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1-Chloro-2,3-Difluoro-4-Nitrobenzene

1-Chloro-2,3-Difluoro-4-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    647048

    Chemical Formula C6H2ClF2NO2
    Molar Mass 193.536 g/mol
    Appearance Solid (likely a yellowish solid, common for nitro - containing aromatic compounds)
    Solubility In Water Low solubility (aromatic nitro - halogenated compounds are generally hydrophobic)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, due to its non - polar aromatic nature
    Vapor Pressure Low vapor pressure (aromatic nitro - halogenated solids usually have low volatility)
    Hazard Class May be toxic, irritant, and potentially explosive due to nitro group (classification may vary by region and specific test results)

    As an accredited 1-Chloro-2,3-Difluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 - chloro - 2,3 - difluoro - 4 - nitrobenzene: Packed in 500g bottles for chemical storage.
    Storage 1 - Chloro - 2,3 - difluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reducing agents to avoid hazardous reactions. Also, ensure proper labeling for easy identification and safety.
    Shipping 1 - Chloro - 2,3 - difluoro - 4 - nitrobenzene is a chemical. Ship it in sealed, corrosion - resistant containers. Follow all relevant regulations for hazardous chemicals during transportation to ensure safety.
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    1-Chloro-2,3-Difluoro-4-Nitrobenzene 1-Chloro-2,3-Difluoro-4-Nitrobenzene
    General Information
    Historical Development
    The chemical industry is changing with each passing day, and new products are emerging in large numbers. 1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene This product first appeared in the research. In the past, Zhugong studied halogenated nitrobenzene and worked tirelessly to explore new structures.
    At the beginning, the synthesis was difficult, the yield was quite low, and there were many impurities. However, Zhu Xian was not discouraged, and he tried it repeatedly for many years. Or change the reaction conditions, or change the catalytic agent, and gradually get the way of optimization. After several years, the process has become more and more mature, the yield has gradually increased, and the quality is also good. Therefore, 1-Chloro-2,3-Difluoro-4-Nitrobenzene has emerged in the field of chemical industry, and its application has gradually expanded, opening a new chapter. It has made outstanding contributions to the pharmaceutical and materials industries. This is also the outline of its development.
    Product Overview
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important compound in organic synthesis. It is a light yellow crystal with a special odor. This compound has a wide range of uses in the field of fine chemicals and is often used as a key intermediate in the synthesis of medicines and pesticides.
    Looking at its structure, chlorine, fluorine, nitro and other functional groups on the benzene ring are cleverly arranged, giving it unique chemical activity. Due to the strong electron absorption of nitro groups, the electron cloud density of the benzene ring is reduced, and nucleophilic substitution reactions are more likely to occur. The introduction of fluorine atoms enhances the stability and biological activity of the compound, and chlorine atoms provide various possibilities for subsequent reactions.
    Preparation of 1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene often requires multi-step reaction, through halogenation, nitrification and other series of operations, the reaction conditions are strictly controlled, and the temperature and proportion of reactants will affect the purity and yield of the product. During storage and transportation, due to its active chemical properties, it is necessary to pay attention to moisture protection and sun protection, and avoid contact with strong oxidizing agents and reducing agents to prevent danger.
    Physical & Chemical Properties
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important chemical substance. Its physical properties are often crystalline in appearance, white or nearly colorless in color, with a certain melting point, about [specific melting point value], stable at room temperature and pressure.
    On its chemical properties, because it contains chlorine, fluorine, nitro and other functional groups, its chemical activity is unique. Chlorine atoms can undergo substitution reactions, and can be replaced by other nucleophiles under suitable conditions. The presence of fluorine atoms enhances molecular stability and hydrophobicity. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, and mainly occurs in the meso. This substance is widely used in the field of organic synthesis and is often used as an intermediate to prepare a variety of drugs, pesticides, and functional materials. It is of great value in chemical research and industrial production.
    Technical Specifications & Labeling
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important chemical raw material. Its preparation process should follow the fine method. The selection of raw materials must be pure and free of impurities, and the proportion of each ingredient must be accurate. When reacting, the temperature, pressure and other conditions must be strictly controlled, and there should be no difference at all.
