The main use of 1 - (hydroxymethyl) - 4 - methoxybenzene is recorded in "Tiangong Kaiwu", which is used for making incense and other things.
According to "Tiangong Kaiwu", all kinds of products in the world have their own uses. This 1 - (hydroxymethyl) - 4 - methoxybenzene is quite important in the production of spices. The production of spices has always paid attention to the delicate materials used. Adding this substance can make the aroma more mellow, long, and has a unique charm.
The ancient incense-making, craftsmen have carefully studied, and the selection of materials must be fine. 1 - (hydroxymethyl) -4 -methoxybenzene is used in the fragrance formula, either as the finishing touch or as the key to reconciling the fragrances. It can make the flavors of different fragrances blend with each other and complement each other to create a quiet and elegant or rich and strong aroma atmosphere.
Incense is widely used in ceremonies, smoked clothes, clean rooms and other occasions. And this substance can improve the quality of incense, so it plays an important role in these activities indirectly. During the sacrifice, the cigarette curls up, and its fragrance is blended with 1- (hydroxymethyl) -4-methoxybenzene, which is more solemn and solemn, so as to achieve the sincerity of worshiping God and worshiping ancestors. When smoking clothes, the clothes are stained with this fragrance, which can add a bit of elegance. When cleaning the room, the aroma pervades the room, which can make the indoor environment more pleasant and calming.
From this perspective, 1- (hydroxymethyl) -4-methoxybenzene has a position and use that cannot be ignored in ancient incense making and related incense activities.

The physical properties of ether methyl-4-chloronaphthalene are particularly important and are related to many applications. This substance has the following physical properties:
Under normal temperature and pressure, it is often in the shape of a solid state. Its texture may be crystalline, and the particles are delicate. It is like fine ice crystals, and it can be seen as bright under light.
When it comes to the melting point, it is about a certain temperature range. This temperature is the critical point for the substance to change from solid to liquid. Accurate determination of its melting point is extremely beneficial for identification and purity judgment. Because impurities exist in it, the melting point may change, drop or rise, depending on the nature and content of the impurities.
Boiling point is also a key physical property. When the temperature rises to a specific value, ether methyl-4-chloronaphthalene self-liquefies into a gaseous state, and this temperature is the boiling point. The boiling point is determined by the intermolecular forces, and its molecular structure makes the intermolecular forces different, and the boiling points are also different. Knowing the boiling point is essential for operations such as distillation and separation, so that it can be accurately separated from the mixture.
In terms of solubility, it is particularly specific for organic solvents. In some organic solvents, it is soluble, such as common aromatic hydrocarbon solvents such as benzene and toluene. Due to the similar miscibility principle of molecular structure, ether methyl-4-chloronaphthalene can be uniformly dispersed in it. However, in water, the solubility is very small, because its molecular polarity is quite different from water, the polarity of water is strong, and the polarity of the substance is weak, so it is difficult to dissolve.
Density is also a property that cannot be ignored. Its density may be different from that of water, and can be accurately determined by experiments. Density data are of great significance in chemical production, storage, etc., and are related to many aspects of material dosage and container selection.
In addition, the color of ether methyl-4-chloronaphthalene is either colorless or yellowish, and the smell may have a special aromatic aroma. However, it is also necessary to smell it carefully, because it may be toxic. The various physical properties are interrelated, and together outline the characteristics of the substance, laying the foundation for its research and application.

(Alcohol methyl) -4 -thiophene, an organic compound with multiple chemical properties, is very important in the field of organic synthesis.
Bearing the brunt, it has the property of substitution reaction. Due to its structure, the carbon atoms attached to the thiophene ring and (alcohol methyl) have different electron cloud densities, which can attract electrophilic reagents. In the case of halogenated reagents, such as bromine or chlorine, under appropriate conditions, the hydrogen atoms on the thiophene ring or (alcohol methyl) will be replaced by halogen atoms. This substitution reaction can lay the foundation for the subsequent construction of more complex organic molecules, because after the introduction of halogen atoms, many reactions, such as nucleophilic substitution, can be used to connect other functional groups.
Furthermore, it may also be oxidized. The hydroxyl group in (alcohol methyl) can be oxidized by a specific oxidant. In case of mild oxidants, such as Sarit reagent, the hydroxyl group may be oxidized to an aldehyde group; in case of stronger oxidants, such as potassium permanganate, the hydroxyl group may be further oxidized to a carboxyl group. Although the thiophene ring is relatively stable, it may also be destroyed or oxidized to open the ring under strong oxidation conditions.
In addition, the compound may also participate in addition reactions. As a conjugated system, the thiophene ring exhibits addition activity to certain electrophilic or nucleophilic reagents. For example, with some unsaturated compounds, under the action of specific catalysts, [4 + 2] cycloaddition reactions can occur, generating new cyclic compounds and enriching the structural diversity of molecules.
In acid-base environments, (alcohol methyl) -4-thiophene also behaves differently. Because the hydroxyl group has a certain acidity, in the strong base environment, the hydroxyl hydrogen can be taken away by the base to form the corresponding alkoxide negative ion, which is quite active in nucleophilic reactions. At the same time, although the nitrogen atom of the thiophene ring is weakly basic, it may accept protons in the strong acid environment, which affects the electron cloud distribution and reactivity of the molecule.
In conclusion, the chemical properties of (alcohol methyl) -4-thiophene are rich and diverse. With the in-depth understanding and rational use of these properties, organic synthesis chemists can skillfully design and realize the synthesis of various complex organic compounds.

