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1-(Bromomethyl)-4-(Trifluoromethyl)Benzene

1-(Bromomethyl)-4-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

699231

Chemical Formula C8H6BrF3
Molecular Weight 239.03
Appearance Typically a colorless to light - yellow liquid
Boiling Point Around 190 - 195 °C
Density Approximately 1.65 - 1.75 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, toluene
Flash Point Caution: Flammable, flash point likely in the range of 60 - 70 °C
Purity Commercially available in high purity, often >95%
Odor May have a characteristic, pungent odor
Packing & Storage
Packing 100 g of 1-(bromomethyl)-4-(trifluoromethyl)benzene packaged in a sealed glass bottle.
Storage 1-(Bromomethyl)-4-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably in a cabinet dedicated to chemicals. Due to its reactivity and potential hazards, store it separately from oxidizing agents, bases, and incompatible substances to prevent reactions.
Shipping 1-(Bromomethyl)-4-(trifluoromethyl)benzene is shipped in specialized, well - sealed containers. Compliance with chemical shipping regulations is ensured, including proper labeling for its hazardous nature to safeguard transport and handling.
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1-(Bromomethyl)-4-(Trifluoromethyl)Benzene 1-(Bromomethyl)-4-(Trifluoromethyl)Benzene
General Information
Historical Development
The industry of chemical industry is changing with each passing day, and all kinds of products have their own origins. Today, 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene has a history of development.
In the past, chemical industry was just emerging and has not yet been explored. Researchers are committed to the expansion of organic synthesis and strive to create new products. During the long search, halogen-containing organic compounds have been deeply studied. After repeated experiments, bromine, trifluoromethyl and other groups have been cleverly connected to the benzene ring in an exquisite way, resulting in 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene.
Since its inception, it has emerged in various fields such as medicine and materials. Pharmaceutical research and development relies on its characteristics to open up new paths; material creation relies on its advantages to bring out new ones. Over the years, researchers have continuously refined the preparation process, improved yield and purity, and made this product more and more shining on the chemical stage, contributing a lot to the progress of various industries.
Product Overview
Today there is a substance called 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene. Its shape is also, with bromomethyl and trifluoromethyl attached to the benzene ring. This compound has a wide range of uses in the field of organic synthesis.
Looking at its properties, it has unique activity due to the presence of halogenated methyl and special fluorinated groups. The halogen atom of bromomethyl can lead to nucleophilic substitution reactions, so that this substance can combine with various nucleophilic reagents to derive a variety of new compounds. Trifluoromethyl gives it special physical and chemical properties, such as enhancing fat solubility and affecting the distribution of molecular electron clouds. It has potential in drug development and material creation.
The method of preparation, or through a specific organic reaction path, manipulates the reaction conditions, so that the reactants are precisely combined to obtain this product. And its position in the chemical industry, scientific research and exploration is gradually emerging, contributing to the development of many fields and promoting its progress.
Physical & Chemical Properties
1- (Bromomethyl) -4- (Trifluoromethyl) Benzene, which is also a physical property can be investigated. Its color is often from yellow to light-colored transparent liquid, and it has a special taste. In terms of physical properties, the boiling temperature is special. Under a certain force, the boiling degree can make this material difficult. Melting also has its important properties. In a specific low-temperature environment, it can be solidified by the liquid.
The presence of bromomethyl trifluoromethyl in its molecules makes it have a certain anti-activity. Bromine atoms are active, easy to replace and react, and can generate new compounds through nuclear reactions. Trifluoromethyl, due to its strong absorptive properties, affects the distribution of molecules, and affects the rate of transformation in the direction of reaction. Therefore, the physicalization of 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene is important in chemical research and phase application.
