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What is the chemical structure of 1-Chloro-2- [ (1Z) -3-Chloro-2- (4-Fluorophenyl) Prop-1-En-1-Yl] Benzene?
1-Chloro-2- [ (1Z) -3-chloro-2- (4-fluorophenyl) propane-1-ene-1-yl] benzene, this is an organic compound. According to its naming, its structure can be inferred according to the chemical naming rules.
It can be seen from "1-chloro-2-" that there are substituents at the 1st and 2nd positions of the benzene ring, respectively. The 1st position is a chlorine atom, which is directly connected to the benzene ring. The substituent at position 2 is [ (1Z) -3 -chloro-2- (4 -fluorophenyl) propane-1-ene-1-yl].
For [ (1Z) -3 -chloro-2- (4 -fluorophenyl) propane-1-ene-1-yl], where " (1Z) " indicates that the configuration of the double bond is Z-type, that is, the larger groups at both ends of the double bond are on the same side. " 3-Chloro "means that there is a chlorine atom substituted at position 3 of propane-1-ene." 2- (4-fluorophenyl) "means that there is a phenyl group attached at position 2 of propane-1-ene, and this phenyl group is replaced by a fluorine atom at position 4. Propane-1-ene indicates that this is a propylene-based structure containing a carbon-carbon double bond at position 1, and the 1 position of this propylene group is connected to the 2 position of the benzene ring.
To sum up, in the structure of this compound, the No. 1 position of the benzene ring is a chlorine atom, and the No. 2 position is connected with a propylene group containing a chlorine atom and a fluorophenyl group of a specific configuration. In this way, the chemical structure of this compound can be clarified.
What are the physical properties of 1-Chloro-2- [ (1Z) -3-Chloro-2- (4-Fluorophenyl) Prop-1-En-1-Yl] Benzene?
1-Chloro-2 - [ (1Z) -3-chloro-2 - (4-fluorophenyl) propane-1-enyl-1-yl] benzene is one of the organic compounds. Its physical properties are particularly important, so let me describe them in detail.
Looking at its properties, under normal circumstances, it may be a colorless to light yellow liquid, pure or have a specific clarity, but if it contains impurities, it may be slightly cloudy. Its smell may be slightly irritating, although not pungent and intolerable, but it is also one end of its characteristics.
As for the melting point, it has been determined by various experiments to be within a certain temperature range. This temperature is the critical value for the compound to change from solid to liquid. The determination of the melting point is crucial in the identification and purification of the compound. Its boiling point is also fixed. Under specific pressure conditions, the temperature at which a liquid boils into a gaseous state is an important indicator of the substance. The boiling point is closely related to the intermolecular forces, and the molecular structure of this compound determines that its boiling point is in the corresponding range.
Furthermore, its density is also important for physical properties. Compared with water, it is either light or heavy, and this characteristic is related to its distribution in the liquid phase system. If the density is greater than water, it will settle in the aqueous solution; if it is less than water, it will float on the water.
In terms of solubility, the compound may have a certain solubility in organic solvents such as ethanol and ether. The polarity and molecular structure of the organic solvent interact with the compound to cause it to dissolve. However, in water, the solubility may be very small due to the degree of matching between molecular polarity and water molecules.
The refractive index is also a parameter that characterizes its physical properties. When light passes through the compound, the degree to which the direction of light changes is reflected by the refractive index. This parameter is also of considerable value when analyzing and identifying the substance.
In summary, the physical properties of 1-chloro-2 - [ (1Z) -3-chloro-2 - (4-fluorophenyl) propylene-1-alkene-1-yl] benzene, such as properties, melting point, boiling point, density, solubility, refractive index, etc., are all key elements for understanding and studying this compound, and have important applications in many fields of organic chemistry.
What are the main uses of 1-Chloro-2- [ (1Z) -3-Chloro-2- (4-Fluorophenyl) Prop-1-En-1-Yl] Benzene?
1-Chloro-2- [ (1Z) -3-chloro-2- (4-fluorophenyl) propane-1-alkenyl] benzene, which is an organic compound. Looking at its structure, derived from a benzene ring, the chlorine atom on it is connected to a specific alkenyl group, and the alkenyl group is connected with a fluorophenyl group, which gives it a variety of characteristics and uses.
In the field of organic synthesis, its use is quite critical. First, it can be used as a key intermediate for the construction of more complex organic molecules. Due to the presence of chlorine atoms and unsaturated double bonds in molecules, functional groups can be converted through many chemical reactions, such as nucleophilic substitution and addition reactions, etc., and then connected with other organic fragments to achieve the construction of complex compounds. For example, under specific catalyst and reaction conditions, chlorine atoms can be replaced by nucleophiles, introducing other functional groups, opening up new paths for subsequent synthesis.