    The quality standard of this product should be a specific color and no foreign matter impurities. Its purity must reach a very high level, and the impurity content must be strictly controlled in a very low range. The physical parameters such as melting point and boiling point must also meet the established specifications to be qualified.
    Only according to this process specification and quality standard can high-quality 1-Chloro-2,3-Difluoro-4-Nitrobenzene be prepared to meet the needs of all parties and play its role in the chemical industry.
    Preparation Method
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important chemical compound. Its preparation method is quite critical.
    In terms of raw materials, it is necessary to carefully select suitable starting materials. The commonly used combination of raw materials can be prepared through a specific reaction. In the preparation process, the reaction steps are rigorous and orderly. The starting material undergoes a multi-step reaction, first substituting a specific group, and then undergoing a series of conversions.
    In the reaction step, the first step is often to allow the raw material to undergo a nucleophilic substitution reaction at a suitable temperature and in the presence of a catalyst, so that the chlorine atom is introduced into a specific position. Subsequently, the reaction conditions are adjusted so that the fluorine atom gradually replaces the corresponding hydrogen atom, which requires strict reaction environment. Finally, nitro groups are introduced precisely through nitrification.
    The activation mechanism is indispensable. Specific catalysts can reduce the activation energy of the reaction and accelerate the reaction process. Suitable pH, temperature and pressure environments can also effectively promote the progress of each step of the reaction, ensuring the yield and purity of the product. In this way, 1-Chloro-2,3-Difluoro-4-Nitrobenzene can be efficiently prepared.
    Chemical Reactions & Modifications
    Wenfu 1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene, its chemical reaction and change, I will try to study it.
    The chemical reaction of the husband is the change of the phase of the substance. The reaction of this compound is related to its structure and properties. The positions of chlorine, fluorine and nitro all affect the direction of its reaction. Chlorine can be replaced by nucleophiles, because of its halogen atom, it is easy to separate and lead to other groups. Although fluorine is small, it has strong electronegativity, and its stability and modification activity. Nitro has strong electrosorption, which makes the electron cloud of the benzene ring spread out, the adjacent para-activity decreases, and the meta-position increases relatively.
    To change its properties, or to adjust the law, such as temperature, pressure, catalyst. To raise its temperature, it should be accelerated, molecular energy should be increased, and effective contact should also be increased. Catalyst, lower the energy barrier of the response, so that it is easy to do. Or change its structure, increase or decrease a certain foundation, in order to achieve the required properties, in medicine, agriculture, and materials, are of great use, and can be the foundation of new things to meet all kinds of requirements.
    Synonyms & Product Names
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important chemical substance. In our field of chemical research, this substance is often found in the literature under many synonymous names and trade names.
    Its synonymous name is derived from its chemical structure and properties. From the structural analysis, because it contains functional groups such as chloro, fluoro and nitro, it is also called by different functional groups.
    As for the trade names, they are produced by different manufacturers to show their uniqueness. Although the names are mixed, they all refer to this specific chemical substance. In the process of chemical research, it is crucial to understand its synonymous names and trade names. It can enable researchers to communicate accurately, avoid errors due to name ambiguity in experimental design and results comparison, and promote the smooth development of chemical research and knowledge inheritance.
    Safety & Operational Standards
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is an important chemical. During its preparation and use, safety and operating practices are of paramount importance.
    All operations involving this substance must be done in a well-ventilated place. This is because the substance may be toxic and irritating. If it is operated in a poorly ventilated place, its volatile gaseous components may easily cause the operator to inhale, damage the respiratory system, or even endanger life.
    Operators must wear complete protective equipment, such as protective clothing, protective gloves and protective masks. Protective clothing should be able to effectively block the substance from contacting the skin, gloves should be chemically resistant, and face masks can protect the eyes to prevent it from splashing into the eyes and causing irreparable damage.
    For storage, 1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its certain chemical activity, high temperature or open flame may cause dangerous chemical reactions, causing fire or explosion.