Technical Specifications & Labeling
1- (Bromomethyl) -4- (Trifluoromethyl) Benzene technical specifications and identification (commodity parameters), related to the preparation of this compound, the raw materials must be pure and accurate proportions. When synthesizing, it should be operated according to a specific process at a suitable temperature and pressure. The reaction device should be clean and well sealed to prevent impurities from mixing. After being made, its appearance should be a colorless liquid with a specific odor. After precise measurement, parameters such as density and boiling point must meet established standards. In terms of identification, the packaging should clearly indicate the name, chemical formula, hazard warning and other information for identification and safe use, to ensure that this chemical can be used in all aspects of compliance and safety.
Preparation Method
1 - (Bromomethyl) -4 - (Trifluoromethyl) Benzene is an organic compound, and its preparation method, raw materials, production process, reaction steps and catalytic mechanism are crucial.
When preparing, 4 - (Trifluoromethyl) toluene can be selected as the initial raw material, and N - Bromosuccinimide (NBS) can be used as the bromination reagent. Under the action of an initiator such as benzoyl peroxide (BPO), the radical substitution reaction is carried out by heating. In this reaction step, the bromine atom in NBS under the action of the initiator generates an active free radical, attacks the methyl group of 4 - (Trifluoromethyl) toluene, and replaces the hydrogen atom on it to generate the target product 1 - (Bromomethyl) -4 - (Trifluoromethyl) Benzene.
In terms of catalytic mechanism, BPO is decomposed by heat to produce free radicals, which initiates the generation of bromine free radicals in NBS, accelerates the reaction process, and improves the product generation rate and yield. The whole preparation process needs to pay attention to the reaction temperature, reagent ratio and other conditions, and precise control can achieve better results.
Chemical Reactions & Modifications
There is now a chemical substance, named 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene. In the reaction and modification of chemistry, it is crucial.
Looking at the reaction of this substance, its bromomethyl and trifluoromethyl are both active. Bromomethyl can be substituted due to the attack of nucleophiles. If the nucleophile is an alkoxide, it can form an ether; if it is an amine, it can be replaced by an amine.
As for modification, chemical means can be used to adjust its physical and chemical properties. For example, introduce a specific group, or change its spatial structure to suit different purposes. Or make it more soluble, or increase its chemical stability.
In the fields of chemical industry, medicine, etc., this substance can be reacted and modified to produce new materials, research new drugs, etc. It has a great role in the progress of chemistry.
Synonyms & Product Names
1 - (bromomethyl) -4- (trifluoromethyl) benzene, this substance has attracted much attention in today's chemical research. Its alias and trade name are the key to our in-depth investigation.
Looking at ancient chemical literature, although this substance has not been directly described, its related properties and uses can be deduced from similar substances. Today's 1 - (bromomethyl) -4- (trifluoromethyl) benzene may have important functions in the field of organic synthesis. Its alias may be determined by predecessors according to chemical rules due to its structural characteristics; its trade name may involve commercial considerations and is related to the manufacturer and market positioning.
If we want to understand the whole picture, we need to study the origin of its naming in detail. Starting from the chemical structure, explore the relationship between it and the naming of similar compounds. In today's research, the sorting of aliases and trade names helps us to accurately grasp this object, which is of great significance for scientific research and production applications.
Safety & Operational Standards
1 - (bromomethyl) -4 - (trifluoromethyl) benzene, this chemical is related to safety and operating practices, and it is extremely important to detail its details.
It is essential for safety and is the first to be toxic. This substance may be toxic, exposed to various routes, or penetrated through the skin, or inhaled through the respiratory tract, or accidentally ingested. After skin contact, rinse with plenty of water as soon as possible. If you feel unwell, you must seek medical attention immediately. If inhaled, you should quickly move to a fresh place in the air to maintain smooth breathing. If the symptoms do not slow down, seek medical attention urgently. If you eat it by mistake, you must seek medical attention immediately without delay.
Furthermore, the risk of explosion should not be underestimated. In case of open flame, hot topic or risk of combustion and explosion, the storage place must be kept away from fire and heat sources and keep well ventilated. When handling, it should be handled lightly to prevent damage to packaging and containers and cause leakage accidents.
