptoms.
    Storage should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to mixing with oxidants, or severe oxidative reactions, fire or explosion may occur. And it needs to be stored separately to prevent interaction with other chemicals.
    In case of inadvertent contact, flush the contact area with plenty of water as soon as possible. If it comes into contact with the eyes, seek medical attention after flushing. If inhaled by mistake, go to a fresh air and seek medical attention if necessary.
    In conclusion, the safety and operating practices of 1-Chloro-2,3-Difluoro-5-Nitrobenzene should be used with extreme caution to ensure the safety of personnel and the stability of the experimental environment.
    Application Area
    1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is a unique chemical substance. In many application fields, its effectiveness is quite obvious.
    In the field of pharmaceutical development, this compound is often used as a key intermediate. Through subtle chemical reactions, it can be converted into substances with specific pharmacological activities, which can help create new drugs to cure various diseases.
    In the field of materials science, 1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene also has its uses. It can participate in the material synthesis process, endow materials with special electrical, optical and other properties, and then expand the application range of materials, and play a role in electronic devices.
    And in the chemical production process, as an important raw material, through a series of process processing, it can derive a variety of downstream products, promote the development of the chemical industry, and contribute greatly to the progress of many industrial fields.
    Research & Development
    Modern chemistry has advanced, and the research on various compounds has changed with each passing day. Today, there is 1-Chloro-2,3-Difluoro-5-Nitrobenzene, whose properties and uses are quite important in the academic community.
    We have devoted ourselves to exploring the secrets of its structure and studying its reaction rules. In the synthesis method, we strive to improve, hoping to obtain efficient and pure products. After repeated experiments, improve the old method, or innovate the way, with the hope of improving the yield and optimizing the quality.
    It also examines its application in various fields, such as medicine and materials, which have potential potential. Although the road ahead is long, we are determined to understand its mechanism and expand its function. Over time, I hope this compound can contribute to the advancement of science and technology and the benefit of people's livelihood, and live up to the research and exploration.
    Toxicity Research
    Recently, in the genus chlorofluoronitrobenzene, there is a substance called 1-Chloro-2,3-Difluoro-5-Nitrobenzene, and the study of its toxicity is quite important.
    This substance contains halogen atoms and nitro groups, which are structurally dependent or have specific toxicity. Halogen atoms are active and can cause chemical reactions in organisms, causing chaos in cellular biochemical processes. Nitro groups are also not good, and can interact with biological macromolecules, such as proteins, nucleic acids, etc., damaging their structure and function.
    From an experimental point of view, this substance was applied to the tested organism. At first, it was seen that its action was slightly different, or impatient or slow. Over time, the physiological function was impaired, growth was stagnant, and reproduction was also affected by it. The inspection of the organs shows the pathological changes, especially the liver and kidneys, which are responsible for detoxification and excretion, and bear the brunt.
    From this perspective, the toxicity of 1-Chloro-2,3-Difluoro-5-Nitrobenzene cannot be underestimated. Its production and use should be carefully controlled to prevent it from harming life and polluting the environment, and to ensure ecological safety and people's well-being.
    Future Prospects
    Husband 1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene is also a chemical substance. In today's world, chemical research is advancing day by day, and this substance also has an unlimited future prospect.
    Looking at its properties and uses, it can have extraordinary effects in the synthesis of medicine. In the way of medicine, it is crucial to save people's lives and heal people's diseases. Based on this substance, it may be a medicine that can create special effects and relieve the pain of everyone.
    In the field of material science, it may be the key element. New materials emerge one after another, improving lives and enhancing the effectiveness of all things. 1 - Chloro - 2,3 - Difluoro - 5 - Nitrobenzene may promote the innovation of materials and inspire new trends in the future.
    Although it is currently used or not widely known, scientific researchers will study it day and night. With time, it will be able to dig deep into its capabilities and shine in medicine, materials and other fields, for the well-being of the world, and to develop an endless future.