    During operation, the use of this substance must be accurate to avoid waste and environmental hazards caused by excessive use. In the event of leakage, emergency measures should be taken immediately. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection; in the case of a large leak, it is necessary to evacuate personnel in time, seal off the scene, and notify professional emergency response personnel.
    In addition, equipment using this substance also needs to be regularly inspected and maintained to ensure that it is in good operating condition and avoid material leakage due to equipment failure. Adherence to operating standards and implementation of safety measures are the keys to ensuring personnel safety and production stability, and must not be slack.
    Application Area
    1-Chloro-2,3-difluoro-4-nitrobenzene is also the essence of chemistry. It is widely used in the field of medicine, and can be used to make special agents and treat various diseases. Cover its unique structure, can enter the focus, adjust the body often. In the land of agriculture, it can be used as a good agent to protect seedlings and insecticides, and keep the harvest abundant. And in the industry of materials, it can participate in the production of special materials, additive properties, make it strong and durable, and use it for a long time. Its nature is lively, and it can combine with various substances to form a variety of qualities and meet the needs of the world. Therefore, 1-chloro-2,3-difluoro-4-nitrobenzene is actually a useful thing, and it has its work in many domains. It is important for the industry and promotes the progress of the world.
    Research & Development
    Today there is a product named 1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene. As a chemical researcher, I am very dedicated to its research and development.
    This compound has unique characteristics. The combination of chlorine, fluorine and nitro groups in its structure gives it many potential uses. After repeated experiments and investigations, its chemical activity may be found in the field of organic synthesis.
    In order to promote its development, we study various reaction conditions, hoping to improve the yield and purity. Optimizing the process, reducing energy consumption and reducing pollution are the key to development. Although there is a long way to go, I firmly believe that with unremitting efforts, this compound will surely shine in the fields of materials science, drug research and development, and contribute to scientific and technological progress.
    Toxicity Research
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is a chemical substance, and its toxicity study is quite important. This substance, a genus of chlorine, fluorine, and nitro, may have unique chemical properties, causing signs of toxicity.
    Taste, the existence of nitro groups may cause chemical reactions in organisms, damaging the structure and energy of cells. The reactivity of fluorine atoms, or changing the lipophilicity of substances, promotes its entry into biological membranes, and increases the role of biomolecules. And chlorine atoms are not idle, or involve toxicological mechanisms.
    However, if you want to know its toxicity, you must use scientific methods to test various biological models. To observe its influence on cell growth and metabolism, and to explore the rules of its distribution and metabolism in animals. Only in this way, Fang Ming 1-Chloro-2,3-Difluoro-4-Nitrobenzene toxicity is the basis for protection and application, avoiding its harm and using it to achieve harmony between chemical industry and safety.
    Future Prospects
    1 - Chloro - 2,3 - Difluoro - 4 - Nitrobenzene is also a chemical product. Today, I have yet to see the development of its future, and there are still many people to look forward to.
    This physical property is special, and it can be used as an important raw material in the process of diversification and reflection. Not yet, it may be used in manufacturing, in order to assist in the research and development of new products and cure diseases. In the field of development, it is also expected to develop its talents, develop high-efficiency and low-toxicity products, and improve the production of crops.
    And its synthesis method is not necessarily more refined. The scientific person studies the theory, seeks better work, improves its efficiency, and reduces its cost. In this way, it can make this thing easier to obtain and apply to all walks of life. I am convinced that in the next few days, 1 - Chloro - 2, 3 - Difluoro - 4 - Nitrobenzene will be greatly colored, and the world will be transformed and related.
    Where to Buy 1-Chloro-2,3-Difluoro-4-Nitrobenzene in China?
    As a trusted 1-Chloro-2,3-Difluoro-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-2,3-Difluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-Chloro-2, 3-Difluoro-4-Nitrobenzene?
    1-Chloro-2,3-difluoro-4-nitrobenzene is also an organic compound. Its main use covers the field of organic synthesis.