In terms of operating specifications, operators must undergo special training and strictly follow the operating procedures. When operating, protective clothing, protective gloves and goggles are required to protect yourself in all aspects.
In storage, it should be placed in a cool, dry and well-ventilated place, away from oxidants, strong alkalis and other substances to prevent chemical reactions. The storage area should be equipped with suitable materials to contain leaks.
In the unfortunate event of a leak, personnel in the contaminated area of the leak should be quickly evacuated to a safe area and quarantined, and access should be strictly restricted. Emergency responders need to wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let leaks come into contact with combustible substances. In the event of a small leak, collect it with sand, dry lime or soda ash; in the event of a large leak, build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or special collector for recycling or transportation to a waste treatment site for disposal.
Strictly abide by safety and operating standards in order to effectively avoid risks and ensure the safety of personnel and the environment.
Application Area
1 - (bromomethyl) -4 - (trifluoromethyl) benzene has a wide range of applications. In the field of medicinal chemistry, it can be used as a raw material for the synthesis of special drugs, and can help physicians make good medicines to cure diseases. In the field of materials science, it can be the key to creating novel materials, enhancing the characteristics of materials and making them used in various scientific and technological devices. In the industry of organic synthesis, it is often an essential agent, leading to various complex reactions and expanding the structure of organic molecules. Although this thing is invisible and invisible, it has made great achievements in many practical environments, making the progress of science and the prosperity of industry depend on it. It is a chemical quality that cannot be ignored. Its use is limitless. It is waiting for my generation of scholars to explore its mysteries more, so as to make it beneficial to the world.
Research & Development
In recent years, Yu devoted himself to the research of chemical substances, focusing on the compound 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene. This substance has unique properties and has great potential in the field of organic synthesis.
Yu studied its reaction mechanism in detail, and after repeated experiments, observed its effect with various reagents. With a rigorous attitude, temperature control, speed regulation, and strive for accuracy.
At the beginning, the experiment encountered difficulties repeatedly, the product was impure, and the yield was quite low. However, Yu was not discouraged, and analyzed the process and adjusted the parameters. Finally, the method of optimization was obtained to improve the purity and yield of the product.
The research of this compound may be useful in the pharmaceutical, materials and other industries. Yu will continue to study, hoping to expand its application, contribute to the development of the chemical field, and promote the material from research to wider application, so that its potential can be fully developed and it can generate heat in many fields.
Toxicity Research
Since modern times, the chemical refinement has improved, and new substances have emerged one after another. Today there is 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene, which is related to toxicity research and is quite important.
At the beginning of the research, observe its physical properties, know its appearance, and the number of melting boils. Then try it with all kinds of creatures, observe its behavior in the body, and the rules of metabolism. Or enter the genus of rodents, observe its diet, movement, and changes in organs.
The procedure of the experiment, strictly abide by the regulations, prevent it from escaping, and avoid harming the surroundings. The results obtained are recorded in detail in the book. Investigating the toxicity of this substance, it is clear that it may damage the liver and spleen, and the ability to disrupt the nerves. For the health of living beings, there is a hidden danger.
It is the right way to study all kinds of chemical substances, to study toxicity, to protect life, to protect the environment, to advance science and technology, and to be harmless to the world.
Future Prospects
The prospect of the future concerns the 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene. We will devote ourselves to our research, hoping that in the future, we can understand its properties and make good use of it. Hope to find subtle ways to improve the efficiency of preparation of this product, reduce its cost, and make it shine in various fields. Or it can be used to create new drugs, save diseases and suffering; or it can help materials innovation and open up new paths of science and technology. Although the road ahead is long, we scientific researchers should have a determined heart and unremitting pursuit. Hope that in the future, based on this product, we will build a grand building of science and technology, and seek well-being for the world, so that our research will eventually achieve good results and live up to our expectations.
Frequently Asked Questions
What are the main uses of 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene?
1 - (bromomethyl) -4 - (trifluoromethyl) benzene, named p-trifluoromethyl bromide benzyl, is a key intermediate in the field of organic synthesis and is widely used in many fields.