Second, in materials science, it may have potential application value. In view of its fluorophenyl-containing structure, it may endow materials with specific physical and chemical properties, such as enhancing the stability of materials and improving their electrical properties. Or it can be used to develop new polymer materials, electronic materials, etc., to contribute to material innovation.
Third, in the field of medicinal chemistry, such structures may contain certain biological activities. Some compounds with similar structures have been found to have effects on specific biological targets after research, or can become precursors for the development of new drugs. Scientists can modify and optimize their structures to explore their pharmacological activities and search for molecules with medicinal potential.
In summary, 1-chloro-2 - [ (1Z) -3-chloro-2 - (4-fluorophenyl) propylene-1-ene-1-yl] benzene has important uses in organic synthesis, materials science, medicinal chemistry and other fields, providing the basis and possibility for many scientific research and industrial applications.
What are the synthesis methods of 1-Chloro-2- [ (1Z) -3-Chloro-2- (4-Fluorophenyl) Prop-1-En-1-Yl] Benzene?
The synthesis of 1-chloro-2 - [ (1Z) - 3-chloro-2 - (4-fluorophenyl) propane-1-ene-1-yl] benzene has various paths.
First, it can be started by fluorobenzene derivatives. First, 4-fluorobenzaldehyde and a suitable chloroallyl reagent are catalyzed by alkali to carry out hydroxyaldehyde condensation reaction. Weak bases such as potassium carbonate and sodium carbonate can be selected for the base, and alcohols such as ethanol and isopropanol are suitable for the solvent. The reaction temperature should be controlled at 40-60 degrees Celsius for about 3-5 hours, and the key intermediate can be obtained. This intermediate is then reacted with chlorobenzene derivatives, catalyzed by palladium, with triphenylphosphine as ligand and cesium carbonate as base, in toluene solvent, at 100-120 degrees Celsius for 6-8 hours, and then the target product is obtained.
Second, chlorobenzene can also be started from chlorobenzene. First, chlorobenzene reacts with butyl lithium to generate a benzene-lithium reagent, and then condensates with trichloroacetaldehyde to obtain a chlorine-containing intermediate. This intermediate was dechlorinated and isomerized, then reacted with 4-fluorophenylboronic acid, under the conditions of palladium-catalyzed Suzuki reaction, with potassium carbonate as a base, in a mixed solvent of dioxane and water at 80-100 degrees Celsius for 4-6 hours, and finally obtained 1-chloro-2 - [ (1Z) -3-chloro-2 - (4-fluorophenyl) propyl-1-ene-1-yl] benzene.
Or, using 3-chloro-2- (4-fluorophenyl) acronaldehyde as raw material, with chlorobenzene under the catalysis of Lewis acid, such as aluminum trichloride, in dichloromethane solvent, reacted at 0-20 degrees Celsius for 2-4 hours, and the target product can also be synthesized by electrophilic substitution reaction. Each method has its own advantages and disadvantages, and it needs to be selected according to the availability of raw materials and the ease of control of reaction conditions.
What are the precautions for using 1-Chloro-2- [ (1Z) -3-Chloro-2- (4-Fluorophenyl) Prop-1-En-1-Yl] Benzene?
1-Chloro-2 - [ (1Z) -3-chloro-2 - (4-fluorophenyl) propane-1-enyl] benzene, this is an organic compound. During use, many key matters should be paid attention to.
Bear the brunt, safety protection is essential. Because of its chemical activity, or potential harm to the human body. Be sure to wear appropriate protective equipment, such as protective gloves, goggles, and gas masks. Gloves can avoid direct contact with the skin to prevent skin irritation or absorption; goggles can protect the eyes from accidental splashing; gas masks can ensure the safety of the respiratory system in scenarios involving inhalation risks.
Furthermore, the operating environment should not be underestimated. Relevant operations should be carried out in a well-ventilated place, and the best choice is a laboratory with a fume hood. Good ventilation can disperse volatile harmful gases in time, reduce their concentration in the air, and greatly reduce the risk of inhalation. At the same time, the operating table must be kept clean and dry to prevent the presence of impurities or moisture from affecting the reaction or causing other accidents.
Proper storage is also a key link. According to its chemical properties, it should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Because it may be flammable or react violently with oxidizing agents, following this storage requirement can effectively avoid serious accidents such as fires and explosions.
When taking and transferring, the operation should be cautious and precise. Use clean, dry and suitable equipment, such as pipettes, droppers, etc., to operate according to the needs of accurate measurement. During the transfer process, beware of dripping and leakage. Once it occurs, effective cleaning and treatment measures should be taken immediately.
In addition, in-depth understanding of its chemical properties is required. Knowing its stability, reactivity, and possible chemical reactions can help to develop appropriate operating procedures and coping strategies when using it. For example, if it is known that it is sensitive to specific substances, it can be avoided during operation.
After use, the remaining substances and waste should be properly disposed of in accordance with regulations. Do not dump at will, and should be collected and disposed of in accordance with relevant environmental regulations to prevent pollution to the environment.