To prepare 1- (hydroxymethyl) -4 -bromobenzene, the following methods can be used:
First, p-bromotoluene is used as the starting material. First, p-bromotoluene and N-bromosuccinimide (NBS) are light-reacted in a carbon tetrachloride solvent in the presence of an initiator such as benzoyl peroxide. This reaction takes advantage of the reactivity of benzyl hydrogen. NBS can selectively replace benzyl hydrogen with bromine atoms to obtain p-bromobenzyl bromide. Subsequently, p-bromobenzyl bromide is reacted with ulotropine, and then hydrolyzed with dilute acid to introduce hydroxymethyl to obtain 1- (hydroxymethyl) -4 -bromobenzene. The steps of this pathway are clear, the reaction conditions of each step are relatively mild, and the yield is also considerable.
Second, p-bromobenzoic acid is used as the starting material. First, p-bromobenzoic acid is reduced with lithium aluminum hydride (LiAlH) in anhydrous ethyl ether and other solvents, and the carboxyl group can be reduced to hydroxymethyl to obtain p-bromobenzyl alcohol. After that, p-bromobenzyl alcohol reacts with phosphorus tribromide (PBr
) or hydrobromic acid, and the hydroxyl group is replaced by bromine atoms, and the final product is 1 - (hydroxymethyl) -4 -bromobenzene. However, lithium aluminum hydride is a strong reducing agent, and attention should be paid to anhydrous operation when using it for safety.
Third, p-bromo First, p-bromophenol and formaldehyde undergo phenolic condensation reaction under the action of basic catalysts such as sodium hydroxide, and hydroxymethyl groups can be introduced into the phenolic hydroxyl group to obtain 4-bromo-2-hydroxybenzyl alcohol. Then it reacts with hydrobromic acid or phosphorus tribromide to replace the hydroxyl group with bromine, and under appropriate conditions, the phenolic hydroxyl group can be converted into bromine atoms to obtain the target product. Although the raw materials are common in this process, there are slightly more reaction steps, and the reaction conditions need to be carefully controlled to ensure the smooth progress of each step of the reaction and improve the purity and yield of the product.

When storing and transporting ether-4-thiophene, pay attention to many matters.
First, be careful to check the environmental conditions. These two are delicate and sensitive to temperature and humidity. High temperature can easily cause it to decompose and deteriorate, so it should be stored in a cool place. The temperature is usually controlled at 5 to 25 degrees Celsius, and it must be moisture-proof. The air humidity should be maintained at 40% to 60%. If the humidity is too high, or adverse reactions such as hydrolysis can damage its quality.
Second, the packaging must be proper. Use a sealed and corrosion-resistant container to prevent contact with air, moisture and other substances. If it is held in a glass or special plastic container, it can block external factors from interfering. At the same time, the name of the product, properties, hazards and other information should be clearly marked on the outside of the container for identification and treatment.
Third, do not slack off during transportation. To avoid violent vibration and collision, its structure or damage. Smooth transportation should be selected, and the means of transportation should be clean, dry, and free of other chemical residues to prevent cross-contamination.
Fourth, fire and explosion protection is also the key. Ether-4-thiophene is flammable, and fireworks should be strictly prohibited in the transportation storage place, and fire protection facilities should be prepared. Operators must be professionally trained and familiar with emergency treatment methods. In case of emergencies, they can respond quickly and reduce hazards.
Fifth, isolation from other substances should not be ignored. Do not co-store and transport with oxidants, strong acids, strong bases, etc., because it is easy to chemically react with it and cause danger. It must be classified and stored and transported according to its chemical properties to ensure its safety.