First, in the field of medicinal chemistry, it plays an extremely important role. With its special chemical structure, it can be integrated into many drug molecules as a key structural unit. For example, when developing drugs with specific biological activities, by introducing the substance into the drug molecule, the lipophilicity, metabolic stability and interaction with specific targets of the drug can be significantly improved. Studies have shown that the synthesis of some new anti-tumor drugs is the ingenious use of p-trifluoromethylbenzyl bromide to build a molecular skeleton with unique pharmacological activities, providing new possibilities for conquering tumor diseases.
Second, in the field of materials science, this substance also has extraordinary performance. It can be used to prepare functional polymer materials. For example, when synthesizing some high-performance polymers, it can be used as a reaction monomer or modifier to give the polymer excellent properties such as chemical resistance and low surface energy. Some special-purpose coatings and plastics can still maintain good properties in harsh environments due to the application of trifluoromethylbromide, thus expanding the range of materials used.
Third, in the field of pesticide chemistry, trifluoromethylbenzyl bromide also has an indispensable position. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its unique chemical properties, pesticide varieties with high selectivity, strong insecticidal or bactericidal activity can be designed and synthesized. These pesticides ensure crop yield and quality while minimizing the negative impact on the environment, in line with the needs of modern green agriculture development.
What are the physical properties of 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene
1 - (bromomethyl) -4 - (trifluoromethyl) benzene, is one of the organic compounds. It has unique physical properties, which are described in detail by you today.
First of all, its phase and appearance, under normal temperature and pressure, often appear colorless to light yellow liquid, looking clear and transparent, like the morning dew.

and its boiling point, about a specific temperature range, this temperature causes the compound to change from liquid to gaseous. The boiling point is related to the volatility of the compound, and the boiling point of 1- (bromomethyl) -4 - (trifluoromethyl) benzene makes it volatile and dissipate under specific conditions.
Furthermore, the melting point is also an important physical property. At a certain low temperature, the compound will condense from liquid to solid. The value of the melting point reflects the critical conditions for the transformation of its solid state and liquid state.
In terms of solubility, it has good solubility in organic solvents, such as common ether and dichloromethane, and can be miscible with them, just like water emulsion. However, in water, its solubility is very small, almost insoluble, just like oil floating in water, distinct.
Density is also one of its physical properties. Compared with water, the density of 1- (bromomethyl) -4- (trifluoromethyl) benzene may be different. This property makes it float or sink when mixed with liquids such as water.
In addition, the compound has a certain smell, although it is not pungent and unpleasant, it also has its unique smell, which can be slightly perceived in the air.
In summary, the physical properties of 1- (bromomethyl) -4- (trifluoromethyl) benzene are of great significance in the fields of organic synthesis, chemical production, etc., and are related to its application, separation, storage, and many other aspects.
What are the chemical synthesis methods of 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene?
The synthesis of 1 - (bromomethyl) -4- (trifluoromethyl) benzene is an important task in organic chemistry. A common method can be started with p-trifluoromethyltoluene. P-trifluoromethyltoluene reacts with a brominating agent such as N-bromosuccinimide (NBS) under the conditions of light or a radical initiator. In this reaction, NBS provides a bromine radical to attack the hydrogen atom of the benzyl position of p-trifluoromethyltoluene. Through the radical substitution mechanism, 1 - (bromomethyl) -4- (trifluoromethyl) benzene can be obtained.
Furthermore, the corresponding alcohol can also be used as the starting material. If there is 4- (trifluoromethyl) benzyl alcohol, it can be reacted with hydrobromic acid or bromine-containing reagents. Bromine ions in hydrobromic acid form a good leaving group with alcohol hydroxyl groups. After nucleophilic substitution, the hydroxyl groups are replaced by bromine atoms to obtain the target product 1- (bromomethyl) -4- (trifluoromethyl) benzene.