    In the synthesis of medicine, it is often a key intermediate. With its structural characteristics, specific functional groups can be introduced, and various biologically active drug molecules can be obtained through a series of reactions. For example, the preparation of antibacterial and anti-inflammatory drugs depends on the participation of this compound in the reaction to assist in the construction of drug molecules, so as to exert its pharmacological effects.
    It is also an important raw material in the synthesis of pesticides. It can be chemically modified to give pesticides better insecticidal and herbicidal properties. Through a specific reaction path, it is converted into high-efficiency, low-toxicity and environmentally friendly pesticide ingredients to protect farmers and mulberry, increase crop yield, and reduce pest and disease disturbances.
    In addition, in the field of materials science, 1-chloro-2,3-difluoro-4-nitrobenzene is also useful. It can be used as a precursor for the synthesis of special functional materials, and can be used in polymerization or other reactions to prepare materials with specific electrical and optical properties for use in electronic devices, optical instruments, etc., to promote the progress and innovation of materials science.
    Its wide range of uses is due to its unique chemical structure and active reaction properties. It has made important contributions in various fields and is one of the important cornerstones of chemical synthesis.
    1-Chloro-2, what are the physical properties of 3-Difluoro-4-Nitrobenzene
    1-Chloro-2,3-difluoro-4-nitrobenzene is also an organic compound. Its physical properties are quite important and related to various chemical applications.
    First appearance, at room temperature, it is mostly white to light yellow crystalline powder. This form is easy to identify, and it is also convenient for storage and transportation. It is quite convenient for the operation of chemical processes.
    As for the melting point, it is about 54 ° C to 58 ° C. The characteristics of the melting point have a great impact on the separation and purification process of the compound. With this melting point range, its purity can be accurately identified according to the method of melting point determination, and during heating treatment, the temperature can be controlled according to the melting point to prevent excessive changes in its morphology, and the accuracy of the reaction can be achieved.
    The other is the boiling point, but the exact boiling point is limited by the data, or there may be differences. However, its boiling point characteristics, in the separation operation such as distillation, have the ability of key guidance, helping chemical workers to divide them from others by the difference in boiling points to obtain pure products.
    Solubility is also an important physical property. 1-Chloro-2,3-difluoro-4-nitrobenzene is insoluble in water, because water is a polar solvent, and the polarity of this compound is weak. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in many organic solvents, such as ether and acetone. This property provides a good choice of reaction medium in organic synthesis reactions, so that the reaction can proceed smoothly.
    In addition, although the density characteristics of this compound are not well-defined, according to its molecular structure and similar compounds, the density may be higher than that of water. The value of density is of great significance in the process of material ratio and phase separation in chemical production.
    In summary, the physical properties of 1-chloro-2,3-difluoro-4-nitrobenzene are of great value in chemical synthesis, separation, storage, and other aspects. They are indispensable knowledge for chemical practitioners to help them use this compound properly to achieve various chemical targets.
    Is 1-Chloro-2, 3-Difluoro-4-Nitrobenzene chemically stable?
    The stability of the chemical properties of 1-chloro-2,3-difluoro-4-nitrobenzene is related to many factors. This compound contains chlorine, fluorine, nitro and other functional groups. Each functional group has its own characteristics and affects each other, resulting in different chemical properties.
    Let's talk about nitro first, which is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, in the nucleophilic substitution reaction, it can make the benzene ring more vulnerable to the attack of nucleophilic reagents. The presence of nitro groups changes the chemical activity of 1-chloro-2,3-difluoro-4-nitrobenzene.
    Chlorine and fluorine atoms are both halogen atoms. Fluorine atoms have a small radius and large electronegativity, which has a great influence on the electron cloud of the benzene ring. The radius of chlorine atoms is larger than that of fluorine, and the substitution positions of the two on the benzene ring also affect the reactivity of compounds. Halogen atoms can undergo substitution reactions under specific conditions, but due to the influence of nitro and other halogen atoms, their reactivity is different from that of single halobenzene.
    Under common conditions, 1-chloro-2,3-difluoro-4-nitrobenzene is relatively stable. In case of extreme conditions such as high temperature, strong alkali, and strong oxidizing agent, its chemical properties change. If in a strong alkali environment, the halogen atom may undergo nucleophilic substitution reaction, and the nitro group may participate in reduction and other reactions. In case of strong oxidants, due to the existence of nitro groups, the compound may be deeply oxidized, resulting in structural and property changes.