    Where to Buy 1-Chloro-2,3-Difluoro-5-Nitrobenzene in China?
    As a trusted 1-Chloro-2,3-Difluoro-5-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-2,3-Difluoro-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-Chloro-2, 3-Difluoro-5-Nitrobenzene?
    1-Chloro-2,3-difluoro-5-nitrobenzene is one of the organic compounds. Its main uses are quite extensive, and it is often used as a key intermediate in organic synthesis in the chemical industry.
    First, in the synthesis of medicine, this compound has an important position. Due to its special chemical structure, it can be introduced into the molecular structure of drugs through a series of chemical reactions, which helps to construct specific active groups and makes great contributions to the development of antibacterial, anti-inflammatory and many other types of drugs. With exquisite organic synthesis techniques, it can be skillfully spliced with other organic fragments to obtain new drug molecules with precise pharmacological activity, opening up new paths for pharmaceutical research and development.
    Second, in the creation of pesticides, 1-chloro-2,3-difluoro-5-nitrobenzene is also indispensable. It can be used as an important starting material for the synthesis of high-efficiency and low-toxicity pesticides. After chemical modification and transformation, pesticides are endowed with unique insecticidal, herbicidal or bactericidal properties. Its structural characteristics help to improve the efficacy of pesticides on specific targets, and can reduce the adverse effects on the environment and non-target organisms to a certain extent, which is in line with the current trend of green pesticide development.
    Furthermore, in the field of materials science, it may participate in the synthesis of some functional materials. For example, through a specific reaction path, materials with special photoelectric properties are prepared for use in the field of organic optoelectronics, such as organic Light Emitting Diode (OLED), solar cells, etc., providing new opportunities for material performance optimization and innovation. In short, 1-chloro-2,3-difluoro-5-nitrobenzene, with its unique chemical structure, plays an important role in many fields such as chemical industry, medicine, pesticides and materials, and promotes technological innovation and development in various fields.
    1-Chloro-2, what are the physical properties of 3-Difluoro-5-Nitrobenzene
    1-Chloro-2,3-difluoro-5-nitrobenzene is also an organic compound. It has unique physical properties and is worth studying.
    Looking at its properties, at room temperature, this substance is mostly solid, but it also varies depending on specific conditions. Its color may be light yellow or nearly colorless, depending on purity and environmental factors.
    As for the melting point, it is within a specific range, which is one of its important physical indicators. By measuring the melting point, the purity of its purity can be identified. If there are many impurities, the melting point may drop and the melting range will also increase.
    The boiling point is also a key physical property. When this temperature is reached, the substance changes from liquid to gaseous state, which is related to its phase change under different conditions. The level of boiling point is determined by factors such as intermolecular forces.
    In terms of solubility, organic solvents such as ethanol and ether may have a certain solubility. In water, because of the large difference between polarity and water, the solubility is poor. This property is crucial when separating, purifying and selecting reaction media.
    Density is also one of its physical properties. Knowing the density is very beneficial for accurate calculation of material dosage in chemical production and experimental operations.
    In addition, its volatility is relatively low, and it is not easy to evaporate quickly under normal circumstances. This property guarantees stability during storage and use.
    In short, the physical properties of 1-chloro-2,3-difluoro-5-nitrobenzene are of great significance in the fields of organic synthesis and chemical production. Only by in-depth understanding can we make good use of them.
    What is the chemical synthesis method of 1-Chloro-2, 3-Difluoro-5-Nitrobenzene
    The chemical synthesis of 1-chloro-2,3-difluoro-5-nitrobenzene is a very important topic in the field of organic synthesis. In the past, many wise people have repeatedly explored and practiced to obtain several effective synthesis paths.
    One method also uses a specific benzene derivative as the starting material. First, the benzene derivative interacts with a chlorine-containing reagent. The chlorine-containing reagent must be carefully selected, and the reaction conditions must be strictly controlled, such as temperature, pressure, reaction time, and the type and amount of catalyst. In this process, chlorine atoms subtly replace the atoms at the corresponding positions on the benzene ring according to a specific chemical mechanism, so as to initially construct the chlorine-containing benzene structure.