Another method is to synthesize by a multi-step reaction with halogenated aromatics as starting materials. For example, halogenated benzene containing suitable substituents is first prepared, and then trifluoromethyl is introduced through a metal-catalyzed coupling reaction, and then bromomethyl is introduced at the benzyl position under suitable conditions. This process requires precise control of the reaction conditions. The choice of metal catalyst, reaction temperature, reaction time and other factors have a significant impact on the reaction yield and selectivity. In short, there are various methods for synthesizing 1- (bromomethyl) -4- (trifluoromethyl) benzene, and the appropriate method should be selected according to actual needs and conditions.
What are the precautions for 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene during storage and transportation?
1 - (bromomethyl) -4 - (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be paid careful attention.
The first to bear the brunt is related to the temperature and humidity of storage. This compound should be stored in a cool, dry and well-ventilated place. If the temperature and humidity are too high, it may cause its chemical properties to change. Under high temperature, or accelerate its chemical reaction process, causing adverse consequences such as decomposition; if the humidity is too high, it may be damp and affect the purity and quality.
Furthermore, the storage place must be kept away from fire and heat sources. Due to its certain flammability, in case of open flames and hot topics, there is a risk of combustion and explosion, endangering the safety of personnel and facilities.
The tightness of the packaging is also crucial. Be sure to ensure that the packaging is intact to prevent leakage. Because of its irritation, the volatile gases released after leakage may irritate the respiratory tract, eyes and other parts of the human body, causing damage to human health; and leakage in the environment will also cause pollution to the surrounding environment.
When transporting, it should be operated according to the specifications of hazardous chemicals. Transportation vehicles need to be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. During loading and unloading, operators should load and unload lightly to avoid collisions and falls to prevent package damage.
In addition, smoking and eating should be strictly prohibited in storage and transportation places. This compound may contaminate food, and open flames caused by smoking can easily cause danger. Clear warning signs should also be set up in relevant places to remind personnel to pay attention to safety. Only by strictly following the above precautions can we ensure the safety of 1- (bromomethyl) -4- (trifluoromethyl) benzene during storage and transportation.
What is the market price of 1- (Bromomethyl) -4- (Trifluoromethyl) Benzene?
1 - (bromomethyl) -4- (trifluoromethyl) benzene, an important compound in organic chemistry, is often found in the field of organic synthesis and is widely used. Its market price changes are influenced by multiple factors.
The first to bear the brunt is the cost of raw materials. The price fluctuation of the raw materials required for the synthesis of this compound has a profound impact on its final selling price. If the price of starting materials, reagents, etc. required for preparation rises due to production, supply and demand, or other reasons, the cost of 1 - (bromomethyl) -4- (trifluoromethyl) benzene will also rise, resulting in an increase in market prices.
Furthermore, the difficulty of the preparation process should not be underestimated. If the synthesis process of this compound is complicated, requires multiple steps of reaction, or requires harsh reaction conditions, such as specific temperature, pressure, catalyst, etc., the cost of the production process will inevitably increase, which will be reflected in the market price and will increase accordingly. On the contrary, if the process is optimized to become simpler and more efficient, the price may decrease.
Market supply and demand relationship is also a key factor. If many industries, such as pharmaceuticals, pesticides, materials science, etc., have strong demand for 1- (bromomethyl) -4- (trifluoromethyl) benzene, and the production supply is difficult to meet this demand, the price will rise. On the contrary, if the market demand is weak and there is excess capacity, the price tends to go down.
The size of the production scale is also related to the price. In large-scale production, due to the scale effect, the production cost per unit product may be reduced, such as improved equipment utilization and favorable prices for purchasing raw materials, which in turn makes the market price more competitive. In small-scale production, the unit cost is relatively high, and the price will also be higher.
In addition, the macroeconomic situation, policies and regulations, and the impact of the international market will all affect the market price of 1- (bromomethyl) -4- (trifluoromethyl) benzene. Therefore, in order to determine the exact market price, it is necessary to comprehensively consider the above factors and pay attention to the dynamic situation of the chemical market in real time.