    1-chloro-2,3-difluoro-4-nitrobenzene The chemical properties of stable or not depend on the specific environment and conditions. In normal times, it may show a certain stability; however, in a special chemical environment, it is easy to react and its properties are difficult to stabilize.
    What are the synthesis methods of 1-Chloro-2, 3-Difluoro-4-Nitrobenzene
    There are many ways to synthesize 1-chloro-2,3-difluoro-4-nitrobenzene. First, halogenated aromatic hydrocarbons can be used. A suitable halogenated benzene is used as the starting material, and the nitro group is introduced first. For example, under specific conditions, benzene is co-heated with a mixed acid (a mixture of sulfuric acid and nitric acid), and the nitro group is introduced at a specific position in the benzene ring through nitrification reaction. After that, the halogenation step is carried out. By using halogenated reagents, such as reagents containing chlorine and fluorine, chlorine atoms and fluorine atoms are introduced into the benzene ring through careful regulation of reaction conditions, such as temperature, reaction time, reagent ratio, etc., and the corresponding check points are
    Second, it can also start from aromatic hydrocarbons containing fluorine and chlorine. First, nitrate and modify them in an appropriate way. Select suitable nitrogenation reagents and reaction environments to successfully connect the nitro group to the aromatic hydrocarbon ring. Subsequent reactions are used to adjust and supplement the remaining check points of halogen atoms to achieve the synthesis of 1-chloro-2,3-difluoro-4-nitrobenzene.
    Furthermore, the strategy of conversion through intermediates can be considered. First prepare an intermediate with part of the target structure, which may already contain a benzene ring and some of the desired substituents. Then, through a series of organic reactions, such as nucleophilic substitution, elimination, addition, etc., the functional groups in the intermediate body are gradually transformed and modified, and finally 1-chloro-2,3-difluoro-4-nitrobenzene is generated.
    Each synthesis method requires fine control of the reaction conditions, such as precise regulation of temperature, too high or too low may affect the reaction process and product purity; the dosage ratio of reagents is also very important, which is related to the selectivity and yield of the reaction. And the connection between each step must also be properly arranged, so that 1-chloro-2,3-difluoro-4-nitrobenzene can be synthesized efficiently and with high quality.
    1-Chloro-2, 3-Difluoro-4-Nitrobenzene What are the precautions in storage and transportation?
    1-Chloro-2,3-difluoro-4-nitrobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
    First words storage, this material is dangerous and should be stored in a cool and ventilated warehouse. The temperature of the warehouse should not be too high to prevent it from decomposing due to heat or causing other dangerous reactions. Under the high temperature of the cover, its chemical activity may increase, but the stability will decrease, which is prone to accidents. And it is necessary to keep away from fire and heat sources, both of which can cause fire or explosion. Fire, heat sources may cause it to burn, and once such organic compounds burn, it is quite difficult to fight.
    Furthermore, it should be stored separately from oxidants and edible chemicals, and must not be mixed. Oxidants have strong oxidizing properties, or react violently with the compound, causing an explosion; edible chemicals are mixed with it, if there is leakage, or cause pollution, endangering food safety and human health. Storage places should also be equipped with suitable materials to contain leaks, such as sand, vermiculite, etc., to prevent the spread of harmful substances after leakage and pollute the environment.
    As for transportation, there are also many details. Before transportation, be sure to ensure that the packaging is complete and the loading is safe. If the packaging is damaged, it may leak during transportation. And the means of transportation must be clean, dry, and no other substances that can react with it remain. During transportation, the traffic should be stable to avoid bumps and shocks to prevent damage to the packaging. Transport personnel should also be familiar with the dangerous characteristics of the chemical and emergency treatment methods. In case of emergencies, they can respond in time to reduce the harm. In short, the storage and transportation of 1-chloro-2,3-difluoro-4-nitrobenzene should be cautious and follow the norms to ensure safety.