    Then, fluorine atoms are introduced. Select a suitable fluorine-containing reagent, the activity and selectivity of which are crucial to the success or failure of the reaction. With the ingenious design of the reaction process, fluorine atoms precisely replace the atoms at the predetermined position on the benzene ring to achieve the purpose of difluorine substitution. In this step, factors such as the choice of solvent and the pH of the reaction environment have a profound impact on the reaction process and product purity.
    Furthermore, in order to introduce nitro groups, a suitable nitrifying reagent needs to be selected. Nitrification has always been known for its complexity and danger, so fine regulation of reaction conditions is indispensable. Strictly control the temperature, reaction rate and other parameters to ensure that the nitro group is smoothly and accurately connected to the designated position of the benzene ring, and finally obtain 1-chloro-2,3-difluoro-5-nitrobenzene.
    When synthesizing this compound, each step needs to be closely monitored during the reaction process, and means such as chromatographic analysis and spectroscopic determination are used to ensure the purity and structure of the product. Only in this way can high-purity 1-chloro-2,3-difluoro-5-nitrobenzene be obtained to meet the needs of scientific research and industrial production.
    1-Chloro-2, 3-Difluoro-5-Nitrobenzene What are the precautions in storage and transportation?
    1-Chloro-2,3-difluoro-5-nitrobenzene chemical substances, when storing and transporting, many matters must be paid attention to.
    This substance is toxic and corrosive, and the storage place must be dry, cool and well ventilated. Do not mix with oxidants, reducing agents, alkalis, etc., to prevent dangerous chemical reactions. Storage containers should also be made of corrosion-resistant materials and sealed tightly to avoid leakage.
    When transporting, relevant laws and standards must be strictly followed. Transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment in case of leakage and other situations, and can be properly disposed of in a timely manner. During handling, operators should be careful and handle light to avoid damage to the container.
    In addition, whether it is storage or transportation, the substance must be clearly marked, indicating its characteristics, hazard warnings and other key information. Relevant operators also need to undergo professional training to be familiar with its hazards and emergency treatment methods. In this way, the safety of 1-chloro-2,3-difluoro-5-nitrobenzene during storage and transportation can be ensured.
    What are the effects of 1-Chloro-2, 3-Difluoro-5-Nitrobenzene on the environment and human health?
    1-Chloro-2,3-difluoro-5-nitrobenzene is also an organic compound. This substance has an impact on the environment and human health.
    In the environment, it may be persistent. Because of its stable chemical structure, it is not easy to decompose rapidly in the natural environment. When released into the soil, it can remain in it for a long time, causing gradual changes in soil properties, or disturbing the soil microbial community, causing its ecological balance to be disrupted, which in turn affects the uptake of nutrients by plant roots and endangers plant growth. If it enters the water body, it will cause water pollution, and aquatic organisms will bear the brunt. Because of its toxicity, or damage the physiological functions of aquatic organisms such as fish and plankton, hinder their growth and reproduction, and in severe cases, it can cause a sharp decrease in the population and destroy the balance of aquatic ecosystems.
    As for human health, 1-chloro-2,3-difluoro-5-nitrobenzene may be ingested into the human body through respiratory tract, skin contact and diet. Inhaled through the respiratory tract, it can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. If skin contact, or cause contact dermatitis, there is redness, swelling, itching, pain. After ingestion in the body, it is metabolized in the body or affects the normal physiological functions of the human body. Or interfere with the human endocrine system, causing hormone imbalance, affecting growth and development, reproductive function, etc. It may also damage the nervous system, causing headaches, dizziness, fatigue, memory loss and other neurological symptoms. Long-term exposure to this substance may increase the risk of cancer, because it is potentially carcinogenic and can cause cell cancer, threatening life and health.